Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies
Open accessAbstract
Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H2S) and the nitric oxide radical (•NO), activating specific oxidations that determine the metabolic response. The reaction triggered determines cell survival or apoptosis, depending on which downstream metabolic pathways are activated. There are several ways to produce H2O2 in cells, and cellular systems tightly control its concentration. At the cellular level, the accumulation of hydrogen peroxide can trigger inflammation and even apoptosis, and when its concentration in the blood reaches toxic levels, it can lead to bioenergetic failure. This review summarizes existing research from a chemical perspective on the role of H2O2 in various enzymatic pathways and how this biochemistry leads to physiological or pathological responses.
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•O2− is unstable and cannot pass through membranes but is rapidly converted to hydrogen peroxide H2O2, a membrane-permeable species.
“•O2− is unstable and cannot pass through membranes but is rapidly converted to hydrogen peroxide H2O2, a membrane-permeable specie [12].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [12]
Hydrogen peroxide is a strong oxidant but the kinetics of its reaction with biomolecules is rather slow, so it can accumulate in cells in relatively high concentrations.
“Hydrogen peroxide is a strong oxidant but the kinetics of its reaction with biomolecules is rather slow and therefore it can be accumulated in cells in relatively high concentrations (Andres et al. 2022).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Andres et al. 2022
Two thiyl radicals can combine and form non-radical oxidized glutathione (GSSG).
“Two thiyl radicals can combine and form a non-radical oxidized glutathione (GSSG)23”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as [23]
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- Authors
- Andrés, C. M. C., Pérez de la Lastra, J. M., Juan, C. A., Plou, F. J., & Pérez-Lebeña, E.
- Affiliations
- Hospital Clínico Universitario de Valladolid (ES)
- Institute of Natural Products and Agrobiology, CSIC-Spanish Research Council, Avda. Astrofísico Fco. Sánchez, 3, 38206 La Laguna, Spain
- Cinquima Institute and Department of Organic Chemistry, Faculty of Sciences, Valladolid University, Paseo de Belén, 7, 47011 Valladolid, Spain
- Consejo Superior de Investigaciones Científicas (ES)
- Sistemas de Biotecnología y Recursos Naturales, 47625 Valladolid, Spain
- Venue
- Stresses
- Publisher
- MDPI AG
- Published
- 2022-07-25
- Volume
- 2
- Issue
- 3
- Pages
- 256-274
- ISSN
- 2673-7140 (ISSN-L)
- OpenAlex
- W4287879577
- Cited by
- 218
- References
- 107
- Citations by year
- 2026: 29 · 2025: 65 · 2024: 68 · 2023: 51 · 2022: 5
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stresses (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Junta de Castilla y León (FEDER-VA115P17, VA149G18, ProID2020010134, 2019SP43, PID2019-105838RB-C31)
- European Funds for Regional Development-FEDER (FEDER-VA115P17, VA149G18, ProID2020010134, 2019SP43, PID2019-105838RB-C31)
- Caja Canarias (FEDER-VA115P17, VA149G18, ProID2020010134, 2019SP43, PID2019-105838RB-C31)
- Spanish Ministry of Economy and Competitiveness (FEDER-VA115P17, VA149G18, ProID2020010134, 2019SP43, PID2019-105838RB-C31)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- hydrogen peroxide, redox signaling, hydrogen sulfide, nitric oxide, apoptosis, inflammation, oxidative stress, bioenergetic failure, enzymatic pathways, mammalian cells, pathology
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