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Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo
Open accessAbstract
The circulating level of the inflammatory cytokine interleukin (IL)-6 is elevated in various insulin-resistant states including type 2 diabetes, obesity, cancer, and HIV-associated lipodystrophy. To determine the role of IL-6 in the development of insulin resistance, we examined the effects of IL-6 treatment on whole-body insulin action and glucose metabolism in vivo during hyperinsulinemic-euglycemic clamps in awake mice. Pretreatment of IL-6 blunted insulin’s ability to suppress hepatic glucose production and insulin-stimulated insulin receptor substrate (IRS)-2–associated phosphatidylinositol (PI) 3-kinase activity in liver. Acute IL-6 treatment also reduced insulin-stimulated glucose uptake in skeletal muscle, and this was associated with defects in insulin-stimulated IRS-1–associated PI 3-kinase activity and increases in fatty acyl-CoA levels in skeletal muscle. In contrast, we found that co-treatment of IL-10, a predominantly anti-inflammatory cytokine, prevented IL-6–induced defects in hepatic insulin action and signaling activity. Additionally, IL-10 co-treatment protected skeletal muscle from IL-6 and lipid-induced defects in insulin action and signaling activity, and these effects were associated with decreases in intramuscular fatty acyl-CoA levels. This is the first study to demonstrate that inflammatory cytokines IL-6 and IL-10 alter hepatic and skeletal muscle insulin action in vivo, and the mechanism may involve cytokine-induced alteration in intracellular fat contents. These findings implicate an important role of inflammatory cytokines in the pathogenesis of insulin resistance.
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In the citing paper
“and causes hepatic and muscle insulin resistance in humans and in mice (39,55-60).”
From Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle (2005) · cites this paper as [57]
Experimental — accuracy not yet measuredIn the citing paper
“Recent studies in rodents have demonstrated that acute infusions of IL-6 caused insulin resistance in both liver and skeletal muscle (32).”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [32]
In the citing paper
“In contexts of chronically increased IL6 such as obesity or rheumatoid arthritis, IL6 has been shown to induce insulin resistance (Castaneda et al., 2019; Kim et al., 2004; Perry et al., 2015).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Kim et al., 2004
In the citing paper
“IL-6 infusion in mice has been reported to reduce the effect of insulin to suppress hepatic glucose output and reduce insulin-stimulated skeletal muscle glucose uptake (32), whereas others report no effect of IL-6 on whole-body glucose disposal (33).”
From Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal Muscle (2006) · cites this paper as [32]
In the citing paper
“In vitro studies demonstrate that IL-6 can induce insulin resistance in isolated 3T3-L1 adipocytes [51, 52] and in mice [53].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [53]
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Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
Carr, A., Samaras, K., Burton, S., Law, M. G., Freund, J., Chisholm, D. J., & Cooper, D. A. (1998) · AIDS · doi:10.1097/00002030-199807000-00003 · Cited by 2,364
Kishimoto, T. (1989) · Blood · doi:10.1182/blood.v74.1.1.bloodjournal7411 · Cited by 2,068
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
Cited by
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Items 101–200 of 534
Inflammation during obesity is not all bad: evidence from animal and human studies
Ye, J., & McGuinness, O. P. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00266.2012 · Cited by 178
Ye, R., Jung, D. Y., Jun, J. Y., Li, J., Luo, S. D., Ko, H. J., Kim, J. K., & Lee, A. S. (2009) · Diabetes · doi:10.2337/db09-0755 · Cited by 178
