The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Candida Biofilms: Threats, Challenges, and Promising Strategies
Open accessAbstract
Candida species are fungal pathogens known for their ability to cause superficial and systemic infections in the human host. These pathogens are able to persist inside the host due to the development of pathogenicity and multidrug resistance traits, often leading to the failure of therapeutic strategies. One specific feature of Candida species pathogenicity is their ability to form biofilms, which protects them from external factors such as host immune system defences and antifungal drugs. This review focuses on the current threats and challenges when dealing with biofilms formed by Candida albicans, Candida glabrata, Candida tropicalis and Candida parapsilosis, highlighting the differences between the four species. Biofilm characteristics depend on the ability of each species to produce extracellular polymeric substances (EPS) and display dimorphic growth, but also on the biofilm substratum, carbon source and other factors. Additionally, the transcriptional control over processes like adhesion, biofilm formation, filamentation and EPS production displays great complexity and diversity within pathogenic yeasts of the Candida genus. These differences not only have implications in the persistence of colonization and infections, but also on antifungal resistance typically found in Candida biofilm cells, potentiated by EPS, that functions as a barrier to drug diffusion, and by the overexpression of drug resistance transporters. The ability to interact with different species in in vivo Candida biofilms is also a key factor to consider when dealing with this problem. Despite many challenges, the most promising strategies that are currently available or under development to limit biofilm formation or to eradicate mature biofilms are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“biofilms are known to hinder the penetration of antifungal drugs and host immune effectors and also trigger the formation of Candida persister cells, leading to poor clinical outcomes [52,53].”
From Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of Candida auris and displays potent synergistic interactions with azole drugs (2020) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Flemming, H.-C., & Wingender, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2415 · Cited by 10,137
Biofilm formation as microbial development
O'Toole, G., Kaplan, H. B., & Kolter, R. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.49 · Cited by 3,571
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Lewis, K. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.4.999-1007.2001 · Cited by 2,005
Chandra, J., Kuhn, D. M., Mukherjee, P. K., Hoyer, L. L., McCormick, T., & Ghannoum, M. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5385-5394.2001 · Cited by 1,578
Guidelines for the management of intravascular catheter-related infections
Mermel, L. A., Farr, B. M., Sherertz, R. J., Raad, I. I., O'Grady, N., Harris, J. S., & Craven, D. E. (2001) · Clinical Infectious Diseases · doi:10.1086/320001 · Cited by 1,449
Biofilms and Device-Associated Infections
Donlan, R. M. (2001) · Emerging infectious diseases · doi:10.3201/eid0702.010226 · Cited by 1,425
Candida biofilms and their role in infection
Douglas, L. J. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00002-1 · Cited by 1,150
Candida Infections of Medical Devices
Kojic, E. M., & Darouiche, R. O. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.255-267.2004 · Cited by 1,055
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2982-2992.2001 · Cited by 983
Flagged first, then by citations
Cited by
Sorted by citations
Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Talapko, J., Juzbašić, M., Matijević, T., Pustijanac, E., Bekić, S., Kotris, I., & Škrlec, I. (2021) · Journal of Fungi · doi:10.3390/jof7020079 · Cited by 794
Biocontrol yeasts: mechanisms and applications
Freimoser, F. M., Rueda-Mejia, M. P., Tilocca, B., & Migheli, Q. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2728-4 · Cited by 462
Architecture of the dynamic fungal cell wall
Gow, N. A. R., & Lenardon, M. D. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00796-9 · Cited by 447
Candida parapsilosis: from genes to the bedside
Tóth, R., Nosek, J., Mora-Montes, H. M., Gabaldon, T., Bliss, J. M., Nosanchuk, J. D., Turner, S. A., Butler, G., Vágvölgyi, C., & Gácser, A. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00111-18 · Cited by 327
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Arastehfar, A. A., Gabaldón, T., Garcia‐Rubio, R., Jenks, J. D., Hoenigl, M., Salzer, H. J. F., İlkit, M., Lass‐Flörl, C., & Perlin, D. S. (2020) · Antibiotics · doi:10.3390/antibiotics9120877 · Cited by 302
Candida albicans biofilms and polymicrobial interactions
Ponde, N. O., Lortal, L., Ramage, G., Naglik, J. R., & Richardson, J. P. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1843400 · Cited by 281
Mechanistic Understanding of Candida albicans Biofilm Formation and Approaches for Its Inhibition
Atriwal, T., Azeem, K., Husain, F. M., Hussain, A., Khan, M. N., Alajmi, M. F., & Abid, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.638609 · Cited by 222
Invasive candidiasis: current clinical challenges and unmet needs in adult populations
Soriano, À., Honoré, P. M., Puerta‐Alcalde, P., García‐Vidal, C., Pagotto, A., Gonçalves, D. C., & Verweij, P. E. (2023) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkad139 · Cited by 215
Invasive fungal disease in humans: are we aware of the real impact?
