Monoamine involvement in the antidepressant-like effect induced by P2 blockade
Open accessAbstract
Depression is a common mental disorder that affects millions of individuals worldwide. Available monoaminergic antidepressants are far from ideal since they show delayed onset of action and are ineffective in approximately 40% of patients, thus indicating the need of new and more effective drugs. ATP signaling through P2 receptors seems to play an important role in neuropathological mechanisms involved in depression, since their pharmacological or genetic inactivation induce antidepressant-like effects in the forced swimming test (FST). However, the mechanisms involved in these effects are not completely understood. The present work investigated monoamine involvement in the antidepressant-like effect induced by non-specific P2 receptor antagonist (PPADS) administration. First, the effects of combining sub-effective doses of PPADS with sub-effective doses of fluoxetine (FLX, selective serotonin reuptake inhibitor) or reboxetine (RBX, selective noradrenaline reuptake inhibitor) were investigated in mice submitted to FST. Significant antidepressant-like effect was observed when subeffective doses of PPADS was combined with subeffective doses of either FLX or RBX, with no significant locomotor changes. Next, the effects of depleting serotonin and noradrenaline levels, by means of PCPA (p-Chlorophenylalanine) or DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride) pretreatment, respectively, was investigated. Both, PCPA and DSP-4 pretreatment partially attenuated PPADS-induced effects in FST, without inducing relevant locomotor changes. Our results suggest that the antidepressant-like effect of PPADS involves modulation of serotonin and noradrenaline levels in the brain.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The antidepressant-like effect in mice induced by systemic treatment with PPADS was blocked by 5-HT or NA depletion, implicating these monoamines in the drug effect.
“In a recent study, it was shown that the antidepressant-like effect in mice induced by systemic treatment with PPADS (P2R inhibitor) was blocked by 5-HT or NA depletion, implicating these monoamines in the drug effect [96].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [96]
Co-treatment with sub-effective doses of PPADS and serotonergic (fluoxetine) or noradrenergic (desipramine) antidepressants had synergistic effects.
“Indeed, co-treatment with sub-effective doses of PPADS and serotonergic (fluoxetine) or noradrenergic (desipramine) antidepressants had synergistic effects [96].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [96]
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Chou, T.-C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.10 · Cited by 5,163 · see citing works
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258 · see citing works
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Burnstock, G. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06930-3 · Cited by 1,852 · see citing works
p-CHLOROPHENYLALANINE: A SPECIFIC DEPLETOR OF BRAIN SEROTONIN
Koe, B. K., & Weissman, A. (1966) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27497-3 · Cited by 1,785 · see citing works
Assessing antidepressant activity in rodents: recent developments and future needs
Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551 · cited 4× · see citing works
“In fact, immobility time of rats exposed to swim session is increased after uncontrollable stress and decreased by antidepressant treatment (Porsolt et al., 1977; Cryan et al., 2002a; Nestler and Hyman, 2010).”
InfluentialGliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308 · see citing works
Astrocytic Purinergic Signaling Coordinates Synaptic Networks
Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280 · see citing works
Analysis of drug combinations: current methodological landscape
Foucquier, J., & Guedj, M. (2015) · Pharmacology Research & Perspectives · doi:10.1002/prp2.149 · Cited by 1,115 · see citing works
Purinoceptors: Are there families of P2X and P2Y purinoceptors?
