Cited by 1,450S100 Proteins and AnnexinsBiomarkers in Disease MechanismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.

S100A8/A9 in Inflammation

Open access

Wang, Siwen, Song, Rui, Wang, Ziyi, Jing, Zhaocheng, Wang, Shaoxiong, Ma, Jian·2018·Frontiers in Immunology

DOI 10.3389/fimmu.2018.01298PMC PMC6004386

Open this paper in CoChat — free account Open PDF

Abstract

S100A8 and S100A9 (also known as MRP8 ang MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fimmu.2018.01298

Cites

165 of 165 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · cited 2×
“S100A9−/− mice are less sensitive to LPS stimulation and more resistant to LPS-induced septic shock (69).”
Background
Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion
Ryckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 861
Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Corbin, B. D., Seeley, E. H., Raab, A., Feldmann, J., Miller, M. R., Torres, V. J., Anderson, K. L., Dattilo, B. M., Dunman, P. M., Gerads, R., et al. (2008) · Science · doi:10.1126/science.1152449 · Cited by 857
Nutritional immunity beyond iron: a role for manganese and zinc
Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634
Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
Nagareddy, P. R., Kraakman, M. J., Masters, S. L., Stirzaker, R. A., Gorman, D. J., Grant, R. W., Dragoljevic, D., Hong, E. S., Abdel‐Latif, A., Smyth, S. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.029 · Cited by 530
Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin
Steinbakk, M., Naess-Andresen, C. F., Fagerhol, M. K., Lingaas, E., Dale, I., & Brandtzaeg, P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93237-j · Cited by 512
Inflammation – Cause or Consequence of Heart Failure or Both?
Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 484
S100A8/A9: From basic science to clinical application
Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 463
Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., et al. (2008) · Diabetes · doi:10.2337/db07-1808 · Cited by 407