Self-citationRole of Rho-kinase in regulation of insulin action and glucose homeostasis
Furukawa, N., Ongusaha, P. P., Jahng, W. J., Araki, K., Choi, C. S., Kim, H.-J., Lee, Y. H., Kaibuchi, K., Kahn, B. B., Masuzaki, H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.011 · Cited by 172
Self-citationcJun NH2-terminal kinase 1 (JNK1): Roles in metabolic regulation of insulin resistance
Sabio, G., & Davis, R. J. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.004 · Cited by 170
Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
Tang, Y., Wallace, M., Sánchez-Gurmaches, J., Hsiao, W., Li, H., Lee, P. L., Vernia, S., Metallo, C. M., & Guertin, D. A. (2016) · Nature Communications · doi:10.1038/ncomms11365 · Cited by 188
Delibegović, M., Bence, K. K., Mody, N., Hong, E., Ko, H. J., Kim, J. K., Kahn, B. B., & Neel, B. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00959-07 · Cited by 173
Self-citationImmunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases
Bleve, A., Motta, F., Durante, B., Pandolfo, C., Selmi, C., & Sica, A. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08909-7 · Cited by 185
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice
Franckhauser, S., Elias, I., Sopasakis, V. R., Ferré, T., Nagaev, I., Andersson, C. X., Agudo, J., Ruberte, J., Bosch, F., & Smith, U. (2008) · Diabetologia · doi:10.1007/s00125-008-0998-8 · Cited by 175
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Sadagurski, M., Norquay, L., Farhang, J., D’Aquino, K. E., Copps, K. D., & White, M. F. (2009) · Diabetologia · doi:10.1007/s00125-009-1580-8 · Cited by 160
Tang, T., Zhang, J., Yin, J., Staszkiewicz, J., Gawrońska‐Kozak, B., Jung, D. Y., Ko, H. J., Ong, H., Kim, J. K., Mynatt, R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068007 · Cited by 164
Self-citationKo, H. J., Zhang, Z., Jung, D. Y., Jun, J. Y., Ma, Z., Jones, K. E., Chan, S. Y., & Kim, J. K. (2009) · Diabetes · doi:10.2337/db08-1361 · Cited by 160
Self-citationLee, J. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0023-8 · Cited by 161
Kobayasi, R., Akamine, E. H., Davel, A. P., Rodrigues, M. A. M., Carvalho, C. R. D. O., & Rossoni, L. V. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833ca68c · Cited by 157
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis
Dubois, M.-J., Bergeron, S., Kim, H., Dombrowski, L., Perreault, M., Fournès, B., Faure, R. L., Olivier, M., Beauchemin, N., Shulman, G. I., et al. (2006) · Nature Medicine · doi:10.1038/nm1397 · Cited by 152
Self-citationIL‐10 prevents aging‐associated inflammation and insulin resistance in skeletal muscle
Dağdeviren, S., Jung, D. Y., Friedline, R. H., Noh, H. L., Kim, J. H., Patel, P. R., Tsitsilianos, N., Inashima, K., Tran, D. A., Hu, X., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600832r · Cited by 151
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Ayala, J. E., Bracy, D. P., Malabanan, C. M., James, F. D., Ansari, T., Fueger, P. T., McGuinness, O. P., & Wasserman, D. H. (2011) · Journal of Visualized Experiments · doi:10.3791/3188 · Cited by 157
Lee, E., Jung, D. Y., Kim, J. H., Patel, P. R., Hu, X., Lee, Y., Azuma, Y., Wang, H.-F., Tsitsilianos, N., Shafiq, U., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-268300 · Cited by 147
Self-citationRole of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance
Sabio, G., Kennedy, N. J., Cavanagh, J., Jung, D. Y., Ko, H. J., Ong, H., Barrett, T., Kim, J. K., & Davis, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01162-09 · Cited by 150
Self-citationMechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity
Orliaguet, L., Dalmas, É., Drareni, K., Venteclef, N., & Alzaïd, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00062 · Cited by 151
New insights into insulin resistance in the diabetic heart
Gray, S., & Kim, J. K. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.05.001 · Cited by 147
