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S100A8/A9 in Inflammation
Open accessAbstract
S100A8 and S100A9 (also known as MRP8 ang MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.
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“Importantly, S100A8/A9 has been recognized as both a biomarker of colitis and a promoter of inflammation-associated tumorigenesis [16–18].”
From Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis (2026) · cites this paper as [16]
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“Moreover, S100A8/A9 has been shown to potentiate NF-κB signaling activation [16].”
From Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis (2026) · cites this paper as [16]
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“It is predominantly secreted by monocytes, macrophages, and neutrophils, serving as a key amplifier of inflammatory responses [16].”
From Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis (2026) · cites this paper as [16]
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Metadata
- Authors
- Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J.
- Affiliations
- Central South University (CN)
- Corresponding author
- Ma, Jian
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2018-06-11
- Volume
- 9
- Pages
- 1298-1298
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6004386
- OpenAlex
- W2808305854
- Cited by
- 1,450
- References
- 165
- Citations by year
- 2026: 176 · 2025: 217 · 2024: 248 · 2023: 225 · 2022: 236 · 2021: 184 · 2020: 119 · 2019: 40 · 2018: 4
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81672889, 81472694)
- Hunan Provincial Science and Technology Department (2016JC2035)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- S100A8/A9, S-100 protein, heterodimer, calcium-binding proteins, inflammation, neutrophils, monocytes, leukocyte recruitment, cytokine production, arachidonic acid metabolism, biomarkers, therapeutic target, small molecule inhibitors
- MeSH terms
- Animals, Disease Susceptibility, Gene Expression Regulation, Humans, Immunity, Inflammation, Biomarkers, Autoimmunity, Protein Transport, Calgranulin A, Calgranulin B, Host-Pathogen Interactions, Molecular Targeted Therapy
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