Firacative, C. (2020) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760200430 · Cited by 190
Promising Therapeutic Strategies Against Microbial Biofilm Challenges
Zhang, K., Li, X., Yu, C., & Wang, Y. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00359 · Cited by 193
Gao, S., Liu, G., Li, J., Chen, J., Li, L., Li, Z., Zhang, X., Zhang, S., Thorne, R. F., & Zhang, S. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.603858 · Cited by 187
Candida albicans and Candida glabrata : global priority pathogens
Katsipoulaki, M., Stappers, M. H. T., Malavia-Jones, D., Brunke, S., Hube, B., & Gow, N. A. R. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00021-23 · Cited by 180
Biofilm formation in medically important Candida species
Malinovská, Z., Čonková, E., & Váczi, P. (2023) · Journal of Fungi · doi:10.3390/jof9100955 · Cited by 167
Plant-Derived Products as Antibacterial and Antifungal Agents in Human Health Care
Kokoška, L., Klouček, P., Leuner, O., & Nový, P. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180831144344 · Cited by 165
Biofilms and vulvovaginal candidiasis
Rodríguez‐Cerdeira, C., Carnero-Gregorio, M., Molares-Vila, A., López-Bárcenas, A., Fabbrocini, G., Bardhi, B., Sinani, A., Sánchez-Blanco, E., Arenas, R., & Hernández‐Castro, R. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.11.011 · Cited by 159
Jafri, H., & Ahmad, I. (2019) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2019.100911 · Cited by 163
Candida spp./Bacteria Mixed Biofilms
Rodrigues, M. E., Gomes, F., & Rodrigues, C. F. (2019) · Journal of Fungi · doi:10.3390/jof6010005 · Cited by 152
The Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens
Arastehfar, A., Lass-Flörl, C., Garcia-Rubio, R., Daneshnia, F., Ilkit, M., Boekhout, T., Gabaldon, T., & Perlin, D. S. (2020) · Journal of Fungi · doi:10.3390/jof6030138 · Cited by 145
Mechanism of Candida pathogenesis: Revisiting the vital drivers
Mba, I. E., & Nweze, E. I. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-03912-w · Cited by 143
Branco, J., Miranda, I. M., & Rodrigues, A. G. (2023) · Journal of Fungi · doi:10.3390/jof9010080 · Cited by 145
Adapting to survive: How Candida overcomes host-imposed constraints during human colonization
Alves, R. M. A., Barata-Antunes, C., Casal, M., Brown, A. J. P., Dijck, P. V., & Paiva, S. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008478 · Cited by 126
Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis
Rodríguez‐Cerdeira, C., Martínez-Herrera, E. O., Carnero-Gregorio, M., López-Bárcenas, A., Fabbrocini, G., Fida, M., El-Samahy, M., & González-Cespón, J. L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.544480 · Cited by 132
Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants
Ceresa, C., Fracchia, L., Fedeli, E., Porta, C., & Banat, I. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040466 · Cited by 126
Prevalence of biofilms in Candida spp. bloodstream infections: A meta-analysis
Atiencia-Carrera, M. B., Cabezas-Mera, F. S., Tejera, E., & Machado, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263522 · Cited by 116
Prasath, K. G., Tharani, H., Kumar, M. S., & Pandian, S. K. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00864 · Cited by 111
The role of Lactobacillus species in the control of Candida via biotrophic interactions