Self-citationWeigert, C., Hennige, A. M., Lehmann, R., Brodbeck, K., Baumgärtner, F., Schaüble, M., Häring, H. U., & Schleicher, E. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509782200 · Cited by 142
Skeletal muscle dysfunction in chronic renal failure: effects of exercise
Adams, G. R., & Vaziri, N. D. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00296.2005 · Cited by 138
Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Michailidou, Z., Gomez-Salazar, M. A., & Alexaki, V. I. (2021) · Journal of Innate Immunity · doi:10.1159/000515117 · Cited by 143
Circulating visfatin level is correlated with inflammation, but not with insulin resistance
Oki, K., Yamane, K., Kamei, N., Nojima, H., & Kohno, N. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02966.x · Cited by 136
Role of interleukins in obesity: implications for metabolic disease
Febbraio, M. A. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.02.004 · Cited by 134
Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132
Vascular biology of metabolic syndrome
Vykoukal, D. M., & Davies, M. G. (2011) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2011.01.003 · Cited by 135
Cardiovascular Biology of Interleukin-6
Abeywardena, M. Y., Leifert, W. R., Warnes, K., Varghese, J. N., & Head, R. J. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788186290 · Cited by 128
Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance
Balakrishnan, R., & Thurmond, D. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094636 · Cited by 143
Role of interleukin‐6 signalling in glucose and lipid metabolism
Glund, S., & Krook, A. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01779.x · Cited by 129
gp130 receptor ligands as potential therapeutic targets for obesity
Febbraio, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30453 · Cited by 124
Obesity and Metabolic Syndrome: An Inflammatory Condition
Scarpellini, E., & Tack, J. F. (2012) · Digestive Diseases · doi:10.1159/000336664 · Cited by 124
Requirement of the ATM/p53 Tumor Suppressor Pathway for Glucose Homeostasis
Armata, H. L., Golebiowski, D., Jung, D. Y., Ko, H. J., Kim, J. K., & Sluss, H. K. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00347-10 · Cited by 121
Self-citationTheurich, S., Tsaousidou, E., Hanßen, R., Lempradl, A. M., Mauer, J., Timper, K., Schilbach, K., Folz‐Donahue, K., Heilinger, C., Sexl, V., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.018 · Cited by 127
Park, S., Cho, Y.-R., Finck, B. N., Kim, H.-J., Higashimori, T., Hong, E., Lee, M., Danton, C., Deshmukh, S. D., Cline, G. W., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2514 · Cited by 122
Self-citationRui, K., Hong, Y., Zhu, Q., Shi, X., Xiao, F., Fu, H., Yin, Q., Xing, Y., Wu, X., Kong, X., et al. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00587-3 · Cited by 121
Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy
Roy, B., Curtis, M. E., Fears, L., Nahashon, S. N., & Fentress, H. M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00439 · Cited by 122
Role of the hypothalamic–pituitary–thyroid axis in metabolic regulation by JNK1Preprint
Sabio, G., Cavanagh, J., Barrett, T., Jung, D. Y., Ko, H. J., Ong, H., Morel, C., Mora, A., Reilly, J., Kim, J. K., et al. (2010) · Genes & Development · doi:10.1101/gad.1878510 · Cited by 119
Self-citationThe effect of exercise on IL‐6‐induced cachexia in the ApcMin/+ mouse
Puppa, M., White, J. P., Velázquez, K. T., Baltgalvis, K. A., Sato, S., Baynes, J., & Carson, J. A. (2011) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0047-1 · Cited by 120
Wang, H., Knaub, L. A., Jensen, D. R., Young Jung, D., Hong, E.-G., Ko, H.-J., Coates, A. M., Goldberg, I. J., de la Houssaye, B. A., Janssen, R. C., et al. (2009) · Diabetes · doi:10.2337/db07-1839 · Cited by 91
Self-citationLipolytic and thermogenic depletion of adipose tissue in cancer cachexia
