The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Longitudinal Assessment of Neuropsychological Function in Major Depression
Abstract
Neuropsychological impairment is a core component of major depression, yet its relationship to clinical state is unclear. The aims of the present review were to determine which neuropsychological domains and tasks were most sensitive to improvement in clinical state in major depression and to highlight the methodological issues in such research. Studies that included a baseline and at least one follow-up neuropsychological testing session in adults with major depression were identifed using MEDLINE, Web of Science and ScienceDirect databases. Thirty studies were included in the review. Findings in younger adult populations suggested that improvement in mood was most strongly related to improved verbal memory and verbal fluency, while measures of executive functioning and attention tended to remain impaired across treatment. In late-life major depression, improved psychomotor speed was most closely related to treatment response, but there was much inconsistency between study findings, which may be due to methodological issues. In major depression, particular neuropsychological domains are more strongly related to clinical state than others. The findings from the present review suggest that the domains most sensitive to clinical state are verbal learning and memory, verbal fluency and psychomotor speed. In contrast, measures of attention and executive functioning perhaps represent more trait-like markers of major depression. With further methodologically sound research, the changes in neuropsychological function associated with treatment response may provide a means of evaluating different treatment strategies in major depression.
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In the citing paper
“Cognitive dysfunction in major depressive disorder (MDD) encompasses several domains, including but not limited to executive function, verbal memory, and attention.”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [8]
In the citing paper
“Notwithstanding the heterogeneity across individual studies, the most replicated findings indicate that cognitive impairment in MDD encompasses several domains, notably attention, memory, psychomotor speed, and executive function [7–9].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [8]
Citations
Cites
Hippocampal volume and depression: a meta-analysis of MRI studies
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Self-citationAttention and executive functions in remitted major depression patients
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Grinberg, A. (2020) · CUNY Academic Works (City University of New York)
Iacono, A. J. (2021) · UWSpace (University of Waterloo)
Language in depressive disorder – a blueprint for cognitive, affective and perceptual changes
TRIFU, R. N. (2022) · Revista Română de Terapia Tulburărilor de Limbaj şi Comunicare · doi:10.26744/rrttlc.2022.8.1.10
Psychiatric Disturbances of Attention
Cohen, R. A. (2013) · Springer eBooks · doi:10.1007/978-0-387-72639-7_17
Berdzenishvili, E., Roinishvili, M., Okruashvili, M., Machavariani, E., & Chkonia, E. D. (2023) · Georgian Biomedical News · doi:10.52340/gbmn.2023.01.01.34
Nöropsikoloji ve Nöropsikolojik Psikoterapi
Özen, Y. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3077
Hanabusa, K., Sugisawa, S., Yamamoto, K., Okino, K., Nakatsubo, T., & Inamoto, A. (2025) · Research Square · doi:10.21203/rs.3.rs-7704919/v1
Çoban, C., & Bulut, S. D. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116778
Kuruoğlu, R., Wootton, R. E., Madley‐Dowd, P., & Penton‐Voak, I. S. (2025) · medRxiv · doi:10.1101/2025.10.28.25338883
“Additionally, some cognitive deficits (e.g. attention, long term memory, working memory) can persist in remitted depression (Douglas & Porter, 2009; Semkovska et al., 2019) and may hinder functional recovery (Baune et al., 2010; Jaeger et al., 2006).”
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Gülpen, J., Legemaat, A. M., van Dis, E. A. M., Geurtsen, G. J., Wekking, E. M., Burger, H., Denys, D. A. J. P., & Bockting, C. (2026) · Clinical Psychology in Europe · doi:10.32872/cpe.20989
“Several hypotheses have been put forward to explain the nature of cognitive deficits in depression (Allott et al., 2016; Ang et al., 2020; Douglas & Porter, 2009; Hammar et al., 2022).”
Investigating Sensorimotor Decision-Making in Depressed Individuals Using a Bayesian Approach
Song, X., Manavalan, M., Griem, J., Nolte, T., Fonagy, P., & Vilares, I. (2026) · Computational Psychiatry · doi:10.5334/cpsy.195
Metadata
- Authors
- Douglas, K. M., & Porter, R. J.
- Affiliations
- University of Otago (NZ)
- Venue
- Australian & New Zealand Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2009-12
- Volume
- 43
- Issue
- 12
- Pages
- 1105-1117
- ISSN
- 0004-8674 (ISSN-L)
- 1440-1614
- OpenAlex
- W2055084163
- Cited by
- 217
- References
- 60
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 16 · 2020: 17 · 2019: 16 · 2018: 21 · 2017: 11 · 2016: 14 · 2015: 21 · 2014: 14 · 2013: 20 · 2012: 10
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian & New Zealand Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- major depressive disorder, neuropsychological deficits, treatment response, verbal memory, verbal fluency, psychomotor speed, executive function, attention, geriatric depression, longitudinal assessment, trait markers
- MeSH terms
- Age Factors, Attention, Major Depressive Disorder, Depressive Disorder, Major, Humans, Memory, Neuropsychological Tests, Psychomotor Performance, Verbal Learning, Executive Function
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