Hippocampal shape analysis in Alzheimer's disease and frontotemporal lobar degeneration subtypes
Open accessAbstract
Hippocampal pathology is central to Alzheimer's disease (AD) and other forms of dementia such as frontotemporal lobar degeneration (FTLD). Autopsy studies have shown that certain hippocampal subfields are more vulnerable than others to AD and FTLD pathology, in particular the subiculum and cornu ammonis 1 (CA1). We conducted shape analysis of hippocampi segmented from structural T1 MRI images on clinically diagnosed dementia patients and controls. The subjects included 19 AD and 35 FTLD patients [13 frontotemporal dementia (FTD), 13 semantic dementia (SD), and 9 progressive nonfluent aphasia (PNFA)] and 21 controls. Compared to controls, SD displayed severe atrophy of the whole left hippocampus. PNFA and FTD also displayed atrophy on the left side, restricted to the hippocampal head in FTD. Finally, AD displayed most atrophy in left hippocampal body with relative sparing of the hippocampal head. Consistent with neuropathological studies, most atrophic deformation was found in CA1 and subiculum areas in FTLD and AD.
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The finding of preferential atrophy of CA1 and subiculum in both AD and SD groups is consistent with a recent surface-based study of the hippocampus in SD.
“this finding is consistent with a recent surface-based study of the hippocampus in SD (Lindberg et al., 2012).”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Lindberg et al., 2012
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358 · see citing works
Scheltens, P., Leys, D., Barkhof, F., Huglo, D. G., Weinstein, H. C., Vermersch, P., Kuiper, M. A., Steinling, M., Wolters, E. C., & Valk, J. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.10.967 · Cited by 1,781 · see citing works
Cairns, N. J., Bigio, E. H., Mackenzie, I. R. A., Neumann, M., Lee, V. M.-Y., Hatanpaa, K. J., White, C. L., Schneider, J. A., Grinberg, L. T., Halliday, G., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0237-2 · Cited by 1,110 · see citing works
Focal cortical presentations of Alzheimer's disease
Alladi, S., Xuereb, J., Bak, T., Nestor, P., Knibb, J., Patterson, K., & Hodges, J. R. (2007) · Brain · doi:10.1093/brain/awm213 · Cited by 581 · see citing works
Conversion of Mild Cognitive Impairment to Alzheimer Disease Predicted by Hippocampal Atrophy Maps
Apostolova, L. G., Dutton, R. A., Dinov, I. D., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.693 · Cited by 553 · see citing works
Frontotemporal Lobar Degeneration
Rabinovici, G. D., & Miller, B. L. (2010) · CNS Drugs · doi:10.2165/11533100-000000000-00000 · Cited by 504 · see citing works
Shi, F., Liu, B., Zhou, Y., Yu, C., & Jiang, T. (2009) · Hippocampus · doi:10.1002/hipo.20573 · Cited by 470 · see citing works
Water diffusion compartmentation and anisotropy at high b values in the human brain
Clark, C. A., & Bihan, D. L. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200012)44:6 · Cited by 424 · see citing works
Gérardin, E., Chételat, G., Marie Chupin, A., Cuingnet, R., Desgranges, B., Kim, H., Niethammer, M., Dubois, B., Lehéricy, S., Garnero, L., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.036 · Cited by 415 · see citing works
Marie Chupin, A., Gérardin, E., Cuingnet, R., Boutet, C., Lemieux, L., Lehéricy, S., Benali, H., Garnero, L., & Colliot, O. (2009) · Hippocampus · doi:10.1002/hipo.20626 · Cited by 341 · see citing works
Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal
Apostolova, L. G., Mosconi, L., Thompson, P. M., Green, A. E., Hwang, K., Ramírez, A., Mistur, R. L., Tsui, W. H., & de Leon, M. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.008 · Cited by 313 · see citing works
Pruessner, J. C. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.12.1342 · Cited by 297 · see citing works
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer’s disease
Frisoni, G. B., Laakso, M. P., Beltramello, A., Geroldi, C., Bianchetti, A., Soininen, H. S., & Trabucchi, M. (1999) · Neurology · doi:10.1212/wnl.52.1.91 · Cited by 284 · see citing works
Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla
Frisoni, G. B., Ganzola, R., Canu, E., Rub, U., Pizzini, F. B., Alessandrini, F., Zoccatelli, G., Beltramello, A., Caltagirone, C., & Thompson, P. M. (2008) · Brain · doi:10.1093/brain/awn280 · Cited by 256 · see citing works
3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease
Apostolova, L. G., Dinov, I. D., Dutton, R. A., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006) · Brain · doi:10.1093/brain/awl274 · Cited by 251 · see citing works
Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer’s disease
van de Pol, L. A., Hensel, A., van der Flier, W. M., Visser, P., Pijnenburg, Y., Barkhof, F., Gertz, H.-J., & Scheltens, P. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.075341 · Cited by 223 · see citing works
Morra, J. H., Tu, Z., Apostolova, L. G., Green, A. E., Avedissian, C., Madsen, S. K., Parikshak, N., Hua, X., Toga, A. W., Jack, C. R., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20708 · Cited by 212 · see citing works
Pathologically proven frontotemporal dementia presenting with severe amnesia
Graham, A. (2005) · Brain · doi:10.1093/brain/awh348 · Cited by 203 · see citing works
Insights from semantic dementia on the relationship between episodic and semantic memory
Graham, K. S., Simons, J. S., Pratt, K. H., Patterson, K. E., & Hodges, J. R. (2000) · Neuropsychologia · doi:10.1016/s0028-3932(99)00073-1 · Cited by 198 · see citing works
Laakso, M. P., Frisoni, G. B., Könönen, M., Mikkonen, M., Beltramello, A., Geroldi, C., Bianchetti, A., Trabucchi, M., Soininen, H. S., & Aronen, H. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00306-6 · Cited by 181 · see citing works
Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia
Apostolova, L. G., Beyer, M. K., Green, A. E., Hwang, K., Morra, J. H., Chou, Y., Avedissian, C., Aarsland, D., Janvin, C. C., Larsen, J. O., et al. (2010) · Movement Disorders · doi:10.1002/mds.22799 · Cited by 173 · see citing works
Barnes, J., Whitwell, J. L., Frost, C. D., Josephs, K. A., Rossor, M. N., & Fox, N. C. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1434 · Cited by 152 · see citing works
In vivo quantification of hippocampal subfields using 4.7 T fast spin echo imaging
Malykhin, N. V., Lebel, R. M., Coupland, N. J., Wilman, A. H., & Carter, R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.042 · Cited by 138 · see citing works
Self-citationMalykhin, N. V., Bouchard, T. P., Ogilvie, C. J., Coupland, N. J., Seres, P., & Camicioli, R. M. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.11.011 · Cited by 131 · see citing works
Self-citationIn vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study
Frisoni, G. B., Sabattoli, F., Lee, A. D., Dutton, R. A., Toga, A. W., & Thompson, P. M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.015 · Cited by 128 · see citing works
Hippocampal shape analysis in Alzheimer’s disease: A population-based study
Scher, I., Xu, Y., Korf, E. S. C., White, L. R., Scheltens, P., Toga, A. W., Thompson, P. M., Hartley, S. W., Witter, M. P., Valentino, D. J., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.036 · Cited by 116 · see citing works
Kersaitis, C., Halliday, G. M., & Kril, J. J. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0917-0 · Cited by 113 · see citing works
Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration
Amador, C., Ahmed, Z., Zehr, C., & Dickson, D. W. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0183-4 · Cited by 100 · see citing works
Hippocampal sclerosis dementia: a reappraisal
Probst, A., Taylor, K. I., & Tolnay, M. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0262-1 · Cited by 89 · see citing works
Episodic memory: new insights from the study of semantic dementia
Graham, K. S., Patterson, K. E., & Hodges, J. R. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80035-x · Cited by 70 · see citing works
Wahlund, L.-O., Julin, P., Lindqvist, J., et al. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00016-5 · Cited by 66 · see citing works
Self-citationCaudate Nucleus Volumes in Frontotemporal Lobar Degeneration: Differential Atrophy in Subtypes
Looi, J. C., Lindberg, O. E., Zandbelt, B. B., Östberg, P., Andersen, C., Botes, L., Svensson, L. A., & Wahlund, L. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1168 · Cited by 58 · see citing works
Self-citationShape alterations in the striatum in chorea-acanthocytosis
Walterfang, M., Looi, J. C., Styner, M. A., et al. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.10.006 · Cited by 57 · see citing works
Self-citationHippocampal shape differences in dementia with Lewy bodies
Sabattoli, F., Boccardi, M., Galluzzi, S., Treves, A., Thompson, P. M., & Frisoni, G. B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.060 · Cited by 54 · see citing works
Miller, M. I., Priebe, C. E., Qiu, A., Fischl, B. R., Kolasny, A., Brown, T., Park, Y., Ratnanather, J. T., Busa, E., Jovicich, J., et al. (2008) · Human Brain Mapping · doi:10.1002/hbm.20655 · Cited by 53 · see citing works
Clinical phenotypes in autopsy-confirmed Pick disease
