S100A8/A9 in Inflammation

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · cited 2×

Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion

Ryckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 861

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

Corbin, B. D., Seeley, E. H., Raab, A., Feldmann, J., Miller, M. R., Torres, V. J., Anderson, K. L., Dattilo, B. M., Dunman, P. M., Gerads, R., et al. (2008) · Science · doi:10.1126/science.1152449 · Cited by 857

Nutritional immunity beyond iron: a role for manganese and zinc

Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

Nagareddy, P. R., Kraakman, M. J., Masters, S. L., Stirzaker, R. A., Gorman, D. J., Grant, R. W., Dragoljevic, D., Hong, E. S., Abdel‐Latif, A., Smyth, S. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.029 · Cited by 530

Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin

Steinbakk, M., Naess-Andresen, C. F., Fagerhol, M. K., Lingaas, E., Dale, I., & Brandtzaeg, P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93237-j · Cited by 512

Inflammation – Cause or Consequence of Heart Failure or Both?

Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 484

S100A8/A9: From basic science to clinical application

Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 463

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., et al. (2008) · Diabetes · doi:10.2337/db07-1808 · Cited by 407

The Mechanisms of the Development of Atherosclerosis in Prediabetes

Liang, Y. T., Wang, M., Wang, C., Liu, Y., Naruse, K., & Takahashi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084108 · Cited by 43

Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19

Wang, C., Li, X., Ning, W., Gong, S., Yang, F., Fang, C., Gong, Y., Wu, D., Huang, M., Gou, Y., et al. (2021) · Theranostics · doi:10.7150/thno.61832 · Cited by 39

Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing

Schirmer, L., Atallah, P., Freudenberg, U., & Werner, C. (2021) · Advanced Science · doi:10.1002/advs.202100293 · Cited by 42

High‐throughput competitive fluorescence polarization assay reveals functional redundancy in the S100 protein family

Simon, M. A., Ecsédi, P., Kovács, G. M., Póti, Á., Reményi, A., Kardos, J., Gógl, G., & Nyitray, L. (2019) · FEBS Journal · doi:10.1111/febs.15175 · Cited by 38

Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease

Railwah, C., Lora, A., Zahid, K., Goldenberg, H., Campos, M., Wyman, A. E., Jundi, B., Ploszaj, M. A., Rivas, M., Dabo, A. J., et al. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00207.2020 · Cited by 42

Immunomodulatory assessment of Portulaca oleracea L. extract in a mouse model of colitis

Alfwuaires, M. A., Algefare, A. I., Afkar, E., Salam, S. A., El‐Moaty, H. I. A., & Badr, G. M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112148 · Cited by 39

Long COVID (PASC) Is Maintained by a Self-Sustaining Pro-Inflammatory TLR4/RAGE-Loop of S100A8/A9 > TLR4/RAGE Signalling, Inducing Chronic Expression of IL-1b, IL-6 and TNFa: Anti-Inflammatory Ezrin Peptides as Potential Therapy

Holms, R. (2022) · Immuno · doi:10.3390/immuno2030033 · Cited by 38

PAPA spectrum disorders

Genovese, G., Moltrasio, C., Garcovich, S., & Marzano, A. V. (2020) · Giornale Italiano di Dermatologia e Venereologia · doi:10.23736/s0392-0488.20.06629-8 · Cited by 37

Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic Escherichia coli Nissle 1917

Dušek, O., Fajstová, A., Klímová, A., Svozílková, P., Hrncir, T., Kverka, M., Coufal, Š., Šlemín, J., Tlaskalová‐Hogenová, H., Forrester, J. V., et al. (2020) · Cells · doi:10.3390/cells10010023 · Cited by 37

Proteomic analysis reveals some common proteins in the kidney stone matrix

Yang, Y., Hong, S., Li, C., Zhang, J., Hu, H., Chen, X., Jiang, K., Sun, F., Wang, Q., & Wang, S. (2021) · PeerJ · doi:10.7717/peerj.11872 · Cited by 37

Time-Resolved Gene Expression Analysis Monitors the Regulation of Inflammatory Mediators and Attenuation of Adaptive Immune Response by Vitamin D

Hänel, A., & Carlberg, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020911 · Cited by 40

DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets

Cai, C., Meng, C., He, S., Gu, C., Lhamo, T., Draga, D., Luo, D., & Qiu, Q. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00927-y · Cited by 36

Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis

Laky, K., Kinard, J. L., Li, J. M., Moore, I. N., Lack, J., Fischer, E. R., Kabát, J., Latanich, R., Zachos, N. C., Limkar, A. R., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.abp9940 · Cited by 38

Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review

Vegivinti, C. T. R., Keesari, P. R., Veeraballi, S., Maia, C., Mehta, A. K., Lavu, R. R., Thakur, R., Tella, S. H., Patel, R. J., Kakumani, V. K., et al. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00422-1 · Cited by 43

Discovery of large molecules as new biomarkers in wastewater using environmental proteomics and suitable polymer probes

Carrascal, M., Abián, J., Ginebreda, A., & Barceló, ‪. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141145 · Cited by 36

Progress in the development of kynurenine and quinoline-3-carboxamide-derived drugs

Boros, F. A., & Vécsei, L. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1813716 · Cited by 38

S100A9 Upregulation Contributes to Learning and Memory Impairments by Promoting Microglia M1 Polarization in Sepsis Survivor Mice

Liao, Y., Zhou, X., Ji, M., Qiu, L., Chen, X.-H., Gong, C., Lin, Y., Guo, Y.-H., & Yang, J. (2020) · Inflammation · doi:10.1007/s10753-020-01334-6 · Cited by 36

Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury

Lin, Y.-H., Platt, M. P., Fu, H., Gui, Y., Wang, Y., González-Juarbe, N., Zhou, D. F., & Yu, Y. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra120.002235 · Cited by 38

Diabetes and Metabolic Drivers of Trained Immunity

Choudhury, R. P., Edgar, L., Rydén, M., & Fisher, E. A. A. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314211 · Cited by 37

A systematic dissection of human primary osteoblasts in vivo at single-cell resolution

Gong, Y., Yang, J., Li, X., Zhou, C., Chen, Y., Wang, Z., Qiu, X., Liu, Y., Zhang, H., Greenbaum, J., et al. (2021) · Aging · doi:10.18632/aging.203452 · Cited by 35

Correlation between systemic S100A8 and S100A9 levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus

Lim, R. R., Vaidya, T. A., Gadde, S. G. K., Yadav, N. K., Sethu, S., Hainsworth, D. P., Mohan, R. R., Ghosh, A., & Chaurasia, S. S. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.03.014 · Cited by 38

Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation

Zha, Z., Lin, Y., Wang, K., Zhang, Y., Li, D., Xu, G., Xu, Q., & Liu, Y.-L. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00933-3 · Cited by 35

TLR9 Mediates Periodontal Aging by Fostering Senescence and Inflammaging

Albuquerque‐Souza, E., Crump, K. E., Rattanaprukskul, K., Li, Y., Shelling, B., Xia, X., Jiang, M., & Sahingur, S. E. (2022) · Journal of Dental Research · doi:10.1177/00220345221110108 · Cited by 40

S100 proteins in cardiovascular diseases

Zhou, Y., Zha, Y., Yang, Y., Ma, T., Li, H., & Liang, J. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00662-1 · Cited by 35

Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions

Gibellini, L., Borella, R., Santacroce, E., Serattini, E., Boraldi, F., Quaglino, D., Aramini, B., Biasi, S. D., & Cossarizza, A. (2023) · Cancers · doi:10.3390/cancers15133327 · Cited by 35

The JAK-STAT Pathway as a Therapeutic Strategy in Cancer Patients with Immune Checkpoint Inhibitor-Induced Colitis: A Narrative Review

Gravina, A. G., Pellegrino, R., Esposito, A., Cipullo, M., Romeo, M., Palladino, G., Iodice, P., Federico, A., & Troiani, T. (2024) · Cancers · doi:10.3390/cancers16030611 · Cited by 36

Role of Calprotectin as a Biomarker in Periodontal Disease

Wei, L., Liu, M., & Xiong, H. (2019) · Mediators of Inflammation · doi:10.1155/2019/3515026 · Cited by 35

