Cited by 615Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular and exercise physiology

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes

Open access

Holten, Mads K., Zacho, Morten, Gaster, Michael, Juel, Carsten, Wojtaszewski, Jørgen F.P., Dela, Flemming·2004·Diabetes

DOI 10.2337/diabetes.53.2.294

Open this paper in CoChat — free account Open PDF

Abstract

Strength training represents an alternative to endurance training for patients with type 2 diabetes. Little is known about the effect on insulin action and key proteins in skeletal muscle, and the necessary volume of strength training is unknown. A total of 10 type 2 diabetic subjects and 7 healthy men (control subjects) strength-trained one leg three times per week for 6 weeks while the other leg remained untrained. Each session lasted no more than 30 min. After strength training, muscle biopsies were obtained, and an isoglycemic-hyperinsulinemic clamp combined with arterio-femoral venous catheterization of both legs was carried out. In general, qualitatively similar responses were obtained in both groups. During the clamp, leg blood flow was higher (P < 0.05) in trained versus untrained legs, but despite this, arterio-venous extraction glucose did not decrease in trained legs. Thus, leg glucose clearance was increased in trained legs (P < 0.05) and more than explained by increases in muscle mass. Strength training increased protein content of GLUT4, insulin receptor, protein kinase B-α/β, glycogen synthase (GS), and GS total activity. In conclusion, we found that strength training for 30 min three times per week increases insulin action in skeletal muscle in both groups. The adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2337/diabetes.53.2.294

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Effects of Exercise on Glycemic Control and Body Mass in Type 2 Diabetes Mellitus: A Meta-analysis of Controlled Clinical Trials
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2001) · JAMA · doi:10.1001/jama.286.10.1218 · Cited by 1,889
A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose
Thomas, J. A., Schlender, K. K., & Larner, J. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90127-9 · Cited by 1,198
A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes
Castaneda, C., Layne, J. E., Munoz-Orians, L., Gordon, P. L., Walsmith, J., Foldvari, M., Roubenoff, R., Tucker, K. L., & Nelson, M. E. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2335 · Cited by 844
High-intensity resistance training improves glycemic control in older patients with type 2 diabetes
Dunstan, D. W., Daly, R. M., Owen, N., Jolley, D., de Courten, M., Shaw, J., & Zimmet, P. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1729 · Cited by 771
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
Kim, Y.-B., Nikoulina, S. E., Ciaraldi, T. P., Henry, R. R., & Kahn, B. B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6928 · Cited by 487
Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
Krook, A., Björnholm, M., Galuska, D., Jiang, X. J., Fahlman, R., Myers, M. G., Wallberg-Henriksson, H., & Zierath, J. R. (2000) · Diabetes · doi:10.2337/diabetes.49.2.284 · Cited by 375
Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM. Effects of branched-chain amino acid supplements
Mourier, A., Gautier, J.-F., Kerviler, E. D., Bigard, A. X., Villette, J.-M., Garnier, J.-P., Duvallet, A., Guezennec, C. Y., & Cathelineau, G. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.385 · Cited by 361
Blood flow and muscle metabolism: a focus on insulin action
Clark, M. G., Wallis, M. G., Barrett, E. J., Keske, M. A., Richards, S. M., Clerk, L. H., & Rattigan, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00408.2002 · Cited by 359
Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes
Maiorana, A., O’Driscoll, G., Goodman, C., Taylor, R. R., & GREEN, D. J. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00368-0 · Cited by 353
Insulin-Stimulated Muscle Glucose Clearance in Patients With NIDDM: Effects of One-Legged Physical Training
Dela, F., Larsen, J. J., Mikines, K. J., Ploug, T., Petersen, L. N., & Galbo, H. (1995) · Diabetes · doi:10.2337/diab.44.9.1010 · Cited by 286
Self-citation

Show all 48 references

Sorted by citations

Items 201–300 of 612

Skeletal Muscle and Metabolic Health: How Do We Increase Muscle Mass and Function in People with Type 2 Diabetes?
