Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Measuring inconsistency in meta-analyses

Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)

The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138 · see citing works

Amenorrhea associated with bilateral polycystic ovaries

Stein, I. F., & Leventhal, M. L. (1935) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30642-6 · Cited by 2,121 · see citing works

Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.024 · Cited by 1,976 · see citing works

Thiazolidinediones

Yki-Järvinen, H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041001 · Cited by 1,830 · see citing works

The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria

March, W. A., Moore, V. M., Willson, K. J., Phillips, D. I. W., Norman, R. J., & Davies, M. J. (2010) · Human Reproduction · doi:10.1093/humrep/dep399 · Cited by 1,799 · see citing works

Maternal Morbid Obesity and the Risk of Adverse Pregnancy Outcome

Cedergren, M. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000107291.46159.00 · Cited by 1,352 · see citing works

Metformin—mode of action and clinical implications for diabetes and cancer

Pernicova, I., & Korbonits, M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.256 · Cited by 1,345 · see citing works

Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis

Gillies, C. L., Abrams, K. R., Lambert, P. C., Cooper, N. J., Sutton, A. J., Hsu, R. T., & Khunti, K. (2007) · BMJ · doi:10.1136/bmj.39063.689375.55 · Cited by 1,171 · see citing works

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome

Legro, R. S., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Cataldo, N. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063971 · Cited by 1,027 · see citing works

Prevalence and Characteristics of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Apridonidze, T., Essah, P. A., Iuorno, M. J., & Nestler, J. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1045 · Cited by 931 · see citing works

Improvement in Endocrine and Ovarian Function during Dietary Treatment of Obese Women with Polycystic Ovary Syndrome

Kiddy, D. S., Hamilton‐Fairley, D., Bush, A., Short, F., Anyaoku, V., Reed, M. J., & Franks, S. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02909.x · Cited by 921 · see citing works

Effects of Metformin on Spontaneous and Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome

Nestler, J. E., Jakubowicz, D. J., Evans, W. S., & Pasquali, R. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806253382603 · Cited by 781 · see citing works

Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp

Stepto, N. K., Cassar, S., Joham, A. E., Hutchison, S. K., Harrison, C. L., Goldstein, R. F., & Teede, H. J. (2013) · Human Reproduction · doi:10.1093/humrep/des463 · Cited by 747 · see citing works

Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome

Nestler, J. E., & Jakubowicz, D. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608293350902 · Cited by 743 · see citing works

Lifestyle changes in women with polycystic ovary syndrome

Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725 · see citing works

Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials

Lago, R. M., Singh, P. P., & Nesto, R. W. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61514-1 · Cited by 710 · see citing works

The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global who guidance

Balen, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., Stener-Victorin, E., Fauser, B. C. J. M., Norman, R. J., & Teede, H. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw025 · Cited by 705 · see citing works

Prevalence and Predictors of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R. S., & Ghazzi, M. N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1329 · Cited by 703 · see citing works

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Tang, T., Lord, J. M., Norman, R. J., Yasmin, E., & Balen, A. H. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053.pub5 · Cited by 698 · see citing works

Metformin Effects on Clinical Features, Endocrine and Metabolic Profiles, and Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled 6-Month Trial, followed by Open, Long-Term Clinical Evaluation¹

Moghetti, P., Castello, R., Negri, C., Tosi, F., Perrone, F., Caputo, M., Zanolin, E., & Muggeo, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6293 · Cited by 660 · see citing works

Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome

Pasquali, R., Gambineri, A., Biscotti, D., Vicennati, V., Gagliardi, L., Colitta, D., Fiorini, S., Cognigni, G. E., Filicori, M., & Morselli-Labate, A. M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6738 · Cited by 635 · see citing works

The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome

Dunaif, A. E., Scott, D., Finegood, D. T., Quintana, B., & Whitcomb, R. W. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784087 · Cited by 560 · see citing works

Obesity and reproductive disorders in women

Pasquali, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg024 · Cited by 540 · see citing works

Health care-related economic burden of the polycystic ovary syndrome during the reproductive life Span

Azziz, R., Marin, C., Hoq, L., Badamgarav, E., & Song, P. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0628 · Cited by 537 · see citing works

Troglitazone Improves Ovulation and Hirsutism in the Polycystic Ovary Syndrome: A Multicenter, Double Blind, Placebo-Controlled Trial1

Azziz, R., Ehrmann, D. A., Legro, R. S., Whitcomb, R. W., Hanley, R. M., Fereshetian, A. G., O’Keefe, M., & Ghazzi, M. N. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7375 · Cited by 537 · see citing works

Ovulatory and Metabolic Effects of d-<i>Chiro</i>-Inositol in the Polycystic Ovary Syndrome

Nestler, J. E., Jakubowicz, D. J., Reamer, P., Gunn, R. D., & Allan, G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401703 · Cited by 518 · see citing works

The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study

Ford, E. S. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.12.022 · Cited by 501 · see citing works

Lean Women with Polycystic Ovary Syndrome Respond to Insulin Reduction with Decreases in Ovarian P450c17 Activity and Serum Androgens

Nestler, J. E., & Jakubowicz, D. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4431 · Cited by 394 · see citing works

Troglitazone Improves Ovulation and Hirsutism in the Polycystic Ovary Syndrome: A Multicenter, Double Blind, Placebo-Controlled Trial

Azziz, R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.4.1626 · Cited by 378 · see citing works

Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome

Tang, T. H., Norman, R. J., Balen, A. H., & Lord, J. M. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053 · Cited by 369 · see citing works

Ovarian Function and Metabolic Factors in Women with Oligomenorrhea Treated with Metformin in a Randomized Double Blind Placebo-Controlled Trial

Fleming, R., Hopkinson, Z. E., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8261 · Cited by 366 · see citing works

Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone

Vandermolen, D. T., Ratts, V. S., Evans, W. S., Stovall, D. W., Kauma, S. W., & Nestler, J. E. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01675-7 · Cited by 356 · see citing works

Prevalence and Characteristics of the Polycystic Ovary Syndrome in Overweight and Obese Women

Álvarez‐Blasco, F., Botella-Carretero, J. I., Millán, J. L. S., & Escobar-Morreale, H. F. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.19.2081 · Cited by 348 · see citing works

Metformin Effects on Clinical Features, Endocrine and Metabolic Profiles, and Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled 6-Month Trial, followed by Open, Long-Term Clinical Evaluation

Moghetti, P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.1.139 · Cited by 342 · see citing works

Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study

Tang, T., Glanville, J., Hayden, C. J., White, D., Barth, J. H., & Balen, A. H. (2006) · Human Reproduction · doi:10.1093/humrep/dei311 · Cited by 335 · see citing works

Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome (PCOS) among South Asians and Caucasians: is there a difference?