Piguet, O., Halliday, G. M., Reid, W., Casey, B. J., Carman, R., Huang, Y. M., Xuereb, J. H., Hodges, J. R., & Kril, J. J. (2011) · Neurology · doi:10.1212/wnl.0b013e318207b1ce · Cited by 47 · see citing works
Looi, J. C., Svensson, L., Lindberg, O. E., Zandbelt, B. B., Östberg, P., Örndahl, E., & Wahlund, L. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1640 · Cited by 47 · see citing works
Self-citationCortical Morphometric Subclassification of Frontotemporal Lobar Degeneration
Lindberg, O. E., Östberg, P., Zandbelt, B. B., Öberg, J., Zhang, Y., Andersen, C., Looi, J. C., Bogdanović, N., & Wahlund, L. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1545 · Cited by 45 · see citing works
Self-citationvan de Pol, L. A., Verhey, F. R. J., Frisoni, G. B., Tsolaki, M., Papapostolou, P., Nobili, F. M., Wahlund, L., Minthon, L., Frölich, L., Hampel, H. J., et al. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.158881 · Cited by 45 · see citing works
Self-citationFully‐automated, multi‐stage hippocampus mapping in very mild Alzheimer disease
Wang, L., KHAN, A. R., Csernansky, J. G., Fischl, B. R., Miller, M. I., Morris, J. C., & Beg, M. F. (2009) · Hippocampus · doi:10.1002/hipo.20616 · Cited by 35 · see citing works
Looi, J. C., Walterfang, M., Styner, M. A., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.017 · Cited by 28 · see citing works
Self-citationLooi, J. C., Walterfang, M., Styner, M. A., Niethammer, M., Svensson, L. A., Lindberg, O. E., Östberg, P., Botes, L., Örndahl, E., Chua, P. M.-L., et al. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.09.014 · Cited by 21 · see citing works
Self-citationGraham, K. S., Murre, J. M. J., & Hodges, J. R. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)63066-6 · Cited by 12 · see citing works
Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways.
Lavenex (2000) · Pure Amsterdam UMC · doi:10.1002/1098-1063(2000)10:4 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Duvernoy HM The human hippocampus: functional anatomy, vascularization, and serial sections with MRI 2005 Springer Berlin; New York 3rd ed
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La Joie, R., Perrotin, A., de La Sayette, V., Egret, S., Doeuvre, L., Belliard, S., Eustache, F., Desgranges, B., & Chételat, G. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.08.007 · Cited by 290 · see citing works
Carlesimo, G. A., Piras, F., Orfei, M. D., Iorio, M., Caltagirone, C., & Spalletta, G. (2015) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2014.12.001 · Cited by 159 · see citing works
Zhang, Y., Tartaglia, M. C., Schuff, N., Chiang, G. C., Ching, C., Rosen, H. J., Gorno-Tempini, M. L., Miller, B. L., & Weiner, M. W. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-121156 · Cited by 94 · see citing works
Meta-analytic review of memory impairment in behavioral variant frontotemporal dementia
Poos, J. M., Jiskoot, L. C., Papma, J. M., van Swieten, J. C., & van den Berg, E. (2018) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617718000115 · Cited by 57 · see citing works
- Authors
- Lindberg, O., Walterfang, M., Looi, J. C. L., Malykhin, N., Östberg, P., Zandbelt, B., Styner, M., Paniagua, B., Velakoulis, D., Örndahl, E., & Wahlund, L.-O.
- Affiliations
- Karolinska Institutet (SE)
- The Royal Melbourne Hospital (AU)
- Australian National University (AU)
- University of Alberta (CA)
- Uppsala University (SE)
- University Medical Center Utrecht (NL)
- University of North Carolina at Chapel Hill (US)
- Karolinska University Hospital (SE)
- Corresponding author
- Lindberg, Olof
- ORCID
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2012-05-21
- Volume
- 30
- Issue
- 2
- Pages
- 355-365
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC4862006
- OpenAlex
- W1489802292
- Cited by
- 103
- References
- 48
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 17 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 9 · 2012: 3
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Funders
- Swedish Brain Power
- National Institute of Biomedical Imaging and Bioengineering (U54EB005149)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P40HD03110, P30HD003110)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Keywords
- Alzheimer's disease
- MeSH terms
- Adult, Aged, Alzheimer Disease, Atrophy, Dementia, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Dentate Gyrus, CA1 Region, Hippocampal, CA2 Region, Hippocampal, CA3 Region, Hippocampal, Frontotemporal Lobar Degeneration, Primary Progressive Nonfluent Aphasia
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