Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study
Abstract
Oxidative stress is part of the entire pathological process that underlies the development of Alzheimer's disease (AD), including the mild cognitive impairment (MCI) stage. Twendee X (TwX) is a supplement containing a strong antioxidative mix of eight antioxidants, which has been shown to have a clinical and therapeutic benefit in AD model mice. Here, we conducted a multicenter, randomized, double-blind, and placebo-controlled prospective interventional study to evaluate the efficacy of TwX in mitigating MCI. The primary outcomes were differences in Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-revised (HDS-R) scores between baseline and six months for placebo and TwX groups. Seventy-eight subjects with MCI were randomized into placebo (n = 37) and TwX (n = 41) groups. MMSE scores at six months differed significantly between the TwX and placebo groups (p = 0.018), and HDS-R scores for the TwX group exhibited a significant improvement at six months relative to baseline (p = 0.025). The TwX group did not show any change in affective or activities of daily living scores at six months. The present study indicates that strong antioxidative supplement TwX is clinical beneficial for cognitive function in subjects with MCI.
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The multicenter interventional study conducted on MCI patients indicates that the antioxidant supplement TwX is beneficial for cognitive function in MCI.
“The multicenter interventional study conducted on MCI patients indicates that the antioxidant supplement TwX is beneficial for cognitive function in MCI [161].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [161]
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- Authors
- Tadokoro, K., Morihara, R., Ohta, Y., Hishikawa, N., Kawano, S., Sasaki, R., Matsumoto, N., Nomura, E., Nakano, Y., Takahashi, Y., Takemoto, M., Yamashita, T., Ueno, S., Wakutani, Y., Takao, Y., Morimoto, N., Kutoku, Y., Sunada, Y., Taomoto, K., Manabe, Y., Deguchi, K., Higashi, Y., Inufusa, H., You, F., Yoshikawa, T., von Greiffenclau, M. M., & Abe, K.
- Affiliations
- Okayama University (JP)
- Department of Neurology, Kurashiki Heisei Hospital, Kurashiki, Japan
- Kagawa Prefectural Central Hospital (JP)
- Kawasaki Medical School (JP)
- Ohnishi Neurological Center (JP)
- Okayama Medical Center (JP)
- Okayama City Hospital (JP)
- Himeji Medical Center (JP)
- Gifu University (JP)
- Louis Pasteur Center for Medical Research (JP)
- European Medical Foundation, TIMA Est., Balzers, Liechtenstein
- Corresponding author
- Abe, Koji
- ORCID
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2019-08-24
- Volume
- 71
- Issue
- 3
- Pages
- 1063-1069
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2970534723
- Cited by
- 35
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 11 · 2023: 9 · 2022: 5 · 2021: 3 · 2020: 2
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (17H04196)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- antioxidant supplements
- MeSH terms
- Mental Status and Dementia Tests, Activities of Daily Living, Aged, Aged, 80 and over, Antioxidants, Ascorbic Acid, Cognition, Cystine, Double-Blind Method, Female, Glutamine, Humans, Male, Prospective Studies, Treatment Outcome, Dietary Supplements, Cognitive Dysfunction
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