Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer’s Disease
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We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer's disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.
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Aerosol-mediated treatment of young 5XFAD mice with curcumin averted Aβ buildup and memory deficits in adulthood compared to untreated mice.
“A different approach was followed by McClure et al. [135], where aerosol-mediated treatment of young 5XFAD mice with curcumin averted Aβ buildup and memory deficits in adulthood as compared to the untreated mice.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [135]
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Phytochemicals and brain health: The effects of curcumin, isoflavonoids, and ouabain
Cantanzaro, A. B., & Orellana, A. M. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.05.004
Emerging Trends in Therapeutic Potential of Curcumin in Alzheimer’s Disease
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Health benefits of functional foods
Maity, S., Premjit, Y., Pandhi, S., Rawat, V. R. S., Kumar, A., & Mahato, D. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33853-3.00003-x
- Authors
- McClure, R., Ong, H., Janve, V., Barton, S., Zhu, M., Li, B., Dawes, M., Jerome, W. G., Anderson, A., Massion, P., Gore, J. C., & Pham, W.
- Affiliations
- Vanderbilt University (US)
- Vanderbilt University
- Corresponding author
- Pham, Wellington
- ORCID
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2016-10-12
- Volume
- 55
- Issue
- 2
- Pages
- 797-811
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC5848215
- OpenAlex
- W2531338698
- Cited by
- 54
- References
- 47
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 4
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Vanderbilt-Ingram Cancer Center
- Vanderbilt University Medical Center
- National Institutes of Health (1s10od018075-01a1, UL1TR000445)
- National Cancer Institute (R01CA160700)
- National Institute of Biomedical Imaging and Bioengineering (T32EB014841, T32EB001628)
- National Center for Research Resources (UL1RR024975)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD083211)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- curcumin, aerosol drug delivery
- MeSH terms
- Administration, Inhalation, Alzheimer Disease, Analysis of Variance, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cognition Disorders, Curcumin, Disease Models, Animal, Hippocampus, Humans, Memory, Short-Term, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Neurons, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Maze Learning, Microscopy, Electron, Transmission, Dendritic Spines, Mice, Presenilin-1
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