S100A8/A9 in Inflammation

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · cited 2×

Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion

Ryckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 861

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

Corbin, B. D., Seeley, E. H., Raab, A., Feldmann, J., Miller, M. R., Torres, V. J., Anderson, K. L., Dattilo, B. M., Dunman, P. M., Gerads, R., et al. (2008) · Science · doi:10.1126/science.1152449 · Cited by 857

Nutritional immunity beyond iron: a role for manganese and zinc

Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

Nagareddy, P. R., Kraakman, M. J., Masters, S. L., Stirzaker, R. A., Gorman, D. J., Grant, R. W., Dragoljevic, D., Hong, E. S., Abdel‐Latif, A., Smyth, S. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.029 · Cited by 530

Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin

Steinbakk, M., Naess-Andresen, C. F., Fagerhol, M. K., Lingaas, E., Dale, I., & Brandtzaeg, P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93237-j · Cited by 512

Inflammation – Cause or Consequence of Heart Failure or Both?

Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 484

S100A8/A9: From basic science to clinical application

Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 463

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., et al. (2008) · Diabetes · doi:10.2337/db07-1808 · Cited by 407

S100A9 Activates the Immunosuppressive Switch Through the PI3K/Akt Pathway to Maintain the Immune Suppression Function of Testicular Macrophages

Fan, Z., Peng, M. L., Chen, Y. Y., Xia, Y., Liu, C. Y., Zhao, K., & Zhang, H. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.743354 · Cited by 27

Identification of COVID-19-Specific Immune Markers Using a Machine Learning Method

Li, H., Huang, F., Liao, H., Li, Z., Feng, K., Huang, T., & Cai, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.952626 · Cited by 27

The Receptor for Advanced Glycation Endproducts (RAGE) and Its Ligands S100A8/A9 and High Mobility Group Box Protein 1 (HMGB1) Are Key Regulators of Myeloid-Derived Suppressor Cells

Ostrand‐Rosenberg, S., Huecksteadt, T. P., & Sanders, K. A. (2023) · Cancers · doi:10.3390/cancers15041026 · Cited by 29

Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota

Sabui, S., Skupsky, J., Kapadia, R., Cogburn, K., Lambrecht, N. W. G., Agrawal, A., & Said, H. M. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00172.2019 · Cited by 28

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and RejuvenationPreprint

Tyshkovskiy, A., Kholdina, D., Ying, K., Davitadze, M., Molière, A., Tongu, Y., Kasahara, T., Kats, L., Vladimirova, A., Moldakozhayev, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.04.601982 · Cited by 32

Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72

Chai, N., Haney, M. S., Couthouis, J., Morgens, D. W., Benjamin, A., Wu, K., Ousey, J., Fang, S., Finer, S., Bassik, M. C., et al. (2020) · Brain Research · doi:10.1016/j.brainres.2019.146601 · Cited by 26

S100A8 and S100A9, both transcriptionally regulated by PU.1, promote epithelial-mesenchymal transformation (EMT) and invasive growth of dermal keratinocytes during scar formation post burn

Xu, Z., Cheng, C., Kong, R., Liu, Y., Wang, S., Ma, Y., & Xing, X. (2021) · Aging · doi:10.18632/aging.203112 · Cited by 26

Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis

Tanaka, K., Enomoto, N., Hozumi, H., Isayama, T., Naoi, H., Aono, Y., Katsumata, M., Yasui, H., Karayama, M., Suzuki, Y., et al. (2021) · Respiratory Investigation · doi:10.1016/j.resinv.2021.05.008 · Cited by 26

Comparative Transcriptome Analysis of the Expression of Antioxidant and Immunity Genes in the Spleen of a Cyanidin 3-O-Glucoside-Treated Alzheimer’s Mouse Model

Jaiswal, V. K., Park, M., & Lee, H. (2021) · Antioxidants · doi:10.3390/antiox10091435 · Cited by 26