Tsoli, M., Swarbrick, M. M., & Robertson, G. R. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.039 · Cited by 113
Rosa Neto, J. C., Lira, F. S., Oyama, L. M., Zanchi, N. E., Yamashita, A. S., Batista, M. L., Oller do Nascimento, C. M., & Seelaender, M. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1070-1 · Cited by 112
Insulin resistance in patients with rheumatoid arthritis: effect of anti‐TNFα therapy
Rosenvinge, A., Krogh‐Madsen, R., Baslund, B., & Pedersen, B. K. (2007) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740601179605 · Cited by 112
Scarpelli, D., Cardellini, M., Andreozzi, F., Laratta, E., Hribal, M. L., Marini, M. A., Tassi, V., Lauro, R., Perticone, F., & Sesti, G. (2006) · Diabetes · doi:10.2337/db06-0047 · Cited by 111
The dual function of hepatic SOCS3 in insulin resistance in vivo
Torisu, T., Sato, N., Yoshiga, D., Kobayashi, T., Yoshioka, T., Mori, H., Iida, M., & Yoshimura, A. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01044.x · Cited by 118
Impact of Alcohol on Glycemic Control and Insulin Action
Steiner, J. L., Crowell, K. T., & Lang, C. H. (2015) · Biomolecules · doi:10.3390/biom5042223 · Cited by 110
Caputo, T., Gilardi, F., & Desvergne, B. (2017) · FEBS Letters · doi:10.1002/1873-3468.12742 · Cited by 112
Yin, Y., Hao, H., Cheng, Y., Zang, L., Liu, J., Gao, J., Xue, J., Xie, Z., Zhang, Q., Han, W., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0801-9 · Cited by 109
Capozza, F., Combs, T. P., Cohen, A. W., Cho, Y.-R., Park, S., Schubert, W., Williams, T. M., Brasaemle, D., Jelicks, L. A., Scherer, P. E., et al. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00489.2004 · Cited by 107
Self-citationRole of Cytokines in the Pathogenesis of Non-Alcoholic Fatty Liver Disease
Das, S. K., & Balakrishnan, V. (2011) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-011-0121-7 · Cited by 114
Depression and Obesity: Analysis of Common Biomarkers
Milano, W., Ambrosio, P., Carizzone, F., Biasio, V. D., Munzio, W. D., Foia, M. G., & Capasso, A. (2020) · Diseases · doi:10.3390/diseases8020023 · Cited by 109
Park, S., Kim, H., Wang, S., Higashimori, T., Dong, J., Kim, Y. J., Cline, G. W., Li, H., Prentki, M., Shulman, G. I., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00251.2004 · Cited by 112
Self-citationNerstedt, A., Johansson, A., Andersson, C. X., Cansby, E., Smith, U., & Mahlapuu, M. (2010) · Diabetologia · doi:10.1007/s00125-010-1856-z · Cited by 106
Bonner, J. S., Lantier, L., Hasenour, C. M., James, F. D., Bracy, D. P., & Wasserman, D. H. (2013) · Diabetes · doi:10.2337/db12-0354 · Cited by 107
Fat uses a TOLL-road to connect inflammation and diabetes
Kim, J. K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.008 · Cited by 105
Self-citationMuscle insulin resistance: assault by lipids, cytokines and local macrophages
Kewalramani, G., Bilan, P. J., & Klip, A. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833aabd9 · Cited by 105
Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice
Verty, A. N. A., Stefanidis, A., McAinch, A. J., Hryciw, D. H., & Oldfield, B. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140592 · Cited by 103
Haddad, F., Adams, G., Bodell, P. W., & Baldwin, K. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01203.2005 · Cited by 109
The role of interleukin-6 in glucose homeostasis and lipid metabolism
Lehrskov, L. L., & Christensen, R. H. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00747-2 · Cited by 114
DEFECTIVE GLUCOSE HOMEOSTASIS DURING INFECTION
McGuinness, O. P. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132159 · Cited by 104
The role of insulin and the adipocytokines in regulation of vascular endothelial function
Ritchie, S. A., Ewart, M., Perry, C. G., Connell, J., & Salt, I. P. (2004) · Clinical Science · doi:10.1042/cs20040190 · Cited by 98
Inflammatory markers and cardiovascular risk in the metabolic syndrome.
