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Cited by 78Per- and polyfluoroalkyl substances researchSynthesis and properties of polymersFluorine in Organic Chemistry

Exposure to per- and polyfluoroalkyl substances (PFAS) and type 2 diabetes risk

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Roth, Katherine, Petriello, Michael C.·2022·Frontiers in Endocrinology
DOI 10.3389/fendo.2022.965384PMC PMC9388934
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Abstract

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous man-made chemicals found in consumer products including fabrics, food packaging, non-stick coatings, and aqueous film-forming foams. PFAS are stable and extremely resistant to degradation, resulting in high persistence throughout the environment as well as in human blood. PFAS consist of a large family of synthetic chemicals, with over 4000 distinct varieties having been identified and around 250 currently being manufactured at globally relevant levels. Numerous epidemiological studies have linked exposure to PFAS with adverse health effects ranging from immunotoxicity, cardiometabolic disease, developmental and reproductive effects, cancer, and recently type 2 diabetes. Several studies have demonstrated associations between serum PFAS concentrations and glycemic indicators of type 2 diabetes including glucose, insulin, and HOMA-IR in adolescent and adult cohorts. In addition, some studies have shown positive associations with incident type 2 diabetes and multiple PFAS. However, the link between PFAS exposure and the development of diabetes continues to be a disputed area of study, with conflicting data having been reported from various epidemiological studies. In this mini review we will summarize the current state of the literature linking PFAS to type 2 diabetes and discuss important future directions including the use of more complex mixtures-based statistical analyses.

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Sorted by citations

Authors
Roth, K., & Petriello, M. C.
Affiliations
Wayne State University (US)
Corresponding author
Petriello, Michael C.
ORCID
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2022-08-05
Volume
13
Pages
965384-965384
ISSN
1664-2392 (ISSN-L)
DOI
10.3389/fendo.2022.965384
PMC
PMC9388934
OpenAlex
W4289942538
Cited by
78
References
13
Citations by year
2026: 14 · 2025: 25 · 2024: 24 · 2023: 12 · 2022: 3
FWCI
1.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Environmental Health Sciences (R00ES028734)
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Physical Sciences › Materials Science › Polymers and Plastics › Synthesis and properties of polymers
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
Keywords
per- and polyfluoroalkyl substances, PFAS exposure, type 2 diabetes, diabetes risk, serum PFAS concentrations, insulin resistance, HOMA-IR, cardiometabolic disease, chemical mixtures, environmental pollutants
MeSH terms
Adolescent, Adult, Blood Glucose, Diabetes Mellitus, Type 2, Fluorocarbons, Humans, Reproduction

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