Lipocalin-2, S100A8/A9, and cystatin C: Potential predictive biomarkers of cardiovascular complications in COVID-19

Gupta, A., Al‐Tamimi, A. O., Halwani, R., AlSaidi, H., Kannan, M., & Ahmad, F. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221091990 · Cited by 26

PE_PGRS31-S100A9 Interaction Promotes Mycobacterial Survival in Macrophages Through the Regulation of NF-κB-TNF-α Signaling and Arachidonic Acid Metabolism

Liu, S., Xie, Y., Luo, W., Dou, Y., Xiong, H., Xiao, Z., & Zhang, X. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00845 · Cited by 26

The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions

Salgar, S., Bolívar, B. E., Flanagan, J. M., Anum, S. J., & Bouchier‐Hayes, L. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.011 · Cited by 28

Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Chen, Y., Smith, M. K., Ying, Y.-L., Makridakis, M., Noonan, J. E., Kanellakis, P., Rai, A., Salim, A., Murphy, A. J., Bobik, A., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04641-4 · Cited by 25

Achilles’ Heel—The Significance of Maintaining Microenvironmental Homeostasis in the Nucleus Pulposus for Intervertebral Discs

Luo, Z., Wei, Z., Zhang, G., Chen, H., Li, L., & Kang, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316592 · Cited by 25

S100A9 exacerbates sepsis-induced acute lung injury via the IL17-NFκB-caspase-3 signaling pathway

Pei, H., Chen, J., Qu, J., & Lu, Z. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149832 · Cited by 25

Proteomics of plasma-derived extracellular vesicles reveals S100A8 as a novel biomarker for Alzheimer's disease: A preliminary study

Zhang, Y., Yuan, Z. K., Zhang, J., Gao, Y., Gao, X., Li, S., Cui, C., & Yang, G. (2024) · Journal of Proteomics · doi:10.1016/j.jprot.2024.105279 · Cited by 26

Single‐cell transcriptome atlas revealed bronchoalveolar immune features related to disease severity in pediatric Mycoplasma pneumoniae pneumonia

Shen, X., Jin, Z., Chen, X., Wang, Z., Lu, Y., Ou, Y., Gong, L., Zhu, C., Xu, G., & Wang, Y. (2024) · MedComm · doi:10.1002/mco2.748 · Cited by 28

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Jones, E. J., Matthews, Z. J., Gul, L., Sudhakar, P., Treveil, A., Divekar, D. P., Buck, J., Wrzesiński, T., Jefferson, M. A., Armstrong, S. D., et al. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.037069 · Cited by 25

Fc-gamma receptors and S100A8/A9 cause bone erosion during rheumatoid arthritis. Do they act as partners in crime?

Ceglie, I. D., Kruisbergen, N., van den Bosch, M. V. D., & van Lent, P. V. (2019) · Rheumatology · doi:10.1093/rheumatology/kez218 · Cited by 20

Calprotectin (S100A8/S100A9)-induced cytotoxicity and apoptosis in human gastric cancer AGS cells: Alteration in expression levels of Bax, Bcl-2, and ERK2

Shabani, F., Mahdavi, M., Imani, M., Feizi, M. A. H., & Gheibi, N. (2020) · Human & Experimental Toxicology · doi:10.1177/0960327120909530 · Cited by 25

S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation

Viemann, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00688 · Cited by 23

Tobacco Smoke Exposure Exacerbated Crystalline Silica-Induced Lung Toxicity in Rats

Sager, T. M., Umbright, C., Mustafa, G. M., Yanamala, N. V. K., Leonard, H. D., McKinney, W., Kashon, M. L., & Joseph, P. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa146 · Cited by 25

Multi-Omics Identifies Circulating miRNA and Protein Biomarkers for Facioscapulohumeral Dystrophy

