Cited by 297Nerve injury and regenerationTissue Engineering and Regenerative MedicineNeuroscience and Neural Engineering

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Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit

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Carvalho, Cristiana R., Oliveira, Joaquim M., Reis, Rui L.·2019·Frontiers in Bioengineering and Biotechnology

DOI 10.3389/fbioe.2019.00337PMC PMC6882937

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Abstract

Peripheral nerve repair and regeneration remains among the greatest challenges in tissue engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are capable of some degree of regeneration, frail recovery is seen even when the best microsurgical technique is applied. PNIs are known to be very incapacitating for the patient, due to the deprivation of motor and sensory abilities. Since there is no optimal solution for tackling this problem up to this day, the evolution in the field is constant, with innovative designs of advanced nerve guidance conduits (NGCs) being reported every day. As a basic concept, a NGC should act as a physical barrier from the external environment, concomitantly acting as physical guidance for the regenerative axons across the gap lesion. NGCs should also be able to retain the naturally released nerve growth factors secreted by the damaged nerve stumps, as well as reducing the invasion of scar tissue-forming fibroblasts to the injury site. Based on the neurobiological knowledge related to the events that succeed after a nerve injury, neuronal subsistence is subjected to the existence of an ideal environment of growth factors, hormones, cytokines, and extracellular matrix (ECM) factors. Therefore, it is known that multifunctional NGCs fabricated through combinatorial approaches are needed to improve the functional and clinical outcomes after PNIs. The present work overviews the current reports dealing with the several features that can be used to improve peripheral nerve regeneration (PNR), ranging from the simple use of hollow NGCs to tissue engineered intraluminal fillers, or to even more advanced strategies, comprising the molecular and gene therapies as well as cell-based therapies.

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MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Tissue engineering
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
Chan, K. Y., Jang, M. J., Yoo, B. B., Greenbaum, A., Ravi, N., Wu, W.-L., Sánchez-Guardado, L., Lois, C., Mazmanian, S. K., Deverman, B. E., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4593 · Cited by 1,578
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
Lee, K., Silva, E. A., & Mooney, D. J. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0223 · Cited by 1,424
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Science · doi:10.1126/science.2321006 · Cited by 1,322
Illuminating the silence: understanding the structure and function of small RNAs
Rana, T. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2085 · Cited by 1,083
Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies
Grinsell, D., & Keating, C. P. (2014) · BioMed Research International · doi:10.1155/2014/698256 · Cited by 1,049
Analysis of Upper and Lower Extremity Peripheral Nerve Injuries in a Population of Patients with Multiple Injuries
Noble, J., Munro, C. A., Prasad, V. S. S. V., & Midha, R. (1998) · doi:10.1097/00005373-199807000-00025 · Cited by 998
Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms
Jensen, T. S., & Finnerup, N. B. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70102-4 · Cited by 976
Neural plasticity after peripheral nerve injury and regeneration
Navarro, X., Vivó, M., & Valero‐Cabré, A. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.005 · Cited by 908
Progress in Brain Research
(1968) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt196896815 · Cited by 828
Schwann Cells: Development and Role in Nerve RepairPreprint
Jessen, K. R., Mirsky, R., & Lloyd, A. C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020487 · Cited by 759
Peripheral nerve regeneration and neurotrophic factors
Terenghi, G. (1999) · Journal of Anatomy · doi:10.1046/j.1469-7580.1999.19410001.x · Cited by 697
A 25-year perspective of peripheral nerve surgery: Evolving neuroscientific concepts and clinical significance
Lundborg, G. (2000) · The Journal Of Hand Surgery · doi:10.1053/jhsu.2000.4165 · Cited by 654
Nerve regeneration in silicone chambers: Influence of gap length and of distal stump components
Lundborg, G., Dahlin, L. B., Danielsen, N., Gelberman, R. H., Longo, F. M., Powell, H. C., & Varon, S. S. (1982) · Experimental Neurology · doi:10.1016/0014-4886(82)90215-1 · Cited by 618
Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy
Ding, D., Chang, Y., Shyu, W., & Lin, S. (2015) · Cell Transplantation · doi:10.3727/096368915x686841 · Cited by 615
Advances in 3D cell culture technologies enabling tissue‐like structures to be created in vitro
Knight, E., & Przyborski, S. A. (2014) · Journal of Anatomy · doi:10.1111/joa.12257 · Cited by 569
The discovery of Hepatocyte Growth Factor (HGF) and its significance for cell biology, life sciences and clinical medicine
Nakamura, T., & Mizuno, S. (2010) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.86.588 · Cited by 562
Wallerian degeneration: the innate-immune response to traumatic nerve injury
Rotshenker, S. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-109 · Cited by 538
Topography, Cell Response, and Nerve Regeneration
Hoffman–Kim, D., Mitchel, J. A., & Bellamkonda, R. V. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105351 · Cited by 525
Neurotrophic Factors and Their Receptors in Axonal Regeneration and Functional Recovery After Peripheral Nerve Injury
Boyd, J. G., & Gordon, T. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:277 · Cited by 517
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
Witte, T.-M. D., Fratila-Apachitei, L. E., ZADPOOR, A. A., & Peppas, N. A. (2018) · Regenerative Biomaterials · doi:10.1093/rb/rby013 · Cited by 513
Repairing injured peripheral nerves: Bridging the gap
Deumens, R., Bozkurt, A., Meek, M. F., Marcus, M. A. E., Joosten, E. A. J., Weis, J., & Brook, G. A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.002 · Cited by 508
Spatial‐Temporal progress of peripheral nerve regeneration within a silicone chamber: Parameters for a bioassay
Williams, L. R., Longo, F. M., Powell, H. C., Lundborg, G., & Varon, S. S. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902180409 · Cited by 496
Chapter 8 Current Techniques and Concepts in Peripheral Nerve Repair
Siemionow, M., & Brzezicki, G. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)87008-6 · Cited by 454
The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps
Kim, Y.-T., Haftel, V. K., Kumar, S., & Bellamkonda, R. V. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.03.042 · Cited by 452
Peripheral nerve regeneration through guidance tubes
Belkas, J. S., Shoichet, M. S., & Midha, R. (2004) · Neurological Research · doi:10.1179/016164104225013798 · Cited by 417
Human mesenchymal stem cells: from basic biology to clinical applications
Abdallah, B. M., & Kassem, M. S. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303067 · Cited by 402
Smart biomaterials design for tissue engineering and regenerative medicine
Furth, M. E., Atala, A., & Dyke, M. E. V. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.042 · Cited by 400
Biomaterials for the Development of Peripheral Nerve Guidance Conduits
Nectow, A. R., Marra, K. G., & Kaplan, D. L. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0240 · Cited by 395
Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk‐1 receptor
Sondell, M., Sundler, F., & Kanje, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01326.x · Cited by 376
Effectiveness of three extraction techniques in the development of a decellularized bone–anterior cruciate ligament–bone graft
Woods, T., & Gratzer, P. F. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.066 · Cited by 375
Freeze casting – A review of processing, microstructure and properties via the open data repository, FreezeCasting.net
Scotti, K. L., & Dunand, D. C. (2018) · Progress in Materials Science · doi:10.1016/j.pmatsci.2018.01.001 · Cited by 375
Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)–collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves
Matsumoto, K., Ohnishi, K., Kiyotani, T., Sekine, T., Ueda, H. R., Nakamura, T., Endo, K., & Shimizu, Y. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02207-1 · Cited by 371
Peripheral nerve regeneration: An opinion on channels, scaffolds and anisotropy
Bellamkonda, R. V. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.030 · Cited by 368
Structure and biomechanics of peripheral nerves: nerve responses to physical stresses and implications for physical therapist practice
Topp, K. S., & Boyd, B. S. (2006) · Physical Therapy · doi:10.1093/ptj/86.1.92 · Cited by 361
Skin-Derived Precursors Generate Myelinating Schwann Cells for the Injured and Dysmyelinated Nervous System
McKenzie, I. A., Biernaskie, J. A., Toma, J. G., Midha, R., & Miller, F. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1007-06.2006 · Cited by 328
NGF and Its Receptors in the Regulation of Inflammatory Response
Minnone, G., Benedetti, F. D., & Bracci‐Laudiero, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051028 · Cited by 328
Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors
Woodhall, E., West, A. K., & Chuah, M. I. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00044-4 · Cited by 325
Bioactive poly(l-lactic acid) conduits seeded with Schwann cells for peripheral nerve regeneration
Evans, G. R. D., Brandt, K. E., Katz, S. A., Chauvin, P., Otto, L., Bogle, M. A., Wang, B., Meszlenyi, R. K., Lu, L., Mikos, A. G., et al. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00190-9 · Cited by 319
Peripheral Nerve Repair and Reconstruction
Griffin, J. W., Hogan, M. V., Chhabra, A. B., & Deal, D. N. (2013) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.l.00704 · Cited by 310
Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise
Gordon, T., & ENGLISH, A. W. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13005 · Cited by 307
VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy
HOBSON, M. I., Green, C. J., & Terenghi, G. (2000) · Journal of Anatomy · doi:10.1046/j.1469-7580.2000.19740591.x · Cited by 298
Nerve conduits and growth factor delivery in peripheral nerve repair
Pfister, L. A., Papaloïzos, M., Merkle, H. P., & Gander, B. A. (2007) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2007.00125.x · Cited by 293
Magnetically Aligned Collagen Gel Filling a Collagen Nerve Guide Improves Peripheral Nerve Regeneration
Ceballos, D., Navarro, X., Dubey, N., Wendelschafer‐Crabb, G., Kennedy, W. R., & Tranquillo, R. T. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7111 · Cited by 292
Functional reorganization in somatosensory cortical areas 3b and 1 of adult monkeys after median nerve repair: possible relationships to sensory recovery in humans
Wall, J., Kaas, J. H., Sur, M., Nelson, R., Felleman, D. J., & Merzenich, M. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-01-00218.1986 · Cited by 277
Neuronal and vascular interactions
Andreone, B. J., Lacoste, B., & Gu, C. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033835 · Cited by 256
Electrical Stimulation to Promote Peripheral Nerve Regeneration
Willand, M. P., Nguyen, M.-A., Borschel, G. H., & Gordon, T. (2015) · Neurorehabilitation and neural repair · doi:10.1177/1545968315604399 · Cited by 247
Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps
Aebischer, P., Salessiotis, A. N., & Winn, S. R. (1989) · Journal of Neuroscience Research · doi:10.1002/jnr.490230306 · Cited by 243
Understanding microRNAs in neurodegeneration
Eacker, S. M., Dawson, T. M., & Dawson, V. L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2726 · Cited by 239
Biaxial strength of multilaminated extracellular matrix scaffolds
Freytes, D. O., Badylak, S. F., Webster, T. J., Geddes, L. A., & Rundell, A. E. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.015 · Cited by 235
Acellular nerve allografts in peripheral nerve regeneration: A comparative study
Moore, A. M., MacEwan, M. R., Santosa, K. B., Chenard, K. E., Ray, W. Z., Hunter, D. A., Mackinnon, S. E., & Johnson, P. J. (2011) · Muscle & Nerve · doi:10.1002/mus.22033 · Cited by 226
Immobilized Concentration Gradients of Neurotrophic Factors Guide Neurite Outgrowth of Primary Neurons in Macroporous Scaffolds
Moore, K., Macsween, M., & Shoichet, M. S. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.267 · Cited by 221
Tissue Engineering and Regenerative Medicine: Concepts for Clinical Application
Atala, A. (2004) · Rejuvenation Research · doi:10.1089/154916804323105053 · Cited by 220
Current progress in the derivation and therapeutic application of neural stem cells
Tang, Y., Yu, P., & Cheng, L. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.504 · Cited by 218
Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord
Lankford, K. L., Arroyo, E. J., Nazimek, K., Bryniarski, K., Askenase, P. W., & Kocsis, J. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190358 · Cited by 217
Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance
Rose, J. C., Cámara-Torres, M., Rahimi, K., Köhler, J., Möller, M., & Laporte, L. D. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b01123 · Cited by 213
Urethral replacement using cell seeded tubularized collagen matrices.
