The DOI matches its Crossref record; 181 of the 183 references it cites were found in a registry or an index, and 2 are not checked yet.
Leptin and Obesity: Role and clinical implication.
Open accessAbstract
The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese ( ob ) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). LEP-R distribution facilitates leptin’s pleiotropic effects, playing a crucial role in regulating body mass via a negative feedback mechanism between adipose tissue and the hypothalamus. Leptin resistance is characterized by reduced satiety, over-consumption of nutrients, and increased total body mass. Often this leads to obesity, which reduces the effectiveness of using exogenous leptin as a therapeutic agent. Thus, combining leptin therapies with leptin sensitizers may help overcome such resistance and, consequently, obesity. This review examines recent data obtained from human and animal studies related to leptin, its role in obesity, and its usefulness in obesity treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Elevated leptin and cholesterol levels are characteristic of obesity, and therefore these results further demonstrate the extent of the obese phenotype observed in Abi3–/– mice (Klop et al., 2013; Obradovic et al., 2021).”
From Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice (2022) · cites this paper as Obradovic et al., 2021
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Calle, E. E., & Kaaks, R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1408 · Cited by 3,613
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Research works printed but not linked: 2
- 2019, World Health Statistics Overview 2019: Monitoring Health for the SDGs, Sustainable Development Goals.
- 2008, Worldwide Prevalence of Anaemia 1993-2005
Cited by
Sorted by citations
Items 101–200 of 1,000
Jia, Z., Wang, Z., Pan, H., Zhang, J., Wang, Q., Zhou, C., & Liu, J. (2024) · European journal of medical research · doi:10.1186/s40001-024-02176-w · Cited by 35
Leptin in Human Milk—One of the Key Regulators of Nutritional Programming
Sinkiewicz‐Darol, E., Adamczyk, I., Łubiech, K., Pilarska, G., & Twarużek, M. (2022) · Molecules · doi:10.3390/molecules27113581 · Cited by 36
Therapeutic potential of gallic acid in obesity: Considerable shift!
Behera, P. K., Devi, S., & Mittal, N. (2022) · Obesity Medicine · doi:10.1016/j.obmed.2022.100473 · Cited by 31
Ferrazzano, G. F., D’Ambrosio, F., Caruso, S., Gatto, R., & Caruso, S. (2023) · Nutrients · doi:10.3390/nu15214611 · Cited by 31
Research advances in the therapy of metabolic syndrome
Lin, Z., & Sun, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1364881 · Cited by 33
Raji, H., Dinesh, S., & Sharma, S. (2025) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-024-00930-9 · Cited by 39
Obesity as a Neuroendocrine Disorder
Ferreira‐Hermosillo, A., Miguel-Ibáñez, R. D., Pérez-Dionisio, E. K., & Villalobos-Mata, K. A. (2023) · Archives of Medical Research · doi:10.1016/j.arcmed.2023.102896 · Cited by 33
Immunomodulatory effects of exercise in cancer prevention and adjuvant therapy: a narrative review
Lyu, D. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1292580 · Cited by 31
Chen, C., Zhang, D., Ye, M., You, Y., Song, Y., & Chen, X. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01649-6 · Cited by 33
Understanding the Role of Adipokines in Cardiometabolic Dysfunction: A Review of Current Knowledge
Datta, S., Koka, S., & Boini, K. M. (2025) · Biomolecules · doi:10.3390/biom15050612 · Cited by 33
Shinjyo, N., & Kita, K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.765217 · Cited by 29
Yang, S., Zhu, T., Wakefield, J. S., Mauro, T. M., Elias, P. M., & Man, M. (2023) · Experimental Dermatology · doi:10.1111/exd.14801 · Cited by 31
The “Sweet Spot” of Targeting Tumor Metabolism in Ovarian Cancers
Tondo-Steele, K., & McLean, K. (2022) · Cancers · doi:10.3390/cancers14194696 · Cited by 29
The cellular and immunological dynamics of early and transitional human milk
LeMaster, C., Pierce, S. H., Geanes, E. S., Khanal, S., Elliott, S., Scott, A., Louiselle, D. A., McLennan, R., Maulik, D., Lewis, T. R., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04910-2 · Cited by 29
