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Cited by 386Cancer Immunotherapy and BiomarkersT-cell and B-cell ImmunologyImmunotherapy and Immune Responses

The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.

T Cell Dysfunction and Exhaustion in Cancer

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Zhang, Zhen, Liu, Shasha, Zhang, Bin, Qiao, Liang, Zhang, Yi, Zhang, Yi·2020·Frontiers in Cell and Developmental Biology
DOI 10.3389/fcell.2020.00017PMC PMC7027373
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Abstract

Tumor immunotherapy is a promising therapeutic strategy for patients with advanced cancers. T cells are key mediators of antitumor function that specifically recognize and react to tumor-expressing antigens and have proven critical for cancer immunotherapy. However, T cells are not as effective against cancer as expected. This is partly because T cells enter a dysfunctional or exhausted state, which is characterized by sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. T cell dysfunction induces the out of control of tumors. Recently, T cell dysfunction has been investigated in many experimental and clinical settings. The molecular definition of T cell dysfunction and the underlying causes of the T cell dysfunction has been advanced regardless of the fact that the pathways involved are not well elucidated, which proposing promising therapeutic opportunities in clinic. In this review, we will discuss the recent advances in the molecular mechanisms that affect TME and induce T cell dysfunction, and the development of promising immunotherapies to counteract the mechanisms of tumor-induced T cell dysfunction. Better understanding these underlying mechanisms may lead to new strategies to improve the clinical outcome of patients with cancer.

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Crossref · 10.3389/fcell.2020.00017

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FIGURE 1 The intrinsic factors regulating T cell dysfunction. In response to T cell receptors (TCRs), co-stimulatory and growth factor cytokines activate PI3K/Akt/mTOR signaling pathways, which induce glucose transporter-1 (Glut-1) expression and enhance T cell proliferation and cytokine production. Activation of mTOR leads to the expression of downstream transcriptional regulators such as HIF-1α and c-Myc. However, an increased AMP to ATP ratio activates AMP-activated protein kinase (AMPK), which in turn inhibits mTOR activity and enhances fatty acid oxidation, which maintains long term T-cell survival and formation of memory T cells. The Transcription factors such as HIF-1α, NR4A1, TOX, Eomes, T-bet, Blimp-1, NFAT and BATF regulate PD-1 expression and have been implicated in T cell exhaustion and dysfunction.
FIGURE 1 The intrinsic factors regulating T cell dysfunction. In response to T cell receptors (TCRs), co-stimulatory and growth factor cytokines activate PI3K/Akt/mTOR signaling pathways, which induce glucose transporter-1 (Glut-1) expression and enhance T cell proliferation and cytokine production. Activation of mTOR leads to the expression of downstream transcriptional regulators such as HIF-1α and c-Myc. However, an increased AMP to ATP ratio activates AMP-activated protein kinase (AMPK), which in turn inhibits mTOR activity and enhances fatty acid oxidation, which maintains long term T-cell survival and formation of memory T cells. The Transcription factors such as HIF-1α, NR4A1, TOX, Eomes, T-bet, Blimp-1, NFAT and BATF regulate PD-1 expression and have been implicated in T cell exhaustion and dysfunction.CC BY · PubMed Central
FIGURE 2 Immunosuppressive cells or factors have been implicated in CD8+ T cell dysfunction in TME. The ARG1, iNOS, TGF-β and ROS are secreted by MDSCs or TAMs and induce CD8+ T cell dysfunction. Both MDSCs and tumor cells may suppress CD8+ T cell proliferation through IDO hydrolyzation of tryptophan in the presence of IFN-γ. Kynurenine inhibits CD8+ T cell activation. MDSCs may additionally produce immunosuppressive cytokines like IL-10, TGF-β and induce Tregs. The upregulation of PD-L1 on MDSCs, TAMs and tumor cells induced CD8+ T cell exhaustion by binding to PD-1 on T cells. Tumor cells also express CD39 and CD73 on their surface, facilitating the metabolism of extracellular ATP into AMP and finally into adenosine, which induce CD8+ T cell dysfunction. CAFs are involved in impairing anti-tumor T cell responses by secreting chemokines such as CXCL1 and CXCL2 to tumors and polarizing them toward the M2 phenotype. Furthermore, the expression of PD-L2 or FASL on CAFs bind to corresponding PD-1 and FAS receptors, respectively, causing CD8+ T cell dysfunction.
FIGURE 2 Immunosuppressive cells or factors have been implicated in CD8+ T cell dysfunction in TME. The ARG1, iNOS, TGF-β and ROS are secreted by MDSCs or TAMs and induce CD8+ T cell dysfunction. Both MDSCs and tumor cells may suppress CD8+ T cell proliferation through IDO hydrolyzation of tryptophan in the presence of IFN-γ. Kynurenine inhibits CD8+ T cell activation. MDSCs may additionally produce immunosuppressive cytokines like IL-10, TGF-β and induce Tregs. The upregulation of PD-L1 on MDSCs, TAMs and tumor cells induced CD8+ T cell exhaustion by binding to PD-1 on T cells. Tumor cells also express CD39 and CD73 on their surface, facilitating the metabolism of extracellular ATP into AMP and finally into adenosine, which induce CD8+ T cell dysfunction. CAFs are involved in impairing anti-tumor T cell responses by secreting chemokines such as CXCL1 and CXCL2 to tumors and polarizing them toward the M2 phenotype. Furthermore, the expression of PD-L2 or FASL on CAFs bind to corresponding PD-1 and FAS receptors, respectively, causing CD8+ T cell dysfunction.CC BY · PubMed Central
FIGURE 3 Combinatorial therapeutic strategies to reverse the T cell dysfunction. A growing number of studies propose to evaluate the efficacy of immune checkpoint blockade antibodies together with: (a) CAR-T cell therapy; (b) inhibitors of soluble mediators targeting IL-10, TGF-β, DNA methyltransferase and histone deacetylase; (c) CSF1R antibody targeting activating receptors on TAMs to inhibit the polarization of TAM; and (d) neoantigen vaccines.
FIGURE 3 Combinatorial therapeutic strategies to reverse the T cell dysfunction. A growing number of studies propose to evaluate the efficacy of immune checkpoint blockade antibodies together with: (a) CAR-T cell therapy; (b) inhibitors of soluble mediators targeting IL-10, TGF-β, DNA methyltransferase and histone deacetylase; (c) CSF1R antibody targeting activating receptors on TAMs to inhibit the polarization of TAM; and (d) neoantigen vaccines.CC BY · PubMed Central

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Metadata

Authors
Zhang, Z., Liu, S., Zhang, B., Qiao, L., Zhang, Y., & Zhang, Y.
Affiliations
  • First Affiliated Hospital of Zhengzhou University (CN)
  • Northwestern University (US)
  • Loyola University Chicago (US)
ORCID
Venue
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Published
2020-02-11
Volume
8
Pages
17-17
ISSN
2296-634X (ISSN-L)
DOI
10.3389/fcell.2020.00017
PMC
PMC7027373
OpenAlex
W3006138994
Cited by
385
References
120
Citations by year
2026: 39 · 2025: 52 · 2024: 70 · 2023: 64 · 2022: 65 · 2021: 60 · 2020: 34
FWCI
5.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (U1804281, 81771781, 81702810, 81773060)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
T cell dysfunction, T cell exhaustion, cancer immunotherapy, tumor microenvironment, inhibitory receptors, antitumor immunity, immunotherapy resistance

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