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Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation

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Schaaf, M. J. M., De Kloet, E. R., Vreugdenhil, E.·2000·Stress

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Abstract

The adrenal steroid corticosterone has profound effect on the structure and function of the hippocampus. Probably as a result of that, it modulates memory formation. In this review, the question is addressed if the corticosterone effects on memory processes are mediated by alterations in the expression of the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus. First, studies are described investigating the effect of corticosterone on BDNF expression in the rat hippocampus. It appears that corticosterone suppresses the BDNF expression at the mRNA and protein level in a subfield-specific way. Second, a model for the mechanism of action is proposed. In this model, activated mineralocorticoid and glucocorticoid receptors repress transcriptional activity of the BDNF promoter site-specifically via interaction with other transcription factors. Third, the implications for learning and memory are discussed. Studies show that during water maze training, corticosterone levels rise significantly, but the BDNF expression is not suppressed in any hippocampal subfield. Furthermore, high BDNF expression levels in specific subfields correlate with a good memory performance. Therefore, we suggest that the resistance of the hippocampal BDNF expression to suppression by corticosterone, as seen after water maze training, may contribute to an optimal memory performance.

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Authors: Schaaf, M. J. M., De Kloet, E. R., & Vreugdenhil, E.
Affiliations: National Institutes of Health (US)
Corresponding author: Vreugdenhil, E.
ORCID: Schaaf, M. J. M.
Vreugdenhil, E.
Venue: Stress
Publisher: Informa UK Limited
Published: 2000-01
Volume: 3
Issue: 3
Pages: 201-208
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.3109/10253890009001124
OpenAlex: W2109158936
Semantic Scholar: 93f10485ac4eabd2252567c71e95e9ce8d112ad1
Cited by: 270
References: 59
Citations by year: 2025: 6 · 2024: 9 · 2023: 10 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 11 · 2018: 15 · 2017: 11 · 2016: 14 · 2015: 15 · 2014: 16 · 2013: 11 · 2012: 11
FWCI: 0.67
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stress (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: corticosterone, brain-derived neurotrophic factor, hippocampus, memory formation, learning, mineralocorticoid receptor, glucocorticoid receptor, transcriptional repression, BDNF promoter, hippocampal subfields, stress hormones
MeSH terms: CRF Receptor, Type 1, Adrenalectomy, Animals, Corticosterone, Dose-Response Relationship, Drug, Hippocampus, Kainic Acid, Learning, Memory, Models, Biological, Neurons, Promoter Regions, Genetic, Receptors, Glucocorticoid, RNA, Messenger, Serotonin Antagonists, Stress, Physiological, Transcription, Genetic, Down-Regulation, Receptors, Corticotropin-Releasing Hormone, Receptors, Mineralocorticoid, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Rats

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Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation

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