A subcortical pathway to the right amygdala mediating “unseen” fear
Open accessAbstract
Neuroimaging studies have shown differential amygdala responses to masked (“unseen”) emotional stimuli. How visual signals related to such unseen stimuli access the amygdala is unknown. A possible pathway, involving the superior colliculus and pulvinar, is suggested by observations of patients with striate cortex lesions who show preserved abilities to localize and discriminate visual stimuli that are not consciously perceived (“blindsight”). We used measures of right amygdala neural activity acquired from volunteer subjects viewing masked fear-conditioned faces to determine whether a colliculo-pulvinar pathway was engaged during processing of these unseen target stimuli. Increased connectivity between right amygdala, pulvinar, and superior colliculus was evident when fear-conditioned faces were unseen rather than seen. Right amygdala connectivity with fusiform and orbitofrontal cortices decreased in the same condition. By contrast, the left amygdala, whose activity did not discriminate seen and unseen fear-conditioned targets, showed no masking-dependent changes in connectivity with superior colliculus or pulvinar. These results suggest that a subcortical pathway to the right amygdala, via midbrain and thalamus, provides a route for processing behaviorally relevant unseen visual events in parallel to a cortical route necessary for conscious identification.
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Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688 · see citing works
(2005) · Choice Reviews Online · doi:10.5860/choice.43-0626 · Cited by 4,726 · see citing works
Spatial registration and normalization of images
Friston, K. J., Ashburner, J., Frith, C., Poline, J.-B., Heather, J. D., & Frackowiak, R. S. J. (1995) · Human Brain Mapping · doi:10.1002/hbm.460030303 · Cited by 3,744 · see citing works
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097 · see citing works
Self-citationAdolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360 · see citing works
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205 · see citing works
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013 · see citing works
Self-citationResponse and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711 · see citing works
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665 · see citing works
Self-citationMechanisms of emotional arousal and lasting declarative memory.
Cahill, L., & McGaugh, J. L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01214-9 · Cited by 1,575 · see citing works
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536 · see citing works
VISUAL CAPACITY IN THE HEMIANOPIC FIELD FOLLOWING A RESTRICTED OCCIPITAL ABLATION
WEISKRANTZ, L., WARRINGTON, E. K., SANDERS, M. D., & MARSHALL, J. (1974) · Brain · doi:10.1093/brain/97.1.709 · Cited by 1,465 · see citing works
Bechara, A., Tranel, D., Damasio, H., Adolphs, R., Rockland, C., & Damasio, A. R. (1995) · Science · doi:10.1126/science.7652558 · Cited by 1,400 · see citing works
Schneider, G. E. (1969) · Science · doi:10.1126/science.163.3870.895 · Cited by 1,389 · see citing works
Eye movements evoked by collicular stimulation in the alert monkey
Robinson, D. A. (1972) · Vision Research · doi:10.1016/0042-6989(72)90070-3 · Cited by 1,350 · see citing works
A neuromodulatory role for the human amygdala in processing emotional facial expressions
Morris, J. (1998) · Brain · doi:10.1093/brain/121.1.47 · Cited by 1,291 · see citing works
Self-citationSpence, S. (1996) · BMJ · doi:10.1136/bmj.312.7024.193 · Cited by 1,177 · see citing works
