Role of SCN in Daily Rhythms of Plasma Glucose, FFA, Insulin and Glucagon
Abstract
The daily changes in plasma glucose, FFA, insulin and glucagon concentrations in rats under 12 hr-12 hr light-dark conditions, and the role of the suprachiasmatic nucleus (SCN) of the hypothalamus in these changes were examined. In sham-operated rats, the four parameters showed significant daily rhythms. However, after bilateral lesions of the SCN, daily rhythms could not be detected in these parameters under the present experimental conditions. Furthermore, after the SCN lesions the plasma glucose concentration remained at the minimum level of that in sham-operated rats, while the plasma insulin and glucagon concentrations reduced to approximately the mean level and about half the minimum level of sham-operated rats, respectively, and the FFA concentration lowered to somewhat below the minimum level. Gradual increase in the plasma insulin concentration at the end of the light period was observed in intact rats even after starvation for 24 hr. These findings suggest that the SCN is essential for generation of the daily changes in the plasma glucose, FFA, insulin and glucagon concentrations and also that it plays critical roles in regulation of the secretion of pancreatic hormones. The gradual increase in the plasma insulin level observed at the end of the light period is discussed in connection with initiation of spontaneous feeding behaviour.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SCN lesions abolish the daily rhythms in plasma concentrations of glucose and insulin.
“Nagai and Nakagawa, who showed that SCN lesions abolished the daily rhythms in plasma concentrations of glucose and insulin [53]”
From Circadian control of glucose metabolism (2014) · cites this paper as [53]
Cites
The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem
König, J. F. R., & Klippel, R. (1986) · Medical Entomology and Zoology · Cited by 4,134 · see citing works
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135 · see citing works
Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039 · see citing works
Neural regulation of circadian rhythms.
Rusak, B., & Zucker, I. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.449 · Cited by 1,402 · see citing works
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114 · see citing works
Inouye, S. T., & Kawamura, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5962 · Cited by 985 · see citing works
Hunger: Basic mechanisms and clinical implications
(1976) · Neuroscience · doi:10.1016/0306-4522(76)90139-1 · Cited by 917 · see citing works
Abnormal Alpha-Cell Function in Diabetes: Response to Carbohydrate and Protein Ingestion
Müller, W. A., Faloona, G. R., Aguilar-Parada, E., & Unger, R. H. (1970) · New England Journal of Medicine · doi:10.1056/nejm197007162830301 · Cited by 626 · see citing works
Stereotaxic atlases for the cat, rabbit and rat
Fifkova´, E., & Marsala, J. (1967) · Elsevier eBooks · doi:10.1016/b978-0-12-142956-0.50017-5 · Cited by 517 · see citing works
Steffens, A. B. (1969) · Physiology & Behavior · doi:10.1016/0031-9384(69)90126-7 · Cited by 499 · see citing works
Biological Rhythms and Their Central Mechanism
Suda, M., Hayaishi, O., & Nakagawa, H. (1979) · The Annual of Animal Psychology · doi:10.2502/janip1944.29.105 · Cited by 385 · see citing works
Self-citationSuprachiasmatic Nucleus: Use of <sup>14</sup> C-Labeled Deoxyglucose Uptake as a Functional Marker
Schwartz, W. J., & Gainer, H. (1977) · Science · doi:10.1126/science.887940 · Cited by 358 · see citing works
Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels
La, F., & Bernardis, L. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.6.1596 · Cited by 295 · see citing works
Shimazu, T., Fukuda, A., & Tadayasu, B. A. N. (1966) · Nature · doi:10.1038/2101178a0 · Cited by 243 · see citing works
Effect of bilateral lesions of the suprachiasmatic nuclei on the circadian rhythm of food-intake
Nagai, K., Nishio, T., Nakagawa, H., Nakamura, S., & Fukuda, Y. (1978) · Brain Research · doi:10.1016/0006-8993(78)90648-0 · Cited by 217 · see citing works