Wijeyaratne, C. N., Balen, A. H., Barth, J. H., & Belchetz, P. E. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01603.x · Cited by 315 · see citing works

Menstrual Cyclicity After Metformin Therapy in Polycystic Ovary Syndrome

M, E., Acosta, A., & Mendoza, S. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00296-2 · Cited by 310 · see citing works

The Finnish Diabetes Prevention Study

Uusitupa, M. I. J., Louheranta, A. M., Lindström, J., Valle, T. T., Sundvall, J., Eriksson, J. G., & Tuomilehto, J. O. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500001070 · Cited by 306 · see citing works

Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women

Crave, J. C., Fimbel, S., Lejeune, H., Cugnardey, N., Déchaud, H., & Pugeat, M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.7.7608255 · Cited by 301 · see citing works

Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity

Baillargeon, J.-P., Jakubowicz, D. J., Iuorno, M. J., Jakubowicz, S., & Nestler, J. E. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.02.127 · Cited by 300 · see citing works

Lifestyle changes in women with polycystic ovary syndrome

Moran, L. J., Hutchison, S. K., Norman, R. J., & Teede, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub3 · Cited by 292 · see citing works

The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries

Robinson, S., Kiddy, D. S., Gelding, S. V., Willis, D., Niththyananthan, R., Bush, A., Johnston, D. G., & Franks, S. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02376.x · Cited by 282 · see citing works

Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial

Moll, E., Bossuyt, P., Korevaar, J., Lambalk, C., & van der Veen, F. (2006) · British medical journal · doi:10.1136/bmj.38867.631551.55 · Cited by 280 · see citing works

Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome

Palomba, S., Orio, F., Falbo, A., Manguso, F., Russo, T., Cascella, T., Tolino, A., Carmina, E., Colao, A., & Zullo, F. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2005-0110 · Cited by 279 · see citing works

A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: A pilot study

Hoeger, K. M., Kochman, L., Wixom, N., Craig, K., Miller, R. K., & Guzick, D. S. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.02.104 · Cited by 278 · see citing works

Restoration of Reproductive Potential by Lifestyle Modification in Obese Polycystic Ovary Syndrome: Role of Insulin Sensitivity and Luteinizing Hormone

Huber-Buchholz, M.-M. (1999) · Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.84.4.1470 · Cited by 269 · see citing works

Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome

Koçak, M., Çalışkan, E., ŞİMŞİR, Ç., & Haberal, A. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02941-7 · Cited by 267 · see citing works

Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome

Leo, V. D., Marca, A. L., Ditto, A., Morgante, G., & Cianci, A. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00208-3 · Cited by 266 · see citing works

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome

Tso, L. O., Costello, M., Albuquerque, L. E. T., Andriolo, R. B., & Macedo, C. R. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006105.pub3 · Cited by 255 · see citing works

Effect of the Insulin Sensitizer Pioglitazone on Insulin Resistance, Hyperandrogenism, and Ovulatory Dysfunction in Women with Polycystic Ovary Syndrome

Brettenthaler, N., Geyter, C. D., Huber, P., & Keller, U. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031737 · Cited by 247 · see citing works

Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome

Diamanti‐Kandarakis, E., Christakou, C. D., Kandaraki, E., & Economou, F. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0733 · Cited by 246 · see citing works

Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial

Morin-Papunen, L., Rantala, A. S., Unkila-Kallio, L., Tiitinen, A., Hippeläinen, M., Perheentupa, A., Tinkanen, H., Bloigu, R., Puukka, K., Ruokonen, A., et al. (2012) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-3061 · Cited by 243 · see citing works

Endocrine and Metabolic Effects of MetforminVersusEthinyl Estradiol-Cyproterone Acetate in Obese Women with Polycystic Ovary Syndrome: A Randomized Study1

Morin-Papunen, L. C., Vauhkonen, I., Koivunen, R. M., Ruokonen, A., Martikainen, H. K., & Tapanainen, J. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6792 · Cited by 239 · see citing works

A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome

Costello, M. F., & Eden, J. A. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04554-5 · Cited by 224 · see citing works

Leptin Concentrations in the Polycystic Ovary Syndrome

Mantzoros, C. S., Dunaif, A. E., & Flier, J. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.4017 · Cited by 200 · see citing works

Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome

Costello, M. F., Shrestha, B., Eden, J., Johnson, N., & Moran, L. J. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005552.pub2 · Cited by 197 · see citing works

Troglitazone-induced liver failure: a case study

Graham, D. J., Green, L., Senior, J. R., & Nourjah, P. A. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01529-2 · Cited by 187 · see citing works

Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial

Ng, E. H. Y. (2001) · Human Reproduction · doi:10.1093/humrep/16.8.1625 · Cited by 183 · see citing works

Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial

Yaralı́, H. (2002) · Human Reproduction · doi:10.1093/humrep/17.2.289 · Cited by 171 · see citing works

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)—relationship to newly identified mitochondrial pyruvate carrier proteins

Colca, J. R., McDonald, W. G., Cavey, G. S., Cole, S. L., Holewa, D. D., Brightwell-Conrad, A. S., Wolfe, C. L., Wheeler, J. S., Coulter, K. R., Kilkuskie, P. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061551 · Cited by 171 · see citing works

Insulin Reduction with Metformin Increases Luteal Phase Serum Glycodelin and Insulin-Like Growth Factor-Binding Protein 1 Concentrations and Enhances Uterine Vascularity and Blood Flow in the Polycystic Ovary Syndrome1

Jakubowicz, D. J., Seppälä, M. T., Jakubowicz, S., Rodriguez-Armas, O., Rivas-Santiago, A., Koistinen, H. K., Koistinen, R., & Nestler, J. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7295 · Cited by 164 · see citing works

Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin

Maciel, G. A. R., Soares, J. M., Motta, E. L. A., Haidar, M. A., de Lima, G. R., & Baracat, E. C. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.08.012 · Cited by 161 · see citing works

Untitled work

(2009) · PubMed · Cited by 160 · see citing works

Endocrine and Metabolic Effects of Metformin Versus Ethinyl Estradiol-Cyproterone Acetate in Obese Women with Polycystic Ovary Syndrome: A Randomized Study

Morin-Papunen, L. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.9.3161 · Cited by 157 · see citing works

Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: a randomized controlled study

Elter, K., İmir, G., & Durmuşoğlu, F. (2002) · Human Reproduction · doi:10.1093/humrep/17.7.1729 · Cited by 152 · see citing works

Health-related quality of life in women with polycystic ovary syndrome, a self-administered questionnaire, was validated

Guyatt, G. H., Weaver, B., Cronin, L., Dooley, J. A., & Azziz, R. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2003.10.018 · Cited by 151 · see citing works

First-trimester exposure to metformin and risk of birth defects: a systematic review and meta-analysis

Cassina, M., Donà, M., Di Gianantonio, E., Litta, P., & Clementi, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu022 · Cited by 143 · see citing works

The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study

Ladson, G., Dodson, W. C., Sweet, S. D., Archibong, A. E., Kunselman, A. R., Demers, L. M., Williams, N. I., Coney, P., & Legro, R. S. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.12.002 · Cited by 138 · see citing works

Lean Women With Polycystic Ovary Syndrome Respond to Insulin Reduction With Decreases in Ovarian P450c17 alpha Activity and Serum Androgens

Nestler, J. E., & Jakubowicz, D. J. (1998) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199805000-00018 · Cited by 135 · see citing works

Early Effects of Metformin in Women with Polycystic Ovary Syndrome: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial

Eisenhardt, S., Schwarzmann, N., Henschel, V., Germeyer, A., von Wolff, M., Hamann, A., & Strowitzki, T. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1994 · Cited by 130 · see citing works

Insulin Reduction with Metformin Increases Luteal Phase Serum Glycodelin and Insulin-Like Growth Factor-Binding Protein 1 Concentrations and Enhances Uterine Vascularity and Blood Flow in the Polycystic Ovary Syndrome

Jakubowicz, D. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.3.1126 · Cited by 130 · see citing works

Aromatase inhibitors for subfertile women with polycystic ovary syndrome

Franik, S., Kremer, J. A. M., Nelen, W. L. D. M., & Farquhar, C. M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010287.pub2 · Cited by 125 · see citing works

Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.

Gerli, S., Mignosa, M., & Renzo, G. C. D. (2003) · PubMed · Cited by 125 · see citing works

Additive Effects of Insulin-Sensitizing and Anti-Androgen Treatment in Young, Nonobese Women with Hyperinsulinism, Hyperandrogenism, Dyslipidemia, and Anovulation

Ibáñez, L., Valls, C., Ferrer, A., Ong, K. K., Dunger, D. B., & de Zegher, F. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8568 · Cited by 120 · see citing works

An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate–metformin in patients with polycystic ovary syndrome

Karimzadeh, M. A., & Javedani, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.02.078 · Cited by 118 · see citing works

Consensus on infertility treatment related to polycystic ovary syndrome.