Al‐Ozairi, E., Alsaeed, D., Alroudhan, D., Voase, N., Hasan, A., Gill, J. M. R., Sattar, N. A., Welsh, P. I., Gray, C. M., Boonpor, J., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa835 · Cited by 41
Treadmill exercise training fails to reverse defects in glucose, insulin and muscle GLUT4 content in the db/db mouse model of diabetes
Sennott, J., Morrissey, J., Standley, P. R., & Broderick, T. L. (2008) · Pathophysiology · doi:10.1016/j.pathophys.2008.06.001 · Cited by 43
The role of CaMKII in diabetic heart dysfunction
Daniels, L. J., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015) · Heart Failure Reviews · doi:10.1007/s10741-015-9498-3 · Cited by 38
Effect of recreational physical activity on insulin levels in Mexican/Hispanic children
Macías-Cervantes, M. H., Malacara, J. M., Garay‐Sevilla, M. E., & Díaz-Cisneros, F. J. (2009) · European Journal of Pediatrics · doi:10.1007/s00431-008-0907-7 · Cited by 39
Insulin-Stimulated Muscle Glucose Uptake and Insulin Signaling in Lean and Obese Humans
Ramos, P. A., Lytle, K. A., Delivanis, D. A., Nielsen, S., LeBrasseur, N. K., & Jensen, M. D. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa919 · Cited by 40
Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle
Howlett, K. F., Sakamoto, K., Garnham, A., Cameron-Smith, D., & Hargreaves, M. (2007) · Diabetes · doi:10.2337/db06-1398 · Cited by 37
Exercise-Induced Improvements to Whole Body Glucose Metabolism in Type 2 Diabetes: The Essential Role of the Liver
Warner, S. O., Yao, M. V., Cason, R. L., & Winnick, J. J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00567 · Cited by 43
Role of habitual physical activity in modulating vascular actions of insulin
Padilla, J., Olver, T. D., Thyfault, J. P., & Fadel, P. J. (2015) · Experimental Physiology · doi:10.1113/ep085107 · Cited by 38
High-intensity aerobic, but not resistance or combined, exercise training improves both cardiometabolic health and skeletal muscle mitochondrial dynamics
Ruegsegger, G. N., Pataky, M. W., Simha, S., Robinson, M. M., Klaus, K. A., & Nair, K. S. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00405.2023 · Cited by 38
The training stimulus experienced by the leg muscles during cycling in humans
McPhee, J. S., Williams, A. G., Stewart, C. E., Baar, K., Pérez‐Schindler, J., Aldred, S., Maffulli, N., Sargeant, A. J., & Jones, D. A. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2008.045658 · Cited by 37
Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients
Dela, F., & Stallknecht, B. M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00765.2009 · Cited by 37
Self-citation
Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview
Ghosh, S., Golbidi, S., Werner, I., Verchere, C. B., & Laher, I. (2010) · Clinical Science · doi:10.1042/cs20090389 · Cited by 37
Not All Exercises Are Created Equal
Paoli, A., & Bianco, A. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.10.011 · Cited by 36
Impedance Analysis to Evaluate Nutritional Status in Physiological and Pathological Conditions
Catapano, A., Trinchese, G., Cimmino, F., Petrella, L., D’Angelo, M., Maio, G. D., Crispino, M., Cavaliere, G., Monda, M., & Mollica, M. P. (2023) · Nutrients · doi:10.3390/nu15102264 · Cited by 40
“An additional study [68] sh wed that di betics who exercised 30 min a day three tim s week were shown to have better glycemic control due to i cr ased uscle mass.”
