CSF Aβ42, Tau and Phosphorylated Tau Correlate with Medial Temporal Lobe Atrophy
Abstract
Cerebrospinal fluid (CSF) biomarkers and medial temporal lobe (MTL) atrophy predict the progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD). We investigated the association between the CSF biomarkers and MTL atrophy and the ability of these measures to predict AD in MCI patients in the same study population. The study included 21 MCI patients of whom eight progressed to AD during the study. CSF biomarkers were measured by using ELISA method and volumes of MTL structures were assessed by magnetic resonance imaging (MRI). Abeta42 levels were lower and tau and phospho-tau levels were higher in progressive subjects. The progressive subjects had lower volumes in all MRI measures. Tau and phospho-tau correlated inversely with hippocampal volumes and left entorhinal cortex volume in the whole study group. In the stable group, tau correlated with hippocampal volumes. Phospho-tau [corrected] had a negative correlation whereas Abeta42 [corrected] exhibited a positive correlation with left hippocampal volume in the progressive group. These results indicate that both measures may reflect the ongoing neurodegenerative process in the progressive MCI patients. However, the order of the changes in the CSF biomarkers and MTL atrophy remain unclear due to a small number of studied subjects and study design.
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Some studies observed no relation between CSF tau or Aβ1-42 and whole-brain atrophy, while others found a significant inverse relationship between CSF P-tau and hippocampal volume in MCI.
“Some observed no relation between CSF tau or Aβ1-42 and whole-brain atrophy (Sluimer et al., 2010), while others found a significant inverse relationship between CSF P-tau and hippocampal volume in MCI (Herukka et al., 2008).”
From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Herukka et al., 2008
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- Authors
- Herukka, S.-K., Pennanen, C., Soininen, H., & Pirttilä, T.
- Affiliations
- Department of Neurology, University of Kuopio, Kuopio, Finland
- Kuopio University Hospital (FI)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2008-05-09
- Volume
- 14
- Issue
- 1
- Pages
- 51-57
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W819347612
- Cited by
- 47
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Suomen Lääketieteen Säätiö
- Academy of Finland
- Suomen Kulttuurirahasto
- Kuopion Yliopistollinen Sairaala
- Päivikki ja Sakari Sohlbergin Säätiö
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebrospinal fluid biomarkers, amyloid-beta 42
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Dominance, Cerebral, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Peptide Fragments, Phosphorylation, Statistics as Topic, Temporal Lobe, Biomarkers, Amyloid beta-Peptides, tau Proteins, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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