Hong, K. (2008) · Human Reproduction · doi:10.1093/humrep/dem426 · Cited by 117 · see citing works

The Effect of Metformin on Fat Distribution and the Metabolic Syndrome in Women With Polycystic Ovary Syndrome–A Randomised, Double-Blind, Placebo-Controlled Trial

Lord, J., Thomas, R., Fox, B., Acharya, U., & Wilkin, T. (2006) · BJOG: An International Journal of Obstetrics &amp; Gynaecology · doi:10.1111/j.1471-0528.2006.00966.x · Cited by 113 · see citing works

The Pregnancy in Polycystic Ovary Syndrome Study: baseline characteristics of the randomized cohort including racial effects

Legro, R. S., Myers, E. R., Barnhart, H. X., Carson, S. A., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., McGovern, P. G., Cataldo, N. A., et al. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.03.037 · Cited by 111 · see citing works

Prevalence of the metabolic syndrome and its components in Brazilian women with polycystic ovary syndrome

Soares, E. M. M., Azevedo, G. D., Gadelha, R. G. N., Lemos, T. M. A. M., & Maranhão, T. M. O. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.03.081 · Cited by 106 · see citing works

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial

Zain, M. M., Jamaluddin, R., Ibrahim, A., & Norman, R. J. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.002 · Cited by 105 · see citing works

Soluble CD36 and Risk Markers of Insulin Resistance and Atherosclerosis Are Elevated in Polycystic Ovary Syndrome and Significantly Reduced During Pioglitazone Treatment

Glintborg, D., Højlund, K., Andersen, M., Henriksen, J. E., Beck‐Nielsen, H., & Handberg, A. (2008) · Diabetes Care · doi:10.2337/dc07-1424 · Cited by 103 · see citing works

The effect of metformin on hirsutism in polycystic ovary syndrome

Kelly, C., & Gordon, D. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470217 · Cited by 102 · see citing works

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Tang, T. H., Lord, J. M., Norman, R. J., Yasmin, E., & Balen, A. H. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053.pub4 · Cited by 101 · see citing works

Clomiphene citrate, metformin or both as first‐step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head‐to‐head randomized controlled studies and meta‐analysis

Palomba, S., Pasquali, R., Orio, F., & Nestler, J. E. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03369.x · Cited by 98 · see citing works

Untitled work

(2011) · PubMed · Cited by 91 · see citing works

Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled cross-over trial

Trolle, B., Flyvbjerg, A., Kesmodel, U., & Lauszus, F. F. (2007) · Human Reproduction · doi:10.1093/humrep/dem271 · Cited by 90 · see citing works

Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study

Rautio, K., Tapanainen, J. S., Ruokonen, A., & Morin-Papunen, L. C. (2006) · Human Reproduction · doi:10.1093/humrep/dei505 · Cited by 88 · see citing works

Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome

Azziz, R., Ehrmann, D. A., Legro, R. S., Fereshetian, A. G., O’Keefe, M., & Ghazzi, M. N. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04914-2 · Cited by 87 · see citing works

Short-Term Intervention with Liraglutide Improved Eating Behavior in Obese Women with Polycystic Ovary Syndrome

Jensterle, M., Kocjan, T., Kravos, N. A., Pfeifer, M., & Janez, A. (2015) · Endocrine Research · doi:10.3109/07435800.2014.966385 · Cited by 86 · see citing works

Psychological parameters in the reproductive phenotypes of polycystic ovary syndrome

Moran, L., Deeks, A. A., Gibson‐Helm, M. E., & Teede, H. J. (2012) · Human Reproduction · doi:10.1093/humrep/des114 · Cited by 86 · see citing works

Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial

Fux Otta, C., Wior, M., Iraci, G. S., Kaplan, R., Torres, D., Gaido, M. I., & Wyse, E. P. (2010) · Gynecological Endocrinology · doi:10.3109/09513590903215581 · Cited by 85 · see citing works

Clinical, Metabolic and Endocrine Parameters in Response to Metformin in Obese Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind and Placebo-Controlled Trial

Chou, K. H., Corleta, H. V. E., Capp, E., & Spritzer, P. M. (2003) · Hormone and Metabolic Research · doi:10.1055/s-2003-39056 · Cited by 85 · see citing works

Plasma homocysteine in polycystic ovary syndrome: does it correlate with insulin resistance and ethnicity?

Wijeyaratne, C. N., Nirantharakumar, K., Balen, A. H., Barth, J. H., Sheriff, R., & Belchetz, P. E. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02019.x · Cited by 82 · see citing works

Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis

Misso, M. L., Costello, M. F., Garrubba, M., Wong, J., Hart, R., Rombauts, L., Melder, A. M., Norman, R. J., & Teede, H. J. (2013) · Human Reproduction Update · doi:10.1093/humupd/dms036 · Cited by 81 · see citing works

Prevalence of the Metabolic Syndrome in German Women with Polycystic Ovary Syndrome

Hahn, S., Tan, S., Sack, S., Kimmig, R., Quadbeck, B., Mann, K., & Janssen, O. E. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-967093 · Cited by 80 · see citing works

A randomized controlled trial of the efficacy of rosiglitazone and clomiphene citrate versus metformin and clomiphene citrate in women with clomiphene citrate–resistant polycystic ovary syndrome

Rouzi, A. A., & Ardawi, M. S. M. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.07.1312 · Cited by 80 · see citing works

PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene

JOHNSON, N. P., Stewart, A., Falkiner, J., Farquhar, C. M., Milsom, S. R., Singh, V. P., Okonkwo, Q. L., & Buckingham, K. (2010) · Human Reproduction · doi:10.1093/humrep/deq100 · Cited by 78 · see citing works

Progression to impaired glucose tolerance or type 2 diabetes mellitus in polycystic ovary syndrome: a controlled follow-up study

Celik, C., Taşdemir, N., Abalı, R., Baştu, E., & Yılmaz, M. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.12.050 · Cited by 74 · see citing works

Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome

Khorram, O., Helliwell, J. P., Katz, S., Bonpane, C. M., & Jaramillo, L. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.042 · Cited by 73 · see citing works

Metabolic and Hormonal Changes Induced by Pioglitazone in Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Clinical Trial

Aroda, V. R., Ciaraldi, T. P., Burke, P., Mudaliar, S., Clopton, P., Phillips, S., Chang, R. J., & Henry, R. R. (2009) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2008-1133 · Cited by 71 · see citing works

Predictive value of glucose–insulin ratio in PCOS and profile of women who will benefit from metformin therapy: Obese, lean, hyper or normoinsulinemic?

Önalan, G., Göktolga, Ü., Ceyhan, T., Bağış, T., Önalan, R., & Pabuçcu, R. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.05.010 · Cited by 71 · see citing works

Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice

Sturrock, N. D. C., Lannon, B. M., & Fay, T. N. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01575.x · Cited by 70 · see citing works

Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo‐controlled study in polycystic ovary syndrome

Glintborg, D., Frystyk, J., Højlund, K., Andersen, K. K., Henriksen, J. E., Hermann, A. P., Hagen, C., Flyvbjerg, A., & Andersen, M. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03015.x · Cited by 69 · see citing works

Effect of pioglitazone on glucose metabolism and luteinizing hormone secretion in women with polycystic ovary syndrome

Glintborg, D., Hermann, A. P., Andersen, M., Hagen, C., Beck‐Nielsen, H., Veldhuis, J. D., & Henriksen, J. E. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.12.067 · Cited by 68 · see citing works

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome

Bordewijk, E. M., Nahuis, M. J., Costello, M., van der Veen, F., Tso, L. O., Mol, B. W., & van Wely, M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009090.pub2 · Cited by 65 · see citing works

The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome

Şahin, Y., Yirmibeş, Ü., Keleştimur, F., & Aygen, E. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2003.09.036 · Cited by 61 · see citing works