Heier, C. R., Zhang, A., Nguyen, N., Tully, C., Panigrahi, A. K., Gordish‐Dressman, H., Pandey, S. N., Guglieri, M., Ryan, M. M., Clemens, P. R., et al. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040236 · Cited by 25

S100A8 Promotes Inflammation via Toll-Like Receptor 4 After Experimental Traumatic Brain Injury

He, G., Zhao, C., Wu, D.-G., Cheng, H., Sun, L., Zhang, D., Yang, X., Fan, X.-R., Di, G., & Jiang, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.616559 · Cited by 25

Stratum corneum levels of calprotectin proteins S100A8/A9 correlate with disease activity in psoriasis patients

Matsunaga, Y., Hashimoto, Y., & Ishiko, A. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.16032 · Cited by 25

Intestinal epithelial glucocorticoid receptor promotes chronic inflammation–associated colorectal cancer

Tang, S., Zhang, Z., Oakley, R., Li, W., He, W.-J., Xu, X.-J., Ji, M., Xu, Q., Chen, L., Wellman, A. S., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.151815 · Cited by 18

scTenifoldXct: A semi-supervised method for predicting cell-cell interactions and mapping cellular communication graphs

Yang, Y., Li, G., Zhong, Y., Xu, Q., Lin, Y.-T., Roman-Vicharra, C., Chapkin, R. S., & Cai, J. J. (2023) · Cell Systems · doi:10.1016/j.cels.2023.01.004 · Cited by 26

Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling

Liu, F., Lü, Y., Wang, X., Sun, S., Pan, H., Wang, M., Wang, Z., Zhang, W., Ma, S., Sun, G., et al. (2023) · Protein & Cell · doi:10.1093/procel/pwad060 · Cited by 25

S100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function

Tu, X., Chen, L., Zheng, Y., Mu, C., Zhang, Z., Wang, F., Ren, Y., Duan, Y., Zhang, H., Tong, Z., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-02985-1 · Cited by 23

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Nunes, J. M., Vlok, M., Proal, A. D., Kell, D. B., & Pretorius, E. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02315-x · Cited by 24

An overview of S100 proteins and their functions in skin homeostasis, interface dermatitis conditions and other skin pathologies

Abdi, W., Romasco, A., Alkurdi, D., Santacruz, E., Okinedo, I., Zhang, Y., Kannan, S., Shakiba, S., & Richmond, J. M. (2024) · Experimental Dermatology · doi:10.1111/exd.15158 · Cited by 27

Dysfunctional CD11c − CD21 − extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer

Ruffin, A. T., Casey, A. N., Kunning, S. R., MacFawn, I., Liu, Z., Arora, C., Rohatgi, A., Kemp, F., Lampenfeld, C., Somasundaram, A., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adh1315 · Cited by 24

Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis

Sun, Z., Ye, J., Sun, W. J., Jiang, L., Shan, B., Zhang, M., Xu, J., Li, W., Liu, J., Jing, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57211-z · Cited by 24

Proteomic assessment of serum biomarkers of longevity in older men

ORWOLL, E. S., Wiedrick, J. T., Nielson, C. M., Jacobs, J., Baker, E. S., Piehowski, P., Petyuk, V., Gao, Y., Shi, T., Smith, R. D., et al. (2020) · Aging Cell · doi:10.1111/acel.13253 · Cited by 21

Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1–3 and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 in Whole Blood Cultures of Patients With Rheumatoid Arthritis

Balog, A., Varga, B., Fülöp, F., Lantos, I., Toldi, G., Vécsei, L., & Mándi, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632513 · Cited by 24

Diagnosing pleural effusions using mass spectrometry-based multiplexed targeted proteomics quantitating mid- to high-abundance markers of cancer, infection/inflammation and tuberculosis

Robak, A., Kistowski, M., Wojtas, G., Perzanowska, A., Targowski, T., Michalak, A., Krasowski, G., Dadlez, M., & Domański, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-06924-y · Cited by 25

Proteomic analysis of plasma exosomes in patients with non-small cell lung cancer