Filippo, R. E. D., Yoo, J. J., & Atala, A. (2002) · PubMed · doi:10.1097/01.ju.0000027662.69103.72 · Cited by 210
Urethral Replacement Using Cell Seeded Tubularized Collagen Matrices
Filippo, R. E. D., Yoo, J., & Atala, A. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64414-x · Cited by 200
Peripheral nerve regeneration by transplantation of bone marrow stromal cell—derived Schwann cells in adult rats
Mimura, T., Dezawa, M., Kanno, H., Sawada, H., & Yamamoto, I. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.5.0806 · Cited by 192
3D multi-channel bi-functionalized silk electrospun conduits for peripheral nerve regeneration
Dinis, T., Elia, R., Vidal, G., Dermigny, Q., Denoeud, C., Kaplan, D. L., Egles, C., & Marin, F. (2014) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2014.09.029 · Cited by 191
Nanofiber arrangement regulates peripheral nerve regeneration through differential modulation of macrophage phenotypes
Jia, Y., Yang, W., Zhang, K., Qiu, S., Xu, J., Wang, C., & Chai, Y. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.10.040 · Cited by 189
Prompt peripheral nerve regeneration induced by a hierarchically aligned fibrin nanofiber hydrogel
Du, J., Liu, J. F., Yao, S., Mao, H., Peng, J. C., Sun, X., Cao, Z. H., Yang, Y., Xiao, B., Wang, Y., et al. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.04.010 · Cited by 184
The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met
McGregor, C., & ENGLISH, A. W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00522 · Cited by 184
Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves
Meyer, C., Stenberg, L., González-Pérez, F., Wróbel, S., Ronchi, G., Udina, E., Suganuma, S., Geuna, S., Navarro, X., Dahlin, L. B., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.040 · Cited by 181
Strategic Design and Fabrication of Nerve Guidance Conduits for Peripheral Nerve Regeneration
Sarker, M. D., Naghieh, S., McInnes, A. D., Schreyer, D. J., & Chen, D. (2018) · Biotechnology Journal · doi:10.1002/biot.201700635 · Cited by 178
Growth cone chemotaxis
Mortimer, D., Fothergill, T., Pujic, Z., Richards, L. J., & Goodhill, G. J. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.008 · Cited by 177
Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons
Strickland, I. T., Richards, L. J., Holmes, F. E., Wynick, D., Uney, J. B., & Wong, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023423 · Cited by 170
Evaluation of acellular and cellular nerve grafts in repair of rat peripheral nerve
Gulati, A. K. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.68.1.0117 · Cited by 168
How Nerve Growth Factor Drives Physiological and Inflammatory Expressions of Acid-sensing Ion Channel 3 in Sensory Neurons
Mamet, J., Lazdunski, M., & Voilley, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309468200 · Cited by 166
Nerve Guidance Conduits Based on Double-Layered Scaffolds of Electrospun Nanofibers for Repairing the Peripheral Nervous System
Xie, J., MacEwan, M. R., Liu, W., Jesuraj, N. J., Li, X., Hunter, D. A., & Younan Xia, A. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5018557 · Cited by 164
A possible role for nerve growth factor in the augmentation of sodium channels in models of chronic pain
Gould, H. J., Gould, T. N., England, J. D., Paúl, D., Liu, Z. P., & Levinson, S. R. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02216-7 · Cited by 162
Nerve Guidance Conduits from Aligned Nanofibers: Improvement of Nerve Regeneration through Longitudinal Nanogrooves on a Fiber Surface
Huang, C., Ouyang, Y., Niu, H., He, N., Ke, Q., Jin, X., Li, D., Fang, J., Liu, W. H., Fan, C., et al. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/am509227t · Cited by 156
Delivery of Adipose-Derived Precursor Cells for Peripheral Nerve Repair
Santiago, L. Y., Clavijo‐Alvarez, J. A., Brayfield, C. A., Rubin, J. P., & Marra, K. G. (2009) · Cell Transplantation · doi:10.3727/096368909788341289 · Cited by 155
The effects of gradients of nerve growth factor immobilized PCLA scaffolds on neurite outgrowth in vitro and peripheral nerve regeneration in rats
Tang, S., Zhu, J., Xu, Y., Xiang, A. P., Jiang, M., & Quan, D. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.080 · Cited by 155
3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration
Hu, Y. X., Wu, Y., Gou, Z., Tao, J., Zhang, J., Liu, Q., Kang, T., Jiang, S., Huang, S., He, J., et al. (2016) · Scientific Reports · doi:10.1038/srep32184 · Cited by 154
In Vivo Performance of Decellularized Vascular Grafts: A Review Article
Lin, C., Hsia, K., Ma, H., Lee, H., & Lu, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072101 · Cited by 154
Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries
Liu, X., He, B., Zhu, Z., Zhu, Q., Zhou, X., Zheng, C., Li, P., Zhu, S., & Zhu, J. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.130094 · Cited by 152
Cutting your nerve changes your brain
Taylor, K. S., Anastakis, D. J., & Davis, K. D. (2009) · Brain · doi:10.1093/brain/awp231 · Cited by 152
Neural Tissue Engineering: A Self-Organizing Collagen Guidance Conduit
Phillips, J. B., Bunting, S. C. J., Hall, S. M., & Brown, R. A. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.1611 · Cited by 141
Poly( L ‐Lactide) microfilaments enhance peripheral nerve regeneration across extended nerve lesions
Ngo, T.-T. B., Waggoner, P. J., Romero, A. A., Nelson, K. D., Eberhart, R. C., & Smith, G. M. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10570 · Cited by 141