Ultra‐short metformin pretreatment for clomiphene citrate‐resistant polycystic ovary syndrome

Hwu, Y., Lin, S., Huang, W. Y., Lin, M., & Lee, R. K. K. (2005) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2005.04.004 · Cited by 60 · see citing works

Minimal Response of Circulating Lipids in Women with Polycystic Ovary Syndrome to Improvement in Insulin Sensitivity with Troglitazone

Legro, R. S., Azziz, R., Ehrmann, D. A., Fereshetian, A. G., O’Keefe, M., & Ghazzi, M. N. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030044 · Cited by 60 · see citing works

Metformin versus lifestyle changes in treating women with polycystic ovary syndrome

Curi, D. D. G., Fonseca, A. M., Marcondes, J. A. M., Almeida, J. A. M., Bagnoli, V. R., Soares, J. M., & Baracat, E. C. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.583957 · Cited by 60 · see citing works

Prevalence of the metabolic syndrome in Asian women with polycystic ovary syndrome: Using the International Diabetes Federation criteria

Weerakiet, S., Bunnag, P., Phakdeekitcharoen, B., Wansumrith, S., Chanprasertyothin, S., Jultanmas, R., & Thakkinstian, A. (2007) · Gynecological Endocrinology · doi:10.1080/09513590701214158 · Cited by 59 · see citing works

Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial

Romualdi, D., Giuliani, M., Cristello, F., Fulghesu, A. M., Selvaggi, L., Lanzone, A., & Guido, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.114 · Cited by 58 · see citing works

Definition of insulin resistance using the homeostasis model assessment (HOMA-IR) in IVF patients diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria

Alebić, M. Š., Bulum, T., Stojanović, N., & Duvnjak, L. S. (2014) · Endocrine · doi:10.1007/s12020-014-0182-5 · Cited by 56 · see citing works

Polycystic ovary syndrome and fat distribution: The central issue?

Lord, J. M., & Wilkin, T. J. (2002) · Human Fertility · doi:10.1080/1464727022000198952 · Cited by 55 · see citing works

Correction of Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome By Combined Rosiglitazone and Clomiphene Citrate Therapy

Shobokshi, A., & Shaarawy, M. (2003) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(02)00260-5 · Cited by 52 · see citing works

Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?

Moll, E., Korevaar, J. C., Bossuyt, P. M., & van der Veen, F. (2008) · Human Reproduction · doi:10.1093/humrep/den182 · Cited by 49 · see citing works

Mitochondrial Inhibitor as a New Class of Insulin Sensitizer

Zhang, Y., & Ye, J. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.010 · Cited by 47 · see citing works

A retrospective study of the pregnancy, delivery and neonatal outcome in overweight versus normal weight women with polycystic ovary syndrome

Frène, V. D., Vansteelandt, S., T'Sjoen, G. G., Gerris, J., Somers, S., Vercruysse, L., & Sutter, P. D. (2014) · Human Reproduction · doi:10.1093/humrep/deu154 · Cited by 47 · see citing works

The effect of metformin plus clomiphene citrate on ovulation and pregnancy rates in clomiphene-resistant women with polycystic ovary syndrome

Malkawi, H. Y., & Qublan, H. S. (2002) · Saudi Medical Journal · doi:10.15537/1658-3175.1726 · Cited by 46 · see citing works

Is Metformin Indicated as Primary Ovulation Induction Agent in Women with PCOS? A Systematic Review and Meta-Analysis

Siebert, T. I., Viola, M. I., Steyn, D. W., & Kruger, T. F. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000335253 · Cited by 46 · see citing works

Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome

Palomba, S., Orio, F., Falbo, A. I., Russo, T., Tolino, A., & Zullo, F. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.035 · Cited by 45 · see citing works

Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial

Palomba, S., Falbo, A. I., Cello, A. D., Cappiello, F., Tolino, A., & Zullo, F. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.08.020 · Cited by 45 · see citing works

Twenty years of ovulation induction with metformin for PCOS; what is the best available evidence?

Hashim, H. A. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.09.015 · Cited by 44 · see citing works

Retinol-Binding Protein 4 in Polycystic Ovary Syndrome—Association with Steroid Hormones and Response to Pioglitazone Treatment

Aigner, E. S., Bachofner, N., Klein, K., Geyter, C. D., Hohla, F., Patsch, W., & Datz, C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2156 · Cited by 44 · see citing works

Pioglitazone Treatment Increases Spontaneous Growth Hormone (GH) Secretion and Stimulated GH Levels in Polycystic Ovary Syndrome

Glintborg, D., Støving, R. K., Hagen, C., Hermann, A. P., Frystyk, J., Veldhuis, J. D., Flyvbjerg, A., & Andersen, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0615 · Cited by 43 · see citing works

Type 2 diabetes and polycystic ovary syndrome

Legro, R. S. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.04.010 · Cited by 40 · see citing works

Clomiphene citrate, metformin or a combination of both as the first line ovulation induction drug for Asian Indian women with polycystic ovarian syndrome: A randomized controlled trial

Kar, S., & Sanchita, S. (2015) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.170373 · Cited by 37 · see citing works

The Insulin-Sensitizing Agent Troglitazone Improves Metabolic and Reproductive Abnormalities in the Polycystic Ovary Syndrome

Dunaif, A. E., Scott, D., Finegood, D. T., Quintana, B., & Whitcomb, R. W. (1997) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199702000-00016 · Cited by 32 · see citing works

Rosiglitazone treatment alleviates inflammation and improves liver function in overweight women with polycystic ovary syndrome: a randomized placebo-controlled study

Rautio, K., Tapanainen, J. S., Ruokonen, A., & Morin-Papunen, L. C. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.061 · Cited by 29 · see citing works

Does metformin induce ovulation in normoandrogenic anovulatory women?

Carmina, E., & Løbo, R. A. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.05.030 · Cited by 29 · see citing works

The effect of administration of metformin on lipid profile changes andinsulin resistance in patients with polycystic ovary syndrome

Karimzadeh, M. A., Eftekhar, M., Taheripanah, R., Tayebi, N., Sakhavat, L., & Zare, F. (2007) · TSpace (University of Toronto) · Cited by 25 · see citing works

Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients

Siebert, T., Kruger, T., & Lombard, C. J. (2009) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-009-9304-z · Cited by 23 · see citing works

Ovulation induction with clomiphene citrate and metformin in women with polycystic ovary syndrome.

Leanza, V., Coco, L., Grasso, F., Leanza, G., Zarbo, G., & Palumbo, M. A. (2014) · PubMed · Cited by 22 · see citing works

Efficacy of combined metformin-clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome (PCOS).

Ayaz, A., Alwan, Y., & Farooq, M. U. (2013) · PubMed · Cited by 20 · see citing works

Metformin effects on clomifene-induced ovulation in the polycystic ovary syndrome.

Ayed, B. B., Mlik, S. D. D., Arab, H. B., Trabelsi, H., Chahtour, H., Mathlouthi, N., Dhuib, M., Kassis, M., Saiidane, D., Trabelsi, K., et al. (2009) · PubMed · Cited by 20 · see citing works

Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial

JOHNSON, N. P., Bontekoe, S., & Stewart, A. W. (2011) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2011.01295.x · Cited by 18 · see citing works

[Study on treatment of hyperandrogenism and hyperinsulinism in polycystic ovary syndrome with Chinese herbal formula "tiangui fang"].

