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Cited by 693

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Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve

Lewy, Alfred J., Ahmed, Saeeduddin, Jackson, Jeanne M. Latham, Sack, Robert L.·1992·Chronobiology International
DOI 10.3109/07420529209064550
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Abstract

A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon or early evening. The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel. The human melatonin PRC also provides the strongest evidence to date for a function of endogenous melatonin and its suppression by light in augmenting entrainment of circadian rhythms by the light-dark cycle.

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Cited by

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Metadata

Authors
Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L.
Venue
Chronobiology International
Publisher
Informa UK Limited
Published
1992-01
Volume
9
Issue
5
Pages
380-392
ISSN
  • 0742-0528 (ISSN-L)
  • 1525-6073
DOI
10.3109/07420529209064550
OpenAlex
W2163920027
Cited by
693
References
4
FWCI
16.08
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve. https://app.cochat.ai/papers/10.3109/07420529209064550
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Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992). Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve. Chronobiology International. https://doi.org/10.3109/07420529209064550

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