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Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation
Open accessAbstract
The adrenal steroid corticosterone has profound effect on the structure and function of the hippocampus. Probably as a result of that, it modulates memory formation. In this review, the question is addressed if the corticosterone effects on memory processes are mediated by alterations in the expression of the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus. First, studies are described investigating the effect of corticosterone on BDNF expression in the rat hippocampus. It appears that corticosterone suppresses the BDNF expression at the mRNA and protein level in a subfield-specific way. Second, a model for the mechanism of action is proposed. In this model, activated mineralocorticoid and glucocorticoid receptors repress transcriptional activity of the BDNF promoter site-specifically via interaction with other transcription factors. Third, the implications for learning and memory are discussed. Studies show that during water maze training, corticosterone levels rise significantly, but the BDNF expression is not suppressed in any hippocampal subfield. Furthermore, high BDNF expression levels in specific subfields correlate with a good memory performance. Therefore, we suggest that the resistance of the hippocampal BDNF expression to suppression by corticosterone, as seen after water maze training, may contribute to an optimal memory performance.
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“They also affect neuronal tissue by disruption of BDNF expression (Nibuya et al., 1995;Schaaf et al., 2000).”
From Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood (2005) · cites this paper as Schaaf et al., 2000
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“, 1998), can suppress brain-derived neurotrophic factor (Schaaf et al., 2000) and increases glutamate toxicity in the hippocampus (McEwen, 2002).”
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“Elevated glucocorticoids (stress hormone; corticosterone in animals, cortisole in humans) may impair cognitive function by suppressing BDNF production (Schaaf et al., 2000).”
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“It was supposed that corticosterone represses transcriptional activity of the BDNF promoter site specifically via interaction with other transcription factors [48].”
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“neurotrophic factor (BDNF) and memory difficulties (Schaaf et al., 2000).”
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“As the end product of HPA axis, glucocorticoids recover the activity of HPA axis to normal through a feedback regulation mechanism that depended on the glucocorticoid receptor in the brain, especially in the hippocampus (Schaaf et al., 2000).”
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“In addition, Adx induces an increase of BDNF mRNA expression in the DG (Hansson et al., 2000; Schaaf et al., 2000).”
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Enhancing Cognition after Stress with Gene Therapy
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“We chose BDNF, which has been shown to protect against stressand GC-dependent spatial memory impairment (Almli et al., 2000; Schaaf et al., 2000; Alonso et al., 2002; Radecki et al., 2004).”
Metadata
- Authors
- Schaaf, M. J. M., De Kloet, E. R., & Vreugdenhil, E.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Vreugdenhil, E.
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 3
- Issue
- 3
- Pages
- 201-208
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W2109158936
- Semantic Scholar
- 93f10485ac4eabd2252567c71e95e9ce8d112ad1
- Cited by
- 270
- References
- 59
- Citations by year
- 2025: 6 · 2024: 9 · 2023: 10 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 11 · 2018: 15 · 2017: 11 · 2016: 14 · 2015: 15 · 2014: 16 · 2013: 11 · 2012: 11
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- corticosterone, brain-derived neurotrophic factor, hippocampus, memory formation, learning, mineralocorticoid receptor, glucocorticoid receptor, transcriptional repression, BDNF promoter, hippocampal subfields, stress hormones
- MeSH terms
- CRF Receptor, Type 1, Adrenalectomy, Animals, Corticosterone, Dose-Response Relationship, Drug, Hippocampus, Kainic Acid, Learning, Memory, Models, Biological, Neurons, Promoter Regions, Genetic, Receptors, Glucocorticoid, RNA, Messenger, Serotonin Antagonists, Stress, Physiological, Transcription, Genetic, Down-Regulation, Receptors, Corticotropin-Releasing Hormone, Receptors, Mineralocorticoid, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Rats
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