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Leptin and Obesity: Role and clinical implication.
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The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese ( ob ) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). LEP-R distribution facilitates leptin’s pleiotropic effects, playing a crucial role in regulating body mass via a negative feedback mechanism between adipose tissue and the hypothalamus. Leptin resistance is characterized by reduced satiety, over-consumption of nutrients, and increased total body mass. Often this leads to obesity, which reduces the effectiveness of using exogenous leptin as a therapeutic agent. Thus, combining leptin therapies with leptin sensitizers may help overcome such resistance and, consequently, obesity. This review examines recent data obtained from human and animal studies related to leptin, its role in obesity, and its usefulness in obesity treatment.
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“Elevated leptin and cholesterol levels are characteristic of obesity, and therefore these results further demonstrate the extent of the obese phenotype observed in Abi3–/– mice (Klop et al., 2013; Obradovic et al., 2021).”
From Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice (2022) · cites this paper as Obradovic et al., 2021
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Metadata
- Authors
- Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R.
- Affiliations
- University of Belgrade (RS)
- King Abdullah University of Science and Technology (SA)
- University of St Andrews (GB)
- ORCID
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2021-05-18
- Volume
- 12
- Pages
- 585887-585887
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC8167040
- OpenAlex
- W3161404038
- Cited by
- 1,121
- References
- 182
- Citations by year
- 2026: 168 · 2025: 299 · 2024: 264 · 2023: 246 · 2022: 129 · 2021: 15
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion, other-oa)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
- VinaR (Institute of Nuclear Sciences "Vinča") (submittedVersion, cc-by)
- Funders
- King Abdullah University of Science and Technology
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- leptin, obesity, leptin resistance, leptin receptor, ob gene, white adipose tissue, hypothalamic regulation of appetite, satiety, leptin therapy, food intake regulation, body weight regulation, reproductive function, fetal growth, inflammation, angiogenesis, lipolysis
- MeSH terms
- Animals, Energy Metabolism, Humans, Hypothalamus, Obesity, Risk Factors, Satiety Response, Signal Transduction, Leptin
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