Background
In Defense of Sugar: A Critique of Diet-Centrism
Archer, E. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.04.007 · Cited by 39
Effects of progressive strength training on muscle mass in type 2 diabetes mellitus patients determined by computed tomography
Cauza, E., Strehblow, C., Metz-Schimmerl, S., Strasser, B., Hanusch-Enserer, U., Kostner, K., Dunstan, D., Fasching, P., & Haber, P. (2009) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-009-0641-4 · Cited by 36
Meta-analysis: Resistance Training Improves Cognition in Mild Cognitive Impairment
Zhang, L., Li, B., Yang, J., Wang, F., Tang, Q., & Wang, S. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1186-1272 · Cited by 42
Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high‐force muscle contraction
Katta, A., Karkala, S. K., Wu, M., Meduru, S., Desai, D. H., Rice, K. M., & Blough, E. R. (2009) · Muscle & Nerve · doi:10.1002/mus.21255 · Cited by 37
Orcein-Related Small Molecule O4 Destabilizes hIAPP Protofibrils by Interacting Mostly with the Amyloidogenic Core Region
Zou, Y. F., Qian, Z., Sun, Y., Wei, G., & Zhang, Q. (2017) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.7b08652 · Cited by 35
Exercise as a tool to mitigate metabolic disease
Esteves, J. V. D. C., & Stanford, K. I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2024 · Cited by 39
Functional and Muscular Adaptations in an Experimental Model for Isometric Strength Training in Mice
Krüger, K., Geßner, D. K., Seimetz, M., Banisch, J., Ringseis, R., Eder, K., Weißmann, N., & Mooren, F. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079069 · Cited by 33
Effects of 12-week circuit exercise program on obesity index, appetite regulating hormones, and insulin resistance in middle-aged obese females
Kang, S.-J., Kim, J.-H., Gang, Z., Yook, Y.-S., Yoon, J.-R., Ha, G.-C., & Ko, K.-J. (2018) · Journal of Physical Therapy Science · doi:10.1589/jpts.30.169 · Cited by 34
Hyperandrogenism Enhances Muscle Strength After Progressive Resistance Training, Independent of Body Composition, in Women With Polycystic Ovary Syndrome
Kogure, G. S., Silva, R. C., Furtado, C. L. M., Ribeiro, V. B., Pedroso, D. C. C., de Melo, A. S., Ferriani, R. A., & dos Reis, R. M. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002714 · Cited by 33
Resistance Training in Type II Diabetes Mellitus: Impact on Areas of Metabolic Dysfunction in Skeletal Muscle and Potential Impact on Bone
Wood, R. J., & O’Neill, E. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/268197 · Cited by 32
Muscular Fitness and Cardiovascular Risk Factors in Children and Adolescents: A Systematic Review
de Lima, T. R., Martins, P. C., Guerra, P. H., & Silva, D. A. S. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002840 · Cited by 33
Spirulina Supplementation with High-Intensity Interval Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity
Supriya, R., Delfan, M., Saeidi, A., Samaie, S. S., Kiyumi, M. H. A., Escobar, K. A., Laher, I., Heinrich, K. M., Weiss, K., Knechtle, B., et al. (2023) · Nutrients · doi:10.3390/nu15234891 · Cited by 34
Diabetes and Stem Cell Function
Fujimaki, S., Wakabayashi, T., Takemasa, T., Asashima, M., & Kuwabara, T. (2015) · BioMed Research International · doi:10.1155/2015/592915 · Cited by 34
Efficacy and Safety of Resistance Training for Coronary Heart Disease Rehabilitation: A Systematic Review of Randomized Controlled Trials
Fan, Y., Yu, M., Li, J., Zhang, H., Liu, Q., Zhao, L., Wang, T., & Xu, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.754794 · Cited by 36
Relationships between Exercise, Mitochondrial Biogenesis and Type 2 Diabetes
Joseph, A.-M., & Hood, D. A. (2014) · Medicine and sport science/Medicine and sport · doi:10.1159/000357335 · Cited by 32
Effect of acute exercise on glucose tolerance following post-exercise feeding
Venables, M., Shaw, C. S., Jeukendrup, A. E., & Wagenmakers, A. J. M. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0464-1 · Cited by 31
“Studies have reported that both aerobic and RE training in rats increased GLUT4 protein content and insulin stimulated glucose uptake ( Holten et al. 2004; Yaspelkis et al. 2002).”
Influential
The effect of different training modes on skeletal muscle microvascular density and endothelial enzymes controlling NO availability
Cocks, M. S., & Wagenmakers, A. J. M. (2015) · The Journal of Physiology · doi:10.1113/jp270329 · Cited by 37
Strength Training and Insulin Resistance: The Mediating Role of Body Composition
Niemann, M. J., Tucker, L. A., Bailey, B. W., & Davidson, L. E. (2020) · Journal of Diabetes Research · doi:10.1155/2020/7694825 · Cited by 30
“Results showed that glucose clearance increased in the trained leg compared to the untrained leg in both the men with diabetes and the healthy controls [15].”
