On the discovery of the genetic association of apolipoprotein E genotypes and common late-onset Alzheimer disease

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

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Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

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Insulin and neurodegenerative disease: shared and specific mechanisms

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Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease

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Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

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Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Goedert, M., Weisgraber, K. H., Dong, L. M., Jakes, R., Huang, D. Y., Pericak-Vance, M., Schmechel, D., & Roses, A. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11183 · Cited by 474 · see citing works

The Role of Insulin Resistance in the Pathogenesis of Alzheimer??s Disease

Watson, G. S., & Craft, S. (2003) · CNS Drugs · doi:10.2165/00023210-200317010-00003 · Cited by 396 · see citing works

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

Huang, Y., Liu, X. Q., Wyss-Coray, T., Brecht, W. J., Sanan, D. A., & Mahley, R. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151254698 · Cited by 392 · see citing works

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

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Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer’s disease

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Alzheimer's disease: Genetic aspects and associated clinical disorders

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Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

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Alzheimer's Disease Brain: Alterations in RNA Levels and in a Ribonuclease-Inhibitor Complex

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The role of apolipoprotein E in Alzheimer’s disease: pharmacogenomic target selection

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Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture.

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Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease

Huang, D. Y., Goedert, M., Jakes, R., Weisgraber, K. H., Garner, C. C., Saunders, A. M., Pericak‐Vance, M. A., Schmechel, D. E., Roses, A. D., & Strittmatter, W. J. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90204-6 · Cited by 83 · see citing works

Regionally specific neuronal expression of human APOE gene in transgenic mice

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The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q

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Reversal of presynaptic deficits of apolipoprotein E-deficient mice in human apolipoprotein E transgenic mice

Chapman, S., Sabo, T., Roses, A. D., & Michaelson, D. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00087-7 · Cited by 33 · see citing works

Intraneuronal ApoE in Human Visual Cortical Areas Reflects the Staging of Alzheimer Disease Pathology

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Drug Development and Alzheimer Disease

Roses, A. D., & Pangalos, M. N. (2003) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200303000-00003 · Cited by 16 · see citing works

Linkage studies in familial Alzheimer's disease

Roses, A. D. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90098-k · Cited by 12 · see citing works

Causes or consequences of inflammation and pathological signs of Alzheimer disease

Roses, A. D. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00142-1 · Cited by 8 · see citing works

Linkage analysis in familial Alzheimer disease: Description of the Duke and Boston data sets

Pericak‐Vance, M. A., George‐Hyslop, P. S., Gaskell, P. C., Growdon, J. H., Crain, B. J., Hulette, C., Gusella, J. F., Yamaoka, L. H., Tanzi, R. E., Roses, A. D., et al. (1993) · Genetic Epidemiology · doi:10.1002/gepi.1370100605 · Cited by 5 · see citing works

Review Article: Genetics of Alzheimer Disease

Bekris, L. M., Yu, C.-E., Bird, T. D., & Tsuang, D. W. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383571 · Cited by 1,029 · see citing works

A Hundred Years of Alzheimer's Disease Research

Hardy, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.016 · Cited by 467 · see citing works

Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Ward, A., Crean, S., Mercaldi, C. J., Collins, J. M., Boyd, D., Cook, M. N., & Arrighi, H. M. (2012) · Neuroepidemiology · doi:10.1159/000334607 · Cited by 349 · see citing works

Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention

Iqbal, K., & Grundke, I. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00225.x · Cited by 238 · see citing works

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis

Terwel, D., Steffensen, K. R., Verghese, P. B., Kummer, M. P., Gustafsson, J.-Å., Holtzman, D. M., & Heneka, M. T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6546-10.2011 · Cited by 181 · see citing works

RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-β-Induced Cellular Perturbation?

Yan, S. D., Bierhaus, A., Nawroth, P. P., & Stern, D. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1030 · Cited by 179 · see citing works

Apolipoprotein E ε4 Prevalence in Alzheimer’s Disease Patients Varies across Global Populations: A Systematic Literature Review and Meta-Analysis

Crean, S., Ward, A., Mercaldi, C. J., Collins, J. M., Cook, M. N., Baker, N. L., & Arrighi, H. M. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000321984 · Cited by 163 · see citing works

Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment

Kadish, I., Thibault, O., Blalock, E. M., Chen, K.-C., Gant, J. C., Porter, N. M., & Landfield, P. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4599-08.2009 · Cited by 152 · see citing works

Alzheimer 100 – highlights in the history of Alzheimer research

Jellinger, K. A. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0578-3 · Cited by 124 · see citing works