Defective Proliferation and Osteogenic Potential with Altered Immunoregulatory phenotype of Native Bone marrow-Multipotential Stromal Cells in Atrophic Fracture Non-Union

El‐Jawhari, J. J., Kleftouris, G., El-Sherbiny, Y. M., Saleeb, H., West, R. M., Jones, E., & Giannoudis, P. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-53927-3 · Cited by 34

Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19

Shambat, S. M., Gómez-Mejía, A., Schweizer, T. A., Huemer, M., Chang, C., Acevedo, C., Bergadà-Pijuan, J., Vulin, C., Hofmaenner, D. A., Scheier, T., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010176 · Cited by 34

S100 Proteins in Fatty Liver Disease and Hepatocellular Carcinoma

Delangre, E., Oppliger, E., Berkcan, S., Gjorgjieva, M., de Sousa, M. C., & Foti, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911030 · Cited by 32

Naringenin Prevents Oxidative Stress and Inflammation in LPS-Induced Liver Injury through the Regulation of LncRNA-mRNA in Male Mice

Ji, M., Deng, Z., Rong, X., Li, R., You, Z., Guo, X., Cai, C., Zhao, Y., Gao, P., Cao, G., et al. (2022) · Molecules · doi:10.3390/molecules28010198 · Cited by 34

Biological characteristics of tissue engineered-nerve grafts enhancing peripheral nerve regeneration

Li, X., Xu, H., Li, C., Guan, Y., Liu, Y., Zhang, T., Meng, F., Cheng, H., Song, X., Jia, Z., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03827-9 · Cited by 34

S100a8/A9 proteins: critical regulators of inflammation in cardiovascular diseases

Sun, Y., Han, X., Gao, W., Deng, J., Song, X., Li, J., & Liu, X. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1394137 · Cited by 34

Spatial proteomic profiling elucidates immune determinants of neoadjuvant chemo-immunotherapy in esophageal squamous cell carcinoma

Wu, C., Zhang, G., Wang, L., Hu, J., Ju, Z., Tao, H., Li, Q., Li, J., Zhang, W., Sheng, J., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03123-z · Cited by 35

Diabetes and periodontitis: the role of a high-glucose microenvironment in periodontal tissue cells and corresponding therapeutic strategies

Xiang, D.-D., Sun, Y.-X., Chen, J., Guo, Y.-Q., Fei, Y.-X., Ren, B.-Q., He, X.-T., & Li, X. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04441-z · Cited by 34

Drug-resistance in rheumatoid arthritis: the role of p53 gene mutations, ABC family transporters and personal factors

Zhang, K. X., Ip, C. K., Chung, S. K., Lei, K. K., Zhang, Y. Q., Liu, L., & Wong, V. K. W. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.08.002 · Cited by 34

Sex differences at the platelet–vascular interface

Sabetta, A., Lombardi, L., & Stefanini, L. (2022) · Internal and Emergency Medicine · doi:10.1007/s11739-022-02994-y · Cited by 36

Neutrophil Extracellular Vesicles: A Delicate Balance between Pro-Inflammatory Responses and Anti-Inflammatory Therapies

Zhou, Y., & Bréchard, S. (2022) · Cells · doi:10.3390/cells11203318 · Cited by 33

Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis

El-Fattah, E. E. A., Michel, R., & Borahay, M. A. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.10.002 · Cited by 35

Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice

Jiang, Y. Y., Zhao, B., Pi, Q., Zhou, G., Cheng, Z., Qu, C., Wang, X., Kong, L., Luo, S., Du, D., et al. (2023) · Respiratory Research · doi:10.1186/s12931-023-02594-0 · Cited by 33

S100A8/A9 promotes endometrial fibrosis via regulating RAGE/JAK2/STAT3 signaling pathway

Xin, X., Liu, H., Zhang, S., Li, P., Zhao, X., Zhang, X., Li, S., Wu, S., Zhao, F., & Tan, J. (2024) · Communications Biology · doi:10.1038/s42003-024-05814-5 · Cited by 34

Robust identification of perturbed cell types in single-cell RNA-seq data

Nicol, P. B., Paulson, D., Qian, G., Liu, X. S., Irizarry, R. A., & Sahu, A. D. (2024) · Nature Communications · doi:10.1038/s41467-024-51649-3 · Cited by 35

