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Transcriptional regulation by hypoxia inducible factors

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Dengler, Veronica L., Galbraith, Matthew D., Espinosa, Joaquín M.·2014·Critical Reviews in Biochemistry and Molecular Biology
DOI 10.3109/10409238.2013.838205
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Abstract

The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.

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Metadata

Authors
Dengler, V. L., Galbraith, M. D., & Espinosa, J. M.
Venue
Critical Reviews in Biochemistry and Molecular Biology
Publisher
Informa UK Limited
Published
2013-10-07
Volume
49
Issue
1
Pages
1-15
ISSN
  • 0045-6411 (ISSN-L)
  • 1040-9238
  • 1549-7798
DOI
10.3109/10409238.2013.838205
OpenAlex
W2071361463
Cited by
782
References
45
FWCI
0.66
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Transcriptional regulation by hypoxia inducible factors. https://app.cochat.ai/papers/10.3109/10409238.2013.838205
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Dengler, V. L., Galbraith, M. D., & Espinosa, J. M. (2014). Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology. https://doi.org/10.3109/10409238.2013.838205

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