Linking adipose tissue eosinophils, IL-4, and leptin in human obesity and insulin resistance
Hernandez, J. D., Li, T., Ghannam, H., Rau, C. M., Masuda, M. Y., Madura, J. A., Jacobsen, E. A., & Filippis, E. D. (2024) · JCI Insight · doi:10.1172/jci.insight.170772 · Cited by 33
Al-Marzooqi, S. K., Almarzooqi, F., Sadida, H. Q., Jerobin, J., Ahmed, I., Abou‐Samra, A., Fakhro, K. A., Dhawan, P., Bhat, A. A., & Akil, A. A. (2024) · Obesity Reviews · doi:10.1111/obr.13766 · Cited by 33
Han, L., Xu, S., Zhou, D., Chen, R., Ding, Y., Zhang, M., Bao, M., He, B., & Li, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1401648 · Cited by 29
Manta, A., Georganta, A., Roumpou, A., Zoumpourlis, V., Spandidos, D. A., Rizos, E. N., & Peppa, Μ. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13479 · Cited by 40
The Head-to-Toe Hormone: Leptin as an Extensive Modulator of Physiologic Systems
Misch, M., & Puthanveetil, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105439 · Cited by 30
360-Degree Perspectives on Obesity
Cuciureanu, M. D., Caratașu, C.-C., Gabrielian, L., Frăsinariu, O. E., Checheriță, L. E., Trandafir, L. M., Stanciu, G. D., Szilagyi, A., Pogonea, I., Bordeianu, G., et al. (2023) · Medicina · doi:10.3390/medicina59061119 · Cited by 33
Obesity Management in Children and Adolescents
Wong, G. W., & Srivastava, G. (2023) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2023.03.011 · Cited by 33
Annunziata, C., Pirozzi, C., Lama, A., Senzacqua, M., Comella, F., Bordin, A., Monnolo, A., Pelagalli, A., Ferrante, M. C., Mollica, M. P., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020338 · Cited by 30
Pan, S., Worker, C. J., & Feng, Y. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00533.2022 · Cited by 31
Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity
Amorim, M. R., Wang, X., Aung, O., Bevans‐Fonti, S., Anokye‐Danso, F., Ribeiro, C., Escobar, J. B., Freire, C., Pho, H., Dergacheva, O., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113512 · Cited by 27
Adipokines and Their Role in Heart Failure: A Literature Review
Rafaqat, S. (2023) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2023.14111 · Cited by 30
Anti-obesity activity of human gut microbiota Bacteroides stercoris KGMB02265
Ryu, S. W., Moon, J. C., Oh, B. S., Yu, S. Y., Bak, J. E., Heo, E. S., Jeong, J., & Lee, J. H. (2023) · Archives of Microbiology · doi:10.1007/s00203-023-03750-2 · Cited by 32
Arcuate Nucleus of the Hypothalamus: Anatomy, Physiology, and Diseases
Song, J., & Choi, S. (2023) · Experimental Neurobiology · doi:10.5607/en23040 · Cited by 34
Kukucka, T., Ferencová, N., Višňovcová, Z., Ondrejka, I., Hrtánek, I., Kovacova, V., Macejova, A., Mlyncekova, Z., & Tonhajzerová, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084511 · Cited by 30
Mogna-Peláez, P., Riezu‐Boj, J. I., Milagro, F. I., Herrero, J. I., Elorz, M., Benito, A., Tobaruela-Resola, A. L., Tur, J. A., Martínez, J. A., Abete, I., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.05.042 · Cited by 32
Dhurandhar, Y., Tomar, S., Das, A., Prajapati, J. L., Singh, A. K., Bodakhe, S. H., & Namdeo, K. P. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10509-z · Cited by 27
Papakonstantinou, Ε., Piperigkou, Z., Karamanos, N. K., & Zolota, V. (2022) · Cancers · doi:10.3390/cancers14174139 · Cited by 31
Obesity: A Doorway to a Molecular Path Leading to Infertility
Ahmad, R., & Haque, M. (2022) · Cureus · doi:10.7759/cureus.30770 · Cited by 30
Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats
Henriquez, A. R., Snow, S. J., Jackson, T. W., House, J. S., Motsinger‐Reif, A. A., Ward-Caviness, C. K., Schladweiler, M. C. J., Alewel, D. I., Miller, C. N., Farraj, A. K., et al. (2022) · Environmental Health Perspectives · doi:10.1289/ehp11088 · Cited by 28
Impact of Oats on Appetite Hormones and Body Weight Management: A Review
Shehzad, A., Rabail, R., Munir, S., Jan, H., Fernández‐Lázaro, D., & Aadil, R. M. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00454-3 · Cited by 27
Creeping Fat in the Pathogenesis of Crohn’s Disease: An Orchestrator or a Silent Bystander?