Flagged first, then by citations

Show all 165 references

Sorted by citations

Items 501–600 of 1,001

Critical role of keratinocytes in cutaneous immune responses
Gupta, R. K., Wasnik, P., Mondal, D., & Shukla, D. (2024) · Exploration of Immunology · doi:10.37349/ei.2024.00155 · Cited by 19
Chloroquine and Hydroxychloroquine
Barber, B. E. (2017) · doi:10.1201/9781498747967-175 · Cited by 15
Antimicrobial Effects of Thymosin Beta-4 and Ciprofloxacin Adjunctive Therapy in Pseudomonas aeruginosa Induced Keratitis
Carion, T. W., Ebrahim, A. S., Alluri, S., Ebrahim, T., Parker, T. R., Burns, J., Sosne, G., & Berger, E. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186840 · Cited by 15
Advanced age exacerbates intestinal epithelial permeability after burn injury in mice
Najarro, K. M., Boe, D. M., Walrath, T., Mullen, J. E., Paul, M. T., Frankel, J. H., Hulsebus, H. J., Idrovo, J., McMahan, R. H., & Kovacs, E. J. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111654 · Cited by 16
S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis
Nakatani, A., Tsuda, T., Maeda, Y., Hayama, M., Okuzaki, D., Obata, S., Kishikawa, T., Takeda, K., & Inohara, H. (2022) · Allergology International · doi:10.1016/j.alit.2022.08.005 · Cited by 15
Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis
Moussawi, K. A., Chung, K., Carroll, T. M., Osterburg, C., Smirnov, A., Lotz, R., Miller, P. F., Dedeić, Z., Zhong, S., Oti, M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111503 · Cited by 15
Protective Effects of the Alarmin S100A8 From Monocytes/Macrophages on Sepsis Mortality: Links to Sepsis Risk in Obesity and Diabetes
Miyashita, D., Inoue, R., Tsuno, T., Okuyama, T., Kyohara, M., Nakahashi-Oda, C., Nishiyama, K., Fukushima, S., Inada, Y., Togashi, Y., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105662 · Cited by 13
Immunophenotypic and Functional Characterization of Eosinophil and Migratory Dendritic Cell Subsets during Filarial Manifestation of Tropical Pulmonary Eosinophilia
Ganga, L., Sharma, P. L., Tiwari, S., Satoeya, N., Jha, R., & Srivastava, M. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.3c00051 · Cited by 15
S100A8 acts as an autocrine priming signal for heme-induced human Mϕ pro-inflammatory responses in hemolytic inflammation
Silveira, A. A. A., Mahon, O. R., Cunningham, C. C., Corr, E. M., Mendonça, R., Saad, S. T. O., Costa, F. F., Dunne, A., & Conran, N. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mia1118-418rr · Cited by 14
Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance
Ahmad, R., Akhter, Q. S., & Haque, M. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s312960 · Cited by 15
Myeloid dysregulation and therapeutic intervention in COVID-19
Gu, R., Mao, T., Qiao, L., Su, T. T., & Wang, J. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101524 · Cited by 14
Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During Pulmonary Hypertension
Guo, Y., Gao, Z., Zhang, R., Long, H., Zhang, M., Liu, L., An, Z., Shi, Y., Cui, Y., Jia, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202504397 · Cited by 14
SARS-CoV-2 innate immune recognition and implications for respiratory health
Anang, V., Kumar, P., Pracha, J., Nho, R. S., Mora, A. L., Rojas, M. M., Gowdy, K. M., Yount, J. S., Bednash, J. S., Horowitz, J. C., et al. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.10.008 · Cited by 15
Systemically inducing trained immunity overcomes solid tumors’ immunosuppressive microenvironment
Priem, B., Willemsen, L., Anbergen, T., van Elsas, Y., Deckers, J., Schrijver, D. P., Hofstraat, S. R. J., Messing, I. V., Munitz, J., Honing, D. Y., et al. (2026) · Science Advances · doi:10.1126/sciadv.adu0292 · Cited by 14
Polymorphonuclear myeloid-derived suppressor cells link inflammation and damage response after trauma
Li, X., Liu, J., Xing, Z., Tang, J., Sun, H., Zhang, X., Lv, S., Chen, Z., Shi, M., Chen, M., et al. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma0821-029r · Cited by 14
