Cited by 1,450S100 Proteins and AnnexinsBiomarkers in Disease MechanismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.

S100A8/A9 in Inflammation

Open access

Wang, Siwen, Song, Rui, Wang, Ziyi, Jing, Zhaocheng, Wang, Shaoxiong, Ma, Jian·2018·Frontiers in Immunology

DOI 10.3389/fimmu.2018.01298PMC PMC6004386

Open this paper in CoChat — free account Open PDF

Abstract

S100A8 and S100A9 (also known as MRP8 ang MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fimmu.2018.01298

Cites

165 of 165 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 The binding of S100A8/A9 to toll-like receptor (TLR) 4 triggers the MyD88-dependent pathway, appearing to play a vital role in inflammation. MyD88 recruits and activates IRAKs and TRAF6, which activates TAK1 via a TAB-mediated method. The activation of TAK1 facilitates the phosphorylation and activation of IKK and MAPK. Activated IKK phosphorylates and ubiquitinates I-κB, resulting in the liberation of NF-κB from inhibition. NF-κB translocates to the nucleus and induces the expression of pro-inflammatory cytokines. MAPKs, including p38, JNK, and ERK, have been demonstrated to activate c-Jun and c-fos, which translocate to the nucleus and form heterodimer AP-1, another transcription factor. Moreover, MAPK pathways are also involved in S100A8/A9-induced NF-κB activation during inflammation. The upregulated expression of pro-inflammatory genes amplifies the inflammatory response and severely destructs tissues in inflammation-associated diseases.CC BY · PubMed Central

Figure 2 The mitochondrial pathways of S100A8/A9-induced apoptosis. Cellular apoptosis is a cascade that involves a rapid drop in mitochondrial membrane potential. S100A8/A9 increases reactive oxygen species (ROS) production, resulting in the depolarization of mitochondrial membranes and subsequent inhibition of BNIP3, an atypical pro-apoptotic Bcl2-family member, and activation of Bak. After the translocation of Bak and BNIP3 in mitochondria, cytochrome C, Smac, and HtrA2 are concomitantly released from mitochondria into the cytoplasm. They activate caspase-3 in a direct way or in an IAPs-dependent manner to induce apoptosis. Abbreviations: iBNIP3, inhibited BNIP3; aBak, activated Bak.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · cited 2×
“S100A9−/− mice are less sensitive to LPS stimulation and more resistant to LPS-induced septic shock (69).”
Background
Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion
Ryckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 861
Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Corbin, B. D., Seeley, E. H., Raab, A., Feldmann, J., Miller, M. R., Torres, V. J., Anderson, K. L., Dattilo, B. M., Dunman, P. M., Gerads, R., et al. (2008) · Science · doi:10.1126/science.1152449 · Cited by 857
Nutritional immunity beyond iron: a role for manganese and zinc
Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634
Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
Nagareddy, P. R., Kraakman, M. J., Masters, S. L., Stirzaker, R. A., Gorman, D. J., Grant, R. W., Dragoljevic, D., Hong, E. S., Abdel‐Latif, A., Smyth, S. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.029 · Cited by 530
Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin
Steinbakk, M., Naess-Andresen, C. F., Fagerhol, M. K., Lingaas, E., Dale, I., & Brandtzaeg, P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93237-j · Cited by 512
Inflammation – Cause or Consequence of Heart Failure or Both?
Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 484
S100A8/A9: From basic science to clinical application
Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 463
Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., et al. (2008) · Diabetes · doi:10.2337/db07-1808 · Cited by 407

