Cited by 113vaccines and immunoinformatics approachesImmune responses and vaccinationsSARS-CoV-2 and COVID-19 Research

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Current Challenges in Vaccinology

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Kennedy, Richard B., Ovsyannikova, Inna G., Palese, Peter, Poland, Gregory A.·2020·Frontiers in Immunology

DOI 10.3389/fimmu.2020.01181PMC PMC7329983

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Abstract

The development of vaccines, which prime the immune system to respond to future infections, has led to global declines in morbidity and mortality from dreadful infectious communicable diseases. However, many pathogens of public health importance are highly complex and/or rapidly evolving, posing unique challenges to vaccine development. Several of these challenges include an incomplete understanding of how immunity develops, host and pathogen genetic variability, and an increased societal skepticism regarding vaccine safety. In particular, new high-dimensional omics technologies, aided by bioinformatics, are driving new vaccine development (vaccinomics). Informed by recent insights into pathogen biology, host genetic diversity, and immunology, the increasing use of genomic approaches is leading to new models and understanding of host immune system responses that may provide solutions in the rapid development of novel vaccine candidates.

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See all 113

Authors: Kennedy, R. B., Ovsyannikova, I. G., Palese, P., & Poland, G. A.
Affiliations: Mayo Clinic (US)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Kennedy, Richard B.
ORCID: Kennedy, Richard B.
Ovsyannikova, Inna G.
Palese, Peter
Poland, Gregory A.
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2020-06-25
Volume: 11
Pages: 1181-1181
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2020.01181
PMC: PMC7329983
OpenAlex: W3033639218
Cited by: 113
References: 222
Citations by year: 2026: 22 · 2025: 24 · 2024: 21 · 2023: 16 · 2022: 12 · 2021: 17 · 2020: 1
FWCI: 1.10
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (R01AI033144, R01AI121054, R01AI127365, R01AI132348, R01AI138965, R37AI048793, U01AI089859)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords: vaccine development, vaccinomics, host genetic variation, host immune response, omics technologies, bioinformatics, infectious disease prevention, emerging pathogens
MeSH terms: Vaccinology, Animals, Communicable Disease Control, Humans, Vaccines, Computational Biology

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