Influential
Influence of exercise training on diabetic kidney disease: A brief physiological approach
Amaral, L. S. D. B., Souza, C. S., Lima, H. N., & Soares, T. D. J. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220928986 · Cited by 32
“Exercise training improves glucose homeostasis Skeletal muscle is known to play an important role in glucose homeostasis by increasing insulin-mediated glucose uptake117 and activation of AMP-activated protein kinase (AMPK) during exercise.118 Theses mechanisms have been demonstrated in both healthy individuals and pa…”
Background
Improvement in Muscle Strength and Metabolic Parameters Despite Muscle Mass Loss in the Initial Six Months After Bariatric Surgery
Coral, R. V., Bigolin, A. V., Machry, M. C., Menguer, R. K., Pereira‐Lima, J. C., Contin, I., & Stock, P. V. (2021) · Obesity Surgery · doi:10.1007/s11695-021-05634-0 · Cited by 30
Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State
Lewis, C. T. A., & Ochala, J. (2022) · Physiology · doi:10.1152/physiol.00018.2022 · Cited by 30
The Effect of Metformin on Glucose Homeostasis During Moderate Exercise
Hansen, M., Palsøe, M. K., Helge, J. W., & Dela, F. (2014) · Diabetes Care · doi:10.2337/dc14-1480 · Cited by 31
Self-citation
Physical activity and exercise in the management of type 2 diabetes: where to start?
Harrington, D., & Henson, J. (2021) · Practical Diabetes · doi:10.1002/pdi.2361 · Cited by 29
Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat
Katta, A., Kakarla, S. K., Wu, M., Paturi, S., Gadde, M. K., Arvapalli, R., Kolli, M. B., Rice, K. M., & Blough, E. R. (2009) · Experimental Diabetes Research · doi:10.1155/2009/384683 · Cited by 29
Exercise as Medicine: Key Concepts in Discussing Physical Activity with Patients who have Type 2 Diabetes
Armstrong, M. J., & Sigal, R. J. (2015) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2015.09.081 · Cited by 31
Resistance Training for Individuals With Cardiovascular Disease
Vincent, K. R., & Vincent, H. K. (2006) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200607000-00002 · Cited by 28
Resistance training: the multifaceted side of exercise
Paoli, A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00541.2011 · Cited by 28
Metabolic effects of resistance or high-intensity interval training among glycemic control-nonresponsive children with insulin resistance
Álvarez, C., Ramírez‐Vélez, R., Ramírez‐Vélez, R., Martínez‐Salazar, C., Castro‐Sepúlveda, M., Alonso-Martínez, A. M., & Izquierdo, M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.177 · Cited by 30
Perspective: Pragmatic Exercise Recommendations for Older Adults: The Case for Emphasizing Resistance Training
Tavoian, D., Russ, D. W., Consitt, L. A., & Clark, B. C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00799 · Cited by 26
Síndrome metabólico: una mirada interdisciplinaria
Barrera, M. D. P., Pinilla, A. E., Cortés, É., Mora, G., & Rodríguez, M. N. (2008) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 25
Exercise Training and Work Task Induced Metabolic and Stress-Related mRNA and Protein Responses in Myalgic Muscles
Sjøgaard, G., Zebis, M. K., Kiilerich, K., Saltin, B., & Pilegaard, H. (2012) · BioMed Research International · doi:10.1155/2013/984523 · Cited by 28
Comparison of muscle strength between Japanese men with and without metabolic syndrome.
Miyatake, N., Wada, J., Saito, T., Nishikawa, H., Matsumoto, S., Miyachi, M., Makino, H., & Numata, T. (2007) · PubMed · doi:10.18926/amo/32883 · Cited by 28
Effect of training status on regional disposal of circulating free fatty acids in the liver and skeletal muscle during physiological hyperinsulinemia.
Iozzo, P., Takala, T., Oikonen, V., Bergman, J., Grönroos, T., Ferrannini, E., Nuutila, P., & Knuuti, J. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2172 · Cited by 31
Impact of Genetic Versus Environmental Factors on the Control of Muscle Glycogen Synthase Activation in Twins
Poulsen, P., Wojtaszewski, J. F. P., Petersen, I., Christensen, K., Richter, E. A., Beck‐Nielsen, H., & Vaag, A. A. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1289 · Cited by 28
Self-citation
Physical inactivity affects skeletal muscle insulin signaling in a birth weight-dependent manner
Mortensen, B., Friedrichsen, M. H., Andersen, N. R., Alibegovic, A. C., Højbjerre, L., Sonne, M. P., Stallknecht, B. M., Dela, F., Wojtaszewski, J. F. P., & Vaag, A. A. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.09.002 · Cited by 27
“The expression of the skeletal muscle glucose transporter, GLUT4, has been positively associated with skeletal muscle glucose uptake following exercise (Holten et al., 2004) and following bed rest (Bienso et al.”