Abbracchio, M. P., & Burnstock, G. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00048-4 · Cited by 1,090 · see citing works
Purine and pyrimidine receptors
Burnstock, G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6497-0 · Cited by 929 · see citing works
Purinergic signalling in the nervous system: an overview
Abbracchio, M. P., Burnstock, G., Verkhratsky, A., & Zimmermann, H. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.10.001 · Cited by 856 · see citing works
Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior
Halassa, M. M., & Haydon, P. G. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135843 · Cited by 835 · see citing works
ATP Released from Astrocytes Mediates Glial Calcium Waves
Guthrie, P. B., Knappenberger, J., Segal, M., Bennett, M. V. L., Charles, A. C., & Kater, S. B. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00520.1999 · Cited by 806 · see citing works
A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle
Benham, C. D., & Tsien, R. W. (1987) · Nature · doi:10.1038/328275a0 · Cited by 784 · see citing works
Purinergic signalling and disorders of the central nervous system
Burnstock, G. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2605 · Cited by 640 · see citing works
An Overview of Drug Combination Analysis with Isobolograms
Tallarida, R. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104117 · Cited by 505 · see citing works
Central monoamines and their role in major depression
Elhwuegi, A. S. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.11.018 · Cited by 504 · see citing works
JONSSON, G., Hallman, H., Ponzio, F., & Ross, S. B. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90272-7 · Cited by 459 · see citing works
Purinergic Signaling and Vascular Cell Proliferation and Death
Burnstock, G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0302.105360 · Cited by 414 · see citing works
Iwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works
Page, M. E., Detke, M. J., Dalvi, A., Kirby, L. G., & Lucki, I. (1999) · Psychopharmacology · doi:10.1007/s002130051156 · Cited by 385 · see citing works
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
Zanelati, T., Biojone, C., Moreira, F., Guimarães, F., & Joca, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00521.x · Cited by 366 · see citing works
Yue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0865-y · Cited by 334 · see citing works
Vesicular release of ATP at central synapses
Pankratov, Y. V., Lalo, U., Verkhratsky, A., & North, R. A. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0061-x · Cited by 326 · see citing works
Pharmacology and electrophysiology of ATP-activated ion channels
Bean, B. P. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90032-2 · Cited by 326 · see citing works
Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex
Lalo, U., Palygin, O., Rasooli-Nejad, S., Andrew, J., Haydon, P. G., & Pankratov, Y. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001747 · Cited by 270 · see citing works
The pharmacology of putative early-onset antidepressant strategies
Blier, P. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00173-6 · Cited by 245 · see citing works
Fritschy, J., & Grzanna, R. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90364-3 · Cited by 235 · see citing works
ATP Release from Affinity‐Purified Rat Cholinergic Nerve Terminals
Richardson, P. J., & Brown, S. J. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb04138.x · Cited by 226 · see citing works
Basso, A. M., Bratcher, N. A., Harris, R. R., Jarvis, M. F., Decker, M. W., & Rueter, L. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.018 · Cited by 224 · see citing works
Shannon, N., Gunnet, J., & Moore, K. E. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00704.x · Cited by 221 · see citing works
Alcocer-Gómez, E., Casas-Barquero, N., Williams, M. R., Romero-Guillena, S. L., Cañadas-Lozano, D., Bullón, P., Sánchez-Alcazar, J. A., Navarro-Pando, J. M., & Cordero, M. D. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.028 · Cited by 215 · see citing works
Neuronal P2X receptors: localisation and functional properties
Nörenberg, W., & Illés, P. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000311 · Cited by 214 · see citing works
Ectonucleotidases in the Nervous System
Zimmermann, H. (2006) · Novartis Foundation symposium · doi:10.1002/9780470032244.ch10 · Cited by 210 · see citing works
Burnstock, G. (1976) · Journal of Theoretical Biology · doi:10.1016/0022-5193(76)90133-8 · Cited by 207 · see citing works
Patel, B. A., Arundell, M., Parker, K. H., Yeoman, M. S., & O’Hare, D. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.01.008 · Cited by 197 · see citing works
Cellular and molecular mechanisms in the long-term action of antidepressants.