Show all 165 references

Sorted by citations

Items 701–800 of 1,001

Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung
Wang, T., Hao, J., Li, B., Hyraht, A., Wang, J., Xia, H., Wu, Q., Gao, W., Chen, C., Yu, C., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1609616 · Cited by 8
Euchrenone A10 attenuates septic lung injury though S100A8/A9-dependent TLR4/MyD88/NF-κB signaling
Zhou, L., Xiao, Y., He, J., Ren, H., Zhao, C., Zhang, C., Shu, X., Chen, D., Chen, D., He, X., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157336 · Cited by 8
Chronic Inflammation in Primary Myelofibrosis: In‐Depth Insights Into Pathogenesis and Promising Anti‐Inflammatory Therapeutic Strategies
Chen, M., Zheng, C., Zhang, Y., He, J., & Shi, Z. (2025) · Mediators of Inflammation · doi:10.1155/mi/9967975 · Cited by 10
A cross-sectional cohort study of the activity and turnover of neutrophil granulocytes in juvenile idiopathic arthritis
Backlund, M., Venge, P., & Berntson, L. (2021) · Pediatric Rheumatology · doi:10.1186/s12969-021-00600-7 · Cited by 8
Proteomic identification of novel plasma biomarkers associated with spontaneous preterm birth in women with preterm labor without infection/inflammation
Lee, J. E., Park, K. H., Kim, H. J., Kim, Y. M., Choi, J.-W., Shin, S., & Lee, K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0259265 · Cited by 8
Three Potential Tumor Markers Promote Metastasis and Recurrence of Colorectal Cancer by Regulating the Inflammatory Response: ADAM8, LYN, and S100A9
Liu, J., Li, J., Du, H., Xu, L., Yang, Z., Yuan, M., Zhang, K., Li, J., Xing, W., Wang, S., et al. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/3118046 · Cited by 8
Self-citation
Retracted
Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the Sheep Model
Hassan, S. U., Chua, E. G., Kaur, P., Paz, E. A., Tay, C. Y., Greeff, J. C., Liu, S., & Martin, G. B. (2022) · Functional & Integrative Genomics · doi:10.1007/s10142-022-00864-6 · Cited by 8
Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma
Vantucci, C. E., Guyer, T., Leguineche, K., Chatterjee, P., Lin, A., Nash, K. E., Hastings, M. A., Fulton, T. M., Smith, C. T., Maniar, D., et al. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.934773 · Cited by 8
Functional Blockage of S100A8/A9 Ameliorates Ischemia–Reperfusion Injury in the Lung
Nakata, K., Okazaki, M., Sakaue, T., Kinoshita, R., Komoda, Y., Shimizu, D., Yamamoto, H., Tanaka, S., Suzawa, K., Shien, K., et al. (2022) · Bioengineering · doi:10.3390/bioengineering9110673 · Cited by 8
Serum calprotectin can indicate current and future severity of COVID ‐19
Afra, H. S., Moradi, M., Musavi, H., Moradi‐Sardareh, H., Moradipoodeh, B., Veisari, A. K., Oladi, Z., & Ebrahimi, M. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24809 · Cited by 8
Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca2+ Signaling Similar to Fabry Disease
Elsaid, H. O. A., Tjeldnes, H., Rivedal, M., Serre, C., Eikrem, Ø., Svarstad, E., Tøndel, C., Marti, H., Furriol, J., & Bábíčková, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010358 · Cited by 8
Identification of S100A9 as a Potential Inflammation-Related Biomarker for Radiation-Induced Lung Injury
Liu, Y., Wu, M., Guo, J., Tang, Y., Jiang, H., Yang, B., Wu, M., & Huang, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12030733 · Cited by 8
Quantitative Proteomics of Maternal Blood Plasma in Isolated Intrauterine Growth Restriction
Starodubtseva, N. L., Tokareva, A., Volochaeva, M. V., Kononikhin, A. S., Brzhozovskiy, A. G., Bugrova, A. E., Timofeeva, A. V., Kukaev, E., Tyutyunnik, V. L., Кан, Н. Е., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316832 · Cited by 8
Role of innate host defense proteins in oral cancerogenesis
Winter, J., & Jepsen, S. V. (2024) · Periodontology 2000 · doi:10.1111/prd.12552 · Cited by 8
Computational Deciphering of the Role of S100A8 and S100A9 Proteins and Their Changes in the Structure Assembly Influences Their Interaction with TLR4, RAGE, and CD36
Paramasivam, S., Selvan, P. S., & Ekambaram, S. P. (2024) · The Protein Journal · doi:10.1007/s10930-024-10186-0 · Cited by 10