Tsounis, E. P., Aggeletopoulou, I., Mouzaki, Α., & Triantos, C. K. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad095 · Cited by 28
Quake, S. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.03.626516 · Cited by 35
Gut Microbiota Restores Central Neuropeptide Deficits in Germ-Free Mice
Hamamah, S., & Covasa, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911756 · Cited by 25
Association between the Systemic Immune-Inflammation Index and Thyroid Function in U.S. Adults
Hu, X., Liang, Y.-C., Zhang, H.-H., Li, H.-L., & Liu, D. (2023) · Mediators of Inflammation · doi:10.1155/2023/5831858 · Cited by 27
Valladolid‐Acebes, I. (2024) · Biomedicines · doi:10.3390/biomedicines12112422 · Cited by 28
Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence
Wong, S. K., Ramli, F. F., Ali, A., & Ibrahim, N. ‘. (2022) · Biomedicines · doi:10.3390/biomedicines10123239 · Cited by 27
The anti-obesogenic effects and underpinning mechanisms of fermented plant-based foods: A review
Xiao, X., Li, S., Zhou, X., Li, M., Zhang, Y., & Ye, H. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.04.007 · Cited by 29
Current Perspectives: Obesity and Neurodegeneration - Links and Risks
Kueck, P. J., Morris, J. K., & Stanford, J. A. (2024) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s388579 · Cited by 30
Hassan, N. E., El-Masry, S. A., Shebini, S. M. E., Ahmed, N. H., Mehanna, N. S., Wahed, M. M. A., Amine, D., Hashish, A. F., Selim, M. K., Afify, M. A. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-61130-2 · Cited by 30
Heidari, H., & Lawrence, D. A. (2024) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2024.2378406 · Cited by 28
Recent advances in peptide-based therapies for obesity and type 2 diabetes
Bailey, C. J., Flatt, P. R., & Conlon, J. M. (2024) · Peptides · doi:10.1016/j.peptides.2024.171149 · Cited by 25
Méndez-Albiñana, P., Rodrigues‐Díez, R., Rodríguez‐Rodríguez, P., Moreno, R., Muñoz-Valverde, D., Casaní, L., Villamiel, M., & Blanco‐Rivero, J. (2025) · Current Research in Food Science · doi:10.1016/j.crfs.2025.101014 · Cited by 24
Xie, C., Gao, W., Li, X., Luo, S., Wu, D., & Chye, F. Y. (2023) · NFS Journal · doi:10.1016/j.nfs.2023.02.004 · Cited by 28
Luo, T.-T., Wu, Y., Yin, Q., Chen, W.-G., & Zuo, J. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s398291 · Cited by 25
Association between triglyceride-glucose index and gallstones: a cross-sectional study
Li, H., & Zhang, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-68841-6 · Cited by 24
Lai, P., Hille, S. S., Subramanian, H., Wiegmann, R., Roser, P., Müller, O. J., Nikolaev, V. O., & Jong, K. A. D. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad178 · Cited by 26
Wen, S.-H., Tang, X., Tang, T., & Ye, Z.-R. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03127-9 · Cited by 23
Mitoiu, B. I., Nartea, R., & Miclăuș, R. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158067 · Cited by 26
The Interplay of Uterine Health and Obesity: A Comprehensive Review
Šišljagić, D., Blažetić, S., Heffer, M., Vranješ, M., & Müller, A. (2024) · Biomedicines · doi:10.3390/biomedicines12122801 · Cited by 28
Disrupted adipokine secretion and inflammatory responses in human adipocyte hypertrophy
Gao, D., Chen, B., & Griffiths, H. R. (2025) · Adipocyte · doi:10.1080/21623945.2025.2485927 · Cited by 23
