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Cited by 1,121Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesPharmacology and Obesity Treatment

The DOI matches its Crossref record; 181 of the 183 references it cites were found in a registry or an index, and 2 are not checked yet.

Leptin and Obesity: Role and clinical implication.

Open access
Obradovic, Milan, Sudar-Milovanovic, Emina, Soskic, Sanja, Essack, Magbubah, Arya, Swati, Stewart, Alan J., Gojobori, Takashi, Isenovic, Esma R.·2021·Frontiers in Endocrinology
DOI 10.3389/fendo.2021.585887PMC PMC8167040
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Abstract

The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese ( ob ) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). LEP-R distribution facilitates leptin’s pleiotropic effects, playing a crucial role in regulating body mass via a negative feedback mechanism between adipose tissue and the hypothalamus. Leptin resistance is characterized by reduced satiety, over-consumption of nutrients, and increased total body mass. Often this leads to obesity, which reduces the effectiveness of using exogenous leptin as a therapeutic agent. Thus, combining leptin therapies with leptin sensitizers may help overcome such resistance and, consequently, obesity. This review examines recent data obtained from human and animal studies related to leptin, its role in obesity, and its usefulness in obesity treatment.

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Crossref · 10.3389/fendo.2021.585887

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Figures

Figure 1 Regulation of appetite by leptin acting on the nucleus arcuatus of the hypothalamus. POMC, proopiomelanocortin; NPY, neuropeptide Y; AgRP, agouti-related protein; MCR, melanocortin receptors; GABA, γ-aminobutyric acid.
Figure 1 Regulation of appetite by leptin acting on the nucleus arcuatus of the hypothalamus. POMC, proopiomelanocortin; NPY, neuropeptide Y; AgRP, agouti-related protein; MCR, melanocortin receptors; GABA, γ-aminobutyric acid.CC BY · PubMed Central
Figure 2 Leptin signaling. L- leptin; LEP-R- leptin receptor; IRS 1/2, insulin receptor substrate 1/2; JAK 2, Janus kinase 2; PI3K, phosphoinositide 3-kinase; SH2, Src-like homology 2; SHP-2, SH2 domain-containing protein tyrosine phosphatase; SOCS3, suppressor of cytokine signaling 3; STAT, signal transducer and activator of transcription.
Figure 2 Leptin signaling. L- leptin; LEP-R- leptin receptor; IRS 1/2, insulin receptor substrate 1/2; JAK 2, Janus kinase 2; PI3K, phosphoinositide 3-kinase; SH2, Src-like homology 2; SHP-2, SH2 domain-containing protein tyrosine phosphatase; SOCS3, suppressor of cytokine signaling 3; STAT, signal transducer and activator of transcription.CC BY · PubMed Central

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Research works printed but not linked: 2

  1. 2019, World Health Statistics Overview 2019: Monitoring Health for the SDGs, Sustainable Development Goals.
  2. 2008, Worldwide Prevalence of Anaemia 1993-2005

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Metadata

Authors
Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R.
Affiliations
  • University of Belgrade (RS)
  • King Abdullah University of Science and Technology (SA)
  • University of St Andrews (GB)
ORCID
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2021-05-18
Volume
12
Pages
585887-585887
ISSN
1664-2392 (ISSN-L)
DOI
10.3389/fendo.2021.585887
PMC
PMC8167040
OpenAlex
W3161404038
Cited by
1,121
References
182
Citations by year
2026: 168 · 2025: 299 · 2024: 264 · 2023: 246 · 2022: 129 · 2021: 15
FWCI
20.86
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion, other-oa)
  • St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
  • VinaR (Institute of Nuclear Sciences "Vinča") (submittedVersion, cc-by)
Funders
  • King Abdullah University of Science and Technology
  • Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Keywords
leptin, obesity, leptin resistance, leptin receptor, ob gene, white adipose tissue, hypothalamic regulation of appetite, satiety, leptin therapy, food intake regulation, body weight regulation, reproductive function, fetal growth, inflammation, angiogenesis, lipolysis
MeSH terms
Animals, Energy Metabolism, Humans, Hypothalamus, Obesity, Risk Factors, Satiety Response, Signal Transduction, Leptin

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