BackgroundSelf-citation
Comparisons of low-intensity versus moderate-intensity combined aerobic and resistance training on body composition, muscle strength, and functional performance in older women
Shiotsu, Y., & Yanagita, M. (2018) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001060 · Cited by 28
Effects of resistance training and nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production
Jangjo-Borazjani, S., Dastgheib, M., Kiyamarsi, E., Jamshidi, R., Rahmati-Ahmadabad, S., Helalizadeh, M., Iraji, R., Cornish, S. M., Mohammadi-Darestani, S., Khojasteh, Z., et al. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1886117 · Cited by 28
Physical training may enhance -cell function in type 2 diabetes
Dela, F., Linstow, M., & Galbo, H. (2004) · Cited by 26
Self-citation
Effects of diet and exercise interventions on diabetes risk factors in adults without diabetes: meta-analyses of controlled trials
Appuhamy, R., Kebreab, E., Simon, M., Yada, R. Y., Milligan, L. P., & France, J. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-127 · Cited by 27
Insulin-Sensitivity Response to a Single Bout of Resistive Exercise in Type 1 Diabetes Mellitus
Jimenez, C. C., Santiago, M. C., Sitler, M. R., Boden, G. H., & Homko, C. J. (2009) · Journal of Sport Rehabilitation · doi:10.1123/jsr.18.4.564 · Cited by 26
Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training
Eikenberg, J. D., Savla, J. T., Marinik, E. L., Davy, K. P., Pownall, J., Baugh, M. E., Flack, K. D., Boshra, S. S., Winett, R. A., & Davy, B. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148009 · Cited by 29
“In addition, RT also improves insulin signaling at the level of skeletal muscle [47].”
Background
Biological mechanisms of stroke prevention by physical activity in type 2 diabetes
Agosti, V., Graziano, S., Artiaco, L., & Sorrentino, G. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01080.x · Cited by 25
Dose-response relationships of resistance training in Type 2 diabetes mellitus: a meta-analysis of randomized controlled trials
Su, W., Tao, M., Ma, L., Tang, K., Xiong, F., Dai, X., & Qin, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1224161 · Cited by 31
Early exercise regimen improves insulin sensitivity in the intrauterine growth-restricted adult female rat offspring.
Garg, M., Thamotharan, M., Oak, S. A., Pan, G., Maclaren, D. C., Lee, P., & Devaskar, S. (2009) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.90473.2008 · Cited by 28
The Comparison between Effects of 12 weeks Combined Training and Vitamin D Supplement on Improvement of Sensory-motor Neuropathy in type 2 Diabetic Women
Nadi, M., Marandi, S. M., Esfarjani, F., Saleki, M., & Mohammadi, M. (2017) · Advanced Biomedical Research · doi:10.4103/2277-9175.205528 · Cited by 25
“[24] Studies have shown that by doing regular exercises, the glucose transferring protein (GLUT-4) level in cells will increase.[21,25] In addition, doing an exercise session with muscular contractions causes the transfer of GLUT-4 to the plasma membrane, and this will increase the glucose transfer capacity into muscu…”
Background
Association of Muscular Fitness and Body Fatness with Cardiometabolic Risk Factors: The FUPRECOL Study
Correa‐Rodríguez, M., Ramírez‐Vélez, R., Correa‐Bautista, J. E., Castellanos-Vega, R. D. P., Arias-Coronel, F., González‐Ruíz, K., Carrillo, H. A., Schmidt‐RioValle, J., & González‐Jiménez, E. (2018) · Nutrients · doi:10.3390/nu10111742 · Cited by 26
Repeated prolonged whole-body low-intensity exercise: effects on insulin sensitivity and limb muscle adaptations
Helge, J. W., Overgaard, K., Damsgaard, R., Sørensen, K., Andersen, J. L., Dyrskog, S., Hermansen, K., Saltin, B., & Wojtaszewski, J. F. P. (2006) · Metabolism · doi:10.1016/j.metabol.2005.08.015 · Cited by 26
“In addition, there is evidence that regular strength training leads to improved insulin sensitivity, most likely because of an increase in muscle mass [3,4].”