Hou, J., Yu, J., & Wei, M. (2000) · PubMed · Cited by 16 · see citing works

Extended-Release Metformin Does Not Reduce the Clomiphene Citrate Dose Required to Induce Ovulation in Polycystic Ovary Syndrome

Cataldo, N. A., Barnhart, H. X., Legro, R. S., Myers, E. R., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0287 · Cited by 16 · see citing works

Metformin-clomiphene citrate vs. clomiphene citrate alone: Polycystic ovarian syndrome

Farooq, M., Ayaz, A., & Alwan, Y. (2013) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.112372 · Cited by 16 · see citing works

Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo

Moll, E., van Wely, M., Lambalk, C. B., Bossuyt, P. M., & van der Veen, F. (2012) · Human Reproduction · doi:10.1093/humrep/des310 · Cited by 15 · see citing works

Efficacy of Metformin in Obese and Non-obese Women With Polycystic Ovary Syndrome: A Randomized, Double-Blinded, Placebo-Controlled Cross-Over Trial

Trolle, B., Flyvbjerg, A., Kesmodel, U., & Lauszus, F. F. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000300471.31456.ea · Cited by 14 · see citing works

Clomiphene citrate alone, in combination with metformin or in combination with pioglitazone as first line therapy in induction of ovulation in infertile women with polycystic ovary syndrome, a randomized controlled trial

Abuelghar, W. M., Elkady, O. S., & Khamees, A. A. (2013) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2013.05.002 · Cited by 12 · see citing works

The reproductive and metabolic effect of rosiglitazone on Chinese women with polycystic ovarian syndrome—a double-blind randomized placebo-controlled study

Lam, P. M., Tam, W. H., Ronald, C. W., Cheung, L. P., Tsui, M. H. Y., Tong, P. C. Y., Chow, F. C. C., Lam, C. W. K., Chan, M. H. M., Chan, J. C. N., et al. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.085 · Cited by 12 · see citing works

Infertility in Practice

Balen, A. H. (2014) · CRC Press eBooks · doi:10.1201/b16081 · Cited by 12 · see citing works

Metformin-therapy Effects in 50 Clomiphene Citrate Resistant PCOS Patients

Farzadi, L., & ., S. Z. S. M. (2006) · Journal of Medical Sciences(Faisalabad) · doi:10.3923/jms.2006.765.771 · Cited by 11 · see citing works

Does metformin augment the ovulation inducing effects of clomiphene in non-obese women with polycystic ovary syndrome?

Chaudhury, K., Chaudhury, S., & Chowdhury, S. (2008) · PubMed · Cited by 9 · see citing works

Characteristics of polycystic ovary syndrome with and without insulin resistance and the role of insulinsensitizing drug (metformin) in its management

Refaie, A., Ibrahim, G., & Oash, S. A. (2005) · TSpace (University of Toronto) · Cited by 9 · see citing works

[Indication of metformin in the management of hormonal dysfunction secondary to polycystic ovarian syndrome: prospective comparative study of 63 cases].

Boudhrâa, K., Jellouli, M. A., Amri, M., Farhat, M., Torkhani, F., & Gara, M. F. (2010) · PubMed · Cited by 8 · see citing works

Co-administration of metformin during recombinant follicle stimulating hormone (recombinant FSH) treatment using the low-dose step-up protocol in patients with clomiphene citrate resistant polycystic ovary syndrome (PCOS): a prospective randomized trial.

Yaralı́, H., Yýldýz, B. O., Demi̇rol, A., Zeyneloğlu, H. B., Yigit, N., & Bükülmez, O. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02126-4 · Cited by 6 · see citing works

A randomized, placebo-controlled study of the influence of instant-release metformin on response to clomiphene citrate and time to conception in polycystic ovary syndrome

Williams, C. D., Pastore, L. M., Shelly, W. B., Bailey, A. P., Baras, D. C., & Bateman, B. G. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.07.1076 · Cited by 6 · see citing works

Metabolic risks of the lean PCOS woman

Kar, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.848 · Cited by 5 · see citing works

Effect of Metformin and Clomiphene Citrate in Improving Fertility in Subfertile Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

Begum, H., Chowdhury, T., Begum, F., Begum, S. N., Kabir, N., & Haque, M. A. (2016) · Bangladesh Journal of Obstetrics & Gynaecology · doi:10.3329/bjog.v29i1.30438 · Cited by 5 · see citing works

Insulin sensitizing agent (metformin) improves clinical pregnancy rate in clomiphene citrate resistant polycystic ovarian syndrome patients with acanthosis nigricans

Salman, S. A., Farghaly, T., Attallah, D. A. A., Abdel-Hafeez, H. A., & Shaaban, O. M. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.475 · Cited by 1 · see citing works

Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline

Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., & Welt, C. K. (2013) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2013-2350 · Cited by 1,919 · see citing works

Lifestyle changes in women with polycystic ovary syndrome

Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725 · see citing works

Ovulation: Parallels With Inflammatory Processes

Duffy, D. M., Ko, C. J., Jo, M., Brännström, M., & Curry, T. E. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00075 · Cited by 530 · see citing works

Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge

Fekadu, S., Alemayehu, E., Dewil, R., & der Bruggen, B. V. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.072 · Cited by 501 · see citing works

Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics

Glueck, C. J., & Goldenberg, N. (2019) · Metabolism · doi:10.1016/j.metabol.2018.11.002 · Cited by 442 · see citing works

Endometrial function in women with polycystic ovary syndrome: a comprehensive review

Palomba, S., Piltonen, T., & Giudice, L. C. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa051 · Cited by 385 · see citing works

Complications and challenges associated with polycystic ovary syndrome: current perspectives

Palomba, S., Santagni, S., Falbo, A., & La Sala, G. B. (2015) · International Journal of Women's Health · doi:10.2147/ijwh.s70314 · Cited by 287 · see citing works

Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization

Jungheim, E. S., Macones, G. A., Odem, R. R., Patterson, B. W., Lanzendorf, S. E., Ratts, V. S., & Moley, K. H. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.154 · Cited by 242 · see citing works

A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines

Neven, A., Laven, J., Teede, H., & Boyle, J. (2018) · Seminars in Reproductive Medicine · doi:10.1055/s-0038-1668085 · Cited by 196 · see citing works

Current Knowledge of Obesity’s Effects in the Pre-and Periconceptional Periods and Avenues for Future Research

Jungheim, E. S., & Moley, K. H. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.06.043 · Cited by 190 · see citing works

Recurrent miscarriage: evidence to accelerate action

Coomarasamy, A., Dhillon‐Smith, R. K., Papadopoulou, A., Al‐Memar, M., Brewin, J., Abrahams, V. M., Maheshwari, A., Christiansen, O. B., Stephenson, M. D., Goddijn, M., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00681-4 · Cited by 187 · see citing works

Physiologically Active Molecules and Functional Properties of Soybeans in Human Health—A Current Perspective

Kim, I.-S., Kim, C., & Yang, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084054 · Cited by 170 · see citing works

Polycystic ovarian syndrome-current pharmacotherapy and clinical implications

Rashid, R., Mir, S. A., Kareem, O., Ali, T. F., Ara, R., Malik, A., Amin, F., & Bader, G. N. (2022) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2021.11.009 · Cited by 157 · see citing works

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

Aversa, A., Vignera, S. L., Rago, R., Gambineri, A., Nappi, R. E., Calogero, A. E., & Ferlin, A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00516 · Cited by 159 · see citing works

Recent advances in the understanding and management of polycystic ovary syndrome

Rocha, A. L., Oliveira, F. R., Azevedo, R. C., Silva, V. A., Peres, T. M., Candido, A. L., Gomes, K. B., & Reis, F. M. (2019) · F1000Research · doi:10.12688/f1000research.15318.1 · Cited by 142 · see citing works

Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK

Jin, J., Ma, Y., Tong, X., Yang, W., Dai, Y., Pan, Y., Ren, P., Liu, L., Fan, H., Zhang, Y., et al. (2020) · Human Reproduction · doi:10.1093/humrep/deaa077 · Cited by 137 · see citing works

First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis

Wang, R., Li, W., Bordewijk, E. M., Legro, R. S., Heping Zhang, D., Wu, X., Gao, J., Morin-Papunen, L. C., Homburg, R., König, T. E., et al. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz029 · Cited by 136 · see citing works

