Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
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Abstract
Saliva is an alternative biofluid to serum for detecting and monitoring IgG to SARS-CoV-2 spike and RBD antigens in COVID-19.
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Spike IgG and IgA levels in blood were indicative of levels in saliva.
“Spike IgG and IgA levels in blood were indicative of levels in saliva (Isho et al., 2020).”
From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Isho et al., 2020
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- Authors
- Isho, B., Abe, K. T., Zuo, M., Jamal, A. J., Rathod, B., Wang, J. H., Li, Z., Chao, G., Rojas, O. L., Bang, Y. M., Pu, A., Christie-Holmes, N., Gervais, C., Ceccarelli, D., Samavarchi-Tehrani, P., Guvenc, F., Budylowski, P., Li, A., Paterson, A., Yue, F. Y., Marin, L. M., Caldwell, L., Wrana, J. L., Colwill, K., Sicheri, F., Mubareka, S., Gray-Owen, S. D., Drews, S. J., Siqueira, W. L., Barrios-Rodiles, M., Ostrowski, M., Rini, J. M., Durocher, Y., McGeer, A. J., Gommerman, J. L., & Gingras, A.-C.
- Affiliations
- University of Toronto (CA)
- Mount Sinai Hospital (CA)
- National Research Council Canada (CA)
- Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada.
- University of Saskatchewan (CA)
- Sunnybrook Health Science Centre (CA)
- Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
- University of Alberta (CA)
- St. Michael's Hospital (CA)
- Corresponding author
- Gommerman, Jennifer L.
- Gingras, Anne-Claude
- ORCID
- Isho, Baweleta
- Abe, Kento T.
- Zuo, Michelle
- Jamal, Alainna J.
- Rathod, Bhavisha
- Li, Zhijie
- Chao, Gary
- Rojas, Olga L.
- Bang, Yeo Myong
- Pu, Annie
- Christie-Holmes, Natasha
- Gervais, Christian
- Ceccarelli, Derek
- Guvenc, Furkan
- Yue, Feng Yun
- Marin, Lina M.
- Caldwell, Lauren
- Wrana, Jeffrey L.
- Colwill, Karen
- Sicheri, Frank
- Mubareka, Samira
- Gray-Owen, Scott D.
- Drews, Steven J.
- Siqueira, Walter L.
- Ostrowski, Mario
- Rini, James M.
- Durocher, Yves
- McGeer, Allison J.
- Gommerman, Jennifer L.
- Gingras, Anne-Claude
- Venue
- Science Immunology
- Published
- 2020-10-08
- Volume
- 5
- Issue
- 52
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC8050884
- OpenAlex
- W3092050672
- Cited by
- 822
- References
- 61
- Citations by year
- 2026: 24 · 2025: 48 · 2024: 76 · 2023: 118 · 2022: 198 · 2021: 313 · 2020: 45
- FWCI
- 22.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science Immunology (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- NPARC (acceptedVersion)
- Funders
- Genome Canada (Ontario Genomics OGI-139)
- Government of Ontario (Ontario Together grant)
- Canadian Institutes of Health Research (#VR1-172711, #VR4–172732, FDN15992, FDN143301)
- Canada Foundation for Innovation (N/A)
- Sinai Health System Foundation (N/A)
- CIHR - COVID-19 Rapid Research Funding Opportunity - Diagnostics
- Sunnybrook Foundation (Questcap)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, saliva antibodies, serum antibodies, IgG, IgA, IgM, spike protein, receptor binding domain, antibody persistence, convalescence
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Antibodies, Viral, Antigens, Viral, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Longitudinal Studies, Male, Middle Aged, Pneumonia, Viral, Saliva, Coronavirus Infections, Pandemics, Spike Glycoprotein, Coronavirus
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