The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.
Neural systems underlying approach and avoidance in anxiety disorders
Open accessAbstract
Approach-avoidance conflict is an important psychological concept that has been used extensively to better understand cognition and emotion. This review focuses on neural systems involved in approach, avoidance, and conflict decision making, and how these systems overlap with implicated neural substrates of anxiety disorders. In particular, the role of amygdala, insula, ventral striatal, and prefrontal regions are discussed with respect to approach and avoidance behaviors. Three specific hypotheses underlying the dysfunction in anxiety disorders are proposed, including: (i) over-representation of avoidance valuation related to limbic overactivation; (ii) under- or over-representation of approach valuation related to attenuated or exaggerated striatal activation respectively; and (iii) insufficient integration and arbitration of approach and avoidance valuations related to attenuated orbitofrontal cortex activation. These dysfunctions can be examined experimentally using versions of existing decision-making paradigms, but may also require new translational and innovative approaches to probe approach-avoidance conflict and related neural systems in anxiety disorders.
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“The PFC likely regulates play in a multifactorial manner, contributing to expression of the behavior through its roles in suppressing aggression, monitoring approach/avoid conflict, and modulating the stress response via its projections to the MeA and other stress-modulatory nodes (Aupperle & Paulus, 2010; McEwen & Morrison, 2013; Takahashi et al., 2014).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Aupperle & Paulus, 2010
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“For example, anxiety disorders and mood disorders share hyperactive amygdala responses to negatively valenced stimuli [2,3]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [2]
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Metadata
- Authors
- Robin L., A., & Martin, P. P.
- Affiliations
- Department of Psychiatry, University of California, San Diego (UCSD), California, USA
- Psychiatry Service, Veterans Affairs San Diego Health Care System, San Diego, California, USA
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2010-12-31
- Volume
- 12
- Issue
- 4
- Pages
- 517-531
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- PMC
- PMC3181993
- OpenAlex
- W1574357942
- Cited by
- 227
- References
- 251
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 18 · 2023: 22 · 2022: 25 · 2021: 18 · 2020: 21 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 15 · 2015: 12 · 2014: 14 · 2013: 8 · 2012: 7
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- approach-avoidance conflict, anxiety disorders, decision-making, amygdala, insula, ventral striatum, orbitofrontal cortex
- MeSH terms
- Anxiety Disorders, Avoidance Learning, Brain, Decision Making, Emotions, Humans, Models, Biological, Social Behavior
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