Espinola-Klein, C., Gori, T., Blankenberg, S., & Munzel, T. (2011) · Frontiers in Bioscience · doi:10.2741/3812 · Cited by 100
Fat as an endocrine organ: influence of exercise
Berggren, J. R., Hulver, M. W., & Houmard, J. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00134.2005 · Cited by 95
Hyperglycaemia and pulmonary infection
Baker, E. H., Wood, D. M., Brennan, A. L., Clark, N., Baines, D. L., & Philips, B. J. (2006) · Proceedings of The Nutrition Society · doi:10.1079/pns2006499 · Cited by 92
Clementi, A. H., Gaudy, A. M., van Rooijen, N., Pierce, R. H., & Mooney, R. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.007 · Cited by 95
Tantiwong, P., Shanmugasundaram, K., Monroy, A., Ghosh, S., Li, M., DeFronzo, R. A., Cersósimo, E., Sriwijitkamol, A., Mohan, S., & Musi, N. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00776.2009 · Cited by 93
Weigert, C., Hennige, A. M., Brodbeck, K., Häring, H. U., & Schleicher, E. D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00448.2004 · Cited by 94
Brüünsgaard, H. (2006) · PubMed · Cited by 90
Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice
Chida, D., Osaka, T., Hashimoto, O., & Iwakura, Y. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1250 · Cited by 91
Signaling pathways and intervention for therapy of type 2 diabetes mellitus
Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 98
Interleukin-6 gene transfer reverses body weight gain and fatty liver in obese mice
Ma, Y., Gao, M., Sun, H. Y., & Liu, D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.017 · Cited by 92
Chuang, H., Sheu, W. H., Lin, Y.-T., Tsai, C.-Y., Yang, C. Y., Cheng, Y.-J., Huang, P. Y., Li, J.-P., Chiu, L.-L., Wang, X., et al. (2014) · Nature Communications · doi:10.1038/ncomms5602 · Cited by 88
AMPK‐dependent hormonal regulation of whole‐body energy metabolism
Dzamko, N. L., & Steinberg, G. R. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01969.x · Cited by 90
González‐Rodríguez, Á., Mas‐Gutierrez, J. A., Mirasierra, M., Fernández-Pérez, A., Lee, Y. J., Ko, H. J., Kim, J. K., Romanos, E., Carrascosa, J. M., Ros, M., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00786.x · Cited by 88
Self-citationResistance to type 2 diabetes mellitus: a matter of hormesis?
Kolb, H., & Eizirik, D. L. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.158 · Cited by 87
Costa, G. T., Vasconcelos, Q. D. J. S., & Aragão, G. F. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab115 · Cited by 86
den Boer, M. A. M., Voshol, P. J., der Elst, J. P. S.-V., Korsheninnikova, E., Ouwens, D. M., Kuipers, F., Havekes, L. M., & Romijn, J. A. (2006) · Endocrinology · doi:10.1210/en.2006-0417 · Cited by 85
Owino, S., Sánchez-Bretaño, A., Tchio, C., Cecon, E., Karamitri, A., Dam, J., Jockers, R., Piccione, G., Noh, H., Kim, T., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12462 · Cited by 86
Self-citationShang, Q., Bai, Y., Wang, G., Song, Q., Guo, C. H., Zhang, L., & Wang, Q. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0557 · Cited by 84
The gp130 Receptor Cytokine Family: Regulators of Adipocyte Development and Function
White, U. A., & Stephens, J. M. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795164202 · Cited by 84
Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion
Mizgier, M. L., Casas, M., Contreras‐Ferrat, A. E., Llanos, P., & Galgani, J. E. (2014) · Obesity Reviews · doi:10.1111/obr.12166 · Cited by 88
Hussey, S. E., Liang, H., Costford, S. R., Klip, A., DeFronzo, R. A., Sanchez-Avila, A., Ely, B., & Musi, N. (2012) · Bioscience Reports · doi:10.1042/bsr20120098 · Cited by 83
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Tiwari, S., Singh, R. S., Li, L., Tsukerman, S., Godbole, M. M., Pandey, G., & ECELBARGER, C. A. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012060628 · Cited by 83
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Gao, G., Zhang, B., Ramesh, G., Betterly, D., Tadagavadi, R. K., Wang, W., & Reeves, W. B. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00533.2012 · Cited by 80