Haxby, J., Horwitz, B., Ungerleider, L. G., Maisog, J. M., Pietrini, P., & Grady, C. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06336.1994 · Cited by 1,065 · see citing works
Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning
Schoenbaum, G. M., Chiba, A. A., & Gallagher, M. (1998) · Nature Neuroscience · doi:10.1038/407 · Cited by 849 · see citing works
Facial Emotion Recognition after Bilateral Amygdala Damage: Differentially Severe Impairment of Fear
Calder, A. J. (1996) · Cognitive Neuropsychology · doi:10.1080/026432996381890 · Cited by 690 · see citing works
Impaired fear conditioning following unilateral temporal lobectomy in humans
LaBar, K., LeDoux, J., Spencer, D., & Phelps, E. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06846.1995 · Cited by 631 · see citing works
The ascending projections of the superior colliculus in the rhesus monkey (Macaca mulatta)
Benevento, L. A., & Fallon, J. H. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901600306 · Cited by 460 · see citing works
Neuronal correlates of visibility and invisibility in the primate visual system
Macknik, S. L., & Livingstone, M. S. (1998) · Nature Neuroscience · doi:10.1038/393 · Cited by 419 · see citing works
Processing speed in the cerebral cortex and the neurophysiology of visual masking
Rolls, E. T., & Tovée, M. J. (1994) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1994.0087 · Cited by 398 · see citing works
Contributions of the pulvinar to visual spatial attention
Petersen, S. E., Robinson, D. L., & Morris, J. D. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90046-7 · Cited by 395 · see citing works
Self-citationHow the brain learns to see objects and faces in an impoverished context
Dolan, R. J., Fink, G. R., Rolls, E. T., Booth, M. C. A., Holmes, A., Frackowiak, R. S. J., & Friston, K. J. (1997) · Nature · doi:10.1038/39309 · Cited by 388 · see citing works
Self-citationPulvinar nuclei of the behaving rhesus monkey: visual responses and their modulation
Petersen, S. E., Robinson, D. L., & Keys, W. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.867 · Cited by 378 · see citing works
Properties and tectal projections of monkey retinal ganglion cells
Schiller, P. H., & Malpeli, J. G. (1977) · Journal of Neurophysiology · doi:10.1152/jn.1977.40.2.428 · Cited by 364 · see citing works
Automatically elicited fear: Conditioned skin conductance responses to masked facial expressions
Esteves, F. G., Dimberg, U., & Öhman, A. (1994) · Cognition & Emotion · doi:10.1080/02699939408408949 · Cited by 311 · see citing works
Self-citationWeiskrantz, L., Barbur, J. L., & Sahraie, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.6122 · Cited by 292 · see citing works
HUMAN VISUAL RESPONSES IN THE ABSENCE OF THE GENICULO-CALCARINE PROJECTION
Barbur, J. L., Ruddock, K. H., & Waterfield, V. A. (1980) · Brain · doi:10.1093/brain/103.4.905 · Cited by 283 · see citing works
Pattern of neuronal activity associated with conscious and unconscious processing of visual signals
Sahraie, A., Weiskrantz, L., Barbur, J. L., Simmons, A., Williams, S., & Brammer, M. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9406 · Cited by 270 · see citing works
Superior Colliculus Cell Responses Related to Eye Movements in Awake Monkeys
Wurtz, R. H., & Goldberg, M. E. (1971) · Science · doi:10.1126/science.171.3966.82 · Cited by 245 · see citing works
ORIENTING OF VISUAL ATTENTION IN PROGRESSIVE SUPRANUCLEAR PALSY
Rafal, R. D., Posner, M. I., Friedman, J. H., Inhoff, A. W., & BERNSTEIN, E. (1988) · Brain · doi:10.1093/brain/111.2.267 · Cited by 226 · see citing works
