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Cited by 363

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Human Phase Response Curve (Prc) to Melatonin is About 12 Hours out of Phase with the Prc to Light

Lewy, Alfred J., Bauer, Vance K., Ahmed, Saeeduddin, Thomas, Katherine H., Cutler, Neil L., Singer, Clifford M., Moffit, Mary T., Sack, Robert L.·1998·Chronobiology International
DOI 10.3109/07420529808998671
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Abstract

Melatonin's timekeeping function is undoubtedly related to the fact that it is primarily produced during nighttime darkness; that is, melatonin and light occur at opposite times. The human phase response curve (PRC) to melatonin appears to be about 12h out of phase with the PRC to light. These striking complementarities, together with light's acute suppressant effect on melatonin production, suggest that a function for endogenous melatonin is to augment entrainment of the circadian pacemaker by the light-dark cycle. The melatonin PRC also indicates correct administration times for using exogenous melatonin to treat circadian phase disorders.

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Research works printed but not linked: 56

  1. Moore R Y, 1972, J Comp Neurol, 146, 1, 10.1002/cne.901460102 · DOI · Paper page
  2. Stephan F K, 1972, Proc Natl Acad Sci USA, 69, 1583, 10.1073/pnas.69.6.1583 · DOI · Paper page
  3. Hoffman R A, 1966, Life Sci, 5, 1147, 10.1016/0024-3205(66)90099-3 · DOI
  4. Tamarkin L, 1976, Endocrinol, 99, 1534, 10.1210/endo-99-6-1534 · DOI · Paper page
  5. Turek F W, 1976, Science, 194, 1441, 10.1126/science.1006311 · DOI · Paper page
  6. Gwinner E, 1978, J Comp Physiol, 127, 209, 10.1007/BF01350111 · DOI
  7. DeCoursey P J, 1960, Science, 131, 33, 10.1126/science.131.3392.33 · DOI · Paper page
  8. Daan S, 1976, J Comp Physiol, 106, 253, 10.1007/BF01417857 · DOI · Paper page
  9. Redman J, 1983, Science, 219, 1089, 10.1126/science.6823571 · DOI · Paper page
  10. Armstrong S M, 1989, Pineal research reviews, 157
  11. Sack R L, 1988, Sleep Res, 17, 396
  12. Arendt J, 1985, Photoperiodism, melatonin and the pineal, 266
  13. Mallo C, 1988, Acta Endocrinol (Copenh), 119, 474, 10.1530/acta.0.1190474 · DOI
  14. Reppert S M, 1988, Science, 242, 78, 10.1126/science.2845576 · DOI · Paper page
  15. 10.3109/07420529209064550 · DOI · Paper page
  16. Zaidan R, 1994, Neuroendocrinology, 60, 105, 10.1159/000126726 · DOI · Paper page
  17. Underwood H, 1986, J Pineal Res, 3, 187, 10.1111/j.1600-079X.1986.tb00741.x · DOI
  18. 10.1126/science.675255 · DOI · Paper page
  19. 10.1177/074873049701200614 · DOI
  20. Kennaway D J, 1977, Endocrinology, 101, 119, 10.1210/endo-101-1-119 · DOI
  21. Czeisler C A, 1989, Science, 244, 1328, 10.1126/science.2734611 · DOI · Paper page
  22. Johnson C H, 1990, An atlas of phase response curves for circadian and circatidal rhythms
  23. Boulos Z, 1982, J Comp Physiol [A], 146, 411, 10.1007/BF00609437 · DOI · Paper page
  24. Honma K, 1988, Jap J Psychiatry, 42, 167
  25. Wever R A, 1989, J Biol Rhythms, 4, 161, 10.1177/074873048900400206 · DOI
  26. Minors D S, 1991, Neurosci Lett, 133, 36, 10.1016/0304-3940(91)90051-T · DOI · Paper page
