The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
The Nexus Between Periodontal Inflammation and Dysbiosis
Open accessAbstract
The nexus between periodontal inflammation and the polymicrobial biofilm in the gingival sulcus is critical to understanding the pathobiology of periodontitis. Both play a major role in the etiology and pathogenesis of periodontal diseases and each reinforces the other. However, this nexus is also at the center of a significant conundrum for periodontology. For all mucosal polymicrobial biofilms, the most confounding issue is the paradoxical relationship between inflammation, infection, and disease. Despite significant advances made in both periodontal microbiology and periodontal pathobiology, the issue of which comes first, the inflammatory response or the change to a dysbiotic subgingival microbiota, is still debated. In this paper, we present a model for the pathogenesis of periodontitis based on the central role of inflammation and how this modulates the polymicrobial biofilm within the context of the continuum of health, gingivitis, and periodontitis. We propose a new model termed "Inflammation-Mediated Polymicrobial-Emergence and Dysbiotic-Exacerbation" (IMPEDE), which is designed to integrate into and complement the 2017 World Workshop Classification of Periodontitis.
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Cites
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256
The Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
Caton, J. G., Armitage, G., Berglundh, T., Chapple, I. L. C., Jepsen, S., Kornman, K. S., Mealey, B. L., Papapanou, P. N., Sanz, M., & Tonetti, M. S. (2018) · Journal of Periodontology · doi:10.1002/jper.18-0157 · Cited by 1,845
The keystone-pathogen hypothesis
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Inflammatory and immune pathways in the pathogenesis of periodontal disease
Cekici, A., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2014) · Periodontology 2000 · doi:10.1111/prd.12002 · Cited by 1,415 · cited 1×
“With time, there is an acquired immune response that can be either destructive or reparative in different circumstances (11).”
BackgroundResolvins in inflammation: emergence of the pro-resolving superfamily of mediators
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Cited by
Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
Abdulkareem, A. A., Al-Taweel, F. B., Al-Sharqi, A. J. B., Gul, S. S., Sha, A., & Chapple, I. L. C. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2197779 · Cited by 367
Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling
Sun, X., Gao, J., Meng, X., Lu, X., Zhang, L., & Chen, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763334 · Cited by 291
Outside the limits of bacterial viability: Postbiotics in the management of periodontitis
Moraes, R. M., Schlagenhauf, U., & Anbinder, A. L. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115072 · Cited by 29
Paz, H. E. S., Monteiro, M. F., Stolf, C. S., Altabtbaei, K., Casati, M. Z., Casarin, R. C. V., & Kumar, P. S. (2022) · Journal of Periodontology · doi:10.1002/jper.21-0411 · Cited by 7
Metadata
- Authors
- Van Dyke, T. E., Bartold, P. M., & Reynolds, E. C.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-03-31
- Volume
- 11
- Pages
- 511-511
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3014529666
- Cited by
- 458
- References
- 64
- FWCI
- 44.72
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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