Cellular and molecular mechanisms in the long-term action of antidepressants.

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120

Mammalian neural stem cells.

Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321

Antidepressant effects of ketamine in depressed patients

Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375

Subgenual prefrontal cortex abnormalities in mood disorders

Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693

Transcriptional regulation by the phosphorylation-dependent factor CREB

Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587

Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129

Towards a glutamate hypothesis of depression

Sanacora, G., Treccani, G., & Popoli, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.036 · Cited by 1,036

The Role of BDNF on Neural Plasticity in Depression

Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00082 · Cited by 435

Neural basis of major depressive disorder: Beyond monoamine hypothesis

Boku, S., Nakagawa, S., Toda, H., & Hishimoto, A. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12604 · Cited by 402

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322

From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder

Liu, B., Liu, J., Wang, M., Zhang, Y., & Li, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00305 · Cited by 249

Differences in excitatory and inhibitory neurotransmitter levels between depressed patients and healthy controls: A systematic review and meta-analysis

Godfrey, K. E. M., Gardner, A. C., Kwon, S., Chea, W., & Muthukumaraswamy, S. D. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.08.015 · Cited by 218

The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders

Jin, Y., Sun, L., Yang, W., Cui, R., & Xu, S. B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00515 · Cited by 205

Psychedelics and Other Psychoplastogens for Treating Mental Illness.

Vargas, M. V., Meyer, R., Avanes, A. A., Rus, M., & Olson, D. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727117 · Cited by 166

MicroRNAs and exosomes in depression: Potential diagnostic biomarkers

Tavakolizadeh, J., Roshanaei, K., Salmaninejad, A., Yari, R., Nahand, J. S., Khoshdel‐Sarkarizi, H., Mousavi, S. M., Salarinia, R., Rahmati, M., Mousavi, S. F., et al. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26599 · Cited by 162

Psychiatric and Cognitive Aspects of Phenylketonuria: The Limitations of Diet and Promise of New Treatments

Ashe, K., Kelso, W. M., Farrand, S., Panetta, J., Fazio, T. N., Jong, G. D., & Walterfang, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00561 · Cited by 165

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response

Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J., & Belelli, D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.06.001 · Cited by 149

Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke

Blondeau, N., Nguemeni, C., Debruyne, D. N., Piens, M., Wu, X., Pan, H., Hu, X., Gandin, C., Lipsky, R. H., Plumier, J.-C., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.84 · Cited by 154

Antidepressant‐like effect induced by systemic and intra‐hippocampal administration of DNA methylation inhibitors

Sales, A. J., Biojone, C., Terceti, M. S., Guimarães, F. S., Gomes, M. V., & Joca, S. R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01489.x · Cited by 147

Sigma receptors: Potential targets for a new class of antidepressant drug

Fishback, J. A., Robson, M. J., Xu, Y., & Matsumoto, R. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.003 · Cited by 128

Sigma‐1 receptor chaperones regulate the secretion of brain‐derived neurotrophic factor

Fujimoto, M., Hayashi, T., Urfer, R., Mita, S., & Su, T. (2012) · Synapse · doi:10.1002/syn.21549 · Cited by 127

Dual Role of Autophagy in Diseases of the Central Nervous System

Bar-Yosef, T., Damri, O., & Agam, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00196 · Cited by 128

The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA

Sartori, C. R., Vieira, A. S., Ferrari, E. M., Langone, F., Tongiorgi, E., & Parada, C. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.055 · Cited by 123

A Systematic, Updated Review on the Antidepressant Agomelatine Focusing on its Melatonergic Modulation

Fornaro, M., Prestía, D., Colicchio, S., & Perugi, G. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246227 · Cited by 120

Aromatherapy and the Central Nerve System (CNS): Therapeutic Mechanism and its Associated Genes

Lv, X., Liu, Z., Zhang, H., & Tzeng, C. S. (2013) · Current Drug Targets · doi:10.2174/1389450111314080007 · Cited by 126