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Manieri, E., & Sabio, G. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0146 · Cited by 83
Batran, R. A., Gopal, K., Capozzi, M. E., Chahade, J. J., Saleme, B., Dakhili, S. A. T., Greenwell, A. A., Niu, J., Almutairi, M. G., Byrne, N. J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.017 · Cited by 79
Bastie, C. C., Zong, H., Xu, J., Busa, B., Judex, S., Kurland, I. J., & Pessin, J. E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.04.005 · Cited by 79
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Pestel, J., Blangero, F., Watson, J., Pirola, L., & Eljaafari, A. (2023) · Biochimie · doi:10.1016/j.biochi.2023.04.008 · Cited by 83
Strączkowski, M., Kowalska, I., Nikołajuk, A., Krukowska, A., & Górska, M. (2005) · Diabetes Care · doi:10.2337/diacare.28.8.2036 · Cited by 77
Grant, L., Shearer, K. D., Czopek, A., Lees, E. K., Owen, C., Agouni, A., Workman, J., Martin-Granados, C., Forrester, J. V., Wilson, H. M., et al. (2014) · Diabetes · doi:10.2337/db13-0885 · Cited by 76
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Rasquinha, M. T., Sur, M., Lasrado, N., & Reddy, J. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100565 · Cited by 76
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Zhang, Z., Zhang, W., Jung, D. Y., Ko, H. J., Lee, Y., Friedline, R. H., Lee, E., Jun, J. Y., Ma, Z., Kim, F., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00239.2011 · Cited by 76
Self-citationYego, E. C. K., Vincent, J. A., Sarthy, V. P., Busik, J. V., & Mohr, S. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2082 · Cited by 75
Park, E., Wong, V. S. C., Guan, X., Oprescu, A. I., & Giacca, A. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0005 · Cited by 74
Muscle-Strengthening Activity and Its Association With Insulin Sensitivity
Cheng, Y. J., Gregg, E. W., de Rekeneire, N., Williams, D. E., Imperatore, G., Caspersen, C. J., & Kahn, H. S. (2007) · Diabetes Care · doi:10.2337/dc07-0372 · Cited by 71
Kim, J. K., Kim, H., Park, S., Cederberg, A., Westergren, R., Nilsson, D., Higashimori, T., Cho, Y.-R., Liu, Z., Dong, J., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1657 · Cited by 75
Self-citationKim, T. H., Choi, S., Ha, E. S., Jung, J. G., Han, S. J., Kim, H. J., Kim, D. J., KANG, Y. Y., & Lee, K. W. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0259-z · Cited by 79
Self-citationPatsalos, O., Dalton, B., & Himmerich, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176290 · Cited by 72
Mooney, R. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01208a.2006 · Cited by 75
Metadata
- Authors
- Kim, H.-J., Higashimori, T., Park, S.-Y., Choi, H., Dong, J., Kim, Y.-J., Noh, H.-L., Cho, Y.-R., Cline, G., Kim, Y.-B., & Kim, J. K.
- Affiliations
- Yale University (US)
- Department of Internal Medicine, Section of Endocrinology and Metabolism, Yale University School of Medicine, New Haven, Connecticut
- Beth Israel Deaconess Medical Center (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-04-01
- Volume
- 53
- Issue
- 4
- Pages
- 1060-1067
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2097447032
- Cited by
- 534
- References
- 59
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 13 · 2023: 12 · 2022: 26 · 2021: 20 · 2020: 19 · 2019: 18 · 2018: 20 · 2017: 23 · 2016: 19 · 2015: 37 · 2014: 27 · 2013: 27 · 2012: 22
- FWCI
- 25.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-6, IL-10, insulin resistance, hepatic glucose production, PI3K signaling, insulin receptor substrate 2, IRS-1, fatty acyl-CoA, inflammatory cytokines, hyperinsulinemic-euglycemic clamp, type 2 diabetes
- MeSH terms
- Animals, Blood Glucose, Hyperinsulinism, Infusions, Intravenous, Insulin, Lipids, Liver, Male, Mice, Inbred C57BL, Glucose Clamp Technique, Signal Transduction, Interleukin-6, Interleukin-10, Muscle, Skeletal, Mice
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