Bao, M., Huang, Y., Lang, Z., Zhao, H., Saito, Y., Nagano, T., Kawagoe, I., Divisi, D., Hu, X., & Jiang, G. (2022) · Translational Lung Cancer Research · doi:10.21037/tlcr-22-467 · Cited by 24

Black Ginseng Ameliorates Cellular Senescence via p53-p21/p16 Pathway in Aged Mice

Lee, S., Lee, D., O’Connell, J. F., Egan, J. M., & Kim, Y. (2022) · Biology · doi:10.3390/biology11081108 · Cited by 24

Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non‐Inflammatory Arthritis Periprosthetic Joint Infection: A Meta‐analysis and Systematic Review

Tang, H., Xu, J., Yuan, W., Wang, Y., Yue, B., & Qu, X. (2022) · Orthopaedic Surgery · doi:10.1111/os.13500 · Cited by 26

Single-cell multi-omics topic embedding reveals cell-type-specific and COVID-19 severity-related immune signatures

Zhou, M., Zhang, H., Bai, Z., Mann‐Krzisnik, D., Wang, F., & Li, Y. (2023) · Cell Reports Methods · doi:10.1016/j.crmeth.2023.100563 · Cited by 24

High S100A9 level predicts poor survival, and the S100A9 inhibitor paquinimod is a candidate for treating idiopathic pulmonary fibrosis

Miura, S., Iwamoto, H., Namba, M., Yamaguchi, K., Sakamoto, S., Horimasu, Y., Masuda, T., Miyamoto, S., Nakashima, T., Ohshimo, S., et al. (2024) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2023-001803 · Cited by 25

S100A8 ‐enriched microglia populate the brain of tau‐seeded and accelerated aging mice

Gruel, R., Bijnens, B., Daele, J. V. D., Thys, S., Willems, R., Wuyts, D., Dam, D. V., Verstraelen, P., Verboven, R., Roels, J., et al. (2024) · Aging Cell · doi:10.1111/acel.14120 · Cited by 24

Extensive Changes in Transcriptomic “Fingerprints” and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis

Brusletto, B. S., Løberg, E. M., Hellerud, B. C., Goverud, I. L., Berg, J. P., Olstad, O. K., Gopinathan, U., Brandtzaeg, P., & Øvstebø, R. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00042 · Cited by 24

Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitis

Wang, Y., Guan, Y., Feng, D., Maccioni, L., Parra, M. A., Peiffer, B., Mackowiak, B., Kuwabara, T., Mori, K., Mukoyama, M., et al. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01343-1 · Cited by 23

Lack of FAM20A, Ectopic Gingival Mineralization and Chondro/Osteogenic Modifications in Enamel Renal Syndrome

Escorcia, V. H. S., Diarra, A., Naveau, A., Dessombz, A., Felizardo, R., Cannaya, V., Chatziantoniou, C., Quentric, M., Vikkula, M., Cases, O., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.605084 · Cited by 23

Neutrophil degranulation interconnects over-represented biological processes in atrial fibrillation

Kawasaki, M., Meulendijks, E. R., van den Berg, N. W. E., Nariswari, F. A., Neefs, J., Wesselink, R., Baalman, S. W. E., Jongejan, A., Schelfhorst, T., Piersma, S. R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-82533-5 · Cited by 24

Gut microbes shape microglia and cognitive function during malnutrition

Bauer, K. C., York, E. M., Cirstea, M. S., Radisavljevic, N., Petersen, C., Huus, K. E., Brown, E., Bozorgmehr, T., Berdún, R., Bernier, L., et al. (2022) · Glia · doi:10.1002/glia.24139 · Cited by 26

A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

Gilbertie, J. M., Schaer, T. P., Engiles, J. B., Seiler, G. S., Deddens, B. L., Schubert, A. G., Jacob, M. E., Stefanovski, D., Ruthel, G. T., Hickok, N. J., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.895022 · Cited by 23