BackgroundMethodSelf-citation
The efficacy of resistance exercise training on metabolic health, body composition, and muscle strength in older adults with type 2 diabetes: A systematic review and Meta-Analysis
Feng, M., Gu, L., Zeng, Y., Gao, W., Cai, C., Chen, Y. ‐. I., & Guo, X. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112079 · Cited by 28
Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients
Bazzucchi, I., VITO, G. D., Felici, F., Dewhurst, S., Sgadari, A., & Sacchetti, M. (2015) · Journal of Electromyography and Kinesiology · doi:10.1016/j.jelekin.2015.06.008 · Cited by 24
“Resistance training in particular has been seen to improve both muscle strength and mass as well as insulin sensitivity (Brooks et al., 2007; Cauza et al., 2005; Dunstan et al., 2002; Holten et al., 2004; LeBrasseur et al., 2011; Mann et al., 2014).”
Background
Exercise and health: historical perspectives and new insights
Hargreaves, M. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00242.2021 · Cited by 26
The impact of exercise on insulin action in type 2 diabetes mellitus: Relationship to prevention and control
Colberg, S. R. (2006) · Insulin · doi:10.1016/s1557-0843(06)80018-7 · Cited by 24
Lifestyle Interventions to Reduce Obesity and Diabetes
Hagobian, T. A., & Phelan, S. (2012) · American Journal of Lifestyle Medicine · doi:10.1177/1559827612449600 · Cited by 26
Progressive Resistance Training in Polycystic Ovary Syndrome: Can Pumping Iron Improve Clinical Outcomes?
Cheema, B. S., Vizza, L., & Swaraj, S. (2014) · Sports Medicine · doi:10.1007/s40279-014-0206-6 · Cited by 25
The Resist Diabetes trial: Rationale, design, and methods of a hybrid efficacy/effectiveness intervention trial for resistance training maintenance to improve glucose homeostasis in older prediabetic adults
Marinik, E. L., Kelleher, S. A., Savla, J. T., Winett, R. A., & Davy, B. M. (2013) · Contemporary Clinical Trials · doi:10.1016/j.cct.2013.11.006 · Cited by 23
Effect of adiposity on insulin action after acute and chronic resistance exercise in non-diabetic women
Malin, S. K., Hinnerichs, K. R., Echtenkamp, B. G., Evetovich, T. K., & Engebretsen, B. J. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2725-5 · Cited by 23
Exercise and Vascular Insulin Sensitivity in the Skeletal Muscle and Brain
Olver, T. D., Laughlin, M. H., & Padilla, J. (2019) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000182 · Cited by 23
Heterogeneity in limb fatty acid kinetics in type 2 diabetes
Sacchetti, M., Olsen, D. B., Saltin, B., & van Hall, G. (2005) · Diabetologia · doi:10.1007/s00125-005-1727-1 · Cited by 23
The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Wan, Y., & Su, Z. (2024) · Biological Research For Nursing · doi:10.1177/10998004241246272 · Cited by 28
“RT has the ability to enhance the protein content of GLUT4, and an increase in skeletal muscle mass can boost glucose uptake (Holten et al., 2004).”
A Narrative Review of Non-Pharmacological Strategies for Managing Sarcopenia in Older Adults with Cardiovascular and Metabolic Diseases
Ispoglou, T., Wilson, O. J., McCullough, D., Aldrich, L., Ferentinos, P. P., Lyall, G. K., Stavropoulos‐Kalinoglou, A., Duckworth, L. C., Brown, M. A., Sutton, L., et al. (2023) · Biology · doi:10.3390/biology12070892 · Cited by 24
Glucose homeostasis and cardiovascular disease biomarkers in older alpine skiers
Dela, F., Niederseer, D., Patsch, W., Pirich, C., Müller, E. A., & Niebauer, J. (2011) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2011.01342.x · Cited by 22
Self-citation
The effect of physical exercise and caloric restriction on the components of metabolic syndrome
Torres‐Leal, F. L., de Capitani, M. D., & Tirapegui, J. (2009) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502009000300003 · Cited by 24
Interventions for improving metabolic risk in overweight Latino youth
Davis, J. N., Ventura, E. E., Shaibi, G. Q., Byrd-Williams, C. E., Alexander, K. E., Vanni, A. K., Meija, M. R., Weigensberg, M. J., Spruijt‐Metz, D., & Goran, M. I. (2010) · International Journal of Pediatric Obesity · doi:10.3109/17477161003770123 · Cited by 22
Effectiveness of Resistive Vibration Exercise and Whey Protein Supplementation Plus Alkaline Salt on the Skeletal Muscle Proteome Following 21 Days of Bed Rest in Healthy Males
Kenny, H., Tascher, G., Ziemianin, A., Rudwill, F., Zahariev, A., Chery, I., Gauquelin‐Koch, G., Barielle, M.-P., Heer, M. A., Blanc, S., et al. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00256 · Cited by 24
Linking Physical Activity to Breast Cancer: Text Mining Results and a Protocol for Systematically Reviewing Three Potential Mechanistic Pathways
Lynch, B. M., Milne, R. L., English, D. R., Brown, K. A., Drummond, A. E., Swain, C. T. V., van Roekel, E. H., Moore, M. M., Gaunt, T. R., Martin, R. M., et al. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0435 · Cited by 22