Neutrophils and Neutrophil-Based Drug Delivery Systems in Anti-Cancer Therapy

Wahnou, H., El Kebbaj, R., Hba, S., Ouadghiri, Z., El Faqer, O., Pinon, A., Liagre, B., Limami, Y., & Duval, R. E. (2025) · Cancers · doi:10.3390/cancers17071232 · Cited by 35

Neutrophils and NETs in Pathophysiology and Treatment of Inflammatory Bowel Disease

Ortega-Zapero, M., Gómez-Bris, R., Pascual-Laguna, I., Saéz, Á., & González, J. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157098 · Cited by 41

S100A8 and S100A9 Promote Apoptosis of Chronic Eosinophilic Leukemia Cells

Lee, J.-S., Lee, N. R., Kashif, A., Yang, S.-J., Nam, A. R., Song, I., Gong, S.-J., Hong, M. H., Kim, G., Seok, P. R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01258 · Cited by 33

A proteome signature for acute incisional pain in dorsal root ganglia of mice

Pogatzki-Zahn, E. M., Gómez‐Varela, D., Erdmann, G., Kaschube, K., Segelcke, D., & Schmidt, M. (2021) · Pain · doi:10.1097/j.pain.0000000000002207 · Cited by 33

Key Genes Associated With Non-Alcoholic Fatty Liver Disease and Polycystic Ovary Syndrome

Chen, Y., Ma, L., Ge, Z., Pan, Y., & Xie, L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.888194 · Cited by 34

Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17/ IL ‐17 axis by activating PPARγ

Chen, Y., Song, S.-S., Wang, Y., Zhu, J., & Li, X. (2022) · Phytotherapy Research · doi:10.1002/ptr.7546 · Cited by 33

Metformin Mitigates Sepsis-Induced Acute Lung Injury and Inflammation in Young Mice by Suppressing the S100A8/A9-NLRP3-IL-1β Signaling Pathway

Fan, S., Zhao, Z.-C., Liu, X.-L., Peng, Y.-G., Zhu, H., Yan, S., Liu, Y., Xie, Q., Jiang, Y., & Zeng, S. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s460413 · Cited by 32

Elevated levels of damage-associated molecular patterns HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered monocyte activation are associated with inflammation in patients with myelofibrosis

Luca, G. D., Goette, N. P., Lev, P. R., Pietto, M. C. B., Oyarzún, C. P. M., Ríos, M. A. C., Moiraghi, B., Sackmann, F., Kamiya, L. J., Verri, V., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365015 · Cited by 32

Circadian Rhythm Disruption Aggravates DSS-Induced Colitis in Mice with Fecal Calprotectin as a Marker of Colitis Severity

Amara, J., Saliba, Y., Hajal, J., Smayra, V., Bakhos, J., Sayegh, R., & Farès, N. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05675-7 · Cited by 32

Plasma levels of S100A8/A9, histone/DNA complexes, and cell‐free DNA predict adverse outcomes of immune thrombotic thrombocytopenic purpura

Sui, J., Lu, R., Halkidis, K., Kocher, N. K., Cao, W., Marques, M. B., & Zheng, X. L. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15176 · Cited by 32

Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders

Nakamura, T., Oh, C.-K., Zhang, X., Tannenbaum, S. R., & Lipton, S. A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0081 · Cited by 33

Viral nanoparticle vaccines against S100A9 reduce lung tumor seeding and metastasis

Chung, Y. H., Ortega-Rivera, O. A., Volckaert, B. A., Jung, E., Zhao, Z., & Steinmetz, N. F. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221859120 · Cited by 31

Inflammation and Interferon Signatures in Peripheral B-Lymphocytes and Sera of Individuals With Fibromyalgia

Fineschi, S., Klar, J., Gustafsson, K. A., Jonsson, K., Karlsson, B., & Dahl, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.874490 · Cited by 31

Blockage of S100A8/A9 ameliorates septic nephropathy in mice

Shi, W., Wan, T., Li, H., & Guo, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1172356 · Cited by 31

Immunocompatible elastomer with increased resistance to the foreign body response

Zhou, X., Lu, Z., Cao, W., Zhu, Z., Chen, Y., Ni, Y., Liu, Z., Jia, F., Yang, Y., Han, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52023-z · Cited by 35

Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

Lim, C. L., Or, Y. Z., Ong, Z., Chung, H. H., Hayashi, H., Shrestha, S., Chiba, S., Lin, F., & Lin, V. C. L. (2020) · eLife · doi:10.7554/elife.57274 · Cited by 31

Bmal1 Regulates Macrophage Polarize Through Glycolytic Pathway in Alcoholic Liver Disease

Zhou, Y., Wu, M., Xu, L., Cheng, J., Shen, J., Yang, T., & Zhang, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.640521 · Cited by 30

The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age

Freire, P. P., Marques, A. H. C., Baiocchi, G. C., Schimke, L. F., Fonseca, D. L. M., Salgado, R. C., Filgueiras, I. S., Napoleão, S. M. D. S., Plaça, D. R., Akashi, K. T., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.147535 · Cited by 31

The regulatory effects of PTPN6 on inflammatory process: Reports from mice to men

Kiratikanon, S., Chattipakorn, S. C., Chattipakorn, N., & Kumfu, S. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109189 · Cited by 31

Tumor-Associated Macrophages in Canine Oral and Cutaneous Melanomas and Melanocytomas: Phenotypic and Prognostic Assessment

Porcellato, I., Sforna, M., Giudice, A. L., Bossi, I., Musi, A., Tognoloni, A., Chiaradia, E., Mechelli, L., & Brachelente, C. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.878949 · Cited by 31

Donkey whey proteins ameliorate dextran sulfate sodium-induced ulcerative colitis in mice by downregulating the S100A8-TRAF6-NF-κB axis-mediated inflammatory response

Li, M., Li, Q., Abdlla, R., Chen, J., Yue, X., & Quek, S. Y. (2023) · Food Science and Human Wellness · doi:10.1016/j.fshw.2023.02.045 · Cited by 31

Activation of distinct inflammatory pathways in subgroups of LR-MDS

Schneider, M., Rolfs, C., Trumpp, M., Winter, S., Fischer, L., Richter, M., Menger, V., Nenoff, K., Grieb, N., Metzeler, K. H., et al. (2023) · Leukemia · doi:10.1038/s41375-023-01949-2 · Cited by 32

S-100 Proteins: Basics and Applications as Biomarkers in Animals with Special Focus on Calgranulins (S100A8, A9, and A12)

Cerón, J. M. C., Ortín-Bustillo, A., López-Martínez, M. J., Martínez-Subiela, S., Eckersall, P. D., Tecles, F., Tvarijonaviciute, A., & Muñoz-Prieto, A. (2023) · Biology · doi:10.3390/biology12060881 · Cited by 31

Serum Calprotectin Is a Potential Marker in Patients with Asthma

Lee, Y.-G., Hong, J., Lee, P., Lee, J.-H., Park, S. W., Kim, D.-J., & Jang, A. (2020) · Journal of Korean Medical Science · doi:10.3346/jkms.2020.35.e362 · Cited by 30

Electric neurostimulation regulates microglial activation via retinoic acid receptor α signaling

Goldfarb, S., Fainstein, N., Ganz, T., Vershkov, D., Lachish, M., & Ben‐Hur, T. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.007 · Cited by 32

Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19

Chilunda, V., Martínez-Aguado, P., Xia, L. C., Cheney, L., Murphy, A., Veksler, V., Ruiz, V. Y., Calderon, T. M., & Berman, J. W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.665773 · Cited by 29

Comparative Immunogenomics of Canine Natural Killer Cells as Immunotherapy Target

Gingrich, A. A., Reiter, T. E., Judge, S. J., York, D. S., Yanagisawa, M., Razmara, A. M., Sturgill, I. R., Basmaci, U. N., Brady, R. V., Stoffel, K. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670309 · Cited by 30

Immune-Guided Therapy of COVID-19

Ferraccioli, G., Gremese, E., Goletti, D., Petrone, L., Cantini, F., Ugel, S., Canè, S., & Bronte, V. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0675 · Cited by 30

Carry-over effects of dry period heat stress on the mammary gland proteome and phosphoproteome in the subsequent lactation of dairy cows