Single-Cell RNA Sequencing Reveals Immunomodulatory Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor Treatment in the Brains of Aged APP/PS1 Mice
Gardner, R. S., Kyle, M. M., Hughes, K., & Zhao, L. (2024) · Biomolecules · doi:10.3390/biom14070827 · Cited by 7
One-step engineered mesenchymal stem cell-derived exosomes against hepatic ischemia–reperfusion injury
Lu, X., Hu, H., Zhou, Y., Zhang, H., Xie, C. Z., Sun, Y., Shao, Z., Tang, L., Ren, Y., Chen, J., et al. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125292 · Cited by 8
Combined Analysis of DNA Methylome and Transcriptome Reveal Novel Candidate Genes Related to Porcine Escherichia coli F4ab/ac-Induced Diarrhea
Wang, W., Zhou, C., Tang, H., Yu, Y., & Zhang, Q. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00250 · Cited by 8
Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice
Ribon, M., Leone, C., Chiot, A., Berriat, F., Rampanana, M., Cottin, J., Bohl, D., Millecamps, S., Lobsiger, C. S., Heneka, M. T., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.015 · Cited by 8
Co-expression network analysis identifies innate immune signatures for Albizia julibrissin saponin active fraction-adjuvanted avian influenza vaccine
Du, J., & Sun, H. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107417 · Cited by 8
Antibody microarray analysis of the amniotic fluid proteome for predicting the outcome of rescue cerclage in patients with cervical insufficiency
Hong, S., Park, K. H., Lee, Y. E., Shin, S., Kim, H. J., & Kim, Y. M. (2021) · Bioscience Reports · doi:10.1042/bsr20210174 · Cited by 8
Maternal serum calprotectin level in intrahepatic cholestasis of pregnancy
Ağaoğlu, R. T., CELİK, O. Y., Yakut, K., Çelen, Ş., & Çağlar, A. T. (2021) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14925 · Cited by 8
Alteration of Oral and Perioral Soft Tissue in Mice following Incisor Tooth Extraction
Takagi, T., Yamamoto, M., Sugano, A., Kanehira, C., Kitamura, K., Katayama, M., Sakai, K., Sato, M., & Abe, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23062987 · Cited by 8
Methylomic and transcriptomic characterization of postoperative systemic inflammatory dysregulation
Bain, C., Myles, P. S., Taylor, R., Trahair, H., Lee, Y. P., Croft, L., Peyton, P. J., Painter, T. W., Chan, M. T. V., Wallace, S. K. A., et al. (2022) · Translational research · doi:10.1016/j.trsl.2022.04.004 · Cited by 9
Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein
Loh, J. T., Teo, J. K. H., & Lam, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.996637 · Cited by 9
Metastatic Colon Cancer Treatment Using S100A9-Targeted Cowpea Mosaic Virus Nanoparticles
Chung, Y. H., Volckaert, B. A., & Steinmetz, N. F. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c00873 · Cited by 8
Identification of ulcerative colitis-specific immune cell signatures from public single-cell RNA-seq data
Kim, H., Kim, H. K., Hong, D., Kim, M., Jang, S., Yang, C., & Yoon, S. (2023) · Genes & Genomics · doi:10.1007/s13258-023-01390-w · Cited by 8
Dedifferentiated fat cells administration ameliorates abnormal expressions of fatty acids metabolism-related protein expressions and intestinal tissue damage in experimental necrotizing enterocolitis
Mimatsu, H., Onoda, A., Kazama, T., Nishijima, K., Shimoyama, Y., Go, S., Ueda, K., Takahashi, Y., Matsumoto, T., Hayakawa, M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-34156-1 · Cited by 8
Effects of lactic acid bacteria-fermented formula milk supplementation on colonic microbiota and mucosal transcriptome profile of weaned piglets
Lin, A., Yan, X., Xu, R. X., Wang, H., Su, Y., & Zhu, W. (2023) · animal · doi:10.1016/j.animal.2023.100959 · Cited by 8
A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease
Sun, S., Zhou, Y., Fu, X., Zheng, Y., Xie, C., Qin, G., Liu, F., Chen, C., Wang, F., Liu, C., et al. (2023) · World Journal of Pediatrics · doi:10.1007/s12519-023-00752-4 · Cited by 8
Associations of tissue damage induced inflammatory plasticity in masseter muscle with the resolution of chronic myalgia
Lindquist, K. A., Shein, S. A., Hovhannisyan, A. H., Mecklenburg, J. M., Zou, Y., Lai, Z., Tumanov, A. V., & Akopian, A. N. (2023) · Scientific Reports · doi:10.1038/s41598-023-49280-1 · Cited by 8
Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro
Funeshima, N., Tanikawa, N., Yaginuma, H., Watanabe, H., Iwata, H., Kuwayama, T., Hamano, S., & Shirasuna, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227885 · Cited by 8
Longitudinal Transcriptomic Profiling in Carrageenan-Induced Rat Hind Paw Peripheral Inflammation and Hyperalgesia Reveals Progressive Recruitment of Innate Immune System Components
Goto, T., Sapio, M. R., Maric, D., Robinson, J. M., Saligan, L. N., Mannes, A. J., & Iadarola, M. J. (2020) · Journal of Pain · doi:10.1016/j.jpain.2020.11.001 · Cited by 8
Antibody microarray analysis of amniotic fluid proteomes in women with cervical insufficiency and short cervix, and their association with pregnancy latency length
Hong, S., Park, K. H., Lee, Y. E., Lee, J. E., Kim, Y. M., Joo, E., & Cho, I. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263586 · Cited by 8
Implications for neutrophils in cardiac arrhythmias
Hegemann, N., Barth, L., Döring, Y., Voigt, N., & Grune, J. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00590.2023 · Cited by 9
Predictive potential of various plasma inflammation-, angiogenesis-, and extracellular matrix remodeling-associated mediators for intra-amniotic inflammation and/or microbial invasion of the amniotic cavity in preterm labor
Joo, E., Hong, S., Park, K. H., Kim, H. J., Lee, M. J., & Shin, S. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-024-07378-5 · Cited by 7
Single‐cell transcriptome dissecting the microenvironment remodeled by PD1 blockade combined with photodynamic therapy in a mouse model of oral carcinogenesis
Dong, Y., Zeng, K., Ai, R., Zhang, C., Mao, F., Dan, H., Zeng, X. Y., Ji, N., Li, J., Jin, X., et al. (2024) · MedComm · doi:10.1002/mco2.636 · Cited by 7
Polygenic TB control and the sequence of innate/adaptive immune responses to infection: MHC ‐ II alleles determine the size of the S100A8 /9‐producing neutrophil population
Logunova, N. N., Kapina, M. A., Dyatlov, A. V., Kondratieva, T. K., Rubakova, E. I., Majorov, K. B., Kondratieva, E., Linge, I. A., & Apt, A. S. (2024) · Immunology · doi:10.1111/imm.13836 · Cited by 7
Dictamnus dasycarpus Turcz. Root Bark Improves Skin Barrier Function and Symptoms of Atopic Dermatitis in Mice
Park, S., Yang, J., Sun, K., Park, S., Lee, J., Kim, S.-Y., Lyu, J., & Kim, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313178 · Cited by 7
Transformation of brain myeloid cell populations by SIV in rhesus macaques revealed by multiomics
Xu, X., Niu, M., Lamberty, B. G., Emanuel, K. M., Apostol, M. J. F., & Fox, H. S. (2025) · Communications Biology · doi:10.1038/s42003-024-07443-4 · Cited by 8
LC-MS/MS-Profiling of Human Serum Unveils Significant Increase in Neuroinflammation and Carcinogenesis Following Chronic Organophosphate Exposure
Sandilya, V., El-Gameel, D., Atashi, M., Nguyen, T. T. H., Fowowe, M., Bhuiyan, M. M. A. A., Daramola, O. E., Nwaiwu, J. I., Hamdy, N. A., Ghanem, M., et al. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00995 · Cited by 7
S100A9 in sepsis: A biomarker for inflammation and a mediator of organ damage
Xu, J., Gao, Y., Huang, X. R., Li, J., Sun, T., Wang, X., Zhao, Y., & Wang, T. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151484 · Cited by 7
Tumor Microenvironment in Melanoma Brain Metastasis: A New Potential Target?
Caruso, G., Moreira, C. G. G., Iaboni, E., Tripodo, M., Ferrarotto, R., Abbritti, R. V., Conte, L., & Caffo, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115018 · Cited by 7
Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression
Yi, E., Wang, X., Liu, Y., Wang, Z., Bai, G., Mei, X., Wu, F., Xie, C., Li, Q., Cao, W., et al. (2025) · MedComm · doi:10.1002/mco2.70204 · Cited by 7
Self-citation
Salivary Calprotectin as a Biomarker in Early Onset Inflammatory Bowel Disease: A Pilot Study
Liguori, S., Musella, G., Adamo, D., Miele, E., Coppola, N., Canfora, F., Giudice, C. D., Spagnuolo, G., Rengo, S., Mignogna, M. D., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124232 · Cited by 7