Polyakova, E. A., Mikhaylov, E. N., Galagudza, M. M., & Shlyakhto, E. V. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08491 · Cited by 23
Nawaz, A., Nishida, Y., Takikawa, A., Fujisaka, S., Kado, T., Aminuddin, A., Bilal, M., Jeelani, I., Aslam, M. R., Nishimura, A., et al. (2021) · Nutrients · doi:10.3390/nu13124374 · Cited by 24
Preclinical mouse models of hepatocellular carcinoma: An overview and update
Gu, C. Y., & Lee, T. K. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113042 · Cited by 24
Myokines in Appetite Control and Energy Balance
Grannell, A., Kokkinos, A. D., & le Roux, C. W. (2022) · Muscles · doi:10.3390/muscles1010003 · Cited by 24
Weight cycling based on altered immune microenvironment as a result of metaflammation
Li, W., & Chen, W. (2023) · Nutrition & Metabolism · doi:10.1186/s12986-023-00731-6 · Cited by 26
Connecting the dots in the associations between diet, obesity, cancer, and microRNAs
Otsuka, K., Nishiyama, H., Kuriki, D., Kawada, N., & Ochiya, T. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.05.001 · Cited by 26
Organokines in COVID-19: A Systematic Review
Barbalho, S. M., Minniti, G., Miola, V. F. B., Haber, J. F. D. S., Bueno, P. C. D. S., Haber, L. S. D. A., Gírio, R. J. S., Detregiachi, C. R. P., Dall’Antonia, C., Rodrigues, V. D., et al. (2023) · Cells · doi:10.3390/cells12101349 · Cited by 24
Navalon-Monllor, V., Soriano-Romaní, L., Silva, M., Hazas, M. L. D. L., Hernando-Quintana, N., Suárez-Diéguez, T., Morell, P., & Nieto, J. A. (2023) · Food & Function · doi:10.1039/d3fo01257c · Cited by 25
The interplay between endometriosis and obesity
Rahman, M. S., Park, Y., Hosseinirad, H., Shin, J., & Jeong, J. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.03.011 · Cited by 25
The Beneficial Effects of Bariatric-Surgery-Induced Weight Loss on Renal Function
Moriconi, D., Nannipieri, M., Dadson, P., Rosada, J., Tentolouris, N., & Rebelos, E. (2022) · Metabolites · doi:10.3390/metabo12100967 · Cited by 22
Beneficial effects of Apelin-13 on metabolic diseases and exercise
Wen, R., Huang, R., Xu, K., Cheng, Y., & Yi, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1285788 · Cited by 23
Gupta, A. K., Gupta, P., Singh, A. K., & Gupta, V. (2023) · GHM Open · doi:10.35772/ghmo.2023.01004 · Cited by 26
Kim, H., Kang, S., & Go, G. (2024) · Food Science and Biotechnology · doi:10.1007/s10068-024-01656-3 · Cited by 22
Heymsfield, S. B., Clément, K., Dubern, B., Goldstone, A. P., Haqq, A. M., Kühnen, P., Richards, J. R., Roth, C. L., van den Akker, E. L. T., Wabitsch, M., et al. (2025) · Current Obesity Reports · doi:10.1007/s13679-024-00601-z · Cited by 23
Endocrine consequences of childhood obesity: a narrative review
Badr, M., El-Rabaa, G., FREIHA, M., Kędzia, A. W., & Niechciał, E. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1584861 · Cited by 21
The Interplay Between Obesity and Venous Thromboembolism: From Molecular Aspects to Clinical Issue
Zawadzka, P. S., Imiela, A. M., & Pruszczyk, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110292 · Cited by 27
Regulatory Role of the Adipose Microenvironment on Ovarian Cancer Progression
Chehade, H., Tedja, R., Ramos, H., Bawa, T. S., Adzibolosu, N. K., Gogoi, R. P., Mor, G., & Alvero, A. B. (2022) · Cancers · doi:10.3390/cancers14092267 · Cited by 21
Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure
Sinha, A., Bavishi, A. A., Hibler, E. A., Yang, E. H., Parashar, S., Okwuosa, T. M., DeCara, J. M., Brown, S.-A. N., Guha, A., Sadler, D. B., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.847975 · Cited by 21
Park, M., Jaiswal, V. K., Kim, K. H., Chun, J. L., Lee, M.-J., Shin, J.-H., & Lee, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315215 · Cited by 21
A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review
Besci, Ö., Fırat, S. N., Özen, S., Çetinkaya, S. Ç., Akın, L., Kör, Y., Pekkolay, Z., Özalkak, Ş., Özsu, E., Erdeve, Ş. S., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad099 · Cited by 23
Khalaf, S. S., Shalaby, O. A., Hassan, A. R., El-Kherbetawy, M. K., & Mehanna, E. T. (2023) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2023.03.005 · Cited by 21
Leptin–VEGF crosstalk in excess body mass and related disorders: A systematic review
Skrypnik, D., Skrypnik, K., Suliburska, J., & Bogdański, P. (2023) · Obesity Reviews · doi:10.1111/obr.13575 · Cited by 21
Landgraaf, R. G., Bloem, M. N., Fumagalli, M., Benninga, M. A., de Lorijn, F., & Nieuwdorp, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1236370 · Cited by 21
Hülsmeier, A. J. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106851 · Cited by 22
Neural and hormonal mechanisms of appetite regulation during eating
Sun, X., Liu, B., Yuan, Y., Rong, Y., Pang, R., & Li, Q. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1484827 · Cited by 30
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Groeger, S. E., Yuxi, Z., Yong, J., Wang, L., Ruf, S., & Meyle, J. (2025) · Journal of Periodontal Research · doi:10.1111/jre.70003 · Cited by 26
Dehzad, M. J., Ghalandari, H., Nouri, M., & Askarpour, M. (2023) · Phytotherapy Research · doi:10.1002/ptr.7800 · Cited by 20
Biomarkers of Osteoarthritis—A Narrative Review on Causal Links with Metabolic Syndrome
Lynskey, S. J., Macaluso, M. J., Gill, S. D., McGee, S. L., & Page, R. S. (2023) · Life · doi:10.3390/life13030730 · Cited by 20
Luo, G., Li, Y., Yao, C., Li, M., Li, J., & Zhang, X. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.05.008 · Cited by 18
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
Bettinetti‐Luque, M., Trujillo‐Estrada, L., García‐Fuentes, E., Andreo‐Lopez, J., Sanchez-Varo, R. M., Garrido‐Sánchez, L., Mediavilla, A. G., López, M. G., García‐Caballero, M., Gutiérrez, A., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16243 · Cited by 21
Yu, J., Xia, J., Xu, D., Wang, Y., Yin, S., Lü, Y., Xia, H., Wang, S., & Sun, G. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1256899 · Cited by 21
Leptin- and cytokine-like unpaired signaling in Drosophila
Zandawala, M., & Gera, J. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112165 · Cited by 18
Christensen, S. H., Lewis, J. I., Larnkjær, A., Frøkiær, H., Allen, L. H., Mølgaard, C., & Michaelsen, K. F. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1025439 · Cited by 19
Pharmacological Treatments and Natural Biocompounds in Weight Management
Gasmi, A., Mujawdiya, P. K., Nehaoua, A., Shanaida, M., Semenova, Y. M., Piscopo, S., Menzel, A., Voloshyn, V., Voloshyn, O., Shanaida, V., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16020212 · Cited by 21
Contribution of environmental, genetic and epigenetic factors to obesity-related metabolic syndrome
Ghosh, S., Dhar, S., Bhattacharjee, S., & Bhattacharjee, P. (2023) · The Nucleus · doi:10.1007/s13237-023-00420-y · Cited by 23
Effects of Obesity and Calorie Restriction on Cancer Development
Sergeeva, E. Y., Ruksha, T. G., & Fefelova, Y. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119601 · Cited by 21
Wu, S., Chen, W.-J., Chang, J. P., Guu, T., Hsin, M.-C., Huang, C., Mischoulon, D., Capuron, L., & Su, K. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13061003 · Cited by 19
SGLT-2 Inhibitors for Non-Alcoholic Fatty Liver Disease: A Review
Xu, R., Lian, D., Xie, Y., Chen, Z., Wang, Y., Mu, L., Wang, Y., & Zhang, B. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2807134 · Cited by 22
Dini, I., & Mancusi, A. (2023) · Molecules · doi:10.3390/molecules28145357 · Cited by 21
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Tie, W., Ma, T., Yi, Z., Liu, J., Li, Y., Bai, J. Y., Li, L., & Zhang, L. (2023) · Pathology & Oncology Research · doi:10.3389/pore.2023.1611338 · Cited by 19
Montenegro, L. R., Seraphim, C. E., Tinano, F. R., Piovesan, M. R., Canton, A. P. M., McElreavey, K., Brabant, S., Boris, N. P., Magnuson, M., Carroll, R. S., et al. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad129 · Cited by 19
Tan, L., Mei, J., Tang, R., Huang, D., Qi, K., Ossowski, Z. M., & Wang, X. (2024) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2024.103119 · Cited by 19
Zein, M. A., Akomolafe, A. F., Mahmood, F. R., Khrayzat, A., Sahebkar, A., Pintus, G., Kobeissy, F. H., & Eid, A. H. (2024) · Obesity Reviews · doi:10.1111/obr.13807 · Cited by 18
Downs, T., Costa, F. D. S., Paganoti, C. D. F., Holland, O. J., & Hryciw, D. H. (2024) · Endocrines · doi:10.3390/endocrines5030028 · Cited by 21
van den Oever, S. R., Mulder, R. L., Oeffinger, K. C., Gietema, J. A., Skinner, R., Constine, L. S., Wallace, W. H., Armenian, S. H., Barnea, D., Bárdi, E., et al. (2025) · European Journal of Endocrinology · doi:10.1093/ejendo/lvaf046 · Cited by 18
Multidrug-Resistant Infections and Metabolic Syndrome: An Overlooked Bidirectional Relationship
Acierno, C., Nevola, R., Barletta, F., Rinaldi, L., Sasso, F. C., Adinolfi, L. E., & Caturano, A. (2025) · Biomedicines · doi:10.3390/biomedicines13061343 · Cited by 20
Metadata
- Authors
- Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R.
- Affiliations
- University of Belgrade (RS)
- King Abdullah University of Science and Technology (SA)
- University of St Andrews (GB)
- ORCID
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2021-05-18
- Volume
- 12
- Pages
- 585887-585887
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC8167040
- OpenAlex
- W3161404038
- Cited by
- 1,121
- References
- 182
- Citations by year
- 2026: 168 · 2025: 299 · 2024: 264 · 2023: 246 · 2022: 129 · 2021: 15
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion, other-oa)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
- VinaR (Institute of Nuclear Sciences "Vinča") (submittedVersion, cc-by)
- Funders
- King Abdullah University of Science and Technology
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- leptin, obesity, leptin resistance, leptin receptor, ob gene, white adipose tissue, hypothalamic regulation of appetite, satiety, leptin therapy, food intake regulation, body weight regulation, reproductive function, fetal growth, inflammation, angiogenesis, lipolysis
- MeSH terms
- Animals, Energy Metabolism, Humans, Hypothalamus, Obesity, Risk Factors, Satiety Response, Signal Transduction, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