Self-citationMetabolic correlates of the meal onset in the free food intake of rats
Magnen, J. L., & Devos, M. (1970) · Physiology & Behavior · doi:10.1016/0031-9384(70)90284-2 · Cited by 206 · see citing works
Fuller, R. W., & Diller, E. R. (1970) · Metabolism · doi:10.1016/0026-0495(70)90056-9 · Cited by 114 · see citing works
Circadian feeding rhythm after hypothalamic knife-cut isolating suprachiasmatic nucleus
Nishio, T., Shiosaka, S., Nakagawa, H., Sakumoto, T., & Satoh, K. (1979) · Physiology & Behavior · doi:10.1016/0031-9384(79)90172-0 · Cited by 92 · see citing works
Self-citationCircadian Insulin, GH, Prolactin, Corticosterone and Glucose Rhythms in Fed and Fasted Rats
Bellinger, L. L., Mendel, V. E., & Moberg, G. P. (1975) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093763 · Cited by 86 · see citing works
Kita, H., Shibata, S., Oomura, Y., & Ohki, K. (1982) · Brain Research · doi:10.1016/0006-8993(82)90203-7 · Cited by 55 · see citing works
ROLE OF THE SUPRACHIASMATIC NUCLEUS IN GLUCOSE HOMEOSTASIS
Yamamoto, H., Nagai, K., & Nakagawa, H. (1984) · Biomedical Research · doi:10.2220/biomedres.5.55 · Cited by 43 · see citing works
Self-citationYamamoto, H., Nagai, K., & Nakagawa, H. (1985) · Endocrinology · doi:10.1210/endo-117-2-468 · Cited by 35 · see citing works
Self-citationBilateral lesions of the SCN abolish lipolytic and hyperphagic responses to 2DG.
Yamamoto, H., Nagai, K., & Nakagawa, H. (1984) · Physiology and Behavior · doi:10.1016/0031-9384(84)90295-6 · Cited by 34 · see citing works
Self-citationBILATERAL LESIONS OF THE SUPRACHIASMATIC NUCLEUS ENHANCE GLUCOSE TOLERANCE IN RATS
Yamamoto, H., Nagai, K., & Nakagawa, H. (1984) · Biomedical Research · doi:10.2220/biomedres.5.47 · Cited by 27 · see citing works
Self-citationEFFECT OF INTRACRANIAL INSULIN INFUSION ON THE CIRCADIAN FEEDING RHYTHM OF RATS1
Nagai, K., MORI, T., Nishio, T., et al. (1982) · Biomedical Research · doi:10.2220/biomedres.3.175 · Cited by 22 · see citing works
Self-citationNagai, K., Mori, T., & Nakagawa, H. (1982) · Biomedical Research · doi:10.2220/biomedres.3.294 · Cited by 13 · see citing works
Self-citationNagai, K., Nishio, T., & Nakagawa, H. (1985) · Experientia · doi:10.1007/bf01951695 · Cited by 10 · see citing works
Self-citationEgawa, M., Inoue, S., Sato, S., et al. (2008) · Hormone and Metabolic Research · doi:10.1055/s-2007-1014890 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Crosstalk between metabolism and circadian clocks
Reinke, H., & Asher, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0096-9 · Cited by 598 · see citing works
Circadian control of glucose metabolism
Kalsbeek, A., la Fleur, S., & Fliers, E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.002 · Cited by 338 · see citing works
Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235 · see citing works
DNA microarray analyses of circadian timing: the genomic basis of biological time
Duffield, G. E. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01082.x · Cited by 234 · see citing works
Ruiter, M., La Fleur, S. E., van Heijningen, C., van der Vliet, J., Kalsbeek, A., & Buijs, R. M. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1709 · Cited by 170 · see citing works
- Authors
- Yamamoto, H., Nagai, K., & Nakagawa, H.
- Affiliations
- Institute for Protein Research, The University of Osaka (JP)
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 1987-01
- Volume
- 4
- Issue
- 4
- Pages
- 483-491
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2134513259
- Cited by
- 90
- References
- 28
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 2 · 2013: 7 · 2012: 3
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- suprachiasmatic nucleus, circadian rhythm, plasma glucose, free fatty acids, insulin, glucagon, hypothalamic lesions, light-dark cycle, pancreatic hormone secretion, fasting, feeding behaviour, rats
- MeSH terms
- Animals, Blood Glucose, Circadian Rhythm, Fatty Acids, Nonesterified, Glucagon, Insulin, Male, Rats, Inbred Strains, Suprachiasmatic Nucleus, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