Recent Advances in Treatment of Recurrent Spontaneous Abortion

Deng, T., Liao, X., & Zhu, S. (2022) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000001033 · Cited by 134 · see citing works

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome

Sharpe, A., Morley, L. C., Tang, T. H., Norman, R. J., & Balen, A. H. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013505 · Cited by 133 · see citing works

Polycystic Ovary Syndrome: Pathophysiology and Therapeutic Opportunities

Dong, J., & Rees, D. A. (2023) · BMJ Medicine · doi:10.1136/bmjmed-2023-000548 · Cited by 123 · see citing works

Infertility management in women with polycystic ovary syndrome: a review

Cunha, A., & Póvoa, A. M. (2021) · Porto Biomedical Journal · doi:10.1097/j.pbj.0000000000000116 · Cited by 123 · see citing works

Evidence summaries and recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome: assessment and treatment of infertility

Costello, M., Misso, M. L., Balen, A. H., Boyle, J., Devoto, L., Garad, R. M., Hart, R. J., Johnson, L., Jordan, C., Legro, R. S., et al. (2018) · Human Reproduction Open · doi:10.1093/hropen/hoy021 · Cited by 125 · see citing works

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: A randomized controlled study

Javed, Z., Papageorgiou, M., Deshmukh, H., Rigby, A. S., Qamar, U., Abbas, J., Khan, A. Y., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019) · Clinical Endocrinology · doi:10.1111/cen.13968 · Cited by 121 · see citing works

Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis

Zhao, H., Xing, C., Zhang, J., & He, B. (2021) · Reproductive Health · doi:10.1186/s12978-021-01207-7 · Cited by 124 · see citing works

Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome

de Medeiros, S. F., Rodgers, R. J., & Norman, R. J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab004 · Cited by 107 · see citing works

Ovulation induction in polycystic ovary syndrome

Tanbo, T. G., Mellembakken, J. R., Bjercke, S., Ring, E., Åbyholm, T., & Fedorcsák, P. (2018) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13395 · Cited by 98 · see citing works

Down‐regulation of steroidogenesis‐related genes and its accompanying fertility decline in streptozotocin‐induced diabetic male rats: ameliorative effect of metformin

Nna, V. U., Bakar, A. B. A., Ahmad, A., & Mohamed, M. (2018) · Andrology · doi:10.1111/andr.12567 · Cited by 90 · see citing works

Efficacy of Bariatric Surgery in the Treatment of Women With Obesity and Polycystic Ovary Syndrome

Hu, L., Ma, L., Xia, X., Ying, T., Zhou, M., Zou, S., Yu, H., & Yin, J. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac294 · Cited by 83 · see citing works

Inositol for subfertile women with polycystic ovary syndrome

Showell, M. G., Mackenzie-Proctor, R., Jordan, V., Hodgson, R., & Farquhar, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012378.pub2 · Cited by 76 · see citing works

Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms

Shpakov, A. O. (2021) · Pharmaceuticals · doi:10.3390/ph14010042 · Cited by 81 · see citing works

An update of polycystic ovary syndrome: causes and therapeutics options

Rababa’h, A. M., Matani, B. R., & Yehya, A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11010 · Cited by 73 · see citing works

Ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese: A randomized, open‐label, parallel‐group, controlled pilot trial

Li, J., Bai, W., Jiang, B., Bai, L., Gu, B., Yan, S., Li, F., & Huang, B. (2021) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14650 · Cited by 71 · see citing works

In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond

Wawrzkiewicz–Jałowiecka, A., Kowalczyk, K., Trybek, P., Jarosz, T., Radosz, P., Marcin, S., & Madej, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197054 · Cited by 71 · see citing works

Berberine improves ovulation and endometrial receptivity in polycystic ovary syndrome

Wang, Z., Nie, K., Su, H., Tang, Y., Wang, H., Xu, X., & Dong, H. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153654 · Cited by 63 · see citing works

Molecular Mechanisms of Laparoscopic Ovarian Drilling and Its Therapeutic Effects in Polycystic Ovary Syndrome

Seow, K., Chang, Y.-W., Chen, K.-H., Juan, C., Huang, C.-Y., Lin, L.-T., Tsui, K.-H., Chen, Y., Lee, W.-L., & Wang, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218147 · Cited by 67 · see citing works

Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction

Yang, W., Wang, L., Wang, F., & Yuan, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.593005 · Cited by 63 · see citing works

A brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome

Costello, M., Misso, M. L., Balen, A. H., Boyle, J. A., Devoto, L., Garad, R. M., Hart, R. J., Johnson, L., Jordan, C., Legro, R. S., et al. (2019) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.13051 · Cited by 58 · see citing works

Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care

Sydora, B. C., Wilke, M. S., McPherson, M., Chambers, S., Ghosh, M., & Vine, D. F. (2023) · BMC Women's Health · doi:10.1186/s12905-023-02732-2 · Cited by 60 · see citing works

Effect of Metformin on Microvascular Endothelial Function in Polycystic Ovary Syndrome

Heidari, B., Lerman, A., Lalia, A. Z., Lerman, L. O., & Chang, A. Y. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.06.015 · Cited by 57 · see citing works

Metformin-Induced Epigenetic Toxicity in Zebrafish: Experimental and Molecular Dynamics Simulation Studies

Lin, W., Yan, Y., Ping, S., Li, P., Li, D., Hu, J., Liu, W., Wen, X., & Ren, Y. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c06052 · Cited by 56 · see citing works

Metformin: Past, Present, and Future

Chaudhary, S., & Kulkarni, A. (2024) · Current Diabetes Reports · doi:10.1007/s11892-024-01539-1 · Cited by 59 · see citing works

Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and network meta-analysis

Ruiz‐González, D., Cavero‐Redondo, I., Hernández‐Martínez, A., Baena‐Raya, A., Martínez-Forte, S., Altmäe, S., Fernández‐Alonso, A. M., & Soriano‐Maldonado, A. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmae008 · Cited by 54 · see citing works

Metabolic alterations associated with polycystic ovary syndrome: A UPLC Q-Exactive based metabolomic study

Chen, X., Lu, T., Wang, X., Sun, X. L., Zhang, J., Zhou, K., Ji, X., Sun, R., Wang, X., Chen, M., et al. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.11.016 · Cited by 51 · see citing works

Menstrual dysfunction in polycystic ovary syndrome: association with dynamic state insulin resistance rather than hyperandrogenism

Ezeh, U. I., Ezeh, C., Pisarska, M. D., & Azziz, R. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.12.015 · Cited by 50 · see citing works

Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: A review

Luo, E., Jiang, H., Chen, W., Wang, Y., Tang, M., Guo, W., Diao, H., Cai, N.-Y., Yang, X., Bian, Y., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1065243 · Cited by 50 · see citing works

Hyperandrogenism and menstrual imbalance are the best predictors of metformin response in PCOS patients

Garzia, E., Galiano, V., Marfia, G., Navone, S., Grossi, E., & Marconi, A. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00876-0 · Cited by 25 · see citing works

Fertility treatment in women with polycystic ovary syndrome: a decision analysis of different oral ovulation induction agents

Jungheim, E. S., & Odibo, A. O. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.03.077 · Cited by 46 · see citing works

Efficacy of canagliflozin versus metformin in women with polycystic ovary syndrome: A randomized, open‐label, noninferiority trial

Cai, M., Shao, X., Xing, F., Zhang, Y., Gao, X., Zeng, Q., Dilimulati, D., Qu, S., & Zhang, M. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14583 · Cited by 44 · see citing works

Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress

Chiang, Y., Lin, I., Huang, K., Chen, H.-Y., Ali, M. K., Huang, Y., & Hsia, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115327 · Cited by 43 · see citing works