Zangl, I., Pap, I.-J., Aspöck, C., & Schüller, C. (2020) · Microbial Cell · doi:10.15698/mic2020.01.702 · Cited by 113
Lemos, A. S. D. O., Florêncio, J. R., Pinto, N. D. C. C., Campos, L. M., Silva, T. P. D., Grazul, R. M., Pinto, P. D. F., Tavares, G. D., Scio, E., Apolônio, A. C. M., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01525 · Cited by 106
Kowalska, J., Krzymińska, J., & Tyburski, J. (2022) · Agriculture · doi:10.3390/agriculture12091404 · Cited by 106
Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin
Galocha, M., Pais, P., Cavalheiro, M., Pereira, D., Viana, R., & Teixeira, M. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092345 · Cited by 105
Self-citationCandida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges
de Barros, P. P., Rossoni, R. D., de Souza, C. M., Scorzoni, L., Fenley, J. D. C., & Junqueira, J. C. (2020) · Mycopathologia · doi:10.1007/s11046-020-00445-w · Cited by 106
Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
Kovács, R., & Majoros, L. (2020) · Journal of Fungi · doi:10.3390/jof6030099 · Cited by 99
Candidemia: Evolution of Drug Resistance and Novel Therapeutic Approaches
Tortorano, A. M., Prigitano, A., Morroni, G., Brescini, L., & Barchiesi, F. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s274872 · Cited by 104
Ivanov, M., Kannan, A., Stojković, D. S., Glamočlija, J., Calhelha, R. C., Ferreira, I. C. F. R., Sanglard, D., & Sokóvić, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020483 · Cited by 92
Surfactants of microbial origin as antibiofilm agents
Paraszkiewicz, K., Moryl, M., Płaza, G. A., Bhagat, D., Satpute, S., & Bernat, P. (2019) · International Journal of Environmental Health Research · doi:10.1080/09603123.2019.1664729 · Cited by 88
Bioactive Peptides Against Fungal Biofilms
Oshiro, K. G. N., Rodrigues, G. R., Monges, B. E. D., Cardoso, M. H. E. S., & Franco, O. L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02169 · Cited by 85
Mechanisms and Control Strategies of Antibiotic Resistance in Pathological Biofilms
Ying, L., Yang, Q., Zhang, D., & Yan, W. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2010.10021 · Cited by 82
Rossatto, F. C. P., Tharmalingam, N., Escobar, I. E., d’Azevedo, P. A., Zimmer, K. R., & Mylonakis, E. E. (2021) · Journal of Fungi · doi:10.3390/jof7090763 · Cited by 83
Ahmed, N., Mahmood, M. S., Ullah, M. A., Araf, Y., Rahaman, T. I., Moin, A. T., & Hosen, M. J. (2022) · Current Microbiology · doi:10.1007/s00284-022-02824-6 · Cited by 79
Candida glabrata Antifungal Resistance and Virulence Factors, a Perfect Pathogenic Combination
León, M. G. F.-D., Hernández‐Castro, R., Conde-Cuevas, E., García-Coronel, I. H., Vázquez-Aceituno, V. A., Soriano-Ursua, M. A., Farfán‐García, E. D., Ocharan-Hernández, M. E., Rodríguez‐Cerdeira, C., Arenas, R., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101529 · Cited by 85
Kasza, K., Gurnani, P., Hardie, K. R., Cámara, M., & Alexander, C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113973 · Cited by 78
Bonincontro, G., Scuderi, S. A., Marino, A., & Simonetti, G. (2023) · Pharmaceuticals · doi:10.3390/ph16111531 · Cited by 78
Candida biofilm production is associated with higher mortality in patients with candidaemia
Vitális, E., Nagy, F., Tóth, Z., Forgács, L., Bozó, A., Kardos, G., Majoros, L., & Kovács, R. (2020) · Mycoses · doi:10.1111/myc.13049 · Cited by 74
Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections
Giordani, B., Basnet, P., Mishchenko, E. V., Luppi, B., & Škalko‐Basnet, N. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics12010009 · Cited by 73
Allert, S., Schulz, D., Kämmer, P., Großmann, P., Wolf, T., Schäuble, S., Panagiotou, G., Brunke, S., & Hube, B. (2022) · Virulence · doi:10.1080/21505594.2022.2026037 · Cited by 66
Gupta, P., Gupta, S., Sharma, M., Kumar, N., Pruthi, V., & Poluri, K. M. (2018) · ACS Omega · doi:10.1021/acsomega.8b01856 · Cited by 66
Mixed biofilms of pathogenic Candida-bacteria: regulation mechanisms and treatment strategies
Khan, F., Bamunuarachchi, N. I., Pham, D. T. N., Tabassum, N., Khan, M. S., & Kim, Y. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1921696 · Cited by 63
Evaluation of the biofilm life cycle between Candida albicans and Candida tropicalis
Atiencia-Carrera, M. B., Cabezas-Mera, F. S., Vizuete, K. S., Debut, A., Tejera, E., & Machado, A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.953168 · Cited by 63
Virulence and Biofilms As Promising Targets in Developing Antipathogenic Drugs Against Candidiasis
Khan, M. S., Alshehrei, F. M., Alghamdi, S., Bamaga, M. A., Althubiani, A. S., & Alam, M. Z. (2020) · Future Science OA · doi:10.2144/fsoa-2019-0027 · Cited by 62
Candida albicans enhances meropenem tolerance of Pseudomonas aeruginosa in a dual-species biofilm
Alam, F., Catlow, D., Maio, A. D., Blair, J. M. A., & Hall, R. A. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz514 · Cited by 61
Advances in Biomaterials for the Prevention and Disruption of Candida Biofilms
Vera‐González, N., & Shukla, A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.538602 · Cited by 61
Antifungal drug resistance in Candida: a special emphasis on amphotericin B
Ahmady, L., Gothwal, M., Mukkoli, M. M., & Bari, V. K. (2024) · Apmis · doi:10.1111/apm.13389 · Cited by 61
Dias, L. P., Souza, P. F. N., Oliveira, J. T. A., Vasconcelos, I. M., Araújo, N. M. S., van Tilburg, M. F., Guedes, M. I. F., Carneiro, R. F., Lopes, J. L. D. S., & Sousa, D. O. B. (2019) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2019.183092 · Cited by 57
Eldesouky, H. E., Salama, E. A., Li, X., Hazbun, T. R., Mayhoub, A. S., & Seleem, M. N. (2020) · Scientific Reports · doi:10.1038/s41598-020-64571-7 · Cited by 55
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Schikora-Tamarit, M. À., & Gabaldón, T. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01547-z · Cited by 57
Mohammad, H. T., Eldesouky, H. E., Hazbun, T. R., Mayhoub, A. S., & Seleem, M. N. (2019) · Scientific Reports · doi:10.1038/s41598-019-55379-1 · Cited by 54
The in vivo anti-Candida albicans activity of flavonoids
Nguyen, W., Grigori, L., Just, E., Santos, C., & Seleem, D. (2021) · Journal of Oral Biosciences · doi:10.1016/j.job.2021.03.004 · Cited by 54
Alfuraydi, R. T., Alminderej, F. M., & Mohamed, N. A. (2022) · Polymers · doi:10.3390/polym14081619 · Cited by 54
Nanozyme‐Based Robotics Approach for Targeting Fungal Infection
Oh, M. J., Yoon, S., Babeer, A., Liu, Y., Ren, Z. F., Xiang, Z., Miao, Y., Cormode, D. P., Chen, C., Steager, E. B., et al. (2023) · Advanced Materials · doi:10.1002/adma.202300320 · Cited by 53
Antifungal Carvacrol Loaded Chitosan Nanoparticles
