Cited by 611Pregnancy and preeclampsia studiesBirth, Development, and HealthNeonatal and fetal brain pathology

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Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

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Malhotra, Atul, Allison, Beth J., Castillo-Melendez, Margie, Jenkin, Graham, Polglase, Graeme R., Miller, Suzanne L.·2019·Frontiers in Endocrinology

DOI 10.3389/fendo.2019.00055PMC PMC6374308

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Abstract

Being born small lays the foundation for short-term and long-term implications for life. Intrauterine or fetal growth restriction describes the pregnancy complication of pathological reduced fetal growth, leading to significant perinatal mortality and morbidity, and subsequent long-term deficits. Placental insufficiency is the principal cause of FGR, which in turn underlies a chronic undersupply of oxygen and nutrients to the fetus. The neonatal morbidities associated with FGR depend on the timing of onset of placental dysfunction and growth restriction, its severity, and the gestation at birth of the infant. In this review, we explore the pathophysiological mechanisms involved in the development of major neonatal morbidities in FGR, and their impact on the health of the infant. Fetal cardiovascular adaptation and altered organ development during gestation are principal contributors to postnatal consequences of FGR. Clinical presentation, diagnostic tools and management strategies of neonatal morbidities are presented. We also present information on the current status of targeted therapies. A better understanding of neonatal morbidities associated with FGR will enable early neonatal detection, monitoring and management of potential adverse outcomes in the newborn period and beyond.

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Authors: Malhotra, A., Allison, B. J., Castillo-Melendez, M., Jenkin, G., Polglase, G. R., & Miller, S. L.
Affiliations: Hudson Institute of Medical Research (AU)
ORCID: Allison, Beth J.
Jenkin, Graham
Polglase, Graeme R.
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2019-02-07
Volume: 10
Pages: 55-55
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2019.00055
PMC: PMC6374308
OpenAlex: W2913735792
Cited by: 453
References: 203
Citations by year: 2026: 53 · 2025: 62 · 2024: 68 · 2023: 77 · 2022: 67 · 2021: 63 · 2020: 52 · 2019: 11
FWCI: 7.63
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Monash University Research Portal (Monash University) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Heart Foundation of Australia
State Government of Victoria
Cerebral Palsy Alliance
Medical Research Council
National Health and Medical Research Council
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords: fetal growth restriction, neonatal morbidity, placental insufficiency, fetal hypoxia, organogenesis, perinatal mortality, long-term outcomes, targeted therapy, neonatal diagnosis

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Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact

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