Dynamic Changes in Brain Activations and Functional Connectivity during Affectively Different Tactile Stimuli
Open accessAbstract
In the present study, we compared brain activations produced by pleasant, neutral and unpleasant touch, to the anterior lateral surface of lower leg of human subjects. It was found that several brain regions, including the contralateral primary somatosensory area (SI), bilateral secondary somatosensory area (SII), as well as contralateral middle and posterior insula cortex were commonly activated under the three touch conditions. In addition, pleasant and unpleasant touch conditions shared a few brain regions including the contralateral posterior parietal cortex (PPC) and bilateral premotor cortex (PMC). Unpleasant touch specifically activated a set of pain-related brain regions such as contralateral supplementary motor area (SMA) and dorsal parts of bilateral anterior cingulated cortex, etc. Brain regions specifically activated by pleasant touch comprised bilateral lateral orbitofrontal cortex (OFC), posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), intraparietal cortex and left dorsal lateral prefrontal cortex (DLPFC). Using a novel functional connectivity model based on graph theory, we showed that a series of brain regions related to affectively different touch had significant functional connectivity during the resting state. Furthermore, it was found that such a network can be modulated between affectively different touch conditions.
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The PCC has been previously associated with pleasant touch.
“The PCC has been previously associated with pleasant touch”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Hua et al, 2008
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- Authors
- Hua, Q.-P., Zeng, X.-Z., Liu, J.-Y., Wang, J.-Y., Guo, J.-Y., & Luo, F.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Luo, Fei
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2007-11-14
- Volume
- 28
- Issue
- 1
- Pages
- 57-70
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11515012
- OpenAlex
- W2102871373
- Cited by
- 40
- References
- 63
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2014: 4 · 2013: 7 · 2012: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- affective touch, tactile stimuli, primary somatosensory cortex, secondary somatosensory cortex, insula, pain-related brain regions, supplementary motor area, anterior cingulate cortex, orbitofrontal cortex, medial prefrontal cortex, posterior parietal cortex, premotor cortex, resting-state functional connectivity, graph theory, dynamic brain networks
- MeSH terms
- Adult, Analysis of Variance, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Physical Stimulation, Time Factors, Touch, Prefrontal Cortex
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