The RAGE/multiligand axis: a new actor in tumor biology

Armando Rojas, R., Schneider, I., Lindner, C., González, I., & Morales, M. A. (2022) · Bioscience Reports · doi:10.1042/bsr20220395 · Cited by 24

Serum S100A8/A9 concentrations are associated with neuropsychiatric involvement in systemic lupus erythematosus: a cross-sectional study

Zervides, K. A., Jern, A., Nystedt, J., Gullstrand, B., Nilsson, P. C., Sundgren, P. C., Bengtsson, A. A., & Jönsen, A. (2022) · BMC Rheumatology · doi:10.1186/s41927-022-00268-w · Cited by 23

A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: a therapeutic approach to inflammation

Domínguez-Horta, M. D. C., Díaz, A. S., Hernández-Cedeño, M., Martínez‐Donato, G., & Guillén, G. E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1162739 · Cited by 28

Advances in the study of S100A9 in cardiovascular diseases

Chen, F., He, Z., Wang, C., Si, J., Zhu, C., & Guo, Y. (2024) · Cell Proliferation · doi:10.1111/cpr.13636 · Cited by 23

Short-Term Effects of Sepsis and the Impact of Aging on the Transcriptional Profile of Different Brain Regions

Hamasaki, M. Y., Severino, P., Puga, R., Koike, M. K., Hernandes, C., Barbeiro, H. V., Barbeiro, D. F., Machado, M. C. C., Reis, E. M. R., & da Silva, F. P. (2019) · Inflammation · doi:10.1007/s10753-019-00964-9 · Cited by 23

On the surface

DeVore, S. B., Gonzalez, T., Sherenian, M. G., Herr, A. B., & Hershey, G. K. K. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.08.025 · Cited by 24

Heterogeneity of immune cells and their communications unveiled by transcriptome profiling in acute inflammatory lung injury

Kang, Z.-Y., Huang, Q.-Y., Zhen, N.-X., Xuan, N., Zhou, Q., Zhao, J., Cui, W., Zhang, Z., & Tian, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1382449 · Cited by 22

S100A8-Mediated Inflammatory Signaling Drives Colorectal Cancer Progression via the CXCL5/CXCR2 Axis

Chen, L., Shu, P., Zhang, X., Ye, S., Tian, L., Shen, S., Ma, J., Ai, F., & Li, X. (2024) · Journal of Cancer · doi:10.7150/jca.92588 · Cited by 23

Blood calprotectin as a biomarker for infection and sepsis – the prospective CASCADE trial

Diehl-Wiesenecker, E., Galtung, N., Dickescheid, J., Prpic, M., Somasundaram, R., Kappert, K., & Bauer, W. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-09394-x · Cited by 22

Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma

Macowan, M. G., Pattaroni, C., Bonner, K., Chatzis, R., Daunt, C., Gore, M. L., Čustović, A., Shields, M. D., Power, U. F., Grigg, J., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.08.017 · Cited by 22

Breaking Barriers: Candidalysin Disrupts Epithelial Integrity and Induces Inflammation in a Gut-on-Chip Model

Morelli, M., & Queiroz, K. C. S. (2025) · Toxins · doi:10.3390/toxins17020089 · Cited by 25

The roles of neutrophils in cardiovascular diseases

Lian, Y., Lai, X., Wu, C., Wang, L., Shang, J., Zhang, H., Jia, S., Xing, W., & Liu, H. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1526170 · Cited by 25

Discovery of plasma biomarkers with data‐independent acquisition mass spectrometry and antibody microarray for diagnosis and risk stratification of pulmonary embolism

Han, B., Li, C., Li, H., Li, Y., Luo, X., Liu, Y., Zhang, J., Zhang, Z., Yu, X., Zhai, Z., et al. (2021) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15324 · Cited by 22

Fpr2/CXCL1/2 Controls Rapid Neutrophil Infiltration to Inhibit Streptococcus agalactiae Infection