Label-Free Quantitative Proteomic Analysis Reveals Inflammatory Pattern Associated with Obesity and Periodontitis in Pregnant Women
Foratori-Júnior, G. A., Ventura, T. M. O., Grizzo, L. T., Carpenter, G. H., Buzalaf, M. A. R., & Peres, S. H. D. C. S. (2022) · Metabolites · doi:10.3390/metabo12111091 · Cited by 14
Characterizing the Macrophage Population in Patients With Idiopathic Subglottic Stenosis
Ospino, R., Berges, A. J., Mafla, L. M., Collins, S. L., Chan‐Li, Y., Lina, I. A., Gelbard, A. H., Hillel, A. T., & Motz, K. (2022) · The Laryngoscope · doi:10.1002/lary.30524 · Cited by 14
Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System
Ahmed, S., van Zalm, P., Rudmann, E. A., Leone, M. J., Keller, K., Branda, J. A., Steen, J. A. J., Mukerji, S. S., & Steen, H. (2022) · Viruses · doi:10.3390/v14122757 · Cited by 14
High BM plasma S100A8/A9 is associated with a perturbed microenvironment and poor prognosis in myelodysplastic syndromes
Wang, Y., Lin, C., Yao, C., Amaral, F. M. R., Yu, S., Kao, C., Shih, P., Hou, H., Chou, W., & Tien, H. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022008958 · Cited by 14
Expression of S100A9 in adamantinomatous craniopharyngioma and its association with wet keratin formation
Chuan, Z., Hu, W., Luo, N., Wang, X., Lin, D., & Lin, Z. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.11981 · Cited by 14
Classification of subtypes and identification of dysregulated genes in sepsis
Tong, R., Ding, X., Liu, F., Li, H., Liu, H., Song, H., Wang, Y., Zhang, X., Liu, S., & Sun, T. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1226159 · Cited by 16
Choroidal Mast Cells and Pathophysiology of Age-Related Macular Degeneration
Malih, S., Song, Y., Sorenson, C. M., & Sheibani, N. (2023) · Cells · doi:10.3390/cells13010050 · Cited by 14
Tumor-specific activation of folate receptor beta enables reprogramming of immune cells in the tumor microenvironment
Zhang, F., Huang, B., Utturkar, S. M., Luo, W., Cresswell, G. M., Herr, S. A., Zheng, S., Napoleon, J. V., Jiang, R., Zhang, B., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1354735 · Cited by 15
Pterostilbene Alleviates Dextran Sodium Sulfate (DSS)-Induced Intestinal Barrier Dysfunction Involving Suppression of a S100A8-TLR-4-NF-κB Signaling Cascade
Lv, K., Song, J. T., Wang, J., Zhao, W., Yang, F., Feiya, J., Bai, L., Guan, W., Liu, J., Ho, C., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c03258 · Cited by 14
Self-citation
Biomarkers Identification in the Microenvironment of Oral Squamous Cell Carcinoma: A Systematic Review of Proteomic Studies
Pomella, S., Melaiu, O., Cifaldi, L., Bei, R., GARGARI, M., Campanella, V., & Barillari, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168929 · Cited by 18
Diagnostic Accuracy of Novel Protein Biomarkers in Saliva to Detect Periodontitis Using Untargeted ‘ SWATH ’ Mass Spectrometry
Blanco‐Pintos, T., Regueira‐Iglesias, A., Relvas, M., Alonso‐Sampedro, M., Bravo, S. B., Balsa‐Castro, C., & Tomás, I. (2024) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.14103 · Cited by 14
Differences in plasma proteomes for active tuberculosis, latent tuberculosis and non-tuberculosis mycobacterial lung disease patients with and without ESAT-6/CFP10 stimulation
Teklu, T., Wondale, B., Taye, B., Hailemariam, M., Bekele, S., Tamirat, M., Zewude, A., Mohamed, T., Medhin, G., Legesse, M., et al. (2020) · Proteome Science · doi:10.1186/s12953-020-00165-5 · Cited by 14
Blood transcriptomics to characterize key biological pathways and identify biomarkers for predicting mortality in melioidosis
Yimthin, T., Cliff, J. M., Phunpang, R., Ekchariyawat, P., Kaewarpai, T., Lee, J., Eckold, C., Andrada, M., Thiansukhon, E., Tanwisaid, K., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1858176 · Cited by 14
Longitudinal peripheral tissue RNA‐Seq transcriptomic profiling, hyperalgesia, and wound healing in the rat plantar surgical incision model
Goto, T., Sapio, M. R., Maric, D., Robinson, J. M., Domenichiello, A. F., Saligan, L. N., Mannes, A. J., & Iadarola, M. J. (2021) · The FASEB Journal · doi:10.1096/fj.202100347r · Cited by 12
FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis
Iftikhar, R., Penrose, H. M., King, A. N., Kim, Y., Ruiz, E. M., Kandil, E. H., Machado, H. L., & Savkovic, S. D. (2022) · Metabolites · doi:10.3390/metabo12030250 · Cited by 14
Saliva proteomic profile of early childhood caries and caries-free children
Oliveira, B. P., Buzalaf, M. A. R., Silva, N. C., Ventura, T. M. O., Toniolo, J., & Rodrigues, J. A. (2022) · Acta Odontologica Scandinavica · doi:10.1080/00016357.2022.2118165 · Cited by 14
Calprotectin in chronic rhinosinusitis eosinophil extracellular traps
Ahn, S. H., Shin, K. H., Oh, J. T., Park, S. C., Rha, M., Kim, S. I., Cho, H., Yoon, J., & Kim, C. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23157 · Cited by 14
MDSCs: The Key Players in the Formation of Pre-Metastatic Niche
Cui, W., Wang, Z., Lv, J., Qin, Y., & Shi, H. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2803058 · Cited by 14
Self-citation
Desmoglein-Specific B-Cell−Targeted Single-Cell Analysis Revealing Unique Gene Regulation in Patients with Pemphigus
Egami, S., Watanabe, T., Fukushima‐Nomura, A., Nomura, H., Takahashi, H., Yamagami, J., Ohara, O., & Amagai, M. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.03.1661 · Cited by 14
Calprotectin in acne vulgaris: A possible contributory role
Fouda, I., Obaid, Z. M., Hegazy, S., al-samee, H. A., & Nofal, A. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13574 · Cited by 14
S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells
Zhang, L., Zhou, S., Zhou, T., Yuan, K., Li, X., & Tang, J. (2020) · Oncology Reports · doi:10.3892/or.2020.7841 · Cited by 14
A Review of Selected IBD Biomarkers: From Animal Models to Bedside
Mizoguchi, E., Subramaniam, R., Okada, T., & Mizoguchi, A. (2021) · Diagnostics · doi:10.3390/diagnostics11020207 · Cited by 14
Bioinformatic Analysis of Crosstalk Between circRNA, miRNA, and Target Gene Network in NAFLD
Du, C., Shen, L., Ma, Z., Du, J., & Jin, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.671523 · Cited by 14
Differential Regulation of Circulating Soluble Receptor for Advanced Glycation End Products (sRAGEs) and Its Ligands S100A8/A9 Four Weeks Post an Exercise Intervention in a Cohort of Young Army Recruits
Drosatos, I.-A., Tsoporis, J. N., Izhar, S., Gupta, S., Tsirebolos, G., Sakadakis, E. A., Triantafyllis, A. S., Rigopoulos, A. G., Rigopoulos, D. N., Rallidis, L. S., et al. (2021) · Biomolecules · doi:10.3390/biom11091354 · Cited by 14
Mechanism of action and therapeutic potential of S100A8/A9 in neuroinflammation and cognitive impairment: From molecular target to clinical application (Review)
Guan, X., Zha, L., Zhu, X., Rao, X., Huang, X., Xiong, Y., Guo, Y., Zhang, M., Zhou, D., Tu, Q., et al. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5588 · Cited by 14
Calprotectin Levels and Neutrophil Count Are Prognostic Markers of Mortality in COVID-19 Patients
Cardiero, G., Palma, D., Vano, M., Anastasio, C., Pinchera, B., Ferrandino, M., Gianfico, C., Gentile, L., Savoia, M., Gentile, I., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12102554 · Cited by 14
Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis
Susai, S. R., Healy, C., Mongan, D., Heurich, M., Byrne, J. F., Cannon, M. D., Cagney, G., Wynne, K. J., Markulev, C., Schäfer, M. R., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02217-0 · Cited by 13
New Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8
Galvis, M. M., Soares, C. C., Carnielli, C. M., Buttura, J. R., de Sá, R. S., Kaminagakura, E., Marchi, F. A., Leme, A. F. P., Pinto, C. A. L., Santos‐Silva, A. R., et al. (2023) · Cells · doi:10.3390/cells12091323 · Cited by 13
Correlations between histopathologic findings, serum biomarker levels, and clinical outcomes in Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)
Chuenwipasakul, D., Washrawirul, C., Panpruk, R., Wititsuwannakul, J., Charoenchaipiyakul, K., Buranapraditkun, S., Puangsricharern, V., Klaewsongkram, J., & Rerknimitr, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-40812-3 · Cited by 13
