Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer’s Disease

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

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At the interface of sensory and motor dysfunctions and Alzheimer’s disease.

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Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

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Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model

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A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade

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Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

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Behavioral phenotyping of mice in pharmacological and toxicological research

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BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

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Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

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Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

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Motor signs during the course of Alzheimer disease

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7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

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Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer’s disease

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Motor signs predict poor outcomes in Alzheimer disease

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Behavioral and EEG changes in male 5xFAD mice

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N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

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Lack of Tau Proteins Rescues Neuronal Cell Death and Decreases Amyloidogenic Processing of APP in APP/PS1 Mice

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Relevance of Transgenic Mouse Models to Human Alzheimer Disease

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Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Behavioral Assessment of Alzheimer's Transgenic Mice Following Long-Term A β Vaccination: Task Specificity and Correlations between A β Deposition and Spatial Memory

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Age-dependent axonal degeneration in an Alzheimer mouse model

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Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

Christensen, D. Z., Kraus, S. L., Flohr, A., Cotel, M.-C., Wirths, O., & Bayer, T. A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0451-6 · Cited by 126 · see citing works

Intraneuronal APP/Aβ Trafficking and Plaque Formation in β‐Amyloid Precursor Protein and Presenilin‐1 Transgenic Mice

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Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

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Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β‐induced neurite atrophy

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Cholinergic neuropathology in a mouse model of Alzheimer's disease

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Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

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Intraneuronal Aβ accumulation and neurodegeneration: Lessons from transgenic models

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Deciphering the Molecular Profile of Plaques, Memory Decline and Neuron Loss in Two Mouse Models for Alzheimer’s Disease by Deep Sequencing

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APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

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Motor impairment in Alzheimer’s disease and transgenic Alzheimer’s disease mouse models

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Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer’s disease

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Impaired axonal transport of cortical neurons in Alzheimer’s disease is associated with neuropathological changes

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Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

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Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

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Severe Motor Neuron Degeneration in the Spinal Cord of the Tg2576 Mouse Model of Alzheimer Disease

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APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD)

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Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer's Disease

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Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure

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In vivo imaging of axonal transport using MRI: aging and Alzheimer’s disease

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Transgenic Expression of Intraneuronal Aβ ₄₂ But Not Aβ ₄₀ Leads to Cellular Aβ Lesions, Degeneration, and Functional Impairment without Typical Alzheimer's Disease Pathology

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The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer’s disease

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Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation

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Amyloid Pathology in Spinal Cord of the Transgenic Alzheimer's Disease Mice is Correlated to the Corticospinal Tract Pathway

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Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

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Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease.

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SYK coordinates neuroprotective microglial responses in neurodegenerative disease

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Updates in Alzheimer's disease: from basic research to diagnosis and therapies

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Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease

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Updates on mouse models of Alzheimer’s disease

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Microglial amyloid beta clearance is driven by PIEZO1 channels

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Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice

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A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease

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Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease

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A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion

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ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models

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Behaviour Hallmarks in Alzheimer’s Disease 5xFAD Mouse Model

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Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

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Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer’s Disease

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Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy

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Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models

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The effect of aquaporin-4 mis-localization on Aβ deposition in mice

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N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

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MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

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Rescue of Alzheimer’s disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells

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The contribution of age-related changes in the gut-brain axis to neurological disorders

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A Therapeutic Nanovaccine that Generates Anti‐Amyloid Antibodies and Amyloid‐specific Regulatory T Cells for Alzheimer's Disease

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<i>INPP5D</i> deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease

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Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice

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Search Strategy Analysis of 5xFAD Alzheimer Mice in the Morris Water Maze Reveals Sex- and Age-Specific Spatial Navigation Deficits

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Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

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Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals

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Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice

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RAPGEF2 mediates oligomeric Aβ‐induced synaptic loss and cognitive dysfunction in the 3xTg‐AD mouse model of Alzheimer’s disease

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Relationship between Cognitive Dysfunction and Age-Related Variability in Oxidative Markers in Isolated Mitochondria of Alzheimer’s Disease Transgenic Mouse Brains

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Vortioxetine administration attenuates cognitive and synaptic deficits in 5×FAD mice

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Genotype Load Modulates Amyloid Burden and Anxiety-Like Patterns in Male 3xTg-AD Survivors despite Similar Neuro-Immunoendocrine, Synaptic and Cognitive Impairments

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The Swedish dilemma - the almost exclusive use of APPswe-based mouse models impedes adequate evaluation of alternative β-secretases

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Disrupted Maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer’s Mouse Model of Amyloid Deposition

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Anti‐LINGO‐1 antibody treatment alleviates cognitive deficits and promotes maturation of oligodendrocytes in the hippocampus of APP/PS1 mice

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Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer’s Disease Mice

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Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice

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Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

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CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model

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Single Nucleus Transcriptome Data from Alzheimer’s Disease Mouse Models Yield New Insight into Pathophysiology

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Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer’s Disease

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Increased Expression of KIF11/Kinesin5 Offsets Alzheimer Aβ-Mediated Toxicity and Cognitive Dysfunction in Cell Culture, Mice, and Humans

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Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease

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Selective Regional Loss of Cortical Synapses Lacking Presynaptic Mitochondria in the 5xFAD Mouse Model

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Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model

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Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice

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Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects

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Linking Social Cognition, Parvalbumin Interneurons, and Oxytocin in Alzheimer’s Disease: An Update

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Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP + B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice

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E2F4-Based Gene Therapy Mitigates the Phenotype of the Alzheimer's Disease Mouse Model 5xFAD

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Microglial histone H3K18 crotonylation promotes STAT1 expression and induces cognitive deficit in Alzheimer disease

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Age-dependent impairment of memory and neurofibrillary tangle formation and clearance in a mouse model of tauopathy

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Electrophysiological and Imaging Calcium Biomarkers of Aging in Male and Female 5×FAD Mice

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Intranasal insulin treatment ameliorates spatial memory, muscular strength, and frailty deficits in 5xFAD mice

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Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

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Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility

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Cell Adhesion Molecule Protocadherin-γC5 Ameliorates Aβ Plaque Pathogenesis by Modulating Astrocyte Function in Alzheimer's Disease

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In Vivo Seeding of Amyloid-β Protein and Implications in Modeling Alzheimer’s Disease Pathology

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Interaction of amisulpride with GLUT1 at the blood-brain barrier. Relevance to Alzheimer’s disease

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Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models

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Multi-omics reveals changes in astrocyte fatty acid metabolism during early stages of Alzheimer's disease

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Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

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Dose-dependent evaluation of chronic oleocanthal on metabolic phenotypes and organ toxicity in 5xFAD mice

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Changes in the Activities and Contents of Individual Forms of Proteasomes in Samples of the Cerebral Cortex during Pathology Development in 5xFAD Mice

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Ultrasound enhances glymphatic-associated solute transport via Piezo1-related mechanotransduction in 5xFAD mice

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Behavioural Phenotyping to Study Cognitive and Non-cognitive Symptoms in the Rodent Model of Alzheimer’s Disease

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Viscoelastic and Morphologic Changes in the Lumbar Intervertebral Discs of the 5xFAD Mouse Model of Alzheimer's Disease

Gonzalez, C. E., Schurman, C. A., Wilson, K. A., Schilling, B., Ellerby, L., & Tang, S. Y. (2026) · JOR Spine · doi:10.1002/jsp2.70171 · Cited by 1 · see citing works

The 5XFAD mouse model: a tool for genetic modulation of Alzheime's disease pathology

Jawhar, S. (2012) · doi:10.53846/goediss-3224

Phenotyping age‐sependent changes in the 5xFAD Alzheimer’s Disease Model mice (LB556)

Yang, C. R., Feng, R., Yang, L., Jiang, S., Liu, N., Yan, L., Liu, Y., Yang, C., & Wang, K. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.lb556 · Cited by 1 · see citing works

Behaviour Hallmarks in Alzheimer’s Disease 5xFAD Mouse Model

Pádua, M. S., Guil‐Guerrero, J. L., & Lopes, P. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126766 · Cited by 87 · see citing works

Visuo‐spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments

O’Leary, T. P., & Brown, R. E. (2022) · Genes Brain & Behavior · doi:10.1111/gbb.12794 · Cited by 61 · see citing works

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

Jawhar, S., Trawicka, A., Jenneckens, C., Bayer, T. A., & Wirths, O. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.027 · Cited by 623 · see citing works