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

Fuentealba, R. A., Liu, Q., Zhang, J., Kanekiyo, T., Hu, X., Lee, J.-M., LaDu, M. J., & Bu, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011884 · Cited by 116 · see citing works

Alzheimer disease therapeutics: Focus on the disease and not just plaques and tangles

Iqbal, K., Liu, F., & Gong, C. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.002 · Cited by 110 · see citing works

Possible Role of Serum 25-Hydroxyvitamin D in Black–White Health Disparities in the United States

Grant, W. B., & Peiris, A. N. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.03.013 · Cited by 103 · see citing works

Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum

Ríos, J. A., Cisternas, P., Arrese, M. A., Salesa Barja, Y., & Inestrosa, N. C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.07.004 · Cited by 104 · see citing works

Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

Belinson, H., Lev, D., Masliah, E., & Michaelson, D. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5633-07.2008 · Cited by 101 · see citing works

Journal of Parkinson’s disease & Alzheimer’s disease

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Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease

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Using genetics to enable studies on the prevention of Alzheimer's disease

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Alzheimer’s Disease Risk Genes and Lipid Regulators

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Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

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Meeting report: can we make animal models of human mental illness?

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Calcium in the initiation, progression and as an effector of Alzheimer’s disease pathology

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Aging membranes: Unexplored functions for lipids in the lifespan of the central nervous system

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Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia

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A multicountry ecological study of risk-modifying factors for prostate cancer: apolipoprotein E epsilon4 as a risk factor and cereals as a risk reduction factor.

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Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals

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Mild Cognitive Impairment: An Update in Parkinson’s Disease and Lessons Learned from Alzheimer’s Disease

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ApoE mimetic peptide decreases Aβ production in vitro and in vivo

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Exploring Alzheimer's Disease in Zebrafish

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Galantamine-ER for the treatment of mild-to-moderate Alzheimer’s disease

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Promising Genetic Biomarkers of Preclinical Alzheimer's Disease: The Influence ofAPOEandTOMM40on Brain Integrity

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The Earlier the Better: Alzheimer’s Prevention, Early Detection, and the Quest for Pharmacological Interventions

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Requirements for Vitamin D Across the Life Span

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Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease

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Estimating and disclosing the risk of developing Alzheimer‘s disease: challenges, controversies and future directions

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Failing Compensatory Mechanisms During Working Memory in Older Apolipoprotein E-ε4 Healthy Adults

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Novel strategies for Alzheimer's disease treatment

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Perspective on a pathogenesis and treatment of Alzheimer's disease

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Current Strategies and Novel Drug Approaches for Alzheimer Disease

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Biobanks for biomarkers in neurological disorders

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Apolipoprotein E Related Co-Morbidities and Alzheimer’s Disease

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Alzheimer's Disease and Frontotemporal Dementia: A Review of Pathophysiology and Therapeutic Approaches

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Polygenic risk, population structure and ongoing difficulties with race in human genetics

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Human apolipoprotein E glycosylation and sialylation: from structure to function

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A Brief History of the Progress in Our Understanding of Genetics and Lifestyle, Especially Diet, in the Risk of Alzheimer’s Disease

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Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease

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Genetics of Late-Onset Alzheimer’s Disease: Progress and Prospect

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Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study

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The Genetics of Alzheimer’s Disease and Parkinson’s Disease

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Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle

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Neither Body nor Brain: Comparing Preventive Attitudes to Prostate Cancer and Alzheimer’s Disease

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Alzheimer′s disease: Unique markers for diagnosis & new treatment modalities

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Vascular endothelial growth factor polymorphisms and risk of Alzheimer's disease: A meta-analysis

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Family history and TOMM40 '523 interactive associations with memory in middle‐aged and Alzheimer's disease cohorts

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The turn towards prevention – moral narratives and the vascularization of Alzheimer’s disease

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Significant Positive Correlation Between Sunshine and Lactase Nonpersistence in Europe May Implicate Both in Similarly Altering Risks for Some Diseases

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The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review

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FROM BRAIN DISEASE TO BRAIN HEALTH: PRIMARY PREVENTION OF ALZHEIMER’S DISEASE AND RELATED DISORDERS IN A HEALTH SYSTEM USING AN ELECTRONIC MEDICAL RECORD-BASED APPROACH

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Associations between TOMM40 Poly-T Repeat Variants and Dementia in Cases with Parkinsonism

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Stratification of Patients is the Way to Go to Develop Neuroprotective/Disease-Modifying Drugs for Alzheimer's Disease

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On Short Cuts: The Complexity of Studying the Early Diagnosis and Prevention of Alzheimer’s Disease

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