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Cited by 136Circadian rhythm and melatoninDementia and Cognitive Impairment ResearchSleep and related disorders

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Light therapy and Alzheimer’s disease and related dementia: Past, present, and future

Open access
Hanford, Nicholas, Figueiro, Mariana·2013·Journal of Alzheimer’s Disease
DOI 10.3233/jad-2012-121645PMC PMC3553247
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Abstract

Sleep disturbances are common in persons with Alzheimer's disease or related dementia (ADRD), resulting in a negative impact on the daytime function of the affected person and on the wellbeing of caregivers. The sleep/wake pattern is directly driven by the timing signals generated by a circadian pacemaker, which may or may not be perfectly functioning in those with ADRD. A 24-hour light/dark pattern incident on the retina is the most efficacious stimulus for entraining the circadian system to the solar day. In fact, a carefully orchestrated light/dark pattern has been shown in several controlled studies of older populations, with and without ADRD, to be a powerful non-pharmacological tool to improve sleep efficiency and consolidation. Discussed here are research results from studies looking at the effectiveness of light therapy in improving sleep, depression, and agitation in older adults with ADRD. A 24-hour lighting scheme to increase circadian entrainment, improve visibility, and reduce the risk of falls in those with ADRD is proposed, and future research needs are discussed.

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  • Direct wakefulness consolidation indirectly enhances subsequent SWS, and may thus facilitate the hypothesized mechanism for trazodone's benefits.

    “In turn, direct wakefulness consolidation indirectly enhances subsequent SWS, and may thus facilitate the hypothesized mechanism for trazodone's benefits [27-29, 36]”

    From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [29]

    The Sleep Disturbances section (page unavailable) reports that morning bright light increased daytime wakefulness and improved nighttime sleep in people with Alzheimer’s disease or related dementia. It does not say that consolidated wakefulness enhances subsequent slow-wave sleep (SWS), or connect that proposed mechanism to trazodone. (LLM, conf=0.78)

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Research works printed but not linked: 49

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Metadata

Authors
Hanford, N., & Figueiro, M.
Affiliations
Rensselaer Polytechnic Institute (US)
ORCID
Figueiro, Mariana
Venue
Journal of Alzheimer’s Disease
Publisher
SAGE Publications
Published
2013-01-21
Volume
33
Issue
4
Pages
913-922
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
DOI
10.3233/jad-2012-121645
PMC
PMC3553247
OpenAlex
W1555903886
Cited by
136
References
11
Citations by year
2026: 8 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 21 · 2020: 13 · 2019: 11 · 2018: 11 · 2017: 13 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 6
FWCI
0.92
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Alzheimer s Disease (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG034157)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
phototherapy, Alzheimer's disease
MeSH terms
Alzheimer Disease, Animals, Circadian Rhythm, Dementia, Forecasting, Humans, Phototherapy

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