Racagni, G., & Popoli, M. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.4/gracagni · Cited by 192 · see citing works
Cryan, J. F., Page, M. E., & Lucki, I. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01628-4 · Cited by 184 · see citing works
O’Leary, O. F., Bechtholt, A. J., Crowley, J. J., Hill, T. E., Page, M. E., & Lucki, I. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0728-9 · Cited by 177 · see citing works
Harkin, A., Connor, T. J., Burns, M. P., & Kelly, J. P. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.08.010 · Cited by 164 · see citing works
Mori, M., Heuss, C., Gähwiler, B. H., & Gerber, U. R. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00115.x · Cited by 156 · see citing works
Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors
Harkin, A., Connor, T., Walsh, M. P., John, N., & Kelly, J. P. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00030-3 · Cited by 150 · see citing works
A possible alarm substance in the forced swimming test
Abel, E. L., & Bilitzke, P. J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90306-o · Cited by 138 · see citing works
Csölle, C., Baranyi, M., Zsilla, G., Kittel, Á., Gölöncsér, F., Illes, P., Papp, E., Vizi, E. S., & Sperlágh, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066547 · Cited by 128 · see citing works
Boucher, A. A., Arnold, J. C., Hunt, G. E., Spiro, A., Spencer, J., Brown, C., McGregor, I. S., Bennett, M. R., & Kassiou, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.049 · Cited by 108 · see citing works
Ross, S. B., & Rényi, A. L. (1976) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1976.tb04659.x · Cited by 108 · see citing works
Sperlágh, B., Sershen, H. W., Lajtha, Á., & Vizi, E. S. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00306-0 · Cited by 102 · see citing works
Ross, S. B., & Stenfors, C. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9482-z · Cited by 101 · see citing works
Nitric oxide transforms serotonin into an inactive form and this affects neuromodulation
Fossier, P., Blanchard, B., Ducrocq, C., Leprince, C., Tauc, L., & Baux, G. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00165-7 · Cited by 98 · see citing works
Grzanna, R., Berger, U. V., Fritschy, J., & Geffard, M. (1989) · Journal of Histochemistry & Cytochemistry · doi:10.1177/37.9.2768812 · Cited by 89 · see citing works
Hallman, H., & JONSSON, G. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90487-4 · Cited by 84 · see citing works
Evidence for P2‐purinoceptor‐mediated inhibition of noradrenaline release in rat brain cortex
von Kügelgen, I., Späth, L., & Starke, K. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17066.x · Cited by 82 · see citing works
Excitatory effects of adenosine 5′-triphosphate on rat locus coeruleus neurones
Tschöpl, M., Harms, L., Nörenberg, W., & Illés, P. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90234-u · Cited by 79 · see citing works
Monoamine depletion studies: implications for antidepressant discontinuation syndrome.
Delgado, P. L. (2006) · PubMed · Cited by 74 · see citing works
Fletcher, P. J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00215-3 · Cited by 72 · see citing works
Fornai, F., Bassi, L., Torracca, M. T., Alessandri, M., Scalori, V., & Corsini, G. U. (1996) · Neurodegeneration · doi:10.1006/neur.1996.0032 · Cited by 70 · see citing works
Dailly, É., Chenu, F., Petit‐Demoulière, B., & Bourin, M. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.06.008 · Cited by 69 · see citing works
Pereira, V. S., Casarotto, P. C., Hiroaki-Sato, V. A., Sartim, A. G., Guimarães, F. S., & Joca, S. R. L. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.01.008 · Cited by 66 · see citing works
Pfielschifter, J. (1990) · Cellular Signalling · doi:10.1016/0898-6568(90)90016-4 · Cited by 64 · see citing works
Kuhn, D. M., & Arthur, R. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07245.1997 · Cited by 62 · see citing works
Moreno, F., Parkinson, D., Palmer, C. M., Castro, W. L., Misiaszek, J., Khoury, A. E., Mathé, A. A., Wright, R., & Delgado, P. L. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.10.003 · Cited by 61 · see citing works
Regulation of cell-to-cell communication mediated by astrocytic ATP in the CNS
Koizumi, S., Fujishita, K., & Inoue, K. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-6321-y · Cited by 59 · see citing works
Häring, M., Grieb, M., Monory, K., Lutz, B., & Moreira, F. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.09.002 · Cited by 59 · see citing works
du Jardin, K. G., Müller, H. K., Elfving, B., Dale, E., Wegener, G., & Sánchez, C. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.05.007 · Cited by 54 · see citing works
Kask, A., Harro, J., Tuomainen, P. M., Rägo, L., & Männistö, P. T. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00004942 · Cited by 49 · see citing works
Shen, J., Harada, N., Nakazawa, H., & Yamashita, T. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04135.x · Cited by 49 · see citing works
P2-Receptor-mediated inhibition of noradrenaline release in the rat hippocampus
Koch, H., von Kügelgen, I., & Starke, K. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005003 · Cited by 48 · see citing works
Effect of NOS inhibitor on forced swim test and neurotransmitters turnover in the mouse brain.