Transcriptional Comparison of Human and Murine Retinal Neovascularization
Pauleikhoff, L. J. B., Boneva, S., Boeck, M., Schlecht, A., Schlunck, G., Agostini, H. T., Lange, C., & Wolf, J. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.15.46 · Cited by 13
Far-ultraviolet irradiation at 222 nm destroys and sterilizes the biofilms formed by periodontitis pathogens
Nishikawa, J., Fujii, T., Fukuda, S., Yoneda, S., Tamura, Y., Shimizu, Y., Yanai, A., Kobayashi, Y. O., Harada, K., Kawasaki, K., et al. (2024) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2024.05.005 · Cited by 13
Unraveling the Mechanisms of S100A8/A9 in Myocardial Injury and Dysfunction
Xu, Y., Wang, Y., Ning, K., & Bao, Y. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46090577 · Cited by 13
Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis
Vozza, E. G., Kelly, A. M., Daly, C. M., O’Rourke, S. A., Carlile, S. R., Morris, B., Dunne, A., & McLoughlin, R. M. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02173-2 · Cited by 13
Urinary Biomarkers Associated With Pathogenic Pathways Reflecting Histologic Findings in Lupus Nephritis
Hiramoto, K., Saito, S., Hanaoka, H., Kikuchi, J., Fukui, H., Hashiguchi, A., Suzuki, K., Takeuchi, T., & Kaneko, Y. (2024) · Arthritis & Rheumatology · doi:10.1002/art.43017 · Cited by 13
Evaluation of transcriptomic changes after photobiomodulation in spinal cord injury
Stevens, A. R., Hadis, M. A., Alldrit, H., Milward, M. R., Pietro, V. D., Gendoo, D. M. A., Belli, A., Palin, W. M., Davies, D. J., & Ahmed, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-87300-4 · Cited by 14
Deviant proteome profile of equine granulocytes associates to latent activation status in organ specific autoimmune disease
Weigand, M., Hauck, S. M., Deeg, C. A., & Degroote, R. L. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103989 · Cited by 15
Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura
Basu, M. K., Massicano, F., Yu, L., Halkidis, K., Pillai, V. G., Cao, W., Zheng, L., & Zheng, X. L. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1719030 · Cited by 13
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis
Zhang, J., Jiang, D., Lin, S., Cheng, Y., Pan, J., Ding, W., Chen, Y., & Fan, J. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119131 · Cited by 13
The Persistent Pain Transcriptome: Identification of Cells and Molecules Activated by Hyperalgesia
Sapio, M. R., Kim, J., Loydpierson, A. J., Maric, D., Goto, T., Vazquez, F. A., Dougherty, M. K., Narasimhan, R., Muhly, W. T., Iadarola, M. J., et al. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.03.155 · Cited by 13
The Effects of Melatonin Administration on Intestinal Injury Caused by Abdominal Irradiation from Mice
Wang, Q., Wang, Y., Du, L., Xu, C., Liu, Q., & Fan, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189715 · Cited by 13
Salivary proteomic analysis in asymptomatic and symptomatic SARS-CoV-2 infection: Innate immunity, taste perception and FABP5 proteins make the difference
Aita, A., Battisti, I., Contran, N., Furlan, S., Padoan, A., Franchin, C., Barbaro, F., Cattelan, A. M., Zambon, C., Plebani, M., et al. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.09.023 · Cited by 13
Mast cells selectively produce inflammatory mediators and impact the early response to Chlamydia reproductive tract infection
Mayavannan, A., Shantz, E., Haidl, I. D., Wang, J., & Marshall, J. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1166068 · Cited by 13
Serum level of S100A8/A9 as a biomarker for establishing the diagnosis and severity of community-acquired pneumonia in children
Xie, S., Wang, J., Tuo, W., Zhuang, S., Cai, Q., Yao, C., Feng, H., Zhu, H., Xiang, Y., & Yuan, C. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1139556 · Cited by 13
The Role of Macrophage Populations in Skeletal Muscle Insulin Sensitivity: Current Understanding and Implications
Lee, M., Ryu, H., Van, J. Y., Kim, M., Jeong, H. H., Jung, W., Jun, J. Y., & Lee, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411467 · Cited by 13