Complex I inhibition combined with TLR activation in the breast tumor microenvironment educates cytotoxic neutrophils
Heath, J., Ahn, R., Sabourin, V., Im, Y. K., Richard, S. R., Annett, A., Mirabelli, C., Worme, S. J., Maritan, S. M., Mourcos, C., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu5915 · Cited by 7
Adiposome Proteomics Uncover Molecular Signatures of Cardiometabolic Risk in Obese Individuals
Rakab, M. S., Asada, M. C., Mirza, I., Morsy, M., Mostafa, A., Bianco, F. M., Ali, M. M., Hassan, C., Masrur, M. A., Layden, B. T., et al. (2025) · Proteomes · doi:10.3390/proteomes13030039 · Cited by 7
Prostaglandins prevent long-lasting pain in a mouse model of chronic postsurgical pain
Karaky, M., Lima, L. V., Oveisi, A., Montagna, F., Mogil, J. S., & Diatchenko, L. B. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2025.10.020 · Cited by 7
Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19
Whitcomb, L. A., Berry, K., LaVergne, S. M., Natter, N., Baxter, B. A., Rao, S., Tipton, M., Gritsenko, M. A., Weitz, K., Gerbasi, V. R., et al. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-11824-3 · Cited by 7
Global gene methylation profiling of common warts caused by human papillomaviruses infection
Alghamdi, M. A., AL-Eitan, L. N., Tarkhan, A. H., & Al‐Qarqaz, F. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.10.050 · Cited by 7
Establishment of an Intradermal Ear Injection Model of IL-17A and IL-36γ as a Tool to Investigate the Psoriatic Cytokine Network
Kluwig, D., Huth, S., Abdallah, A. T., Pfaff, C. M., Fietkau, K., Huth, L., Marquardt, Y., Baron, J. M., & Lüscher, B. (2021) · Life · doi:10.3390/life11080846 · Cited by 8
Murine burn lesion model for studying acute and chronic wound infections
Calum, H., Trøstrup, H., Laulund, A. S., Thomsen, K., Christophersen, L., Høiby, N., & Moser, C. E. (2022) · Apmis · doi:10.1111/apm.13228 · Cited by 9
Discovery of protein biomarkers for venous thromboembolism in non-small cell lung cancer patients through data-independent acquisition mass spectrometry
Liu, Y., Gao, L., Fan, Y., Ma, R., An, Y., Chen, G., & Xie, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1079719 · Cited by 7
Biomarkers Found in the Tumor Interstitial Fluid may Help Explain the Differential Behavior Among Keratinocyte Carcinomas
Matas‐Nadal, C., Bech‐Serra, J. J., Gatius, S., Gómez, X., Ribes-Santolaria, M., Guasch‐Vallés, M., Pedraza, N., Casanova, J. M., de la Torre, C., Garí, E., et al. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100547 · Cited by 7
FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice
Malik, B., Vokic, I., Mohr, T. T., Poppelaars, M., Holcmann, M., Novoszel, P., Timelthaler, G., Lendl, T., Krauß, D., Elling, U., et al. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202216758 · Cited by 7
Identification of Breast Cancer LCK Proto-Oncogene as a Master Regulator of TNBC Neutrophil Enrichment and Polarization
Alqutami, F., Halabi, W. A., & Hachim, M. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713269 · Cited by 7
Non‐invasive detection of Crohn's Disease with label‐free detection of calprotectin by impedimetric aptasensor
Aslan, Ç. G., Uygun, H. D. E., Uygun, Z. O., Ünal, N. G., & Akçay, Y. (2023) · Electroanalysis · doi:10.1002/elan.202300119 · Cited by 7
C4BP(β-)-mediated immunomodulation attenuates inflammation in DSS-induced murine colitis and in myeloid cells from IBD patients
Serrano, I., Luque, A., Ruiz‐Cerulla, A., Navas-Yuste, S., Blom, A. M., de Córdoba, S. R., Fernández, F. J., Vega, M. C., Rodríguez‐Moranta, F., Guardiola, J., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106948 · Cited by 7
Potential therapeutic targets for trauma management
Li, Z., Qiao, O., Wang, Y., Li, N., & Gong, Y. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.10.001 · Cited by 7
WTAP-Mediated N6-Methyladenosine of RNAs Facilitate the Pathophysiology of Atopic Dermatitis
Tan, L., Chen, X., Yan, S., Guo, A., Gao, L., Zhou, L., Zhou, Y., Zeng, J., & Lu, J. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.10.032 · Cited by 7
Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9
Wang, T., Zhao, C., Zhang, J., Li, S., Zhang, Y., Gong, Y., Zhou, Y., Yan, L., Zhang, S., Zhang, Z., et al. (2024) · iScience · doi:10.1016/j.isci.2024.108857 · Cited by 8
Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction
Rosa, T. L. S. A., Leal-Calvo, T., Tavares, I. F., Mendes, M. A., Dias, A. A., Piauy, M. H. D. S., Barboza, M. F. D. S., Kapuscinski, M. L., Costa, F. D. M. R., Marques, M. A. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1366125 · Cited by 7
Monkey multi-organ cell atlas exposed to estrogen
Fang, W., Qu, J., Zhao, W., Cao, X., Liu, J., Han, Q., Chen, D., Lv, W., Xie, Y., & Sun, Y. (2024) · Life Medicine · doi:10.1093/lifemedi/lnae012 · Cited by 8
Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19
Peidli, S., Nouailles, G., Wyler, E., Adler, J. M., Kunder, S., Voß, A., Kazmierski, J., Pott, F., Pennitz, P., Postmus, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114328 · Cited by 6
VNN2-expressing circulating monocytes exhibit unique functional characteristics and are decreased in patients with primary Sjögren's syndrome
Bahabayi, A., Alimu, X., Wang, G., Gao, Y., Chen, Y., Zhao, J., Li, Q., Li, Q., Xiong, Z., Zhang, Z., et al. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103275 · Cited by 7
Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients
Didriksson, I., Lengquist, M., Spångfors, M., Leffler, M., Sievert, T., Lilja, G., Frigyesi, A., Friberg, H., & Schiopu, A. (2024) · Journal of Intensive Care · doi:10.1186/s40560-024-00740-4 · Cited by 7
A review of CD4+ T cell differentiation and diversity in dogs
Lang, H. P., Osum, K. C., & Friedenberg, S. G. (2024) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2024.110816 · Cited by 8
Multidisciplinary approaches to study anaemia with special mention on aplastic anaemia (Review)
Sankar, D., & Oviya, I. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5419 · Cited by 7
Blocking S100A9-signaling is detrimental to the initiation of anti-tumor immunity
Demir, M. F., Lin, Y.-H., Cruz, P. H. C., Tajima, M., Honjo, T., & Müller, E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1479502 · Cited by 7
A nutrigenetic approach for investigating the chemopreventive effects of black raspberries during the development of preneoplastic esophagi in rats
Pan, P., Dombkowski, A. A., Wang, L., & Stoner, G. D. (2018) · Journal of Berry Research · doi:10.3233/jbr-180346 · Cited by 7
Adjunctive S100A8/A9 Immunomodulation Hinders Ciprofloxacin Resistance in Pseudomonas aeruginosa in a Murine Biofilm Wound Model
Laulund, A. S., Schwartz, F. A., Trøstrup, H., Thomsen, K., Christophersen, L., Calum, H., Ciofu, O., Høiby, N., & Moser, C. E. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.652012 · Cited by 7
Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis
Hong, M., Wu, J., Ma, L., Han, X., Lu, T., Wang, Z., Zhao, J., Liu, L., Fu, H., Huang, W., et al. (2021) · Biomarker Research · doi:10.1186/s40364-021-00304-w · Cited by 7
Self-citation
Glomerular Expression of S100A8 in Lupus Nephritis: An Integrated Bioinformatics Analysis
Qijiao, W., Zhihan, C., Makota, P., Qing, Y., Fei, G., Zhihong, W., & He, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843576 · Cited by 7
Characteristic analysis of skin keratinocytes in patients with type 2 diabetes based on the single-cell levels
Liao, B., Ouyang, Q., Song, H., Wang, Z., Ou, J., Huang, J., & Liu, L. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002323 · Cited by 7
Self-citation
Detection of serum calprotectin based on molecularly imprinted photonic hydrogels: A novel approach for IBD diagnosis
Resende, S., Frasco, M. F., Freitas, P. P., & Sales, M. G. F. (2023) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2023.100313 · Cited by 7
Gene expression of S100a8/a9 predicts Staphylococcus aureus-induced septic arthritis in mice
Deshmukh, M. V., Subhash, S., Hu, Z., Mohammad, M., Jarneborn, A., Pullerits, R., Jin, T., & Kopparapu, P. K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1146694 · Cited by 7
An Intriguing Structural Modification in Neutrophil Migration Across Blood Vessels to Inflammatory Sites: Progress in the Core Mechanisms
Wang, Z., Guo, Y., Zhang, Y., Wu, L., Wang, L., Lin, Q., & Wan, B. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01198-1 · Cited by 7