Goodale, M. A., & Murison, R. C. C. (1975) · Brain Research · doi:10.1016/0006-8993(75)90388-1 · Cited by 217 · see citing works
A projection from the medial pulvinar to the amygdala in primates
Jones, E. G., & Burton, H. (1976) · Brain Research · doi:10.1016/0006-8993(76)90654-5 · Cited by 181 · see citing works
RESIDUAL VISION IN PATIENTS WITH RETROGENICULATE LESIONS OF THE VISUAL PATHWAYS
Blythe, I. M., Kennard, C., & Ruddock, K. H. (1987) · Brain · doi:10.1093/brain/110.4.887 · Cited by 180 · see citing works
Neural responses to salient visual stimuli
Morris, J. S., Friston, K. J., & Dolan, R. J. (1997) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1997.0109 · Cited by 157 · see citing works
Self-citationExperience–dependent modulation of tonotopic neural responses in human auditory cortex
Morris, J. S., Friston, K. J., & Dolan, R. J. (1998) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1998.0343 · Cited by 139 · see citing works
Self-citationThe Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction
Lauterbach, E. C. (1993) · Journal of Neuropsychiatry · doi:10.1176/jnp.5.2.230 · Cited by 137 · see citing works
Anticipation causes increased blood flow to the anterior cingulate cortex
Murtha, S. J. E., Chertkow, H. M., Beauregard, M., Dixon, R., & Evans, A. C. (1996) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1996)4:2 · Cited by 137 · see citing works
Tomaiuolo, F. (1997) · Brain · doi:10.1093/brain/120.5.795 · Cited by 124 · see citing works
THE CONTRIBUTION OF THE ‘SECOND’ VISUAL SYSTEM TO DIRECTED VISUAL ATTENTION IN MAN
ZIHL, J., & CRAMON, D. V. (1979) · Brain · doi:10.1093/brain/102.4.835 · Cited by 120 · see citing works
Gross, C. G. (1991) · Neuropsychologia · doi:10.1016/0028-3932(91)90007-u · Cited by 111 · see citing works
TARGET DETECTION AND MOVEMENT DISCRIMINATION IN THE BLIND FIELD OF HEMISPHERECTOMIZED PATIENTS
Ptito, A., Leporé, F., Ptito, M., & Lassonde, M. C. (1991) · Brain · doi:10.1093/brain/114.1.497 · Cited by 103 · see citing works
Milner, A. D., Foreman, N. K., & Goodale, M. A. (1978) · Neuropsychologia · doi:10.1016/0028-3932(78)90062-3 · Cited by 81 · see citing works
Localization of unseen visual stimuli by humans with normal vision
Meeres, S. L., & Graves, R. E. (1990) · Neuropsychologia · doi:10.1016/0028-3932(90)90039-q · Cited by 59 · see citing works
Responses of single units in the monkey superior colliculus to stationary flashing stimuli
Moors, J., & Vendrik, A. J. H. (1979) · Experimental Brain Research · doi:10.1007/bf00236619 · Cited by 26 · see citing works
Collin, N. G., & Cowey, A. (1980) · Experimental Brain Research · doi:10.1007/bf00237789 · Cited by 24 · see citing works
Collicular function in human vision
Zihl, J., & CRAMON, D. V. (1979) · Experimental Brain Research · doi:10.1007/bf00236761 · Cited by 11 · see citing works
Worsley (1996) · doi:10.1002/(sici)1097-0193(1996)4:1
Flagged first, then by citations
3 of the 54 references couldn’t be matched to a known paper.
Research works printed but not linked: 10
- [12]12. Aggleton, J. P. (Wiley-Liss, New York), pp. 1-66.
- [16]16. Weiskrantz, L., Barbur, J. L. & Sahraie, A. (1995) Proc. Natl. Acad. Sci. USA 92, 6122-6126.
- [23]23. Sahraie, A., Weiskrantz, L., Barbur, J. L., Simmons, A., Williams, S. C. R. & Brammer, M. J. (1997) Proc. Natl. Acad. Sci. USA 94, 9406-9411.
- [32]32. Rolls, E. T. & Tovee, M. J. (1994) Proc. R. Soc. London Ser. B 257, 9-15.
- [44]44. Morris, J. S., Friston, K. J. & Dolan, R. J. (1997) Proc. R. Soc. London Ser. B 264, 760-775.
- [49]49. Aggleton, J. P. (Wiley-Liss, New York), pp. 143-167.
- [52]52. Gazzaniga, M. S. (MIT Press, Cambridge, MA), pp. 1091-1106.