Melatonin ameliorates atherosclerosis by suppressing S100a9-mediated vascular inflammation
Chen, L., Wang, X., Liu, C., Deng, P., Pan, L., Yang, L., Cheng, J., Zhang, X., Reiter, R. J., Yu, Z., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175965 · Cited by 15
Mechanisms of Mixed Th1/Th2 Responses in Mice Induced by Albizia julibrissin Saponin Active Fraction by in Silico Analysis
Du, J., Jin, J., Wang, J., & Sun, H. (2020) · Vaccines · doi:10.3390/vaccines8010048 · Cited by 12
Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia
Montes, R. I., Costela-Ruiz, V. J., Melguizo‐Rodríguez, L., Luna‐Bertos, E. D., Ruíz, C., & Ramos‐Torrecillas, J. (2021) · Diagnostics · doi:10.3390/diagnostics11010063 · Cited by 19
Machine-learning algorithm-based prediction of a diagnostic model based on oxidative stress-related genes involved in immune infiltration in diabetic nephropathy patients
Zhu, H.-M., Liu, N., Sun, D.-X., & Luo, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1202298 · Cited by 12
Chronic skin and systemic inflammation modulated by S100A8 and S100A9 complexes
Palomo-Irigoyen, M., Bakiri, L., Hendrikx, T., Hayer, S., Schaffenrath, J., Stefanie Widder, A., Bachg, S., Simmons, J., Gallo, R. L., Starkl, P. M., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01504-9 · Cited by 13
Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women
Chang, Q., Wang, S., Mai, Q., & Zhou, C. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01703-5 · Cited by 12
Self-citation
Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease
Krawiec, P., & Pac‐Kożuchowska, E. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s288742 · Cited by 12
Immune-related potential biomarkers and therapeutic targets in coronary artery disease
Liu, C., Liu, J., Zhang, Y., Wang, X., & Guan, Y. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1055422 · Cited by 14
S100A8 alarmin supports IL-6 and metalloproteinase-9 production by fibroblasts in the synovial microenvironment of peripheral spondyloarthritis
Arias, J. L., Funes, S. C., Blas, R., Callegari, E. A., Eliçabe, R. J., Paez, M. D., Munarriz, A., Pardo-Hidalgo, R., Tamashiro, H., & Genaro, M. S. D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1077914 · Cited by 12
Weighted Gene Co-Expression Network Analysis of Oxymatrine in Psoriasis Treatment
Xue, X., Guo, Y., Zhao, Q., Li, Y., Rao, M., Qi, W., & Shi, H. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s402535 · Cited by 12
Biomarker-Development Proteomics in Kidney Transplantation: An Updated Review
Sirolli, V., Piscitani, L., & Bonomini, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065287 · Cited by 12
Identification of Immune-Linked Hub Genes and Diagnostic Model Construction in Schizophrenia
Lian, K., Shen, Z., Yang, R., Ye, J., Shang, B., Dong, L., Li, H., Wu, J., Cheng, Y., & Xu, X. (2023) · Journal of Molecular Neuroscience · doi:10.1007/s12031-023-02138-7 · Cited by 12
Discovery and Verification of Sjögren’s Syndrome Protein Biomarkers in Tears by Targeted LC-MRM
Lépine, M., Robert, M.-C., & Sleno, L. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00163 · Cited by 12
Identification of common genetic factors and immune-related pathways associating more than two autoimmune disorders: implications on risk, diagnosis, and treatment
Rajalingam, A., & Ganjiwale, A. D. (2024) · Genomics & Informatics · doi:10.1186/s44342-024-00004-5 · Cited by 12
S100A8/A9-activated IFNγ+ NK cells trigger β-cell necroptosis in hepatitis B virus-associated liver cirrhosis
Li, X., Liang, H., Ru, M., Cai, R., Meng, Y., Wang, B., Diao, H., Li, L., & Wu, Z. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05365-2 · Cited by 12
Single-cell and spatial sequencing identifies senescent and germinal tumor cells in adamantinomatous craniopharyngiomas
Wang, X., Liu, H., Liu, H., Zhao, C., Xu, D., Xu, D., Zhang, E., Zhou, Z., Qi, X., Wang, X., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01299-1 · Cited by 12
The role of the S100A8/S100A9 in gastric tumor progression