A landscape analysis of the potential role of polyphenols for the treatment of Polycystic Ovarian Syndrome (PCOS)

Rani, R., Hajam, Y. A., Kumar, R., Bhat, R. A., Rai, S., & Rather, M. A. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100161 · Cited by 43 · see citing works

Polycystic ovary syndrome and recurrent pregnancy loss, a review of literature

Wartena, R., & Matjila, M. J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1183060 · Cited by 40 · see citing works

Does metformin improve reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome? Meta-analysis and systematic review

Magzoub, R., Kheirelseid, E. A. H., Perks, C. M., & Lewis, S. J. (2022) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2022.01.025 · Cited by 41 · see citing works

Roles of estrogen and its receptors in polycystic ovary syndrome

Xu, Y., Zhang, Z., Wang, R., Xue, S., Ying, Q., & Jin, L. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1395331 · Cited by 38 · see citing works

Idiopathic intracranial hypertension: Evaluation of births and fertility through the Hospital Episode Statistics dataset

Thaller, M., Mytton, J., Wakerley, B. R., Mollan, S. P., & Sinclair, A. J. (2022) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17241 · Cited by 37 · see citing works

Polycystic ovary syndrome (<scp>PCOS</scp>)

Balen, A. H. (2017) · The Obstetrician &amp; Gynaecologist · doi:10.1111/tog.12345 · Cited by 37 · see citing works

The effect of metformin and myoinositol on metabolic outcomes in women with polycystic ovary syndrome: role of body mass and adiponectin in a randomized controlled trial

Soldat-Stanković, V., Popović-Pejičić, S., Stanković, S., Prtina, A., Malešević, G., Bjekić-Macut, J., Livadas, S., Ognjanović, S., Mastorakos, G., Micić, D., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01691-5 · Cited by 37 · see citing works

Effects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome

Su, Y.-N., Wang, M., Yang, J.-P., Wu, X.-L., Xia, M., Bao, M., Ding, Y., Feng, Q., & Fu, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1122709 · Cited by 37 · see citing works

Effects of combined metformin and semaglutide therapy on body weight, metabolic parameters, and reproductive outcomes in overweight/obese women with polycystic ovary syndrome: a prospective, randomized, controlled, open-label clinical trial

Chen, H., Lei, X., Yang, Z., Xu, Y., Liu, D., Wang, C., & Du, H. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01447-3 · Cited by 38 · see citing works

Polycystic Ovary Syndrome: Novel and Hub lncRNAs in the Insulin Resistance-Associated lncRNA–mRNA Network

Zhao, J., Huang, J., Geng, X., Chu, W., Li, S., Chen, Z., & Du, Y. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00772 · Cited by 37 · see citing works

A Review of the Impact of Bariatric Surgery in Women With Polycystic Ovary Syndrome

Lee, R. H., Mathew, C. J., Jose, M. T., Elshaikh, A. O., Shah, L., & Cancarevic, I. (2020) · Cureus · doi:10.7759/cureus.10811 · Cited by 37 · see citing works

Developmental and Full-Life Cycle Exposures to Guanylurea and Guanylurea–Metformin Mixtures Results in Adverse Effects on Japanese Medaka (Oryzias latipes)

Ussery, E. J., Nielsen, K. M., Pandelides, Z., Kirkwood, A. E., Guchardi, J., & Holdway, D. A. (2019) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4403 · Cited by 36 · see citing works

The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials

Xie, L., Zhang, D., Ma, H., He, H. R., Xia, Q., Shen, W., Chang, H., Deng, Y., Wu, Q., Cong, J., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/7918631 · Cited by 38 · see citing works

Exploring new treatment options for polycystic ovary syndrome: Review of a novel antidiabetic agent SGLT2 inhibitor

Marinkovic-Radosevic, J., Cigrovski Berkovic, M., Kruezi, E., Bilic-Curcic, I., & Mrzljak, A. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i7.932 · Cited by 35 · see citing works

The impact of a standardized micronutrient supplementation on PCOS-typical parameters: a randomized controlled trial

Hager, M., Nouri, K., Imhof, M., Egarter, C., & Ott, J. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-019-05194-w · Cited by 35 · see citing works

Fertility Treatment Options for Women With Polycystic Ovary Syndrome

Sawant, S., & Bhide, P. (2019) · Clinical Medicine Insights Reproductive Health · doi:10.1177/1179558119890867 · Cited by 34 · see citing works

Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance

Xie, Y., Xiao, L. Y., & Li, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.701590 · Cited by 35 · see citing works

The Effect of Oral Antidiabetic Drugs on Improving the Endocrine and Metabolic States in Women with Polycystic Ovary Syndrome: A Systematic Review and Network Meta-analysis

Yang, S., Zhao, L., He, W., & Mi, Y. (2022) · Drugs · doi:10.1007/s40265-022-01779-z · Cited by 33 · see citing works

Current and future aspects of several adjunctive treatment strategies in polycystic ovary syndrome

Banaszewska, B., Pawelczyk, L. A., & Spaczyński, R. (2019) · Reproductive Biology · doi:10.1016/j.repbio.2019.09.006 · Cited by 33 · see citing works

Neurobiology and Applications of Inositol in Psychiatry: A Narrative Review

Concerto, C., Chiarenza, C., Francesco, A. D., Natale, A., Privitera, I., Rodolico, A., Trovato, A., Aguglia, A., Fisicaro, F., Pennisi, M., et al. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45020113 · Cited by 32 · see citing works

Improvement of Insulin Sensitivity Increases Pregnancy Rate in Infertile PCOS Women: A Systemic Review

Liu, Y., Li, J., Yan, Z., Liu, D., Ma, J., & Tong, N. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.657889 · Cited by 32 · see citing works

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

Xiao, N., Wang, J., Wang, T., Xiong, X., Zhou, J., Su, X. W., Peng, J., Yang, C., Li, X., Lin, G., et al. (2022) · eLife · doi:10.7554/elife.74713 · Cited by 32 · see citing works

Factors Associated with White Fat Browning: New Regulators of Lipid Metabolism

Zhang, P., He, Y., Wu, S., Li, X., Lin, X., Gan, M., Chen, L., Zhao, Y., Niu, L., Zhang, S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147641 · Cited by 32 · see citing works

A Review of First Line Infertility Treatments and Supporting Evidence in Women with Polycystic Ovary Syndrome

Costello, M., Garad, R. M., Hart, R. J., Homer, H. A., Johnson, L., Jordan, C., Mocanu, E. V., Qiao, J., Rombauts, L. J. F., Teede, H. J., et al. (2019) · Medical Sciences · doi:10.3390/medsci7090095 · Cited by 32 · see citing works

Metformin and sitagliptin combination therapy ameliorates polycystic ovary syndrome with insulin resistance through upregulation of lncRNA H19

Wang, Q., Shang, J., Zhang, Y., & Zhou, W. Z. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1652036 · Cited by 31 · see citing works

Association of severity of menstrual dysfunction with hyperinsulinemia and dysglycemia in polycystic ovary syndrome

Ezeh, U. I., Pisarska, M. D., & Azziz, R. (2022) · Human Reproduction · doi:10.1093/humrep/deac001 · Cited by 31 · see citing works

Effectiveness of acupuncture in polycystic ovary syndrome

Wu, J., Chen, D., & Liu, N. (2020) · Medicine · doi:10.1097/md.0000000000020441 · Cited by 29 · see citing works

Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?