Self-citation
Potential of plasma inflammatory and angiogenic mediators for predicting spontaneous preterm delivery, intraamniotic infection/inflammation, and composite neonatal morbidity/mortality in women with early preterm premature rupture of membranes
Kim, H. J., Park, K. H., Joo, E., Lee, M. J., & Choi, B. Y. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13809 · Cited by 7
Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery
Holub, M., Bartáková, E., Stráníková, A., Koblihová, E., Arientová, S., Blahutová, M., Máca, J., & Ryska, M. (2019) · Mediators of Inflammation · doi:10.1155/2019/6985703 · Cited by 7
Genetics and Signaling Pathways of Laminitis
Galantino‐Homer, H. L., & Brooks, S. A. (2020) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2020.04.001 · Cited by 7
Salmonella pathogenicity island 1 knockdown confers protection against myocardial fibrosis and inflammation in uremic cardiomyopathy via down-regulation of S100 Calcium Binding Protein A8/A9 transcription
Cai, X., Hong, L., Liu, Y., Huang, X., Lai, H., & Shao, L. (2022) · Renal Failure · doi:10.1080/0886022x.2022.2137421 · Cited by 6
Spatially resolved transcriptomic profiling of placental development in dairy cow
Tan, G.-H., 西北农林大学动物科学技术学院陕西省动物遗传育种与繁殖重点实验室, 陕. 杨., Liu, S., Dou, M., Zhao, D.-F., Zhang, A., Li, H.-K., Luo, F.-N., Shi, T., Wang, H.-P., et al. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2023.205 · Cited by 6
S100A9/RAGE pathway regulation of mitophagy and the effect of JianPi LiShi YangGan formula in acute-on-chronic liver failure
Li, J., Hu, R., Liu, X., Peng, L., Yi, J., Zhong, X., Huang, Q., Sun, J., Feng, W., Ma, W., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119887 · Cited by 6
The Role of Fibroblasts Across Inflammation and Immunity
Cowan, M. J. B., Davidson, S., Coles, M. C., & Buckley, C. D. (2025) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-080624-105114 · Cited by 11
Single-cell transcriptomic analysis reveals a systemic immune dysregulation in intravenous immunoglobulin non-responsive Kawasaki disease
Feng, C., Li, Q., Yang, M., Chen, Y.-H., Zhang, M., Wang, H., & Li, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1702290 · Cited by 6
Elucidating a Myofibroblast-dominated Fibrotic Niche in Crohn’s Disease-associated Fibrostenosis Through High-resolution Spatial Transcriptomics
Zhang, D., Zou, X., He, M., Sun, S., Yu, A., Shi, J., Ouyang, T., Lin, X., Yang, H., Bai, L., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101701 · Cited by 6
S100A8/S100A9 through PAD4 activation of neutrophil extracellular traps promotes granulomatous lobular mastitis
Zhu, T., Yu, H., Wang, W., Sun, Y., Wang, S., Ma, D., & Yao, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1672538 · Cited by 6
Self-citation
Severe fever with thrombocytopenia syndrome virus infection of the male reproductive tract induces pathology and inflammation
Zhang, Y., Zhang, L., Xu, H., Yin, X., Zheng, X., Cui, N., Lv, H., Zhang, X., Fang, L., Zhang, L., et al. (2026) · Nature Microbiology · doi:10.1038/s41564-026-02298-3 · Cited by 6
Integrated methylome–transcriptome profiling reveals epigenetic regulation of immune activation pathways and CSN3-associated lactation repression in bovine subclinical mastitis
Dwivedi, S., kumar, A., De, U. K., Chauhan, A., Agrawal, R. K., Khanna, S., Upadhyay, A., Singh, A., Devatwal, P. C., & Dutt, T. (2026) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-026-01400-3 · Cited by 6
CRISPR-Cas9 based knockout of S100A8 in mammary epithelial cells enhances cell proliferation and triggers oncogenic transformation via the PI3K-Akt pathway: Insights from a deep proteomic analysis
Singh, P., Ali, S. A., Kumar, S., & Mohanty, A. K. (2023) · Journal of Proteomics · doi:10.1016/j.jprot.2023.104981 · Cited by 6
ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9
Ghosh, S., Tamilselvi, S., Williams, C., Jayaweera, S. W., Iashchishyn, I. A., Šulskis, D., Gilthorpe, J. D., Olofsson, A., Smirnovas, V., Svedružić, Ž. M., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042114 · Cited by 6
