Cited by 297Nerve injury and regenerationTissue Engineering and Regenerative MedicineNeuroscience and Neural Engineering

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Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit

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Carvalho, Cristiana R., Oliveira, Joaquim M., Reis, Rui L.·2019·Frontiers in Bioengineering and Biotechnology

DOI 10.3389/fbioe.2019.00337PMC PMC6882937

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Abstract

Peripheral nerve repair and regeneration remains among the greatest challenges in tissue engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are capable of some degree of regeneration, frail recovery is seen even when the best microsurgical technique is applied. PNIs are known to be very incapacitating for the patient, due to the deprivation of motor and sensory abilities. Since there is no optimal solution for tackling this problem up to this day, the evolution in the field is constant, with innovative designs of advanced nerve guidance conduits (NGCs) being reported every day. As a basic concept, a NGC should act as a physical barrier from the external environment, concomitantly acting as physical guidance for the regenerative axons across the gap lesion. NGCs should also be able to retain the naturally released nerve growth factors secreted by the damaged nerve stumps, as well as reducing the invasion of scar tissue-forming fibroblasts to the injury site. Based on the neurobiological knowledge related to the events that succeed after a nerve injury, neuronal subsistence is subjected to the existence of an ideal environment of growth factors, hormones, cytokines, and extracellular matrix (ECM) factors. Therefore, it is known that multifunctional NGCs fabricated through combinatorial approaches are needed to improve the functional and clinical outcomes after PNIs. The present work overviews the current reports dealing with the several features that can be used to improve peripheral nerve regeneration (PNR), ranging from the simple use of hollow NGCs to tissue engineered intraluminal fillers, or to even more advanced strategies, comprising the molecular and gene therapies as well as cell-based therapies.

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Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Tissue engineering
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
Chan, K. Y., Jang, M. J., Yoo, B. B., Greenbaum, A., Ravi, N., Wu, W.-L., Sánchez-Guardado, L., Lois, C., Mazmanian, S. K., Deverman, B. E., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4593 · Cited by 1,578
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
Lee, K., Silva, E. A., & Mooney, D. J. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0223 · Cited by 1,424
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Science · doi:10.1126/science.2321006 · Cited by 1,322
Illuminating the silence: understanding the structure and function of small RNAs
Rana, T. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2085 · Cited by 1,083
Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies
Grinsell, D., & Keating, C. P. (2014) · BioMed Research International · doi:10.1155/2014/698256 · Cited by 1,049
Analysis of Upper and Lower Extremity Peripheral Nerve Injuries in a Population of Patients with Multiple Injuries
Noble, J., Munro, C. A., Prasad, V. S. S. V., & Midha, R. (1998) · doi:10.1097/00005373-199807000-00025 · Cited by 998
Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms
Jensen, T. S., & Finnerup, N. B. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70102-4 · Cited by 976

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Background
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Authors: Carvalho, C. R., Oliveira, J. M., & Reis, R. L.
Affiliations: 3B's Research Group (PT)
Corresponding author: Oliveira, Joaquim M.
ORCID: Carvalho, Cristiana R.
Oliveira, Joaquim M.
Reis, Rui L.
Venue: Frontiers in Bioengineering and Biotechnology
Publisher: Frontiers Media SA
Published: 2019-11-22
Volume: 7
Pages: 337-337
ISSN: 2296-4185 (ISSN-L)
DOI: 10.3389/fbioe.2019.00337
PMC: PMC6882937
OpenAlex: W2990818690
Cited by: 297
References: 244
Citations by year: 2026: 32 · 2025: 34 · 2024: 45 · 2023: 64 · 2022: 54 · 2021: 44 · 2020: 23 · 2019: 1
FWCI: 4.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Funders: Horizon 2020 Framework Programme
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords: peripheral nerve repair, peripheral nerve regeneration, nerve conduits, peripheral nerve injury, nerve growth factor, scar formation, extracellular matrix, gene therapy, cell therapy, tissue engineering

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Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit

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