Skibiel, A. L., Koh, J., Zhu, N., Zhu, F., Yoo, M., & Laporta, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-10461-z · Cited by 30

RAGE pathway activation and function in chronic kidney disease and COVID-19

Curran, C. S., & Kopp, J. B. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.970423 · Cited by 31

Immune cells and their derived microRNA-enriched extracellular vesicles in nonalcoholic fatty liver diseases: Novel therapeutic targets

Liu, Y., Hao, Y., Boeckmans, J., Rodrigues, R. M., & He, Y. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108353 · Cited by 30

Rapid adaptation to a novel pathogen through disease tolerance in a wild songbird

Henschen, A. E., Vinkler, M., Langager, M. M., Rowley, A. A., Dalloul, R. A., Hawley, D. M., & Adelman, J. S. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011408 · Cited by 30

Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023

Yılmaz, M. K., Abbaszadeh, A., Tarabichi, S., Azboy, İ., & Parvizi, J. (2023) · Antibiotics · doi:10.3390/antibiotics12061054 · Cited by 31

Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment

Khan, A. H., Chowers, I., & Lotery, A. J. (2023) · Cells · doi:10.3390/cells12131708 · Cited by 31

Full-length single-molecule protein fingerprinting

Filius, M., van Wee, R., de Lannoy, C., Westerlaken, I., Li, Z., Kim, S. H., de Agrela Pinto, C., Wu, Y., Boons, G.-J., Pabst, M., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-023-01598-7 · Cited by 30

Low-Intensity Pulsed Ultrasound: A Physical Stimulus with Immunomodulatory and Anti-inflammatory Potential

Liang, W., Liang, B., Yan, K., Zhang, G., Zhuo, J., & Cai, Y. (2024) · Annals of Biomedical Engineering · doi:10.1007/s10439-024-03523-y · Cited by 32

Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosacea

Chen, M., Yang, L. C., Zhou, P., Jin, S., Wu, Z. Q., Tan, Z., Xiao, W., Xu, S., Zhu, Y. N., Wang, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52946-7 · Cited by 33

The Role of Calprotectin in the Diagnosis and Treatment of Inflammatory Bowel Disease

Wang, W., Cao, W., Zhang, S., Chen, D., & Liu, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051996 · Cited by 33

S100A8 and S100A9 in saliva, blood and gingival crevicular fluid for screening established periodontitis: a cross-sectional study

Kim, H., Karna, S., Shin, Y., Vu, H., Cho, H., & Kim, S. (2021) · BMC Oral Health · doi:10.1186/s12903-021-01749-z · Cited by 29

A protein microarray analysis of amniotic fluid proteins for the prediction of spontaneous preterm delivery in women with preterm premature rupture of membranes at 23 to 30 weeks of gestation

Kim, H. J., Park, K. H., Kim, Y. M., Joo, E., Ahn, K., & Shin, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0244720 · Cited by 29

Role of RAGE and Its Ligands on Inflammatory Responses to Brain Tumors

Otazu, G. K., Dayyani, M., & Badie, B. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.770472 · Cited by 29

Somatic mutations alter the differentiation outcomes of iPSC-derived neurons

Puigdevall, P., Jerber, J., Danecek, P., Castellano, S., & Kilpinen, H. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100280 · Cited by 29

Looking to the Future of the Role of Macrophages and Extracellular Vesicles in Neuroinflammation in ALS

Carata, E., Muci, M., Giulio, S. D., Mariano, S., & Panzarini, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411251 · Cited by 30

Neonatal Antibiotic Treatment Is Associated With an Altered Circulating Immune Marker Profile at 1 Year of Age

Oosterloo, B. C., Land, B. V., de Jager, W., Rutten, N. B. M. M., Klöpping, M., Garssen, J., Vlieger, A. M., & van Elburg, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02939 · Cited by 29

Darier’s disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour

Amar, Y., Rogner, D. F., Silva, R. L., Foesel, B. U., Ud‐Dean, M., Lagkouvardos, I., Steimle‐Grauer, S. A., Niedermeier, S., Kublik, S., Jargosch, M., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01587-x · Cited by 28

CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients

Hernández-Cedeño, M., Venegas-Rodriguez, R., Peña-Ruiz, R., Béquet‐Romero, M., Santana-Sanchez, R., Pentón‐Arias, E., Martínez-Donato, G., Guillén, G. E., & Domínguez-Horta, M. D. C. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01197-2 · Cited by 28

DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils

Loh, J. T., Lee, K.-G., Lee, A., Teo, J. K. H., Lim, H. L., Kim, S. S.-Y., Tan, A. H., & Lam, K. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04357-5 · Cited by 28

S100A9 induces reactive oxygen species-dependent formation of neutrophil extracellular traps in abdominal sepsis

Du, F., Ding, Z., Rönnow, C.-F. F., Rahman, M., Șchiopu, A., & Thorlacius, H. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113405 · Cited by 28

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

Fan, Y., Lyu, P., Bi, R., Cui, C., Xu, R., Rosen, C. J., Yuan, Q., & Zhou, C. (2023) · eLife · doi:10.7554/elife.82537 · Cited by 30

Single-Cell Transcriptomics Reveals Immune Reconstitution in Patients with R/R T-ALL/LBL Treated with Donor-Derived CD7 CAR-T Therapy

Chen, W., Shi, H., Liu, Z., Yang, F., Liu, J., Zhang, L., Wu, Y., Xia, Y., Ou, Y., Li, R., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2924 · Cited by 28

Integrative proteomic profiling of lung tissues and blood in acute respiratory distress syndrome

Gong, R., Luo, H., Long, G., Xu, J., Huang, C., Zhou, X., Shang, Y., & Zhang, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1158951 · Cited by 27

Relationship of S100 Proteins with Neuroinflammation

García‐Domínguez, M. (2025) · Biomolecules · doi:10.3390/biom15081125 · Cited by 27

The roles of S100A8/A9 and S100A12 in autoimmune diseases: Mechanisms, biomarkers, and therapeutic potential

Wang, X., Luo, Y., Zhou, Q., & Ma, J. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103920 · Cited by 27

Emerging molecular biomarkers for predicting therapy response in psoriatic arthritis: A review of literature

Pouw, J. N., Leijten, E. F. A., Radstake, T. R. D. J., & Boes, M. L. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.108318 · Cited by 26

BRG1 Stimulates Endothelial Derived Alarmin MRP8 to Promote Macrophage Infiltration in an Animal Model of Cardiac Hypertrophy

Li, Z., Zhang, Y., Zhang, Y., Yu, L., Xiao, B., Li, T., Kong, X., & Xu, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00569 · Cited by 27

OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia

Sun, P., Vu, R., Dragan, M., Haensel, D., Gutierrez, G., Nguyen, Q., Greenberg, E. N., Chen, Z., Wu, J., Atwood, S. X., et al. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.10.025 · Cited by 27

Serum calprotectin as new biomarker for disease severity in idiopathic pulmonary fibrosis: a cross-sectional study in two independent cohorts

Machahua, C., Guler, S. A., Horn, M. P., Planas‐Cerezales, L., Montes‐Worboys, A., Geiser, T., Molina‐Molina, M., & Funke-Chambour, M. (2021) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2020-000827 · Cited by 27

Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution

Ong, E. Z., Kalimuddin, S., Chia, W. C., Ooi, S. H., Koh, C. W., Tan, H. C., Zhang, S. L.-X., Low, J. G. H., Ooi, E. E., & Chan, K. R. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103262 · Cited by 25

S100A8/A9: From basic science to clinical application

Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 463

Inflammatory role of S100A8/A9 in the central nervous system non-neoplastic diseases

Tian, Q., Li, Z., Yan, Z., Jiang, S., Zhao, X., Wang, L., & Li, M. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111100 · Cited by 19

S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity

Nacken, W. K. F., Roth, J., Sorg, C., & Kerkhoff, C. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10299 · Cited by 346

S100A8 and S100A9–Critical Mediators of Inflammation in Arthritis

Paramasivam, S., Selvan, P. S., & Ekambaram, S. P. (2025) · Current Proteomics · doi:10.2174/0115701646347924241111071800 · Cited by 2

S100A8 and S100A9 in Cancer

Chen, Y., Ouyang, Y., Li, Z., Wang, X., & Ma, J. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188891 · Cited by 165