Peripheral Nerve Injury: Current Challenges, Conventional Treatment Approaches, and New Trends in Biomaterials-Based Regenerative Strategies
López‐Cebral, R., Silva‐Correia, J., Reis, R. L., Silva, T. H., & Oliveira, J. M. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00655 · Cited by 141
Self-citation
Optimizing neurotrophic factor combinations for neurite outgrowth
Deister, C., & Schmidt, C. (2006) · Journal of Neural Engineering · doi:10.1088/1741-2560/3/2/011 · Cited by 140
A compound scaffold with uniform longitudinally oriented guidance cues and a porous sheath promotes peripheral nerve regeneration in vivo
Huang, L., Zhu, L., Shi, X., Xia, B., Liu, Z., Zhu, S., Yang, Y., Ma, T., Cheng, P., Luo, K., et al. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.12.010 · Cited by 136
Axon Initiation and Growth Cone Turning on Bound Protein Gradients
Mai, J., Fok, L., Gao, H., Zhang, X., & Poo, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1121-09.2009 · Cited by 135
Social impact of peripheral nerve injuries
Wojtkiewicz, D. M., Saunders, J., Domeshek, L. F., Novak, C., Kaskutas, V., & Mackinnon, S. (2015) · HAND · doi:10.1007/s11552-014-9692-0 · Cited by 135
Changes in Plasticity Across the Lifespan
Oberman, L. M., & Pascual‐Leone, Á. (2013) · Progress in brain research · doi:10.1016/b978-0-444-63327-9.00016-3 · Cited by 134
Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer
Ching, R. C., Wiberg, M., & Kingham, P. J. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1017-8 · Cited by 133
Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor
Li, S., Wang, X., Gu, Y., Chen, C., Wang, Y., Jie, L., Hu, W. H., Yu, B., Wang, Y., Ding, F., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.220 · Cited by 131
Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration
Du, J., Chen, H. A., Qing, L., Yang, X., & Jia, X. (2018) · Biomaterials Science · doi:10.1039/c8bm00260f · Cited by 131
Nerve repair with adipose-derived stem cells protects dorsal root ganglia neurons from apoptosis
Reid, A. J., Sun, M., Wiberg, M., Downes, S., Terenghi, G., & Kingham, P. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.064 · Cited by 128
Dual-delivery of VEGF and NGF by emulsion electrospun nanofibrous scaffold for peripheral nerve regeneration
Xia, B., & Lv, Y. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.08.030 · Cited by 128
A Novel Scaffold with Longitudinally Oriented Microchannels Promotes Peripheral Nerve Regeneration
Hu, X., Huang, J., Ye, Z., Lei, X., Li, M., Lv, B., Shen, X., & Luo, Z. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0017 · Cited by 125
Role of fibronectin in topographical guidance of neurite extension on electrospun fibers
Mukhatyar, V. J., Salmerón‐Sánchez, M., Rudra, S. F., Mukhopadaya, S., Barker, T. H., Garcı́a, A. J., & Bellamkonda, R. V. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.015 · Cited by 124
3D printing strategies for peripheral nerve regeneration
Petcu, E. B., Midha, R., McColl, E., Popa‐Wagner, A., Chirilă, T. V., & Dalton, P. D. (2018) · Biofabrication · doi:10.1088/1758-5090/aaaf50 · Cited by 124
Collagen nerve conduits releasing the neurotrophic factors GDNF and NGF
Madduri, S., Feldman, K., Tervoort, T. A., Papaloïzos, M., & Gander, B. A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.12.017 · Cited by 123
Peripheral nerve regeneration using acellular nerve grafts
Kim, B., Yoo, J. J., & Atala, A. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10045 · Cited by 123
VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions
Guaiquil, V. H., Pan, Z., Karagianni, N., Fukuoka, S., Alegre, G., & Rosenblatt, M. I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407227111 · Cited by 120
Different expressions of BDNF, NT3, and NT4 in muscle and nerve after various types of peripheral nerve injuries
Omura, T., Sano, M., Omura, K., Hasegawa, T., Doi, M., Sawada, T., & Nagano, A. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10307.x · Cited by 119
Multichanneled Nerve Guidance Conduit with Spatial Gradients of Neurotrophic Factors and Oriented Nanotopography for Repairing the Peripheral Nervous System
Chang, Y.-C., Chen, M., Liao, S.-Y., Wu, H., Kuan, C., Sun, J., & Wang, T. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b12567 · Cited by 119
Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats
Ma, Y., Dong, L., Zhou, D., Li, L., Zhang, W., Yu, Z., Wang, T., Su, J., Chen, D., Mao, C., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14190 · Cited by 119
Fibrin matrix for suspension of regenerative cells in an artificial nerve conduit
Kalbermatten, D. F., Kingham, P. J., Mahay, D., Mantovani, C., Pettersson, J., Raffoul, W., Balcin, H., Pierer, G., & Terenghi, G. (2008) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2007.12.015 · Cited by 117
Decellularized peripheral nerve supports Schwann cell transplants and axon growth following spinal cord injury
Cerqueira, S. R., Lee, Y., Cornelison, R., Mertz, M. W., Wachs, R. A., Schmidt, C. E., & Bunge, M. B. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.049 · Cited by 117
Stability of Sensory Topographies in Adult Cortex
Makin, T. R., & Bensmaı̈a, S. J. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.002 · Cited by 115
Adipose-Derived Stem Cells Promote Peripheral Nerve Regeneration In Vivo without Differentiation into Schwann-Like Lineage
