A multimodal language region in the ventral visual pathway

Büchel, Christian; Price, Cathy; Friston, Karl

doi:10.1038/28389

Cited by 378Reading and Literacy DevelopmentNeurobiology of Language and BilingualismTactile and Sensory Interactions

A multimodal language region in the ventral visual pathway

Büchel, Christian, Price, Cathy, Friston, Karl·1998·Nature

DOI 10.1038/28389

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Abstract

Reading words and naming pictures involves the association of visual stimuli with phonological and semantic knowledge. Damage to a region of the brain in the left basal posterior temporal lobe (BA37), which is strategically situated between the visual cortex and the more anterior temporal cortex, leads to reading and naming deficits. Additional evidence implicating this region in linguistic processing comes from functional neuroimaging studies of reading in normal subjects and subjects with developmental dyslexia. Here we test whether the visual component of reading is essential for activation of BA37 by comparing cortical activations elicited by word processing in congenitally blind, late-blind and sighted subjects using functional neuroimaging. Despite the different modalities used (visual and tactile), all groups of subjects showed a common activation of BA37 by words relative to non-word letter-strings. These findings agree with the proposal that BA37 is an association area that integrates converging inputs from many regions. Our study confirms a prediction of theories of brain function that depend on convergence zones; the absence of one input (that is, visual) does not alter the response properties of such a convergence region.

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Nearby regions active in word tasks that involve nonvisual modalities are typically significantly more anterior than the VWFA.
“Although nearby regions are active in word tasks that involve nonvisual modalities [17], such regions are typically significantly more anterior than the VWFA [8].”
From The visual word form area: expertise for reading in the fusiform gyrus (2003) · cites this paper as [17]
Words in modalities other than the visual yielded activations more anterior (average y = -43) than those typical of the visual word form (average y = -60).
“As already noted by Bu ¨chel et al. (1998), words in modalities other than the visual yielded activations more anterior (average y = 43) than those typical of the visual word form (average y = 60).”
From Specialization within the ventral stream: the case for the visual word form area (2004) · cites this paper as Büchel et al. (1998)
The VWFA responds more to words or to pseudo-words than to random consonant strings that violate orthographic constraints.
“Second, the VWFA responds more to words or to pseudo-words than to random consonant strings that violate orthographic constraints (Beauregard et al., 1997; Bu ¨chel et al., 1998; Cohen et al., 2002; Price et al., 1996; Rees et al., 1999; Xu et al., 2001).”
From Specialization within the ventral stream: the case for the visual word form area (2004) · cites this paper as Büchel et al., 1998

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Research Article Language and Visual Perception Associations: Meta-Analytic Connectivity Modeling of Brodmann Area 37
Ardila, A., Bernal, B., & Rosselli, M. (2016)

Authors: Büchel, C., Price, C., & Friston, K.
Affiliations: UCL Queen Square Institute of Neurology (GB)
National Hospital for Neurology and Neurosurgery (GB)
Corresponding author: Büchel, Christian
ORCID: Büchel, Christian
Price, Cathy
Friston, Karl
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1998-07
Volume: 394
Issue: 6690
Pages: 274-277
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/28389
OpenAlex: W1679149859
Cited by: 378
References: 29
Citations by year: 2026: 1 · 2025: 7 · 2024: 14 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 6 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 16 · 2013: 14 · 2012: 15
FWCI: 36.40
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Wellcome Trust (051067)
Topics: Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords: ventral stream, reading, word processing, congenital blindness, late blindness, convergence region, multimodal language processing, visual word recognition
MeSH terms: Adult, Blindness, Humans, Language, Middle Aged, Models, Neurological, Parietal Lobe, Reading, Sensory Aids, Temporal Lobe, Tomography, Emission-Computed, Touch, Visual Pathways, Visual Perception

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A multimodal language region in the ventral visual pathway

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