Partial hepatectomy accelerates colorectal metastasis by priming an inflammatory premetastatic niche in the liver
Lünstedt, J., Hoping, F., Feuerstein, R., Mauerer, B., Berlin, C., Rapp, J., Marx, L., Reichardt, W., von Elverfeldt, D., Ruess, D. A., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1388272 · Cited by 6
Mortality prediction model from combined serial lactate, procalcitonin and calprotectin levels in critically ill patients with sepsis: A retrospective study according to Sepsis-3 definition
de Guadiana‐Romualdo, L. G., Albert-Botella, L., Rojas, C. R., Candel, Á. P., Sánchez, R. J., Conesa‐Zamora, P., Albaladejo-Otón, M. D., & Allegue-Gallego, J. M. (2024) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2024.05.015 · Cited by 6
Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet’s disease uveitis
Qin, W., Liang, A., Han, X., Zhang, M., Gao, Y., & Zhao, C. (2024) · BMC Ophthalmology · doi:10.1186/s12886-024-03557-9 · Cited by 6
S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4/IL-10 signaling pathway in glioma
Yang, Y., Cui, H., Li, D., Chen, L., Liu, Y., Zhou, C., Li, L., Feng, M., Chen, X., Cao, Y., et al. (2024) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2024.07.001 · Cited by 6
Calprotectin is regulated by IL-17A and induces steroid hyporesponsiveness in asthma
Sharif‐Askari, N. S., Mdkhana, B., Hafezi, S., Khalil, B. A., Al-Sheakly, B. K. S., Halwani, H., Sharif‐Askari, F. S., & Halwani, R. (2024) · Inflammation Research · doi:10.1007/s00011-024-01937-x · Cited by 6
Comparative analysis of milk fat globule membrane proteins between porcine and human colostrum by a label‐free proteomics approach
Zhao, H., Zhang, Z., Liu, X., Li, J., Song, W., Yue, X., & Liu, X. (2024) · International Journal of Dairy Technology · doi:10.1111/1471-0307.13140 · Cited by 6
Pangolin scales as adaptations for innate immunity against pathogens
Tian, X., Chen, L., Zhou, J., Wang, E., Wang, M., Jakubovics, N. S., Li, J., Song, K., Lau, K. T., Koepfli, K., et al. (2024) · BMC Biology · doi:10.1186/s12915-024-02034-5 · Cited by 6
Mortality prediction model from combined serial lactate, procalcitonin and calprotectin levels in critically ill patients with sepsis: A retrospective study according to Sepsis-3 definition
de Guadiana‐Romualdo, L. G., Albert-Botella, L., Rojas, C. R., Candel, Á. P., Sánchez, R. J., Conesa‐Zamora, P., Albaladejo-Otón, M. D., & Allegue-Gallego, J. M. (2024) · Medicina Intensiva · doi:10.1016/j.medin.2024.05.004 · Cited by 6
Virtual Probing on the Influence of Ca2+ and Zn2+ Bound S100A8 and S100A9 Proteins Towards their Interaction Against Pattern Recognition Receptors Aggravating Rheumatoid Arthritis
Paramasivam, S., Murugesan, J., Vedagiri, H., Perumal, S. S., & Ekambaram, S. P. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01600-6 · Cited by 6

Authors: Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J.
Affiliations: Central South University (CN)
Corresponding author: Ma, Jian
ORCID: Wang, Siwen
Song, Rui
Wang, Ziyi
Jing, Zhaocheng
Wang, Shaoxiong
Ma, Jian
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2018-06-11
Volume: 9
Pages: 1298-1298
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2018.01298
PMC: PMC6004386
OpenAlex: W2808305854
Cited by: 1,450
References: 165
Citations by year: 2026: 176 · 2025: 217 · 2024: 248 · 2023: 225 · 2022: 236 · 2021: 184 · 2020: 119 · 2019: 40 · 2018: 4
FWCI: 8.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81672889, 81472694)
Hunan Provincial Science and Technology Department (2016JC2035)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: S100A8/A9, S-100 protein, heterodimer, calcium-binding proteins, inflammation, neutrophils, monocytes, leukocyte recruitment, cytokine production, arachidonic acid metabolism, biomarkers, therapeutic target, small molecule inhibitors
MeSH terms: Animals, Disease Susceptibility, Gene Expression Regulation, Humans, Immunity, Inflammation, Biomarkers, Autoimmunity, Protein Transport, Calgranulin A, Calgranulin B, Host-Pathogen Interactions, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

S100A8/A9 in Inflammation

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks