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Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression
Abstract
Object Neurosurgical procedures are a viable intervention for severe, treatment-refractory major depression, although they have been associated with only modest rates of efficacy. The purpose of this study was to identify possible neuroimaging predictors of treatment response to anterior cingulotomy in patients with major depression. Methods Thirteen patients underwent stereotactic anterior cingulotomy for treatment-refractory major depression. Symptom severity was measured using the Beck Depression Inventory (BDI) both before and approximately 12 months after surgery. The authors performed [18F]fluorodeoxyglucose-positron emission tomography (PET) studies in all patients preoperatively. Statistical parametric mapping methods were used to test for loci of significant correlation between preoperative regional cerebral metabolism and postoperative reduction in BDI scores. The mean (+/- standard deviation) change in the BDI score from the preoperative period (43.7 +/- 7.8) to the postoperative period (30.5 +/- 21.3) was 33.1 +/- 45.4%. Two loci--the left subgenual prefrontal cortex and left thalamus--were identified as sites at which preoperative metabolism was significantly correlated with subsequent improvement in depressive symptom severity following cingulotomy. Specifically, higher preoperative rates of metabolism at these loci were associated with better postoperative results. Conclusions Possible PET scanning predictors of treatment response were identified in patients wi…
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“while hypermetabolism in the subgenual cingulate and prefrontal cortex may predict favourable responses to anterior cingulotomies in this disorder (Dougherty et al., 2003).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Dougherty et al., 2003
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Metadata
- Authors
- Dougherty, D. D., Weiss, A. P., Cosgrove, G. R., Alpert, N. M., Cassem, E. H., Nierenberg, A. A., Price, B. H., Mayberg, H. S., Fischman, A. J., & Rauch, S. L.
- Affiliations
- Harvard University (US)
- ORCID
- Venue
- Journal of Neurosurgery
- Published
- 2003-12
- Volume
- 99
- Issue
- 6
- Pages
- 1010-1017
- ISSN
- 0022-3085 (ISSN-L)
- OpenAlex
- W1992186274
- Cited by
- 193
- References
- 48
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 4 · 2016: 7 · 2015: 15 · 2014: 18 · 2013: 11 · 2012: 14
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- anterior cingulotomy, major depressive disorder, treatment-resistant depression, neurosurgery, treatment response prediction, subgenual prefrontal cortex, thalamus, 18F-FDG PET, regional cerebral glucose metabolism, stereotactic neurosurgery
- MeSH terms
- Adult, Aged, Major Depressive Disorder, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Stereotaxic Techniques, Telencephalon, Tomography, Emission-Computed, Treatment Outcome
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