Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial
Abstract
The aim of this study was to evaluate the effects of metformin in addition to diet and exercise on endocrine and metabolic disturbances in women with polycystic ovary syndrome (PCOS) in a prospective, double-blind, randomized, placebo (PBO) control trial. Thirty women with insulin resistance and PCOS received lifestyle modification and 1500 mg of metformin or placebo for 4 months. Before and after treatment, body mass index, waist/hip ratio, blood pressure, hirsutism, and menstrual patterns were evaluated. Serum concentrations of gonadotropins, androgens, progesterone, glucose, insulin, and lipids were measured. Lifestyle interventions resulted in similar weight and menstrual cycle's improvements in both groups. A significant reduction in serum fasting insulin, HOMA index, waist and testosterone levels was only observed with metformin. There were no significant changes in androstenedione, dehydroepiandrosterone sulfate, gonadotropins, and lipids levels. No other changes were observed in hirsutism or blood pressure. These findings suggest that metformin has an additive effect to diet and exercise to improve parameters of hyperandrogenism and insulin resistance. Although, a small decrease in body weight trough lifestyle changes could be enough to improve menstrual cycles in insulin-resistant women with PCOS.
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One RCT found HOMA-IR was lower in participants treated with metformin and lifestyle (P=.006).
“One RCT, 41 not included in the meta-analyses, found that HOMA-IR was lower in participants treated with metformin and lifestyle (P = .006).”
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- Authors
- Fux Otta, C., Wior, M., Iraci, G. S., Kaplan, R., Torres, D., Gaido, M. I., & Wyse, E. P.
- Affiliations
- Hospital Privado (AR)
- Universidad Nacional de Córdoba (AR)
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2010-02-12
- Volume
- 26
- Issue
- 3
- Pages
- 173-178
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2003741958
- Cited by
- 85
- References
- 46
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 8 · 2015: 9 · 2014: 6 · 2013: 1 · 2012: 9
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, metformin, lifestyle intervention, diet and exercise, insulin resistance, hyperandrogenism, menstrual cycle, hirsutism, fasting insulin, HOMA index, testosterone, body weight, gonadotropins, androgens, blood pressure
- MeSH terms
- Adult, Blood Pressure, Cholesterol, Double-Blind Method, Female, Follicle Stimulating Hormone, Hirsutism, Humans, Hypoglycemic Agents, Insulin Resistance, Luteinizing Hormone, Life Style, Menstrual Cycle, Metformin, Polycystic Ovary Syndrome, Testosterone, Triglycerides, Body Mass Index, Statistics, Nonparametric, Waist-Hip Ratio, Young Adult
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