Karolewicz, B., Paul, I. A., & Antkiewicz‐Michaluk, L. (2002) · PubMed · Cited by 43 · see citing works
Cholinergic Modulation of Purinergic and GABAergic Co-Transmission at In Vitro Hypothalamic Synapses
Jo, Y., & Role, L. W. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00352.2002 · Cited by 43 · see citing works
Kato, F., Kawamura, M., Shigetomi, E., Tanaka, J.-I., & Inoue, K. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.107 · Cited by 39 · see citing works
Kornum, B. R., Licht, C. L., Weikop, P., Knudsen, G. M., & Aznar, S. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.013 · Cited by 39 · see citing works
P2-receptor-mediated inhibition of serotonin release in the rat brain cortex
Von Kügelgen, I., Koch, H., & Starke, K. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00101-9 · Cited by 38 · see citing works
Ulak, G., Mutlu, O., Tanyerı, P., Komsuoglu, F. I., Akar, F., & Erden, F. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.02.006 · Cited by 36 · see citing works
Do ATP and NO interact in the CNS?
Florenzano, F., Viscomi, M. T., Amadio, S., D’Ambrosi, N., Volonté, C., & Molinari, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.004 · Cited by 35 · see citing works
Long term depletion of serotonin leads to selective changes in glutamate receptor subunits
Shutoh, F., Hamada, S., Shibata, M., Narita, M., Shiga, T., Azmitia, E. C., & Okado, N. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00184-x · Cited by 32 · see citing works
Hughes, Z. A., & Stanford, S. C. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701947 · Cited by 31 · see citing works
Datla, K. P., & Curzon, G. (1996) · Neuropharmacology · doi:10.1016/0028-3908(96)00175-x · Cited by 29 · see citing works
Diniz, C. R. A. F., Casarotto, P. C., & Joca, S. R. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.037 · Cited by 22 · see citing works
Possible antinociceptive mechanisms of opioid receptor antagonists in the mouse formalin test
Choi, S.-S., Han, K.-J., Lee, H., Han, E., & Suh, H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00144-8 · Cited by 20 · see citing works
Wang, Y., Musich, P. R., Serrano, M. A., Zou, Y., Zhang, J., & Zhu, M. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9421-4 · Cited by 15 · see citing works
Purinergic signaling in the gastrointestinal tract
Burnstock, G. (2011) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v2.i2.31 · Cited by 13 · see citing works
Koren-Schwartzer, N., Chen-Zion, M., Ben-Porat, H., & Beitner, R. (1994) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)90147-3 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
P2X7 Receptor Signaling in Stress and Depression
Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works
Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels
Sales, A. J., Crestani, C. C., Guimarães, F. S., & Joca, S. R. L. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.06.002 · Cited by 118 · see citing works
Purinergic Signaling and Related Biomarkers in Depression
Bartoli, F., Burnstock, G., Crocamo, C., & Carrà, G. (2020) · Brain Sciences · doi:10.3390/brainsci10030160 · Cited by 64 · see citing works
Antidepressant effect of helicid in chronic unpredictable mild stress model in rats
Tong, J., Zhou, Z., Qi, W., Jiang, S., Yang, B., Zhong, Z.-L., Jia, Y., Li, X., Xiong, L., & Nie, L. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.11.052 · Cited by 53 · see citing works
Diniz, C. R. A. F., Casarotto, P. C., Fred, S. M., Biojone, C., Ċastrén, E., & Joca, S. R. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.011 · Cited by 50 · see citing works
Ribeiro, D. E., Müller, H. K., Elfving, B., Eskelund, A., Joca, S. R., & Wegener, G. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119872173 · Cited by 45 · see citing works
Abame, M. A., Yang, H., Wu, S., Xie, Z., Zhang, J., Gong, X., Wu, C., & Shen, J. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135594 · Cited by 33 · see citing works
Brain immune cells characterization in UCMS exposed P2X7 knock-out mouse