Sowa, Y., Kishida, T., Imura, T., Numajiri, T., Nishino, K., Tabata, Y., & Mazda, O. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000475762.86580.36 · Cited by 113
BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury
Lopes, C. D. F., Gonçalves, N. P., Gomes, C. P., Saraiva, M. J., & Pêgo, A. P. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.12.025 · Cited by 109
Luminal Fillers in Nerve Conduits for Peripheral Nerve Repair
Chen, M. B., Zhang, F., & Lineaweaver, W. C. (2006) · Annals of Plastic Surgery · doi:10.1097/01.sap.0000237577.07219.b6 · Cited by 108
International Review of Neurobiology
Katzman, R. (1964) · Neurology · doi:10.1212/wnl.14.12.1161 · Cited by 106
AAV1.NT-3 Gene Therapy for Charcot–Marie–Tooth Neuropathy
Sahenk, Z., Galloway, G. M., Clark, K. R., Malik, V., Rodino‐Klapac, L. R., Kaspar, B. K., Chen, L., Braganza, C., Montgomery, C. L., & Mendell, J. R. (2013) · Molecular Therapy · doi:10.1038/mt.2013.250 · Cited by 104
Effect of controlled co-delivery of synergistic neurotrophic factors on early nerve regeneration in rats
Madduri, S., di Summa, P. G., Papaloïzos, M., Kalbermatten, D. F., & Gander, B. A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.052 · Cited by 101
Nerve conduit filled with GDNF gene-modified schwann cells enhances regeneration of the peripheral nerve
Li, Q., Ping, P., Jiang, H., & Liu, K. (2006) · Microsurgery · doi:10.1002/micr.20192 · Cited by 101
Effects of local continuous release of brain derived neurotrophic factor (BDNF) on peripheral nerve regeneration in a rat model
VÖGELIN, E., Baker, J. M., Gates, J. J., Dixit, V., Constantinescu, M. A., & JONES, N. F. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2005.12.029 · Cited by 100
Hepatocyte Growth Factor (HGF) Promotes Peripheral Nerve Regeneration by Activating Repair Schwann Cells
Ko, K. R., Lee, J.-H., Lee, D., Nho, B., & Kim, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-26704-x · Cited by 99
Magnetic Nanoparticles for Efficient Delivery of Growth Factors: Stimulation of Peripheral Nerve Regeneration
Giannaccini, M., Calatayud, M. P., Poggetti, A., Corbianco, S., Novelli, M., Paoli, M., Battistini, P., Castagna, M., Dente, L., Parchi, P. D., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201601429 · Cited by 98
Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via paracrine mechanisms
Wang, Y., Guo, Z., Sun, X., Xu, X., & Peng, J. C. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.155442 · Cited by 96
Aligned Chitosan-Gelatin Cryogel-Filled Polyurethane Nerve Guidance Channel for Neural Tissue Engineering: Fabrication, Characterization, and In Vitro Evaluation
Singh, A., Shiekh, P. A., Das, M., Seppälä, J. V., & Kumar, A. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b01308 · Cited by 95
Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery
Manoukian, O. S., Arul, M. R., Rudraiah, S., Kalajzić, I., & Kumbar, S. G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.013 · Cited by 93
Polymer Scaffolds with Preferential Parallel Grooves Enhance Nerve Regeneration
Mobasseri, S. A., Faroni, A., Minogue, B. M., Downes, S., Terenghi, G., & Reid, A. J. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0266 · Cited by 92
Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration
Wu, X., He, L., Li, W., Li, H., Wong, W.-M., Ramakrishna, S., & Wu, W. (2016) · Regenerative Biomaterials · doi:10.1093/rb/rbw034 · Cited by 92
Micropatterning of biomedical polymer surfaces by novel UV polymerization techniques
Ward, J. H., Bashir, R., & Peppas, N. A. (2001) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(20010905)56:3 · Cited by 90
Olfactory Ensheathing Cells for Spinal Cord Injury
Yao, R., Murtaza, M., Velasquez, J. T., Todorovic, M., Rayfield, A. J., Ekberg, J. A. K., Barton, M., & John, J. A. S. (2018) · Cell Transplantation · doi:10.1177/0963689718779353 · Cited by 90
Neurotrophin-3–enhanced Nerve Regeneration Selectively Improves Recovery of Muscle Fibers Expressing Myosin Heavy Chains 2b
Sterne, G. D., Coulton, G. R., Brown, R. A., Green, C. J., & Terenghi, G. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.3.709 · Cited by 88
Ablation of Dicer from Murine Schwann Cells Increases Their Proliferation while Blocking Myelination
Bremer, J., O'Connor, T., Tiberi, C., Rehrauer, H., Weis, J., & Aguzzi, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012450 · Cited by 87
Experimental abdominal wall defect repaired with acellular matrix
Gamba, P., Conconi, M. T., Piccolo, R. L., Zara, G., Spinazzi, R., & Parnigotto, P. P. (2002) · Pediatric Surgery International · doi:10.1007/s00383-002-0849-5 · Cited by 87
Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination in vitro
Wu, S., Chen, M.-S., Maurel, P., Lee, Y., Bunge, M. B., & Arinzeh, T. L. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aac77f · Cited by 87
The Effect of Collagen Nerve Conduits Filled with Collagen-Glycosaminoglycan Matrix on Peripheral Motor Nerve Regeneration in a Rat Model
Lee, J.-Y., Giusti, G., Friedrich, P. F., Archibald, S. J., Kemnitzer, J. E., Patel, J., Desai, N., Bishop, A. T., & Shin, A. Y. (2012) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.k.00658 · Cited by 86
Nanofibrous nerve conduit-enhanced peripheral nerve regeneration
Jiang, X., Mi, R., Höke, A., & Chew, S. Y. (2012) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1531 · Cited by 85
Axonal Regeneration across Long Gaps in Silicone Chambers Filled with Schwann Cells Overexpressing High Molecular Weight FGF-2