Pharmacogenetics of antidepressants

Crisafulli, C., Fabbri, C., Porcelli, S., Drago, A., Spina, E., De Ronchi, D., & Serretti, A. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00006 · Cited by 113

Stress, glucocorticoids and glutamate release: Effects of antidepressant drugs

Musazzi, L., Racagni, G., & Popoli, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.05.002 · Cited by 118

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Zhong, H., Haddjeri, N., & Sánchez, C. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2463-5 · Cited by 105

An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders

Kuan, P.-F., Waszczuk, M. A., Kotov, R., Marsit, C. J., Guffanti, G., Gonzalez, A., Yang, X., Koenen, K., Bromet, E., & Luft, B. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.130 · Cited by 103

Roles of glutamate signaling in preclinical and/or mechanistic models of depression

Tokita, K., Yamaji, T., & Hashimoto, K. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.016 · Cited by 104

Triple reuptake inhibitors for treating subtypes of major depressive disorder: the monoamine hypothesis revisited

Prins, J., Olivier, B., & Korte, S. M. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.594039 · Cited by 106

Effect of antidepressants on circadian rhythms in fish: Insights and implications regarding the design of behavioural toxicity tests.

Melvin, S. D. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.11.007 · Cited by 98

Common mechanisms of pain and depression: are antidepressants also analgesics?

Nekovářová, T., Yamamotová, A., Valeš, K., Stuchlík, A., Fricová, J., & Rokyta, R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00099 · Cited by 91

Serum levels of brain-derived neurotrophic factor in drug-naïve obsessive–compulsive patients: A case–control study

Maina, G., Rosso, G., Zanardini, R., Bogetto, F., Gennarelli, M., & Bocchio‐Chiavetto, L. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.07.009 · Cited by 94

Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system

Weckmann, K., Deery, M. J., Howard, J. A., Feret, R., Asara, J. M., Dethloff, F., Filiou, M. D., Iannace, J., Labermaier, C., Maccarrone, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16183-x · Cited by 95

The role of the neuroendocrine and immune systems in the pathogenesis of depression

Ogłodek, E., Szota, A. M., Just, M. J., Moś, D., & Araszkiewicz, A. S. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.04.009 · Cited by 87

Onset, time course and trajectories of improvement with antidepressants

Lam, R. W. M. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.07.005 · Cited by 86

G protein-linked signaling pathways in bipolar and major depressive disorders

Tomita, H., Ziegler, M. E., Kim, H. B., Evans, S. J., Choudary, P. V., Li, J. Z., Meng, F., Dai, M., Myers, R., Neal, C. R., et al. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00297 · Cited by 84

Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: A critical review

Pompili, M., Serafini, G., Innamorati, M., Venturini, P., Fusar‐Poli, P., Sher, L., Amore, M., & Girardi, P. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.765593 · Cited by 80

Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain

Xue, W., Zhou, X., Yi, N., Jiang, L., Tao, W., Wu, R., Wang, D., Jiang, J., Ge, X., Wang, Y., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/184367 · Cited by 77

New‐generation, non‐SSRI antidepressants: Drug‐drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others

Protti, M., Mandrioli, R., Marasca, C., Cavalli, A., Serretti, A., & Mercolini, L. (2020) · Medicinal Research Reviews · doi:10.1002/med.21671 · Cited by 71

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

Kara, N. Z., Toker, L., Agam, G., Anderson, G. W., Belmaker, R. H., & Einat, H. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3119-4 · Cited by 64

Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments

Leuchter, A. F., Hunter, A. M., Krantz, D. E., & Cook, I. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12742 · Cited by 75

DNA methylation and clinical response to antidepressant medication in major depressive disorder: A review and recommendations

Lisoway, A. J., Zai, C. C. H., Tiwari, A. K., & Kennedy, J. L. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.071 · Cited by 71