Troubat, R., Leman, S., Pinchaud, K., Surget, A., Barone, P. R., Roger, S., Guisquet, A. L., Brizard, B., Belzung, C., & Camus, V. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.012 · Cited by 33 · see citing works
Moro, N., Ghavim, S. S., & Sutton, R. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10007 · Cited by 25 · see citing works
Purinergic transmission in depressive disorders
Szopa, A., Socała, K., Serefko, A., Doboszewska, U., Wróbel, A., Poleszak, E., & Właź, P. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107821 · Cited by 25 · see citing works
Loganin ameliorates depression-like behaviors of mice via modulation of serotoninergic system
Pan, C., Xia, C., Yan, Y., Han, Y., Shi, R., He, J., Wang, Z., Wang, Y., Zhang, W., & Xu, J. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05922-8 · Cited by 24 · see citing works
Ribeiro, D. E., Casarotto, P. C., Staquini, L., Pinto e Silva, M. A., Biojone, C., Wegener, G., & Joca, S. (2019) · PeerJ · doi:10.7717/peerj.7834 · Cited by 21 · see citing works
Purinergic signaling in cognitive impairment and neuropsychiatric symptoms of Alzheimer's disease
Ribeiro, D. E., Petiz, L. L., Glaser, T., Oliveira‐Giacomelli, Á., Andrejew, R., Saab, F. D. A. R., Milanis, M. D. S., Campos, H. C., Arnaud-Sampaio, V. F., de Oliveira, S. L. B., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109371 · Cited by 20 · see citing works
S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors
Sales, A. J., Maciel, I. D. S., Crestani, C. C., Guimarães, F. S., & Joca, S. R. L. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105442 · Cited by 13 · see citing works
Glial Purinergic Signaling‐Mediated Oxidative Stress (GPOS) in Neuropsychiatric Disorders
Huang, L., Tang, Y., & Sperlágh, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1075440 · Cited by 9 · see citing works
Serotonergic neurons in the treatment of mood disorders: The dialogue with astrocytes
Charvériat, M., & Guiard, B. P. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.01.006 · Cited by 7 · see citing works
Major depressive disorder (mdd): emerging immune targets at preclinical level
Varma, M., Kaur, A., Bhandari, R., Kumar, A., & Kuhad, A. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2225216 · Cited by 5 · see citing works
de Andrade, V. H. B., Rodrigues, E. Y. M., Dias, N. A. F., Ferreira, G. F. C., Carvalho, D. B., das Neves, A. R., Coronel, P. M. V., Yonekawa, M. K. A., Parisotto, E. B., dos Santos, E. D. A., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00443 · Cited by 2 · see citing works
[Heart involvement in patients with multiple myeloma based on echocardiographic data].
Бессмелъцев, С. С., & Abdulkadyrov, K. M. (1991) · PubMed
Purinergic Signaling in Depression
Ribeiro, D. E., Kaster, M. P., Ulrich, H., Lisboa, S. F. D. S., & Joca, S. R. L. (2023) · Springer eBooks · doi:10.1007/978-3-031-26945-5_7
Purinergic signaling: a novel therapeutic target in depression
Cui, Q., Li, Y., Gao, S., Zhou, H., & Peng, Y. (2026) · International Journal of Neuroscience · doi:10.1080/00207454.2026.2666245
- Authors
- Diniz, C. R. A. F., Rodrigues, M., Casarotto, P. C., Pereira, V. S., Crestani, C. C., & Joca, S. R. L.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Estadual Paulista (Unesp) (BR)
- Corresponding author
- Joca, Sâmia R.L.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 1676
- Pages
- 19-27
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2756242994
- Cited by
- 25
- References
- 87
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 3
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- PPADS, antidepressant-like effects, depression, monoamines, serotonin, norepinephrine, fluoxetine, reboxetine, forced swim test, p-chlorophenylalanine, DSP-4, ATP signaling, combination therapy
- MeSH terms
- Reboxetine, Animals, Antidepressive Agents, Benzylamines, Dose-Response Relationship, Drug, Fluoxetine, Frontal Lobe, Hippocampus, Male, Morpholines, Motor Activity, Fenclonine, Random Allocation, Neurotransmitter Uptake Inhibitors, Biogenic Monoamines, Mice, Purinergic P2 Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