Exercise Interventions to Prevent and Manage Type 2 Diabetes: Physiological Mechanisms
Dela, F., Prats, C., & Helge, J. W. (2014) · Medicine and sport science/Medicine and sport · doi:10.1159/000357334 · Cited by 24
Self-citation
Effect of Resistance Training on Microvascular Density and eNOS Content in Skeletal Muscle of Sedentary Men
Cocks, M. S., Shaw, C. S., Shepherd, S. O., Fisher, J. P., Ranasinghe, A. M., Barker, T. A., Tipton, K. D., & Wagenmakers, A. J. M. (2014) · Microcirculation · doi:10.1111/micc.12155 · Cited by 21
Acceleration training for managing nonalcoholic fatty liver disease: a pilot study
Oh, S., Shida, T., Sawai, A., Maruyama, T., Isobe, T., Okamoto, Y., Someya, N., Tanaka, K., Arai, E., Tozawa, A., et al. (2014) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s68322 · Cited by 22
“It has been reported that resistance training restores insulin sensitivity and increases systemic glucose metabolism through induction and activation of skeletal muscle GLUT4, followed by an increase in glucose uptake by skeletal muscle and induction of glycogen synthesis.(11,30) Resistance training has also been show…”
Increased Muscular 5α-Dihydrotestosterone in Response to Resistance Training Relates to Skeletal Muscle Mass and Glucose Metabolism in Type 2 Diabetic Rats
Horii, N., Sato, K., Mesaki, N., & Iemitsu, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165689 · Cited by 21
The effect of endurance and endurance-strength training on body composition and cardiometabolic markers in abdominally obese women: a randomised trial
Jamka, M., Mądry, E., Krzyżanowska-Jankowska, P., Skrypnik, D., Szulińska, M., Mądry, R., Lisowska, A., Арыстангалиевна, Б. Г., Duś-Żuchowska, M., Gotz‐Więckowska, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90526-7 · Cited by 25
Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance
Skov-Jensen, C., Skovbro, M., Flint, A., Helge, J. W., & Dela, F. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-098 · Cited by 20
Self-citation
Simple Resistance Exercise for 24 Weeks Decreases Alanine Aminotransferase Levels in Patients with Non-Alcoholic Fatty Liver Disease
Takahashi, A., Imaizumi, H., Hayashi, M., Okai, K., Abe, K., Usami, K., Tanji, N., & Ohira, H. (2017) · Sports Medicine International Open · doi:10.1055/s-0042-117875 · Cited by 22
Association between domain-specific physical activity and diabetes in Korean adults
Lee, E.-B., Hong, S., Min, J., Park, D., Cho, W., Suh, S., Lee, H., Lee, H., Kimm, H., Lee, D. H., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92560-x · Cited by 23
Does the speed of the treadmill influence the training effect in people learning to walk after stroke? A double-blind randomized controlled trial
Lee, I.-H. (2014) · Clinical Rehabilitation · doi:10.1177/0269215514542637 · Cited by 20
Banaba: The natural remedy as antidiabetic drug
Park, C., & Lee, J. (2011) · Biomedical Research-tokyo · Cited by 20
The American College of Sports Medicine and the American Diabetes Association: joint position statement
Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., Chasan‐Taber, L., Albright, A. L., & Braun, B. (2010) · Cited by 20
Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways
Bai, X., Pei, R., Lei, W., Zhao, M., Zhang, J., Tian, L., & Shang, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.568864 · Cited by 19
Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study
Zhuo, C., Zhao, J., Wang, Q., Lin, Z., Cai, H., Pan, H., Chen, L., Jin, X., Jin, H. L., Xu, L., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.930077 · Cited by 19
The effect of low volume high-intensity interval training on metabolic and cardiorespiratory outcomes in patients with type 2 diabetes mellitus: A systematic review and meta-analysis
Peng, Y., Ou, Y., Wang, K., Wang, Z., & Zheng, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1098325 · Cited by 19
Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity
Søgaard, D., Østergård, T., Błachnio-Zabielska, A. U., Baranowski, M., Vigelsø, A., Andersen, J. L., Dela, F., & Helge, J. W. (2016) · Journal of Diabetes Research · doi:10.1155/2016/2372741 · Cited by 21
Self-citation
Low-Intensity Resistance Exercise Reduces Hyperglycemia and Enhances Glucose Control Over a 24-Hour Period in Women With Type 2 Diabetes
da Cruz, L. C., Teixeira-Araújo, A. A., de Andrade, K. T. P., Rocha, T. C. O. G., Puga, G. M., & Moreira, S. R. (2017) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002410 · Cited by 22
Development of a Tool to Increase Physical Activity among People at Risk for Diabetes in Low-Resourced Communities in Cape Town
Hill, J., Lavigne-Delville, C., Auorousseau, A.-M., Jonathan, D., Peer, N., Oldenburg, B. F., & Kengne, A. P. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17030865 · Cited by 18
Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes.