Medenica, S., Spoltore, M. E., Ormazabal, P., Marina, L., Šojat, A. S., Faggiano, A., Gnessi, L., Mazzilli, R., & Watanabe, M. (2022) · Clinical Endocrinology · doi:10.1111/cen.14785 · Cited by 31 · see citing works

C-reactive protein and ART outcomes: a systematic review

Brouillet, S., Boursier, G., Anav, M., Boissière, B. D. B. D. L., Gala, A., Ferrières-Hoa, A., Touitou, I., & Hamamah, S. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa012 · Cited by 28 · see citing works

High-intensity statin therapy yields better outcomes in acute coronary syndrome patients: a meta-analysis involving 26,497 patients

Yu, S., Jin, J., Chen, Z., & Luo, X. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01369-6 · Cited by 28 · see citing works

Gonadal dysfunction in women with diabetes mellitus

Zaimi, M., Michalopoulou, O., Stefanaki, K., Kazakou, P., Vasileiou, V., Ψαλτοπούλου, Θ., Karagiannakis, D. S., & Paschou, S. Α. (2024) · Endocrine · doi:10.1007/s12020-024-03729-z · Cited by 27 · see citing works

Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus

Andræ, F., Abbott, D. H., Stridsklev, S., Schmedes, A., Odsæter, I. H., Vanky, E., & Salvesen, Ø. O. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa605 · Cited by 28 · see citing works

Therapeutic Potentials of Low-Dose Tacrolimus for Aberrant Endometrial Features in Polycystic Ovary Syndrome

Albaghdadi, A. J. H., & Kan, F. W. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062872 · Cited by 26 · see citing works

The Potential of SGLT-2 Inhibitors in the Treatment of Polycystic Ovary Syndrome: The Current Status and Future Perspectives

Rakic, D., Jakovljevic, V. L., Jović, N., Ilic, M. B., Dimitrijević, A., Vulovic, T. S., Arsenijević, P. S., Sretenovic, J. Z., Muric, M. D., Фисенко, В. П., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11040998 · Cited by 26 · see citing works

The Effect of Acupuncture on Glucose Metabolism and Lipid Profiles in Patients with PCOS: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zheng, R., Qing, P., Han, M., Song, J., Hu, M., Ma, H., & Li, J. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5555028 · Cited by 25 · see citing works

Integrated bioinformatics and network pharmacology to explore the therapeutic target and molecular mechanisms of Bailing capsule on polycystic ovary syndrome

Guan, H.-R., Li, B., Zhang, Z.-H., Wu, H.-S., He, X., Dong, Y., Su, J., Lv, G., & Chen, S. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04280-6 · Cited by 25 · see citing works

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

Javed, Z., Papageorgiou, M., Madden, L. A., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2020) · Endocrine Connections · doi:10.1530/ec-20-0173 · Cited by 24 · see citing works

Molecular Mechanisms in the Etiology of Polycystic Ovary Syndrome (PCOS): A Multifaceted Hypothesis Towards the Disease with Potential Therapeutics

Nisa, K. U., Tarfeen, N., Mir, S. A., Waza, A. A., Ahmad, M. B., & Ganai, B. A. (2023) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-023-01130-7 · Cited by 27 · see citing works

Decreased SFRP5 correlated with excessive metabolic inflammation in polycystic ovary syndrome could be reversed by metformin: implication of its role in dysregulated metabolism

Zhang, Y., Ran, Y., Kong, L., Geng, L.-H., Huang, H., Zhang, H., Hu, J., Qi, H., & Chen, Y. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00847-4 · Cited by 23 · see citing works

Effect of Hyperinsulinemia and Insulin Resistance on Endocrine, Metabolic, and Reproductive Outcomes in Non-PCOS Women Undergoing Assisted Reproduction: A Retrospective Cohort Study

Cai, W.-Y., Luo, X., Song, J., Ji, D., Zhu, J., Duan, C., Wu, W., Wu, X., & Xu, J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.736320 · Cited by 23 · see citing works

Metformin Therapy for the Management of Infertility in Women with Polycystic Ovary Syndrome

(2017) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14764 · Cited by 23 · see citing works

Enhancing health and therapeutic potential: innovations in the medicinal and pharmaceutical properties of soy bioactive compounds

Rahman, U., Younas, Z., Ahmad, I., Yousaf, T., Latif, R., Rubab, U., Hassan, H., Shafi, U., & Mashwani, Z. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1397872 · Cited by 23 · see citing works

The effect of myo‐inositol/di‐chiro‐inositol on markers of ovarian reserve in women with PCOS undergoing IVF / ICSI : A systematic review and meta‐analysis

Bhide, P., Pundir, J., Gudi, A., Shah, A. J., Homburg, R., & Acharya, G. (2019) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13625 · Cited by 22 · see citing works

Menstrual Dysfunction in PCOS

Walker, K. A. B., DeCherney, A. H., & Saunders, R. D. (2020) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000596 · Cited by 21 · see citing works

The Impact of Bariatric Surgery Compared to Metformin Therapy on Pregnancy Outcomes in Patients with Polycystic Ovarian Syndrome: a Systematic Review and Meta-analysis

Chang, C. C. Y., Chang, S. H., Poles, J., & Popov, V. (2021) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-020-04900-3 · Cited by 21 · see citing works

Ovulation induction techniques in women with polycystic ovary syndrome

Vyrides, A., Mahdi, E. E., & Giannakou, K. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.982230 · Cited by 23 · see citing works

Metagenomics study on taxonomic and functional change of gut microbiota in patients with obesity with PCOS treated with exenatide combination with metformin or metformin alone

Gan, J., Chen, J., Ma, R., Deng, Y., Ding, X., Zhu, S., & Sun, A. (2023) · Gynecological Endocrinology · doi:10.1080/09513590.2023.2219342 · Cited by 21 · see citing works

D-Chiro-Inositol Improves Sperm Mitochondrial Membrane Potential: In Vitro Evidence

Condorelli, R. A., Barbagallo, F., Calogero, A. E., Cannarella, R., Crafa, A., & Vignera, S. L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051373 · Cited by 21 · see citing works

PCOS: diagnosis and management of related infertility

Kriedt, K., Chami, A. A., & Davies, M. C. (2018) · Obstetrics Gynaecology & Reproductive Medicine · doi:10.1016/j.ogrm.2018.12.001 · Cited by 21 · see citing works

Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS

Ryssdal, M., Vanky, E., Stokkeland, L. M. T., Jarmund, A. H., Steinkjer, B., Løvvik, T. S., Madssen, T. S., Iversen, A., & Giskeødegård, G. F. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad145 · Cited by 19 · see citing works

Constant light exposure alters gut microbiota and short‐/medium‐chain fatty acids and aggravates PCOS‐like traits in HFD‐fed rats

Yue, F., Lin, X., Wu, S., Lin, W., Zhou, Z., Shi, Y., Lam, S. M., Shui, G., Xiang, X., Russell, R., et al. (2022) · Obesity · doi:10.1002/oby.23380 · Cited by 19 · see citing works

In women with polycystic ovary syndrome, oligoamenorrhea and subfertility, what are the effects of insulin-sensitizing drugs (metformin, rosiglitazone, pioglitazone, d-chiro-inositol)?

Ahmad, G. (2014) · Cochrane Clinical Answers · doi:10.1002/cca.284 · Cited by 1 · see citing works

For women with polycystic ovary syndrome, oligomenorrhea, and subfertility, what are the effects of insulin-sensitizing drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol)?

Ahmad, G. (2018) · Cochrane Clinical Answers · doi:10.1002/cca.1975

Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome

Tang, T. H., Norman, R. J., Balen, A. H., & Lord, J. M. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053 · Cited by 369 · see citing works

Efficacy Of Insulin Sensitizers Metformin, Pioglitazone And Combination Myo-Inositol (MI) Plus D-Chiroinositol (DCI) Plus Folic Acid In Women With Polycystic Ovary Syndrome: A RCT

Dr. Urooj Zafar, D. A. Z. (2023) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2023.14.03.385

[Polycystic ovary syndrome: treatment with insulin-sensitizing agents].

Barbosa, S. L.-S., Rodien, P., & Rohmer, V. (2002) · PubMed · Cited by 6 · see citing works