Sun, Z., Huang, W., Zheng, Y., Liu, P., Yang, W., Guo, Z., Kong, D., Lv, Q., Zhou, X., Du, Z., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.786602 · Cited by 23

Multi-omics approach to COVID-19: a domain-based literature review

Montaldo, C., Messina, F., Abbate, I., Antonioli, M., Bordoni, V., Aiello, A., Ciccosanti, F., Colavita, F., Farroni, C., Fard, S. N., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03168-8 · Cited by 21

Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing

Zhao, P., Zou, J., Zhou, F., Zhu, Y., Song, Q., Yu, D., & Li, X. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108767 · Cited by 21

Pharmacological and Pathological Relevance of S100 Proteins in Neurological Disorders

Goswami, D., Anuradha, U., Angati, A., Kumari, N., & Singh, R. K. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666221128160653 · Cited by 22

Changes in Proteins in Saliva and Serum in Equine Gastric Ulcer Syndrome Using a Proteomic Approach

Muñoz-Prieto, A., Contreras-Aguilar, M. D., Cerón, J. M. C., Ayala, I., Cuervo, M. M., González‐Sánchez, J. C., Jacobsen, S. E., Kuleš, J., Beletić, A. D., Rubić, I., et al. (2022) · Animals · doi:10.3390/ani12091169 · Cited by 22

Correspondence analysis for dimension reduction, batch integration, and visualization of single-cell RNA-seq data

Hsu, L. L., & Culhane, A. C. (2023) · Scientific Reports · doi:10.1038/s41598-022-26434-1 · Cited by 28

S100A9 as a Key Myocardial Injury Factor Interacting with ATP5 Exacerbates Mitochondrial Dysfunction and Oxidative Stress in Sepsis-Induced Cardiomyopathy

Pei, H., Qu, J., Chen, J., Zhao, G., & Lu, Z. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s457340 · Cited by 21

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Jin, H., Li, Z., Tan, S., Xiao, Q., Li, Q., Ye, J., Zhou, Y., Wan, Y., Liu, Q., Menon, B. K., et al. (2025) · Advanced Science · doi:10.1002/advs.202503722 · Cited by 24

Post-Aire Medullary Thymic Epithelial Cells and Hassall’s Corpuscles as Inducers of Tonic Pro-Inflammatory Microenvironment

Laan, M., Salumets, A., Klein, A., Reintamm, K., Bichele, R., Peterson, H., & Peterson, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635569 · Cited by 19

Small Extracellular Vesicles Propagate the Inflammatory Response After Trauma

Seibold, T., Schönfelder, J., Weeber, F., Lechel, A., Armacki, M., Waldenmaier, M., Wille, C., Palmer, A., Halbgebauer, R., Karasu, E., et al. (2021) · Advanced Science · doi:10.1002/advs.202102381 · Cited by 21

A reference genome for the critically endangered woylie, Bettongia penicillata ogilbyi

Peel, E., Silver, L. W., Brandies, P. A., Hogg, C. J., & Belov, K. (2021) · Gigabyte · doi:10.46471/gigabyte.35 · Cited by 20

The Innate Immune Protein Calprotectin Interacts With and Encases Biofilm Communities of Pseudomonas aeruginosa and Staphylococcus aureus

Baishya, J., Everett, J. A., Chazin, W., Rumbaugh, K. P., & Wakeman, C. A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.898796 · Cited by 24

The Relationship between Diabetes Mellitus and Pancreatic Cancer—Diabetes Mellitus as a Red Flag for Pancreatic Cancer

Popovic, K., Smolović, B., Martinović, M., & Vučković, L. (2023) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-22-0951 · Cited by 22

CD74 Promotes a Pro-Inflammatory Tumor Microenvironment by Inducing S100A8 and S100A9 Secretion in Pancreatic Cancer

Hong, W. C., Lee, D. E., Kang, H. W., Kim, M., Kim, M., Kim, J. H., Fang, S., Kim, H. J., & Park, J. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612993 · Cited by 22

S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion

Zhang, Y., Song, Y., Du, J., Liu, W., Dong, C., Huang, Z., Zhang, Z., Liu, Y., Wang, T., Xiong, S., et al. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad030 · Cited by 21

S100A9 is a functional effector of infarct wall thinning after myocardial infarction

Chalise, U., Becirovic‐Agic, M., Daseke, M. J., Konfrst, S. R., Rodriguez‐Paar, J. R., Feng, D., Salomon, J., Anderson, D. R., Cook, L. M., & Lindsey, M. L. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00475.2021 · Cited by 21

Serum S100A8/A9 and MMP-9 levels are elevated in systemic lupus erythematosus patients with cognitive impairment

Muñoz‐Grajales, C., Barraclough, M. L., Díaz-Martínez, J. P., Su, J., Bingham, K. S., Kakvan, M., Kretzmann, R. P., Tartaglia, M. C., Ruttan, L., Choi, M. Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1326751 · Cited by 20

Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution

Hong, N. E., Chaplin, A. M. L., Di, L., Ravodina, A. M., Bevan, G. H., Gao, H., Asase, C., Gangwar, R. S., Cameron, M. J., Mignery, M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114911 · Cited by 20

Protective Effect of Traditional Chinese Medicine Formula RP on Lung Microenvironment in Pre-Metastasis Stage of Breast Cancer

Ye, Y., Pei, L., Wu, C., & Liu, S. (2019) · Integrative Cancer Therapies · doi:10.1177/1534735419876341 · Cited by 20

miRNAs Regulate Cytokine Secretion Induced by Phosphorylated S100A8/A9 in Neutrophils

Jung, N., Schenten, V., Bueb, J., Tolle, F., & Bréchard, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225699 · Cited by 20

Acute Systemic Inflammatory Response Alters Transcription Profile of Genes Related to Immune Response and Ca2+ Homeostasis in Hippocampus; Relevance to Neurodegenerative Disorders

Czapski, G. A., Zhao, Y., Lukiw, W. J., & Strosznajder, J. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217838 · Cited by 20

MDS-associated SF3B1 mutations enhance proinflammatory gene expression in patient blast cells

Pollyea, D. A., Kim, H. M., Stevens, B. M., Lee, F. F.-Y., Harris, C., Hedin, B. R., Knapp, J. R., O’Connor, B. P., Jordan, C. T., Pietras, E. M., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.6ab0520-318rr · Cited by 20

GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice

Efimova, I., Steinberg, I., Zvibel, I., Neumann, A., Mantelmacher, F. D., Drucker, D. J., Fishman, S., & Varol, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643144 · Cited by 20

Role of mTOR in the Development of Asthma in Mice With Cigarette Smoke-Induced Cellular Senescence

Lee, H. S., & Park, H. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab303 · Cited by 20

Transcriptomic Analysis Identifies Differentially Expressed Genes Associated with Vascular Cuffing and Chronic Inflammation Mediating Early Thrombosis in Arteriovenous Fistula

Rai, V., & Agrawal, D. K. (2022) · Biomedicines · doi:10.3390/biomedicines10020433 · Cited by 20

The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19

Bagheri‐Hosseinabadi, Z., Abbasi, M., Kahnooji, M., Ghorbani, Z., & Abbasifard, M. (2022) · Inflammation Research · doi:10.1007/s00011-022-01545-7 · Cited by 21

Salivary Proteomics Reveals Significant Changes in Relation to Alzheimer’s Disease and Aging

Contini, C., Serrao, S., Manconi, B., Olianas, A., Iavarone, F., Bizzarro, A., Masullo, C., Castagnola, M., Messana, I., Diaz, G., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220246 · Cited by 19

The effects of photobiomodulation therapy on inflammatory mediators, immune infiltration, and angiogenesis in a mouse model of rosacea

Wu, S., Su, Y., Wang, L., Sun, B., & Jiang, X. L. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3204 · Cited by 20

Portulaca oleracea alleviates CCl4-induced acute liver injury by regulating hepatic S100A8 and S100A9

Qian, A., Zhou, L., Shi, D., Pang, Z., & Lu, B. (2022) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2022.05.004 · Cited by 20

Myeloid-Derived Suppressor Cells: New Insights into the Pathogenesis and Therapy of MDS

Velegraki, M., Stiff, A. R., Papadaki, H. Α., & Li, Z. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11164908 · Cited by 20

Plasma Calprotectin Levels Associate with Suspected Metabolic-Associated Fatty Liver Disease and All-Cause Mortality in the General Population

Bourgonje, A. R., van den Berg, E. H., Kieneker, L. M., Nilsen, T. I. L., Hidden, C., Bakker, S. J. L., Blokzijl, H., Dullaart, R. P. F., van Goor, H., & Abdulle, A. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415708 · Cited by 20

Toward an understanding of the conformational plasticity of S100A8 and S100A9 Ca2+-binding proteins

Polakowska, M., Steczkiewicz, K., Szczepanowski, R. H., & Wysłouch‐Cieszyńska, A. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102952 · Cited by 20

Integrated Proteomics and Metabolomics Analysis to Explore the Amelioration Mechanisms of Rosa roxburghii Tratt Fruit Polyphenols on Lipopolysaccharide-Induced Acute Lung Injury Mice

Tang, L., Zhang, S., Zhang, M., Wang, P., Liang, G., & Gao, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04344 · Cited by 20

Role of Coxsackievirus B3-Induced Immune Responses in the Transition from Myocarditis to Dilated Cardiomyopathy and Heart Failure

Yip, F., Lai, B., & Yang, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097717 · Cited by 22

Predicting diagnostic biomarkers associated with immune infiltration in Crohn's disease based on machine learning and bioinformatics

Bao, W., Wang, L., Liu, X., & Li, M. (2023) · European journal of medical research · doi:10.1186/s40001-023-01200-9 · Cited by 21

Proteomics-Based Detection of Immune Dysfunction in an Elite Adventure Athlete Trekking Across the Antarctica

Nieman, D. C., Groen, A. J., Pugachev, A., Simonson, A. J., Polley, K. R., James, K., El‐Khodor, B. F., Varadharaj, S., & Hernández-Armenta, C. I. (2020) · Proteomes · doi:10.3390/proteomes8010004 · Cited by 20

Cathelicidin and Calprotectin Are Disparately Altered in Murine Models of Inflammatory Arthritis and Airway Inflammation

Hemshekhar, M., Piyadasa, H., Mostafa, D. H. D., Chow, L. N. Y., Halayko, A. J., & Mookherjee, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01932 · Cited by 20

Salivary S100 proteins screen periodontitis among Korean adults

Karna, S., Shin, Y., Kim, S., & Kim, H. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13059 · Cited by 20

S100A8/A9: From basic science to clinical application

Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 463

Inflammatory role of S100A8/A9 in the central nervous system non-neoplastic diseases

Tian, Q., Li, Z., Yan, Z., Jiang, S., Zhao, X., Wang, L., & Li, M. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111100 · Cited by 19

S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity

Nacken, W. K. F., Roth, J., Sorg, C., & Kerkhoff, C. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10299 · Cited by 346

S100A8 and S100A9–Critical Mediators of Inflammation in Arthritis

Paramasivam, S., Selvan, P. S., & Ekambaram, S. P. (2025) · Current Proteomics · doi:10.2174/0115701646347924241111071800 · Cited by 2

S100A8 and S100A9 in Cancer

Chen, Y., Ouyang, Y., Li, Z., Wang, X., & Ma, J. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188891 · Cited by 165