- [55]55. Gazza- niga, M. S. (MIT Press, Cambridge, MA), pp. 1049-1061.
- [57]57. Gazzaniga, M. S. (MIT Press, Cambridge, MA), pp. 1071-1089.
- [58]58. Morris J. S., Friston, K. J. & Dolan, R. J. (1998) Proc. R. Soc. London Ser. B 265, 649-657.
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LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Porges, S. W. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.06.009 · Cited by 3,415 · see citing works
Fears, phobias, and preparedness: toward an evolved module of fear and fear learning
Öhman, A., & Mineka, S. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.483 · Cited by 3,147 · see citing works
Self-citationRethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520 · see citing works
Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
Dehaene, S. (2001) · Cognition · doi:10.1016/s0010-0277(00)00123-2 · Cited by 2,498 · see citing works
The brain basis of emotion: a meta-analytic review
Lindquist, K. A., Wager, T. D., Kober, H., Bliss-Moreau, E., & Barrett, L. F. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11000446 · Cited by 2,320 · see citing works
“…with the functional integrity of a subcortical network including the pulvinar, amygdala, nucleus accumbens, periaqueductal gray, and locus coeruleus (Morris et al. 1999; Tamietto & de Gelder 2010; Williams et al. 2006) (see our Figure 1b), which may function independently of cortical areas.”
The somatic marker hypothesis: A neural theory of economic decision
Bechara, A., & Damasio, A. R. (2005) · Games and Economic Behavior · doi:10.1016/j.geb.2004.06.010 · Cited by 1,986 · see citing works
Neural systems for recognizing emotion
Adolphs, R. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00301-x · Cited by 1,933 · see citing works
The effects of childhood maltreatment on brain structure, function and connectivity
Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.111 · Cited by 1,856 · see citing works
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834 · see citing works
The Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818 · see citing works
Pessoa, L., & Adolphs, R. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2920 · Cited by 1,794 · see citing works
Effects of Attention and Emotion on Face Processing in the Human Brain
Vuilleumier, P., Armony, J. L., Driver, J., & Dolan, R. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00328-2 · Cited by 1,664 · see citing works
Self-citationRethinking the Emotional Brain
LeDoux, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.004 · Cited by 1,594 · see citing works
“…energy and nutrition maintenance, fluid balance, thermoregulation), rather than on the actual responses controlled by the circuit, a species-independent set of criteria emerge for defining brain systems that detect significant events and control responses that help meet the challenges and…”
Affective picture processing: An integrative review of ERP findings
Olofsson, J. K., Nordin, S., Sequeira, H., & Polich, J. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.11.006 · Cited by 1,595 · see citing works
Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety
Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.109 · Cited by 1,488 · see citing works
Do threatening stimuli draw or hold visual attention in subclinical anxiety?
Fox, E., Russo, R., Bowles, R., & Dutton, K. (2001) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.130.4.681 · Cited by 1,469 · see citing works
Blair, R. J. R. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2005.06.004 · Cited by 1,365 · see citing works
The face in the crowd revisited: A threat advantage with schematic stimuli.