Fang, S., Du, S., Luo, X., Qing, X., Wang, L., Ban, Y., Song, G., Yang, Y., & Wei, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-74695-9 · Cited by 12
Isoproterenol Triggers ROS/P53/S100-A9 Positive Feedback to Aggravate Myocardial Damage Associated with Complement Activation
Fan, S., Zhao, H., Liu, Y., Zhang, P., Wang, Y., Xu, Y., Gu, K., Zhang, T., Yu, J., Qi, W., et al. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00308 · Cited by 12
Immune Resolution Dilemma: Host Antimicrobial Factor S100A8/A9 Modulates Inflammatory Collateral Tissue Damage During Disseminated Fungal Peritonitis
Shankar, M., Uwamahoro, N., Backman, E., Holmberg, S. M., Niemiec, M. J., Roth, J., Vogl, T., & Urban, C. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.553911 · Cited by 13
Short Communication: S100A8 and S100A9, Biomarkers of SARS-CoV-2 Infection and Other Diseases, Suppress HIV Replication in Primary Macrophages
Oguariri, R. M., Brann, T. W., Adelsberger, J. W., Chen, Q., Goswami, S., Mele, A. R., & Imamichi, T. (2022) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2021.0193 · Cited by 12
Dynamic Control Balancing Cell Proliferation and Inflammation is Crucial for an Effective Immune Response to Malaria
Gupta, A. K., Galinski, M. R., & Voit, E. O. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.800721 · Cited by 12
S100A8 as a Promising Biomarker and Oncogenic Immune Protein in the Tumor Microenvironment: An Integrative Pancancer Analysis
Wu, Z., Jiang, D., Huang, X., Cai, M., Yuan, K., & Huang, P. (2022) · Journal of Oncology · doi:10.1155/2022/6947652 · Cited by 12
S100A8 and S100A9 are elevated in chronically threatened ischemic limb muscle and induce ischemic mitochondrial pathology in mice
Salyers, Z. R., Mariani, V. M., Balestrieri, N. P., Kumar, R. A., Vugman, N. A., Thome, T., Villani, K. R., Berceli, S. A., Scali, S. T., Vasilakos, G., et al. (2022) · JVS Vascular Science · doi:10.1016/j.jvssci.2022.03.003 · Cited by 12
A targetable ‘rogue’ neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS
Herrera, V. L. M., Walkey, A. J., Nguyen, M. Q., Gromisch, C. M., Mosaddhegi, J. Z., Gromisch, M. S., Jundi, B., Lukassen, S., Carstensen, S., Denis, R., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-09343-1 · Cited by 17
Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells
Tomonobu, N., Kinoshita, R., Wake, H., Inoue, Y., Ruma, I. M. W., Suzawa, K., Gohara, Y., Komalasari, N. L. G. Y., Jiang, F., Murata, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810300 · Cited by 12
Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition
Iacobucci, I., Monaco, V., Canè, L., Bibbò, F., Cioffi, V., Cozzolino, F., Guarino, A., Zollo, M., & Monti, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.975570 · Cited by 12
Acute response of biomarkers in plasma from capillary blood after a strenuous endurance exercise bout
Reichel, T., Held, S., Schwarz, A., Hacker, S., Wesemann, F., Donath, L., & Krüger, K. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-05068-1 · Cited by 13
Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury
Liu, B., Xu, X., Ge, Q., Yang, M.-S., Zhuang, Y., Zhang, B., Dong, J., Niu, F., & Li, H. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355767 · Cited by 12
Acute physiological effects following Bacillus subtilis DE111 oral ingestion – a randomised, double blinded, placebo-controlled study
Colom, J., Freitas, D., Simon, A., Khokhlova, E. V., Mazhar, S., Buckley, M. J. M., Phipps, C., Deaton, J. G., Brodkorb, A., & Rea, K. (2023) · Beneficial Microbes · doi:10.3920/bm2022.0081 · Cited by 12
Identification of drug candidates targeting monocyte reprogramming in people living with HIV
Knoll, R., Bonaguro, L., dos Santos, J. C., Warnat‐Herresthal, S., Cleophas, M. C. P., Blümel, E. P., Reusch, N., Horne, A., Herbert, M., Nuesch-Germano, M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1275136 · Cited by 12
Molecular Surgery: Proteomics of a Rare Genetic Disease Gives Insight into Common Causes of Blindness