Timmer, M., Robben, S., Müller-Ostermeyer, F., Nikkhah, G., & Grothe, C. (2003) · Cell Transplantation · doi:10.3727/000000003108746821 · Cited by 85
Peripheral Nerve Regeneration through Hydrogel-Enriched Chitosan Conduits Containing Engineered Schwann Cells for Drug Delivery
Meyer, C., Wróbel, S., Raimondo, S., Rochkind, S., Heimann, C., Shahar, A., Ziv‐Polat, O., Geuna, S., Grothe, C., & Haastert‐Talini, K. (2016) · Cell Transplantation · doi:10.3727/096368915x688010 · Cited by 84
Hepatocyte growth factor in physiology and infectious diseases
Imamura, R., & Matsumoto, K. (2017) · Cytokine · doi:10.1016/j.cyto.2016.12.025 · Cited by 82
Bridging a 30‐mm nerve defect using collagen filaments
Yoshii, S., Oka, M., Shima, M., Taniguchi, A., & Akagi, M. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10103 · Cited by 78
Roles of neural stem cells in the repair of peripheral nerve injury
Hu, C.-D., Wang, Y., Wang, C., Lu, C., & Peng, J. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.221171 · Cited by 76
Engineering a multimodal nerve conduit for repair of injured peripheral nerve
Quigley, A. F., Bulluss, K. J., Kyratzis, I. L. B., Gilmore, K. J., Mysore, T. B., Schirmer, K., Kennedy, E. L., O’Shea, M., Truong, Y. B., Edwards, S. L., et al. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/1/016008 · Cited by 75
c-Jun Gene-Modified Schwann Cells: Upregulating Multiple Neurotrophic Factors and Promoting Neurite Outgrowth
Huang, L., Quan, X., Liu, Z., Ma, T., Ya-zhen, W., Ge, J., Zhu, S., Yang, Y., Liu, L., Sun, Z., et al. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0416 · Cited by 74
Nerve injury induces glial cell line‐derived neurotrophic factor (gdnf) expression in schwann cells through purinergic signaling and the pkc‐pkd pathway
Xu, P., Rosen, K. M., Hedstrom, K. L., Rey, O., Guha, S., Hart, C., & Corfas, G. (2013) · Glia · doi:10.1002/glia.22491 · Cited by 73
Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries
Yousefi, F., Arab, F. L., Nikkhah, K., Amiri, H., & Mahmoudi, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.052 · Cited by 73
Developmental Regulation of MicroRNA Expression in Schwann Cells
Gokey, N. G., Srinivasan, R., Lopez‐Anido, C., Krueger, C., & Svaren, J. P. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06270-11 · Cited by 72
Early regenerative effects of NGF-transduced Schwann cells in peripheral nerve repair
Shakhbazau, A., Kawasoe, J. H., Hoyng, S. A., Kumar, R., van Minnen, J., Verhaagen, J., & Midha, R. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.04.004 · Cited by 72
BD™ PuraMatrix™ peptide hydrogel seeded with Schwann cells for peripheral nerve regeneration
McGrath, A. M., Novikova, L. N., Novikov, L. N., & Wiberg, M. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.07.001 · Cited by 70
A Physicochemically Optimized and Neuroconductive Biphasic Nerve Guidance Conduit for Peripheral Nerve Repair
Ryan, A. J., Lackington, W. A., Hibbitts, A., Matheson, A., Alekseeva, T., Stejskalová, A., Roche, P., & O’Brien, F. J. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700954 · Cited by 68
Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration
Tajdaran, K., Chan, K. S., Gordon, T., & Borschel, G. H. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.014 · Cited by 68
Finely Tuned Temporal and Spatial Delivery of GDNF Promotes Enhanced Nerve Regeneration in a Long Nerve Defect Model
Marquardt, L. M., Ee, X., Iyer, N. R., Hunter, D. A., Mackinnon, S. E., Wood, M. D., & Sakiyama‐Elbert, S. E. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0311 · Cited by 67
Schwann cells genetically modified to express neurotrophins promote spiral ganglion neuron survival in vitro
Pettingill, L. N., Minter, R. L., & Shepherd, R. K. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.11.057 · Cited by 67
Differential Gene Expression Profiling and Biological Process Analysis in Proximal Nerve Segments after Sciatic Nerve Transection
Li, S., Liu, Q., Wang, Y., Gu, Y., Liu, D., Wang, C., Ding, G., Chen, J., Liu, J., & Gu, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057000 · Cited by 67
Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo
Frost, H. K., Andersson, T., Johansson, S., Englund-Johansson, U., Ekström, P. A. R., Dahlin, L. B., & Johansson, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-34699-8 · Cited by 66
Traumatic Neuropathies: Spectrum of Imaging Findings and Postoperative Assessment
Tagliafico, A. S., Altafini, L., Garello, I., Marchetti, A., Gennaro, S., & Martinoli, C. (2010) · Seminars in Musculoskeletal Radiology · doi:10.1055/s-0030-1268071 · Cited by 65
Stem cell therapy for nerve injury
Sayad-Fathi, S., & Zaminy, A. (2017) · World Journal of Stem Cells · doi:10.4252/wjsc.v9.i9.144 · Cited by 65
Doxycycline-regulated GDNF expression promotes axonal regeneration and functional recovery in transected peripheral nerve
Shakhbazau, A., Mohanty, C. B., Shcharbin, D., Bryszewska, M. J., Caminade, A., Majoral, J., Alant, J., & Midha, R. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.004 · Cited by 64
The Early History of Tubulation in Nerve Repair
IJpma, F. F. A., van de Graaf, R. C., & Meek, M. F. (2008) · Journal of Hand Surgery (European Volume) · doi:10.1177/1753193408091349 · Cited by 63
MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection
Zhang, H.-Y., Zheng, S., Zhao, J., Zhao, W., Zheng, L., Zhao, D. Y., Li, J., Zhang, X., Chen, Z., & Yi, X. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.067 · Cited by 63
Plasticity of the human motor system following muscle reconstruction: a magnetic stimulation and functional magnetic resonance imaging study
Chen, R. E., Anastakis, D. J., Haywood, C. T., Mikulis, D. J., & Manktelow, R. T. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00283-9 · Cited by 63
Brain-derived neurotrophic factor promotes nerve regeneration by activating the JAK/STAT pathway in Schwann cells
Lin, G., Zhang, H., Sun, F., Lu, Z., Reed-Maldonado, A., Lee, Y.-C., Wang, G.-F., Banie, L., & Lue, T. (2016) · Translational Andrology and Urology · doi:10.21037/tau.2016.02.03 · Cited by 63
Spatially featured porous chitosan conduits with micropatterned inner wall and seamless sidewall for bridging peripheral nerve regeneration
Li, G., Xue, C., Wang, H., Yang, X., Zhao, Y., Zhang, L., & Yang, Y. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.04.049 · Cited by 58
Magnetic Targeting of Growth Factors Using Iron Oxide Nanoparticles
Marcus, M., Smith, A., Maswadeh, A., Shemesh, Z., Zak, I., Motiei, M., Schori, H., Margel, S., Sharoni, A., & Shefi, O. (2018) · Nanomaterials · doi:10.3390/nano8090707 · Cited by 58
Nerve Transfers to Restore upper Extremity Function: A Paradigm Shift
Moore, A. M. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00040 · Cited by 57
Chitosan conduits filled with simvastatin/Pluronic F‐127 hydrogel promote peripheral nerve regeneration in rats
Guo, Q., Liu, C., Hai, B., Ma, T., Zhang, W., Tan, J., Fu, X., Wang, H., Xu, Y., & Song, C. (2017) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33890 · Cited by 57
Schwann Cell Transplantation Subdues the Pro-Inflammatory Innate Immune Cell Response after Spinal Cord Injury
Pearse, D. D., Bastidas, J. C., Izabel, S. S., & Ghosh, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092550 · Cited by 57
A magnetically responsive nanocomposite scaffold combined with Schwann cells promotes sciatic nerve regeneration upon exposure to magnetic field
Liu, Z., Zhu, S., Liu, L., Ge, J., Huang, L., Sun, Z., Zeng, W., Huang, J., & Luo, Z. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s144715 · Cited by 56
Spatially Controlled Delivery of Neurotrophic Factors in Silk Fibroin–Based Nerve Conduits for Peripheral Nerve Repair
Lin, Y.-C., Ramadan, M., Hronik‐Tupaj, M., Kaplan, D. L., Philips, B. J., Sivak, W. N., Rubin, J. P., & Marra, K. G. (2011) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e3182240346 · Cited by 55
Conduits harnessing spatially controlled cell-secreted neurotrophic factors improve peripheral nerve regeneration
Sun, A. X., Prest, T. A., Fowler, J. R., Brick, R. M., Gloss, K. M., Li, X., Dehart, M., Shen, H., Yang, G., Brown, B. N., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.038 · Cited by 55
Neuroregenerative effects of olfactory ensheathing cells transplanted in a multi-layered conductive nanofibrous conduit in peripheral nerve repair in rats
Kabiri, M., Oraee‐Yazdani, S., Shafiee, A., Hanaee‐Ahvaz, H., Dodel, M., Vaseei, M., & Soleimani, M. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0144-0 · Cited by 54
Melt-spun shaped fibers with enhanced surface effects: Fiber fabrication, characterization and application to woven scaffolds
Park, S. J., Lee, B., Na, M. H., & Kim, D. S. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.05.001 · Cited by 54
Neural Stem Cell–Based Intraocular Administration of Ciliary Neurotrophic Factor Attenuates the Loss of Axotomized Ganglion Cells in Adult Mice
Flachsbarth, K., Kruszewski, K., Jung, G., Jankowiak, W., Riecken, K., Wagenfeld, L., Richard, G. W., Fehse, B., & Bartsch, U. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15266 · Cited by 54
Recent advances in strategies for peripheral nerve tissue engineering
Mobini, S., Spearman, B. S., Lacko, C. S., & Schmidt, C. E. (2017) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2017.10.010 · Cited by 54
Adipose-derived stem cell sheets functionalized by hybrid baculovirus for prolonged GDNF expression and improved nerve regeneration
Hsu, M., Liao, H.-T., Li, K., Chen, H., Yen, T., Макаревич, П. И., Parfyonova, Y. V., & Hu, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.004 · Cited by 53
Functional mimetics of neurotrophins and their receptors
Peleshok, J. C., & Saragovi, H. U. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340612 · Cited by 51
Peripheral nerve regeneration using autologous porcine skin-derived mesenchymal stem cells
Park, B.-W., Kang, D.-H., Kang, E., Byun, J., Lee, J.-S., Maeng, G., & Rho, G. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.404 · Cited by 51
Genetic Modification of Neural Stem Cells
Jandial, R., Singeç, I., Ames, C. P., & Snyder, E. Y. (2008) · Molecular Therapy · doi:10.1038/sj.mt.6300402 · Cited by 51
Effect of vegf gene therapy and hyaluronic acid film sheath on peripheral nerve regeneration
Zor, F., Deveci, M., Kilic, A., Ozdag, M. F., Kurt, B., Sengezer, M., & SÖnmez, T. T. (2014) · Microsurgery · doi:10.1002/micr.22196 · Cited by 50
Peripheral nerve regeneration by transplantation of BMSC‐derived Schwann cells as chitosan gel sponge scaffolds
Ishikawa, N., Suzuki, Y., Dezawa, M., Kataoka, K., Ohta, M., Cho, H., & Idé, C. (2009) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32389 · Cited by 50
Caring for the patients with cervical spine injuries: what have we learned?
Ghafoor, A. U., Martin, T. W., Gopalakrishnan, S., & Viswamitra, S. (2005) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2005.04.003 · Cited by 50
Reactive Astrocytes in Glial Scar Attract Olfactory Ensheathing Cells Migration by Secreted TNF-α in Spinal Cord Lesion of Rat
Su, Z., Yuan, Y., Chen, J., Cao, L., Zhu, Y., Gao, L., Qiu, Y., & He, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008141 · Cited by 49
Nano-fibrous and ladder-like multi-channel nerve conduits: Degradation and modification by gelatin
Liu, S., Sun, X., Wang, T., Chen, S., Zeng, C., Xie, G., Zhu, Q., Liu, X., & Quan, D. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.11.020 · Cited by 49
Evaluation of Vascular Endothelial Growth Factor (VEGF) and Its Family Member Expression After Peripheral Nerve Regeneration and Denervation
Muratori, L., Gnavi, S., Fregnan, F., Mancardi, A., Raimondo, S., Perroteau, I., & Geuna, S. (2018) · The Anatomical Record · doi:10.1002/ar.23842 · Cited by 49
The Lin28/let-7 axis is critical for myelination in the peripheral nervous system
Gökbuget, D., Pereira, J. A., Bachofner, S., Marchais, A., Ciaudo, C., Stoffel, M., Schulte, J. H., & Suter, U. (2015) · Nature Communications · doi:10.1038/ncomms9584 · Cited by 48
The use of immobilized neurotrophins to support neuron survival and guide nerve fiber growth in compartmentalized chambers
Yu, L. M. Y., Miller, F. D., & Shoichet, M. S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.070 · Cited by 46
KLF7-transfected Schwann cell graft transplantation promotes sciatic nerve regeneration
Wang, Y., Li, W., Jia, H., Zhai, F., Qu, W., Cheng, Y., Liu, Y., Deng, L., Guo, S.-F., & Jin, Z. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.069 · Cited by 46
A Comparison Between Two Collagen Nerve Conduits and Nerve Autograft: A Rat Model of Motor Nerve Regeneration
Saltzman, E. B., Villa, J. C., Doty, S. B., Feinberg, J. H., Lee, S. K., & Wolfe, S. W. (2018) · The Journal Of Hand Surgery · doi:10.1016/j.jhsa.2018.10.008 · Cited by 46
A systematic evaluation of Schwann cell injection into acellular cold-preserved nerve grafts
Jesuraj, N. J., Santosa, K. B., Newton, P., Liu, Z., Hunter, D. A., Mackinnon, S. E., Sakiyama‐Elbert, S. E., & Johnson, P. J. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.02.015 · Cited by 45
Tunable Enzymatically Cross‐Linked Silk Fibroin Tubular Conduits for Guided Tissue Regeneration
Carvalho, C. R., Costa, J. B., Morais, A. D. S., López‐Cebral, R., Silva‐Correia, J., Reis, R. L., & Oliveira, J. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800186 · Cited by 45
Self-citation
Noninvasive Imaging of Peripheral Nerves
Rangavajla, G., Mokarram, N., Masoodzadehgan, N., Pai, S. B., & Bellamkonda, R. V. (2014) · Cells Tissues Organs · doi:10.1159/000369451 · Cited by 44
Neural stem cells promote nerve regeneration through IL12-induced Schwann cell differentiation
Lee, D.-C., Chen, J., Hsu, T.-Y., Chang, L., Chang, H., Chi, Y., & Chiu, I. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.11.007 · Cited by 42
A longitudinal study of pain, personality, and brain plasticity following peripheral nerve injury
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“The field of surgical nerve repair already employs implants actively modulating biological processes (Carvalho et al., 2019), and may be a useful source for the development of new-generation nerve neuroprosthetics.”
Background
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Bioinspired Multichannel Nerve Guidance Conduit Based on Shape Memory Nanofibers for Potential Application in Peripheral Nerve Repair
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See all 297

Authors: Carvalho, C. R., Oliveira, J. M., & Reis, R. L.
Affiliations: 3B's Research Group (PT)
Corresponding author: Oliveira, Joaquim M.
ORCID: Carvalho, Cristiana R.
Oliveira, Joaquim M.
Reis, Rui L.
Venue: Frontiers in Bioengineering and Biotechnology
Publisher: Frontiers Media SA
Published: 2019-11-22
Volume: 7
Pages: 337-337
ISSN: 2296-4185 (ISSN-L)
DOI: 10.3389/fbioe.2019.00337
PMC: PMC6882937
OpenAlex: W2990818690
Cited by: 297
References: 244
Citations by year: 2026: 32 · 2025: 34 · 2024: 45 · 2023: 64 · 2022: 54 · 2021: 44 · 2020: 23 · 2019: 1
FWCI: 4.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Funders: Horizon 2020 Framework Programme
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords: peripheral nerve repair, peripheral nerve regeneration, nerve conduits, peripheral nerve injury, nerve growth factor, scar formation, extracellular matrix, gene therapy, cell therapy, tissue engineering

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Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit

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