Öhman, A., Lundqvist, D., & Esteves, F. (2001) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.80.3.381 · Cited by 1,366 · see citing works
Self-citationNeural processing of emotional faces requires attention
Pessoa, L., McKenna, M., Gutierrez, E., & Ungerleider, L. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172403899 · Cited by 1,155 · see citing works
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
Functional neuroanatomy of emotions: A meta-analysis
MURPHY, F. C., NIMMO-SMITH, I., & LAWRENCE, A. D. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.3.207 · Cited by 1,135 · see citing works
Distinct spatial frequency sensitivities for processing faces and emotional expressions
Vuilleumier, P., Armony, J. L., Driver, J., & Dolan, R. J. (2003) · Nature Neuroscience · doi:10.1038/nn1057 · Cited by 1,117 · see citing works
Self-citationRecognizing emotion from facial expressions: psychological and neurological mechanisms
Adolphs, R. (2002) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582302001001003 · Cited by 1,432 · see citing works
Schultz, R. T. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.12.012 · Cited by 1,071 · see citing works
Neural bases of the non-conscious perception of emotional signals
Tamietto, M., & de Gelder, B. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2889 · Cited by 1,042 · see citing works
Early processing of the six basic facial emotional expressions
Batty, M., & Taylor, M. J. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00174-5 · Cited by 992 · see citing works
Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI
Pierce, K. (2001) · Brain · doi:10.1093/brain/124.10.2059 · Cited by 898 · see citing works
The polyvagal theory: new insights into adaptive reactions of the autonomic nervous system
Porges, S. W. (2009) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.76.s2.17 · Cited by 879 · see citing works
The science of interpersonal touch: An overview
Gallace, A., & Spence, C. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.004 · Cited by 879 · see citing works
What does the amygdala contribute to social cognition
Adolphs, R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05445.x · Cited by 836 · see citing works
The Facilitated Processing of Threatening Faces: An ERP Analysis.
Schupp, H. T., Öhman, A., Junghöfer, M., Weike, A. I., Stockburger, J., & Hamm, A. O. (2004) · Emotion · doi:10.1037/1528-3542.4.2.189 · Cited by 830 · see citing works
Self-citationDeficits in facial affect recognition among antisocial populations: A meta-analysis
Marsh, A. A., & Blair, J. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.08.003 · Cited by 849 · see citing works
The eye contact effect: mechanisms and development
Senju, A., & Johnson, M. H. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.11.009 · Cited by 797 · see citing works
The functional neuroanatomy of social behaviour
Critchley, H. D., Daly, E. M., Bullmore, E. T., Williams, S. C. R., Van Amelsvoort, T., Robertson, D. M., Rowe, A., Phillips, M., McAlonan, G., Howlin, P., et al. (2000) · Brain · doi:10.1093/brain/123.11.2203 · Cited by 816 · see citing works
Measuring emotional processes in animals: the utility of a cognitive approach
Paul, E. S., Harding, E. J., & Mendl, M. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.01.002 · Cited by 809 · see citing works
Intuition: A social cognitive neuroscience approach.
Lieberman, M. D. (2000) · Psychological Bulletin · doi:10.1037/0033-2909.126.1.109 · Cited by 805 · see citing works
Towards the neurobiology of emotional body language
de Gelder, B. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1872 · Cited by 786 · see citing works
Dissociation of Neural Representation of Intensity and Affective Valuation in Human Gustation
Small, D. M., Gregory, M. D., Mak, Y. E., Gitelman, D. R., Mesulam, M. M., & Parrish, T. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00467-7 · Cited by 789 · see citing works
The Emotional Construction of Morals
PRINZ, J. J. (2009) · doi:10.1093/acprof:oso/9780199571543.001.0001 · Cited by 784 · see citing works
Costafreda, S. G., Brammer, M. J., David, A. S., & Fu, C. H. Y. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.012 · Cited by 772 · see citing works
Frith, C. D., & Frith, U. (2007) · Current Biology · doi:10.1016/j.cub.2007.05.068 · Cited by 759 · see citing works
Neural circuitry underlying the regulation of conditioned fear and its relation to extinction
Delgado, M. R., Nearing, K. I., LeDoux, J. E., & Phelps, E. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.029 · Cited by 716 · see citing works
A higher-order theory of emotional consciousness
LeDoux, J. E., & Brown, R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619316114 · Cited by 690 · see citing works
Winkielman, P., Berridge, K. C., & Wilbarger, J. L. (2005) · Personality and Social Psychology Bulletin · doi:10.1177/0146167204271309 · Cited by 708 · see citing works
A systems approach to appraisal mechanisms in emotion
Sander, D., Grandjean, D., & Scherer, K. R. (2005) · Neural Networks · doi:10.1016/j.neunet.2005.03.001 · Cited by 703 · see citing works
Berridge, K. C. (2003) · Brain and Cognition · doi:10.1016/s0278-2626(03)00014-9 · Cited by 694 · see citing works
The role of the amygdala in human fear: automatic detection of threat
Öhman, A. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.019 · Cited by 691 · see citing works
Self-citationA direct brainstem–amygdala–cortical ‘alarm’system for subliminal signals of fear.
Liddell, B. J., Brown, K. J., Kemp, A. H., Barton, M. J., Das, P., Peduto, A., Gordon, E., & Williams, L. M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.016 · Cited by 670 · see citing works
Electrophysiological Correlates of Rapid Spatial Orienting Towards Fearful Faces
Pourtois, G. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh023 · Cited by 655 · see citing works
Are you always on my mind? A review of how face perception and attention interact
Palermo, R., & Rhodes, G. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.04.025 · Cited by 646 · see citing works
Event-related brain potential correlates of emotional face processing
Martin Eimer, A., & Holmes, A. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.04.022 · Cited by 654 · see citing works
The impact of anxiety upon cognition: perspectives from human threat of shock studies
Robinson, O. J., Vytal, K., Cornwell, B. R., & Grillon, C. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00203 · Cited by 613 · see citing works
See it with feeling: affective predictions during object perception
Barrett, L. F., & Bar, M. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0312 · Cited by 632 · see citing works
Ultra-rapid object detection with saccadic eye movements: Visual processing speed revisited
Kirchner, H., & Thorpe, S. J. (2005) · Vision Research · doi:10.1016/j.visres.2005.10.002 · Cited by 622 · see citing works
Morris, J. S. (2001) · Brain · doi:10.1093/brain/124.6.1241 · Cited by 598 · see citing works
Self-citationBrain mechanisms for emotional influences on perception and attention: What is magic and what is not
Pourtois, G., Schettino, A., & Vuilleumier, P. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2012.02.007 · Cited by 687 · see citing works
Amygdala Response to Fearful Faces in Anxious and Depressed Children
Thomas, K. M. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1057 · Cited by 582 · see citing works
Neural Correlates of the Automatic Processing of Threat Facial Signals
Anderson, A. K., Christoff, K., Panitz, D., De Rosa, E., & Gabrieli, J. D. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05627.2003 · Cited by 574 · see citing works
Dalgleish, T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1432 · Cited by 1,849 · see citing works
Light as a modulator of cognitive brain function.
Vandewalle, G., Maquet, P., & Dijk, D.-J. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.07.004 · Cited by 556 · see citing works
Facial expressions, their communicatory functions and neuro–cognitive substrates
Blair, J. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1220 · Cited by 533 · see citing works
Activation of the visual cortex in motivated attention
Bradley, M. M., Sabatinelli, D., Lang, P. J., Fitzsimmons, J. R., King, W., & Desai, P. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.369 · Cited by 528 · see citing works
Attentional control of the processing of neutral and emotional stimuli
Pessoa, L., Kästner, S., & Ungerleider, L. G. (2002) · Cognitive Brain Research · doi:10.1016/s0926-6410(02)00214-8 · Cited by 525 · see citing works
de Gelder, B., Snyder, J., Greve, D., Gerard, G., & Hadjikhani, N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407042101 · Cited by 511 · see citing works
A synaptic threshold mechanism for computing escape decisions
Evans, D. A., Stempel, A. V., Vale, R., Ruehle, S., Lefler, Y., & Branco, T. (2018) · Nature · doi:10.1038/s41586-018-0244-6 · Cited by 449 · see citing works
Holmes, A., Vuilleumier, P. O., & Martin Eimer, A. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(02)00268-9 · Cited by 514 · see citing works
Concepts and Categories: A Cognitive Neuropsychological Perspective
Mahon, B. Z., & Caramazza, A. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163532 · Cited by 512 · see citing works
Lateralization of amygdala activation: a systematic review of functional neuroimaging studies
Baas, D., Aleman, A., & Kahn, R. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.02.004 · Cited by 509 · see citing works
Retrieval of emotional memories.
Buchanan, T. W. (2007) · Psychological bulletin · doi:10.1037/0033-2909.133.5.761 · Cited by 494 · see citing works
Neural Correlates of Positive and Negative Emotion Regulation
Kim, S. H., & Hamann, S. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.5.776 · Cited by 615 · see citing works
Adolescent immaturity in attention-related brain engagement to emotional facial expressions
Monk, C. S., McClure, E. B., Nelson, E. E., Zarahn, E., Bilder, R. M., Leibenluft, E., Charney, D. S., Ernst, M., & Pine, D. S. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00355-0 · Cited by 470 · see citing works
Amygdala response to facial expressions in children and adults.
Thomas, K. M., Drevets, W. C., Whalen, P. J., Eccard, C. H., Dahl, R. E., Ryan, N. D., & Casey, B. J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01066-0 · Cited by 470 · see citing works
Martin Eimer, A., HOLMES, A., & McGlone, F. P. (2003) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.3.2.97 · Cited by 467 · see citing works
Fusar-Poli, P., Crippa, J. A., Bhattacharyya, S., Borgwardt, S. J., Allen, P., Martin-Santos, R., Seal, M., Surguladze, S. A., O’Carrol, C., Atakan, Z., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.519 · Cited by 465 · see citing works
The emergence of social cognitive neuroscience.
Ochsner, K. N., & Lieberman, M. D. (2001) · American Psychologist · doi:10.1037/0003-066x.56.9.717 · Cited by 536 · see citing works
Non-conscious recognition of affect in the absence of striate cortex
de Gelder, B., Vroomen, J., Pourtois, G., & Weiskrantz, L. (1999) · Neuroreport · doi:10.1097/00001756-199912160-00007 · Cited by 461 · see citing works
Atypical eye contact in autism: models, mechanisms and development
Senju, A., & Johnson, M. H. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.001 · Cited by 454 · see citing works
The Simulation of Smiles (SIMS) model: Embodied simulation and the meaning of facial expression
Niedenthal, P. M., Mermillod, M., Maringer, M., & Hess, U. (2010) · Behavioral and Brain Sciences · doi:10.1017/s0140525x10000865 · Cited by 618 · see citing works
Snakes as agents of evolutionary change in primate brains
Isbell, L. A. (2006) · Journal of Human Evolution · doi:10.1016/j.jhevol.2005.12.012 · Cited by 451 · see citing works
Chapter 4 Affect as a Psychological Primitive
Barrett, L. F., & Bliss‐Moreau, E. (2009) · Advances in Experimental Social Psychology · doi:10.1016/s0065-2601(08)00404-8 · Cited by 621 · see citing works
Critchley, H. D., Mathias, C. J., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00588-3 · Cited by 441 · see citing works
Self-citationNeural substrates of facial emotion processing using fMRI
West, M. L. K., Andersen, A. H., Smith, C. D., Avison, M. J., Davis, C. E., Kryscio, R. J., & Blonder, L. X. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(00)00073-2 · Cited by 437 · see citing works
The face-specific N170 component is modulated by emotional facial expression
Blau, V. C., Maurer, U., Tottenham, N., & McCandliss, B. D. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-7 · Cited by 439 · see citing works
Functional neuroimaging studies of human emotions
Phan, K. L., Wager, T. D., Taylor, S. F., & Liberzon, I. (2004) · CNS Spectrums · doi:10.1017/s1092852900009196 · Cited by 433 · see citing works
Role of facial expressions in social interactions
Frith, C. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0142 · Cited by 461 · see citing works
Bzdok, D., Laird, A. R., Zilles, K., Fox, P. T., & Eickhoff, S. B. (2012) · Human Brain Mapping · doi:10.1002/hbm.22138 · Cited by 430 · see citing works
Phobias and preparedness: the selective, automatic, and encapsulated nature of fear
Mineka, S., & Öhman, A. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01669-4 · Cited by 414 · see citing works
Self-citationThe Interface Between Emotion and Attention: A Review of Evidence From Psychology and Neuroscience
Compton, R. J. (2003) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582303255278 · Cited by 419 · see citing works
Exogenous (automatic) attention to emotional stimuli: a review
Carretié, L. (2014) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-014-0270-2 · Cited by 412 · see citing works
Implicit and Explicit Processes in Social Cognition
Frith, C., & Uta Frith, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.032 · Cited by 402 · see citing works
Magnocellular Projections as the Trigger of Top-Down Facilitation in Recognition
Kveraga, K., Boshyan, J., & Bar, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3481-07.2007 · Cited by 402 · see citing works
LeDoux, J. E., & Daw, N. D. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.22 · Cited by 391 · see citing works
Victor, T. A., Furey, M. L., Fromm, S. J., Öhman, A., & Drevets, W. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.144 · Cited by 400 · see citing works
Self-citationPrelude to Passion: Limbic Activation by “Unseen” Drug and Sexual Cues
Childress, A. R., Ehrman, R. N., Wang, Z., Li, Y., Sciortino, N., Hakun, J. G., Jens, W., Suh, J. J., Listerud, J., Marquez, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001506 · Cited by 395 · see citing works
Automaticity and the Amygdala: Nonconscious Responses to Emotional Faces
Ohman, A. (2002) · Current Directions in Psychological Science · doi:10.1111/1467-8721.00169 · Cited by 173 · see citing works
Self-citationUnseen facial and bodily expressions trigger fast emotional reactions
Tamietto, M., Castelli, L., Vighetti, S., Perozzo, P., Geminiani, G., Weiskrantz, L., & de Gelder, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908994106 · Cited by 385 · see citing works
Ashwin, C., Baron‐Cohen, S., Wheelwright, S. J., O’Riordan, M., & Bullmore, E. T. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.04.014 · Cited by 382 · see citing works
Processing of visually evoked innate fear by a non-canonical thalamic pathway
Wei, P., Liu, N., Zhang, Z., Liu, X., Tang, Y., He, X., Wu, B., Zhou, Z., Liu, Y., Li, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7756 · Cited by 387 · see citing works
The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm
LeDoux, J. E., Moscarello, J., Sears, R., & Campese, V (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.166 · Cited by 348 · see citing works
- Authors
- Morris, J. S., Öhman, A., & Dolan, R. J.
- Affiliations
- Karolinska University Hospital (SE)
- ORCID
- Dolan, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1999-02-16
- Volume
- 96
- Issue
- 4
- Pages
- 1680-1685
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC15559
- OpenAlex
- W2116366629
- Cited by
- 1,349
- References
- 54
- Citations by year
- 2026: 27 · 2025: 15 · 2024: 24 · 2023: 45 · 2022: 34 · 2021: 42 · 2020: 44 · 2019: 51 · 2018: 37 · 2017: 46 · 2016: 53 · 2015: 63 · 2014: 51 · 2013: 70 · 2012: 55
- FWCI
- 19.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- masked stimuli, right amygdala, superior colliculus, pulvinar, subcortical pathways, fear conditioning, face perception, fusiform cortex, orbitofrontal cortex, thalamus, midbrain, unconscious visual processing, blindsight
- MeSH terms
- Adult, Amygdala, Brain, Brain Mapping, Facial Expression, Fear, Humans, Male, Neural Pathways, Neurons, Pattern Recognition, Visual, Regression Analysis, Superior Colliculi, Thalamus, Tomography, Emission-Computed
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