Velez, G., & Mahajan, V. B. (2020) · iScience · doi:10.1016/j.isci.2020.101667 · Cited by 12
Calprotectin and SARS-CoV-2: A Brief-Report of the Current Literature
Giuffrè, M., Vetrugno, L., Bella, S. D., Moretti, R., Berretti, D., & Crocè, L. S. (2021) · Healthcare · doi:10.3390/healthcare9080956 · Cited by 12
Clinical parameters and biological markers associated with acute severe ocular complications in Stevens-Johnson syndrome and toxic epidermal necrolysis
Panpruk, R., Puangsricharern, V., Klaewsongkram, J., Rerknimitr, P., Kittipibul, T., Chongpison, Y., & Buranapraditkun, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-99370-1 · Cited by 12
Calprotectin-g the Lung during Type 2 Allergic Airway Inflammation
Manni, M. L., & Alcorn, J. F. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0125ed · Cited by 12
Shift of lung macrophage composition is associated with COVID-19 disease severity and recoveryPreprint
Chen, S. T., Park, M. D., Valle, D. M. D., Buckup, M., Tabachnikova, A., Simons, N. W., Mouskas, K., Lee, B. H., Geanon, D., D’souza, D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.11.475918 · Cited by 12
hPDLSC-ApoEVs attenuate periodontitis and enhance bone regeneration via NF-κB/S100A9-Mediated M2 macrophage polarization
Zhang, Z., Zeng, L., Yu, Y., Xu, Z., Zhu, G., Weng, J., Xia, J., Peng, W., Dong, Q., Li, Y., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04617-7 · Cited by 11
Adipocyte death promotes hepatic infiltration of S100A8+ macrophages and steatotic liver disease progression in mice
Guan, Y., Kim, Y. S., Wang, Y., Cho, Y. E., Xiang, X., Kim, S., Yao, T., Feng, D., Hwang, S., & Gao, B. (2025) · Journal of Clinical Investigation · doi:10.1172/jci190635 · Cited by 12
METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils
Cao, D., Lv, M., Hu, C., Li, S., Wang, S., Xu, C., & Pan, W. Q. (2023) · Protein & Cell · doi:10.1093/procel/pwad047 · Cited by 11
Self-citation
Inflammation, the kynurenines, and mucosal injury during human experimental enterotoxigenic Escherichia coli infection
Rim, S., Vedøy, O. B., Brønstad, I., McCann, A., Meyer, K., Steinsland, H., & Hanevik, K. (2024) · Medical Microbiology and Immunology · doi:10.1007/s00430-024-00786-z · Cited by 10
S100 protein family: Emerging role and mechanism in digestive tract cancer (Review)
Li, M., Cui, P. L., Dai, W., Cao, B. W., Zhao, H., Jin, S., Xu, D., Shi, Y., & Yan, S. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5647 · Cited by 11
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice
Gatti, D. M., Tyler, A. L., Mahoney, J. M., Churchill, G. A., Yener, B., Koyuncu, D., Gürcan, M. N., Niazi, M. K., Tavolara, T. E., Gower, A. C., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1011915 · Cited by 13

Authors: Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J.
Affiliations: Central South University (CN)
Corresponding author: Ma, Jian
ORCID: Wang, Siwen
Song, Rui
Wang, Ziyi
Jing, Zhaocheng
Wang, Shaoxiong
Ma, Jian
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2018-06-11
Volume: 9
Pages: 1298-1298
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2018.01298
PMC: PMC6004386
OpenAlex: W2808305854
Cited by: 1,450
References: 165
Citations by year: 2026: 176 · 2025: 217 · 2024: 248 · 2023: 225 · 2022: 236 · 2021: 184 · 2020: 119 · 2019: 40 · 2018: 4
FWCI: 8.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81672889, 81472694)
Hunan Provincial Science and Technology Department (2016JC2035)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: S100A8/A9, S-100 protein, heterodimer, calcium-binding proteins, inflammation, neutrophils, monocytes, leukocyte recruitment, cytokine production, arachidonic acid metabolism, biomarkers, therapeutic target, small molecule inhibitors
MeSH terms: Animals, Disease Susceptibility, Gene Expression Regulation, Humans, Immunity, Inflammation, Biomarkers, Autoimmunity, Protein Transport, Calgranulin A, Calgranulin B, Host-Pathogen Interactions, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

S100A8/A9 in Inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks