Cited by 1,121Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesPharmacology and Obesity Treatment

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Leptin and Obesity: Role and clinical implication.

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Obradovic, Milan, Sudar-Milovanovic, Emina, Soskic, Sanja, Essack, Magbubah, Arya, Swati, Stewart, Alan J., Gojobori, Takashi, Isenovic, Esma R.·2021·Frontiers in Endocrinology

DOI 10.3389/fendo.2021.585887PMC PMC8167040

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Abstract

The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese ( ob ) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). LEP-R distribution facilitates leptin’s pleiotropic effects, playing a crucial role in regulating body mass via a negative feedback mechanism between adipose tissue and the hypothalamus. Leptin resistance is characterized by reduced satiety, over-consumption of nutrients, and increased total body mass. Often this leads to obesity, which reduces the effectiveness of using exogenous leptin as a therapeutic agent. Thus, combining leptin therapies with leptin sensitizers may help overcome such resistance and, consequently, obesity. This review examines recent data obtained from human and animal studies related to leptin, its role in obesity, and its usefulness in obesity treatment.

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Figure 1 Regulation of appetite by leptin acting on the nucleus arcuatus of the hypothalamus. POMC, proopiomelanocortin; NPY, neuropeptide Y; AgRP, agouti-related protein; MCR, melanocortin receptors; GABA, γ-aminobutyric acid.CC BY · PubMed Central

Figure 2 Leptin signaling. L- leptin; LEP-R- leptin receptor; IRS 1/2, insulin receptor substrate 1/2; JAK 2, Janus kinase 2; PI3K, phosphoinositide 3-kinase; SH2, Src-like homology 2; SHP-2, SH2 domain-containing protein tyrosine phosphatase; SOCS3, suppressor of cytokine signaling 3; STAT, signal transducer and activator of transcription.CC BY · PubMed Central

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Authors: Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R.
Affiliations: University of Belgrade (RS)
King Abdullah University of Science and Technology (SA)
University of St Andrews (GB)
ORCID: Obradovic, Milan
Sudar-Milovanovic, Emina
Essack, Magbubah
Arya, Swati
Stewart, Alan J.
Gojobori, Takashi
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2021-05-18
Volume: 12
Pages: 585887-585887
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2021.585887
PMC: PMC8167040
OpenAlex: W3161404038
Cited by: 1,121
References: 182
Citations by year: 2026: 168 · 2025: 299 · 2024: 264 · 2023: 246 · 2022: 129 · 2021: 15
FWCI: 20.86
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion, other-oa)
St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
VinaR (Institute of Nuclear Sciences "Vinča") (submittedVersion, cc-by)
Funders: King Abdullah University of Science and Technology
Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Keywords: leptin, obesity, leptin resistance, leptin receptor, ob gene, white adipose tissue, hypothalamic regulation of appetite, satiety, leptin therapy, food intake regulation, body weight regulation, reproductive function, fetal growth, inflammation, angiogenesis, lipolysis
MeSH terms: Animals, Energy Metabolism, Humans, Hypothalamus, Obesity, Risk Factors, Satiety Response, Signal Transduction, Leptin

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