Effects of DNA methylation inhibitors and conventional antidepressants on mice behaviour and brain DNA methylation levels

Sales, A. J., & Joca, S. R. L. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.40 · Cited by 62

Molecular Neurobiology and Promising New Treatment in Depression

Jeon, S. R., & Kim, Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030381 · Cited by 62

Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood

Iñiguez, S. D., Parise, L. F., Warren, B. L., Riggs, L. M., Parise, E. M., Vialou, V., Wright, K. N., Dayrit, G., Nieto, S. J., Wilkinson, M. B., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5725-12.2014 · Cited by 63

Update on GPCR-based targets for the development of novel antidepressants

Mantas, I., Saarinen, M., Xu, Q., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01040-1 · Cited by 61

Antidepressants elevate GDNF expression and release from C6 glioma cells in a β-arrestin1-dependent, CREB interactive pathway

Golan, M., Schreiber, G., & Avissar, S. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001550 · Cited by 54

Position statement of the European Psychiatric Association (EPA) on the value of antidepressants in the treatment of unipolar depression

Möller, H. ‐., Bitter, I., Bobes, J., Fountoulakis, K. Ν., Höschl, C., & Kasper, S. F. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.08.002 · Cited by 53

Neuronal NOS Inhibitor and Conventional Antidepressant Drugs Attenuate Stress-induced Fos Expression in Overlapping Brain Regions

Silva, M., de Aguiar, D. C., Diniz, C. R. A. F., Guimarães, F. S., & Joca, S. R. L. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9775-1 · Cited by 56

Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice

Gupta, D., Radhakrishnan, M., & Kurhe, Y. (2015) · Steroids · doi:10.1016/j.steroids.2015.01.021 · Cited by 54

The dose makes the poison: From glutamate-mediated neurogenesis to neuronal atrophy and depression

Rubio-Casillas, A., & Fernández-Guasti, A. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0066 · Cited by 49

The Stability of NR2B in the Nucleus Accumbens Controls Behavioral and Synaptic Adaptations to Chronic Stress

Jiang, B., Wang, W., Wang, F., Hu, Z., Xiao, J., Yang, S., Zhang, J., Peng, X., Wang, J., & Chen, J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.031 · Cited by 47

Zinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trials

Yosaee, S., Clark, C. C. T., Keshtkaran, Z., Ashourpour, M., Keshani, P., & Soltani, S. (2020) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2020.08.001 · Cited by 48

Brain-derived neurotrophic factor Val66Met polymorphism association with antidepressant efficacy: A systematic review and meta-analysis: BDNF Val66Met and antidepressant efficacy

Yan, T., Wang, L., Kuang, W., Xu, J., Li, S., Chen, J., & Yang, Y. (2014) · Asia-Pacific Psychiatry · doi:10.1111/appy.12148 · Cited by 46

Targeting astrocytes in bipolar disorder

Peng, L., Li, B., & Verkhratsky, A. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1171144 · Cited by 45

Early induction of CREB activation and CREB-regulating signalling by antidepressants

Tardito, D., Musazzi, L., Tiraboschi, E., Mallei, A., Racagni, G., & Popoli, M. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000376 · Cited by 43

PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway

Fabbri, C., Marsano, A., Albani, D., Chierchia, A., Calati, R., Drago, A., Crisafulli, C., Calabrò, M., Kasper, S. F., Lanzenberger, R. R., et al. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2014.15 · Cited by 41

Lasting effects of chronic fluoxetine treatment on the late developing rat brain: Age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI

Klomp, A., Tremoleda, J. L., Wylezinska, M., Nederveen, A. J., Feenstra, M. G. P., Gsell, W., & Reneman, L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.082 · Cited by 41

Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation

Musazzi, L., Rimland, J. M., Ieraci, A., Racagni, G., Domenici, E., & Popoli, M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001685 · Cited by 40

Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors

Cruceanu, C., Schmouth, J.-F., Torres-Platas, S. G., López, J. P., Ambalavanan, A., Darcq, E., Gross, F., Breton, B., Spiegelman, D., Rochefort, D. L., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.223 · Cited by 38

Isotretinoin has no negative effect on attention, executive function and mood

Ergun, T., Seçkin, D., Özaydın, A., Bakar, Ö., Cömert, A., Atsü, N., Demirçay, Z., Yöney, H., & Zaimoğlu, S. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04089.x · Cited by 38

Atorvastatin and Fluoxetine Prevent Oxidative Stress and Mitochondrial Dysfunction Evoked by Glutamate Toxicity in Hippocampal Slices

Ludka, F. K., Dal-Cim, T. A., Binder, L. B., Constantino, L. C., Massari, C. M., & Tasca, C. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9882-6 · Cited by 38

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

Álvarez-Mon, M. Á., Ortega, M. A., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Lahera, G., Mora, F., Rodríguez-Quiroga, A., Fernández-Rojo, S., Quintero, J., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14080821 · Cited by 38

A novel peripheral biomarker for depression and antidepressant response

Targum, S. D., Schappi, J. M., Koutsouris, A., Bhaumik, R., Rapaport, M. H., Rasgon, N., & Rasenick, M. M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01399-1 · Cited by 42

Clinical features and drug induced side effects in early versus late antidepressant responders

Fabbri, C., Marsano, A., Balestri, M., Ronchi, D. D., & Serretti, A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.020 · Cited by 33

Advances in novel molecular targets for antidepressants

Wang, Q., & Dwivedi, Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110041 · Cited by 33

Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo‐keto reductase

Fry, J. P., Li, K. Y., Devall, A., Cockcroft, S., Honour, J. W., & Lovick, T. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12891 · Cited by 32

Antidepressants and type 2 diabetes: highways to knowns and unknowns

Alruwaili, N. S., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Ragab, A. E., Alenazi, A. A., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01149-z · Cited by 36

Neurochemical and behavioural effects of hypidone hydrochloride (YL‐0919): a novel combined selective 5‐HT reuptake inhibitor and partial 5‐HT1Aagonist

Zhang, L., Wang, X., Zhao, N., Wang, Y., Hu, X., Ran, Y., Liu, Y., Zhang, Y., Yang, R., & Li, Y. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13675 · Cited by 30

Neuroplasticity and Mechanisms of Action of Acute and Chronic Treatment with Antidepressants in Preclinical Studies

Rosas-Sánchez, G. U., Germán-Ponciano, L. J., Guillén-Ruiz, G., Cueto‐Escobedo, J., Limón-Vázquez, A. K., Rodríguez‐Landa, J. F., & Soria-Fregozo, C. (2024) · Biomedicines · doi:10.3390/biomedicines12122744 · Cited by 30

Psychiatric neural networks and neuropharmacology: Selected advances and novel implications

Ghanemi, A. (2013) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.01.008 · Cited by 27

The intersection of pharmacology, imaging, and genetics in the development of personalized medicine

Gerretsen, P., Müller, D. J., Tiwari, A. K., Mamo, D. C., & Pollock, B. G. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.4/pgerretsen · Cited by 27

Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice

Wang, X., Chen, J., Zhang, H., Huang, Z., Zou, Z., Yin, C., Sheng, L., Xue, W., Tang, J., Wu, H., et al. (2018) · Bioscience Reports · doi:10.1042/bsr20181539 · Cited by 26

Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids

Germán-Ponciano, L. J., Rosas-Sánchez, G. U., Cueto‐Escobedo, J., Fernández-Demeneghi, R., Guillén-Ruiz, G., Soria-Fregozo, C., Herrera-Huerta, E. V., & Rodríguez‐Landa, J. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810896 · Cited by 27