Marcus, R. L., Addison, O. R., LaStayo, P. C., Hungerford, R., Wende, A. R., Hoffman, J. M., Abel, E. D., & McClain, D. A. (2013) · PubMed · doi:10.3275/8333 · Cited by 19
Does a GLP-1 receptor agonist change glucose tolerance in patients treated with antipsychotic medications? Design of a randomised, double-blinded, placebo-controlled clinical trial
Larsen, J., Vedtofte, L., Holst, J., Oturai, P., Kjær, A., Corell, C. U., Vilsbøll, T., & Fink-Jensen, A. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-004227 · Cited by 20
Independent and Joint Associations of Cardiorespiratory Fitness and Muscle Fitness with Metabolic Syndrome in Korean Men
Kim, J., Lee, N., Jung, S. H., Kim, E.-J., & Hyun-Chul, C. (2011) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2010.0138 · Cited by 18
Mechanisms for Combined Hypoxic Conditioning and Divergent Exercise Modes to Regulate Inflammation, Body Composition, Appetite, and Blood Glucose Homeostasis in Overweight and Obese Adults: A Narrative Review
Tee, C. C. L., Cooke, M. B., Chong, M. C., Yeo, W. K., & CAMERA, D. M. (2022) · Sports Medicine · doi:10.1007/s40279-022-01782-0 · Cited by 20
Polycystic Ovary Syndrome Presents Higher Sympathetic Cardiac Autonomic Modulation that is not altered by Strength Training.
Ribeiro, V. B., Kogure, G. S., dos Reis, R. M., Gastaldi, A. C., de Araújo, J. E., Mazon, J. H., Borghi‐Silva, A., & de Souza, H. C. D. (2016) · PubMed Central · doi:10.70252/dgcj5295 · Cited by 18

Authors: Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F. P., & Dela, F.
Affiliations: University of Copenhagen (DK)
Rigshospitalet (DK)
Odense University Hospital (DK)
ORCID: Zacho, Morten
Juel, Carsten
Wojtaszewski, Jørgen F.P.
Dela, Flemming
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2004-02-01
Volume: 53
Issue: 2
Pages: 294-305
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.53.2.294
OpenAlex: W2153401503
Cited by: 615
References: 48
Citations by year: 2026: 36 · 2025: 24 · 2024: 18 · 2023: 20 · 2022: 32 · 2021: 38 · 2020: 30 · 2019: 22 · 2018: 35 · 2017: 29 · 2016: 25 · 2015: 32 · 2014: 25 · 2013: 37 · 2012: 39
FWCI: 7.70
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Sundhed og Sygdom, Det Frie Forskningsråd
University of Cambridge
National Research Foundation
Danmarks Grundforskningsfond (504–14)
Diabetesforeningen
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: resistance training, type 2 diabetes, insulin action, skeletal muscle, GLUT4, insulin signaling, glycogen synthase, Akt, insulin receptor, glucose uptake, glucose clearance, muscle blood flow, training volume
MeSH terms: Biological Transport, Capillaries, Denmark, Diabetes Mellitus, Type 2, Glucose, Glycogen, Humans, Insulin, Leg, Male, Monosaccharide Transport Proteins, Muscle Proteins, Physical Fitness, Reference Values, Tensile Strength, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, White People, Glucose Transporter Type 4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks