Nationwide Inpatient Prevalence, Predictors, and Outcomes of Alzheimer’s Disease among Older Adults in the United States, 2002–2012
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In the inpatient setting, prevalence, predictors, and outcomes [mortality risk (MR), length of stay (LOS), and total charges (TC)] of Alzheimer's disease (AD) are largely unknown. We used data on older adults (60+ y) from the Nationwide Inpatient Sample (NIS) 2002-2012. AD prevalence was ∼3.12% in 2012 (total weighted discharges with AD ± standard error: 474, 410 ± 6,276). Co-morbidities prevailing more in AD inpatient admissions included depression (OR = 1.67, 95% CI: 1.63-1.71, p < 0.001), fluid/electrolyte disorders (OR = 1.25, 95% CI: 1.22-1.27, p < 0.001), weight loss (OR = 1.26, 95% CI: 1.22-1.30, p < 0.001), and psychosis (OR = 2.59, 95% CI: 2.47-2.71, p < 0.001), with mean total co-morbidities increasing over time. AD was linked to higher MR and longer LOS, but lower TC. TC rose in AD, while MR and LOS dropped markedly over time. In AD, co-morbidities predicting simultaneously higher MR, TC, and LOS (2012) included congestive heart failure, chronic pulmonary disease, coagulopathy, fluid/electrolyte disorders, metastatic cancer, paralysis, pulmonary circulatory disorders, and weight loss. In sum, co-morbidities and TC increased over time in AD, while MR and LOS dropped. Few co-morbidities predicted occurrence of AD or adverse outcomes in AD.
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A study of inpatient hospitalizations of adults age 60 and older found that those with Alzheimer's dementia were at 7% greater risk of dying during the hospital stay and stayed nearly a day longer than individuals without Alzheimer's dementia.
“A study of inpatient hospitalizations of adults age 60 and older found that those with Alzheimer's dementia were at 7% greater risk of dying during the hospital stay and stayed nearly a day longer than individuals without Alzheimer's dementia. 871”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [871]
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- Authors
- Beydoun, M. A., Beydoun, H. A., Gamaldo, A. A., Rostant, O. S., Dore, G. A., Zonderman, A. B., & Eid, S. M.
- Affiliations
- National Institutes of Health (US)
- Eastern Virginia Medical School (US)
- Johns Hopkins University (US)
- Corresponding author
- Beydoun, May A.
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2015-09-09
- Volume
- 48
- Issue
- 2
- Pages
- 361-375
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC4887139
- OpenAlex
- W1764215983
- Cited by
- 52
- References
- 47
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 5 · 2016: 2
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health (Z99 AG999999)
- Agency for Healthcare Research and Quality
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Health Professions › General Health Professions › Geriatric Care and Nursing Homes
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, older adults
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Depression, Female, Hospitals, Humans, Inpatients, Length of Stay, Male, Middle Aged, Prognosis, Psychotic Disorders, Risk Factors, United States, Weight Loss, Comorbidity, Prevalence, Treatment Outcome, Health Care Costs
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