Monoamine involvement in the antidepressant-like effect induced by P2 blockade

Diniz, C. R. A. F., Rodrigues, M., Casarotto, P. C., Pereira, V. S., Crestani, C. C., & Joca, S. R. L. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.011 · Cited by 25

The role of cytochromes P450 in the metabolism of selected antidepressants and anxiolytics under psychological stress

Zemanová, N., Anzenbacher, P., & Anzenbacherová, E. (2022) · Biomedical Papers · doi:10.5507/bp.2022.019 · Cited by 27

The Role of Beta-Adrenergic Receptors in Depression and Resilience

Zhang, H., Cui, M., Cao, J., & Han, M. (2022) · Biomedicines · doi:10.3390/biomedicines10102378 · Cited by 26

Chronic oral ketamine prevents anhedonia and alters neuronal activation in the lateral habenula and nucleus accumbens in rats under chronic unpredictable mild stress

Kingir, E., Sevinc, C., & Ünal, G. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109468 · Cited by 28

Antidepressants Increase β-Arrestin2 Ubiquitinylation and Degradation by the Proteasomal Pathway in C6 Rat Glioma Cells

Golan, M., Schreiber, G., & Avissar, S. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.160218 · Cited by 24

Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies

Sołek, P., Koszła, O., Mytych, J., Badura, J., Chelminiak, Z., Cuprys, M., Fraczek, J., Tabęcka-Łonczyńska, A., & Koziorowski, M. (2019) · APOPTOSIS · doi:10.1007/s10495-019-01557-5 · Cited by 24

Molecular and Cellular Aspects of Major Depressive Disorder

Chottekalapanda, R. U., Greengard, P., & Sagi, Y. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780190455132.003.0004 · Cited by 23

Extra-Virgin Olive Oil Improves Depression Symptoms Without Affecting Salivary Cortisol and Brain-Derived Neurotrophic Factor in Patients With Major Depression: A Double-Blind Randomized Controlled Trial

Foshati, S., Ghanizadeh, A. J., & Akhlaghi, M. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2021.07.016 · Cited by 26

All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants

Freudenberg, F., Reif-Leonhard, C., Dawson, G. R., McKernan, R. M., & Reif, A. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107918 · Cited by 23

NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress

Diniz, C. R. A. F., Casarotto, P. C., & Joca, S. R. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.037 · Cited by 22

New Therapeutic Strategy for Mood Disorders

Crupi, R., Marino, A., & Cuzzocrea, S. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797200417 · Cited by 20

Licorisoflavan A Exerts Antidepressant-Like Effect in Mice: Involvement of BDNF-TrkB Pathway and AMPA Receptors

Dong, X. Y., Liu, L., Li, Y., Ruan, J., & Wang, H. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02840-2 · Cited by 22

Brain structure and synaptic protein expression alterations after antidepressant treatment in a Wistar–Kyoto rat model of depression

Li, Q., Gao, Y., Li, H., Liu, H., Wang, D., Pan, W. X., Liu, S., & Xu, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.037 · Cited by 21

Multi-matrix assay of the first melatonergic antidepressant agomelatine by combined liquid chromatography-fluorimetric detection and microextraction by packed sorbent

Saracino, M. A., Mercolini, L., Carbini, G., Volterra, V., Quarta, A. L., Amore, M., & Raggi, M. A. (2014) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2014.02.005 · Cited by 21

Antidepressant-induced differential ubiquitination of β-arrestins 1 and 2 in mononuclear leucocytes of patients with depression

Golan, M., Schreiber, G., & Avissar, S. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000291 · Cited by 21

Yoga in major depressive disorder: molecular mechanisms and clinical utility

Tolahunase, M., Gautam, S., Sagar, R., Kumar, M., & Dada, R. (2021) · Frontiers in Bioscience-Scholar · doi:10.52586/s553 · Cited by 22

Research progress on vesicle cycle and neurological disorders

Zhang, C., Zhu, L., & Chen, C. (2021) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps31458 · Cited by 18

Intersecting Relationships of Psychosocial and Structural Syndemic Problems Among People with HIV in South Africa: Using Network Analysis to Identify Influential Problems

Lee, J. S., Bainter, S. A., Tsai, A. C., Andersen, L. S., Stanton, A. M., Magidson, J. F., Kagee, A., Joska, J. A., O’Cleirigh, C. M., & Safren, S. A. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03906-z · Cited by 22

Chronic Fluoxetine Treatment of Socially Isolated Rats Modulates Prefrontal Cortex Proteome

Filipović, D., Novak, B., Xiao, J., Yan, Y., Yeoh, K., & Turck, C. W. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.08.011 · Cited by 22

Astroglia, Glutamatergic Transmission and Psychiatric Diseases

Verkhratsky, A., Steardo, L., Peng, L., & Parpura, V. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-45096-4_12 · Cited by 18

Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior

Lyman, K. A., Han, Y., Zhou, C., Renteria, I., Besing, G.-L., Kurz, J. E., & Chetkovich, D. M. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abl4580 · Cited by 17

Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

Zhao, X., Li, H., & Dai, R. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i3.379 · Cited by 19

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder

Marcin, L. R., Warrier, J., Thangathirupathy, S., Shi, J., Karageorge, G. N., Pearce, B. C., Ng, A., Park, H., Kempson, J., Li, J., et al. (2018) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.8b00080 · Cited by 18

Accuracy in recognising happy facial expressions is associated with antidepressant response to a NOP receptor antagonist but not placebo treatment

Dawson, G. R., Post, A., Smart, T. S., Browning, M. D., & Harmer, C. J. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211044684 · Cited by 16

Wheatgrass extract imparts neuroprotective actions against scopolamine-induced amnesia in mice

Katiyar, P., Rathore, A. S., Banerjee, S., Nathani, S., Zahra, W., Singh, S. P., Sircar, D., & Roy, P. (2022) · Food & Function · doi:10.1039/d2fo00423b · Cited by 16

Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice

Zhang, Y., Jin, C., Wang, X., Shen, M., Zhou, J., Wu, S., Fu, Z., & Jin, Y. (2018) · Environmental Toxicology · doi:10.1002/tox.22653 · Cited by 16

Potential depression and antidepressant-response biomarkers in human lymphoblast cell lines from treatment-responsive and treatment-resistant subjects: roles of SSRIs and omega-3 polyunsaturated fatty acids

Chukaew, P., Leow, A., Saengsawang, W., & Rasenick, M. M. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0724-6 · Cited by 16

Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

Aswar, U. M., ., P. K., Shelke, S. M., Bhosale, S. H., & Bodhankar, S. L. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(13)60012-x · Cited by 17

Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome

Khlebnikova, N. N., Krupina, N. A., Kushnareva, E. Y., Золотов, Н. Н., & Крыжановский, Г. Н. (2012) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-012-1540-z · Cited by 14

Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats

Filipović, D., Costina, V., Findeisen, P., & Inta, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315351 · Cited by 15

New Strategies in the Development of Antidepressants: Towards the Modulation of Neuroplasticity Pathways

Vidal, R., Pilar-Cuéllar, F., Dos-Anjos, S., Linge, R., Treceño, B., Vargas, V. I., Rodríguez‐Gaztelumendi, A., Mostany, R., Castro, E., Díaz, Á., et al. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795164086 · Cited by 55

Antidepressants and neuroplasticity

D'Sa, C. M., & Duman, R. S. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01203.x · Cited by 523

Neurogenesis and Neuroplasticity in Major Depression: Its Therapeutic Implication

Bourin, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_10 · Cited by 19

Molecular and Cellular Mechanisms of Antidepressant Action

Sharp, T. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_216 · Cited by 36

New views on antidepressant action

Baudry, A., Mouillet‐Richard, S., Launay, J., & Kellermann, O. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.03.005 · Cited by 33