The DOI matches its Crossref record; 242 of the 244 references it cites were found in a registry or an index.
Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit
Open accessAbstract
Peripheral nerve repair and regeneration remains among the greatest challenges in tissue engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are capable of some degree of regeneration, frail recovery is seen even when the best microsurgical technique is applied. PNIs are known to be very incapacitating for the patient, due to the deprivation of motor and sensory abilities. Since there is no optimal solution for tackling this problem up to this day, the evolution in the field is constant, with innovative designs of advanced nerve guidance conduits (NGCs) being reported every day. As a basic concept, a NGC should act as a physical barrier from the external environment, concomitantly acting as physical guidance for the regenerative axons across the gap lesion. NGCs should also be able to retain the naturally released nerve growth factors secreted by the damaged nerve stumps, as well as reducing the invasion of scar tissue-forming fibroblasts to the injury site. Based on the neurobiological knowledge related to the events that succeed after a nerve injury, neuronal subsistence is subjected to the existence of an ideal environment of growth factors, hormones, cytokines, and extracellular matrix (ECM) factors. Therefore, it is known that multifunctional NGCs fabricated through combinatorial approaches are needed to improve the functional and clinical outcomes after PNIs. The present work overviews the current reports dealing with the several features that can be used to improve peripheral nerve regeneration (PNR), ranging from the simple use of hollow NGCs to tissue engineered intraluminal fillers, or to even more advanced strategies, comprising the molecular and gene therapies as well as cell-based therapies.
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“Consequently, the PNS exhibits greater reparative capacity and a more favorable prognosis, which also provides a promising application scenario for tissue engineering materials [178].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [178]
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“Injury to the PNS typically does not directly damage the neuronal cell body but rather involves axonal breakage and myelin destruction [178].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [178]
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Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
Carnicer-Lombarte, A., Chen, S.-T., Malliaras, G. G., & Barone, D. G. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.622524 · Cited by 454
“The field of surgical nerve repair already employs implants actively modulating biological processes (Carvalho et al., 2019), and may be a useful source for the development of new-generation nerve neuroprosthetics.”
BackgroundMultifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics
Kurian, A. G., Singh, R. K., Patel, K. D., Lee, J., & Kim, H. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.027 · Cited by 462
Peripheral Nerve Regeneration and Muscle Reinnervation
Gordon, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228652 · Cited by 403
Peripheral Nerve Injury Treatments and Advances: One Health Perspective
Lopes, B., Sousa, P., Alvites, R., Branquinho, M., Sousa, A. C., Mendonça, C., Atayde, L. M., Luís, A. L., Varejão, A. S. P., & Maurício, A. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020918 · Cited by 381
Wang, J., Xiong, H., Zhu, T., Liu, Y., Pan, H., Fan, C., Zhao, X., & Lu, W. W. (2020) · ACS Nano · doi:10.1021/acsnano.0c03570 · Cited by 200
Metadata
- Authors
- Carvalho, C. R., Oliveira, J. M., & Reis, R. L.
- Affiliations
- 3B's Research Group (PT)
- Corresponding author
- Oliveira, Joaquim M.
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2019-11-22
- Volume
- 7
- Pages
- 337-337
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC6882937
- OpenAlex
- W2990818690
- Cited by
- 297
- References
- 244
- Citations by year
- 2026: 32 · 2025: 34 · 2024: 45 · 2023: 64 · 2022: 54 · 2021: 44 · 2020: 23 · 2019: 1
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- Horizon 2020 Framework Programme
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- peripheral nerve repair, peripheral nerve regeneration, nerve conduits, peripheral nerve injury, nerve growth factor, scar formation, extracellular matrix, gene therapy, cell therapy, tissue engineering
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