  27. Lewy A J, 1983, The pineal gland, 77
  28. Daan S, 1984, Psychopharmacol Bull, 20, 566
  29. Lewy A J, 1980, Science, 210, 1267, 10.1126/science.7434030 · DOI · Paper page
  30. Lewy A J, 1991, Advances in pineal research, 285
  31. Lewy A J, 1987, Science, 235, 352, 10.1126/science.3798117 · DOI · Paper page
  32. McArthur A J, 1991, Brain Res, 565, 158, 10.1016/0006-8993(91)91748-P · DOI · Paper page
  33. Lewy A J, 1996, Progress in brain research Vol. Ill, hypothalamic integration of circadian rhythms, 205
  34. Illnerova H, 1986, Circadian rhythms in the mammalian pineal gland
  35. Illnerova H, 1986, Advances in pineal research, 69
  36. Illnerová H, 1982, Vertebrate circadian systems: structure and physiology, 285, 10.1007/978-3-642-68651-1_32 · DOI
  37. Humlová M, 1990, Neuroendocrinology, 52, 196, 10.1159/000125573 · DOI
  38. Lewy A J, 1985, Photoperiodism, melatonin and the pineal, 231
  39. Deacon S, 1995, Brain Res, 688, 77, 10.1016/0006-8993(95)96872-I · DOI · Paper page
  40. Cassone V M, 1990, Trends Neurosci, 13, 457, 10.1016/0166-2236(90)90099-V · DOI · Paper page
  41. Kräuchi K, 1997, Sleep Res, 26, 78
  42. Kräuchi K, 1997, Soc Light Treatment Biol Rhythms Abst, 9, 12
  43. Hätönen T, 1996, Brain Res, 710, 125, 10.1016/0006-8993(95)01397-0 · DOI
  44. Lewy A J, Biological clocks: mechanisms and physiopathology
  45. Trinder J, 1996, Sleep Res, 25, 575
  46. Lewy A J, 1994, Evolution of circadian clock, 291
  47. Sack R L, 1994, Sleep Res, 23, 509
  48. Lewy A J, 1994, Circadian clocks and their adjustment, 303
  49. Lewy A J, 1983, Psychopharmacol Bull, 19, 523
  50. Lewy A J, 1987, Chronobiology and psychiatric disorders, 181
  51. Regestein Q R, 1995, Am J Psychiatry, 152, 602, 10.1176/ajp.152.4.602 · DOI · Paper page
  52. Monk T H, 1989, Principles and practice of sleep medicine, 333
  53. Lewy A J, 1983, J Clin Endocr Metab, 56, 1103, 10.1210/jcem-56-6-1103 · DOI · Paper page
  54. Sack R L, 1992, J Clin Endocr Metab, 75, 127
  55. Sack R L, 1990, Sleep Res, 19, 404
  56. Lewy A J, 1998, Psychiatry Res, 77, 57, 10.1016/S0165-1781(97)00128-5 · DOI

Cited by

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Metadata

Authors
Lewy, A. J., Bauer, V. K., Ahmed, S., Thomas, K. H., Cutler, N. L., Singer, C. M., Moffit, M. T., & Sack, R. L.
Venue
Chronobiology International
Publisher
Informa UK Limited
Published
1998-01
Volume
15
Issue
1
Pages
71-83
ISSN
  • 0742-0528 (ISSN-L)
  • 1525-6073
DOI
10.3109/07420529808998671
OpenAlex
W2003538972
Cited by
363
References
3
FWCI
3.90
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Human Phase Response Curve (Prc) to Melatonin is About 12 Hours out of Phase with the Prc to Light. https://app.cochat.ai/papers/10.3109/07420529808998671
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Lewy, A. J., Bauer, V. K., Ahmed, S., Thomas, K. H., Cutler, N. L., Singer, C. M., Moffit, M. T., & Sack, R. L. (1998). The Human Phase Response Curve (Prc) to Melatonin is About 12 Hours out of Phase with the Prc to Light. Chronobiology International. https://doi.org/10.3109/07420529808998671

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