Vitali, A., Stringaro, A., Colone, M., Muntiu, A., & Angiolella, L. (2021) · Antibiotics · doi:10.3390/antibiotics11010011 · Cited by 52
Ahmed, H. Y., Safwat, N. A., Shehata, R. M., Althubaiti, E. H., Kareem, S. A. E., Atef, A., Qari, S. H., Aljahani, A. H., Al-Meshal, A. S., Youssef, M., et al. (2022) · Membranes · doi:10.3390/membranes12040408 · Cited by 52
Kulig, K., Karnas, E., Woźnicka, O., Kuleta, P., Zuba‐Surma, E. K., Pyza, E., Osyczka, A., Kozik, A., Rąpała‐Kozik, M., & Karkowska‐Kuleta, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.879237 · Cited by 52
Jangjou, A., Zareshahrabadi, Z., Abbasi, M., Talaiekhozani, A., Kamyab, H., Chelliapan, S., Vaez, A., Golchin, A., Tayebi, L., Vafa, E., et al. (2022) · Sustainability · doi:10.3390/su141912942 · Cited by 52
Biofilm: The invisible culprit in catheter-induced candidemia
Wijaya, M., Halleyantoro, R., & Kalumpiu, J. F. (2023) · AIMS Microbiology · doi:10.3934/microbiol.2023025 · Cited by 55
Pais, P., Galocha, M., Viana, R., Cavalheiro, M., Pereira, D., & Teixeira, M. C. (2019) · Microbial Cell · doi:10.15698/mic2019.03.670 · Cited by 54
Self-citationCheeseman, S., Shaw, Z. L., Vongsvivut, J. P., Crawford, R. J., Dupont, M. F., Boyce, K. J., Gangadoo, S., Bryant, S. J., Bryant, G., Cozzolino, D., et al. (2021) · Molecules · doi:10.3390/molecules26133890 · Cited by 51
Mishra, P., Gupta, P., Srivastava, A., Poluri, K. M., & Prasad, R. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121163 · Cited by 51
We need to talk about Candida tropicalis : Virulence factors and survival mechanisms
dos Santos, M. M., & Ishida, K. (2023) · Medical Mycology · doi:10.1093/mmy/myad075 · Cited by 53
Almatroudi, A. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2904133 · Cited by 49
Ferreira, F. V., Mariano, M., Lepesqueur, L. S. S., Pinheiro, I. F., Santos, L., Burga-Sánchez, J., Souza, D. H. S., Koga‐Ito, C. Y., Teixeira-Neto, A. A., Mei, L. H. I., et al. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.044 · Cited by 49
Smolarz, M., Zawrotniak, M., Satała, D., & Rąpała‐Kozik, M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.681030 · Cited by 50
Biocontrol and Probiotic Function of Non-Saccharomyces Yeasts: New Insights in Agri-Food Industry
Comitini, F., Canonico, L., Agarbati, A., & Ciani, M. (2023) · Microorganisms · doi:10.3390/microorganisms11061450 · Cited by 48
Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres
Guin, K., Chen, Y., Mishra, R., Muzaki, S. R. B. M., Thimmappa, B. C., O’Brien, C. E., Butler, G., Sanyal, A., & Sanyal, K. (2020) · eLife · doi:10.7554/elife.58556 · Cited by 45
Vallières, C., Hook, A. L., He, Y., Crucitti, V. C., Figueredo, G. P., Davies, C. R., Burroughs, L., Winkler, D. A., Wildman, R. D., Irvine, D. J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba6574 · Cited by 47
Antifungal and anti‐biofilm effects of 6‐shogaol againstCandida auris
Kim, H.-J., & Eom, Y. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14870 · Cited by 45
Srivastava, A., Verma, N., Kumar, V., Apoorva, P., & Agarwal, V. K. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03938-0 · Cited by 46
Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!
Cavalheiro, M., Pais, P., Galocha, M., & Teixeira, M. C. (2018) · Genes · doi:10.3390/genes9070332 · Cited by 44
Self-citationRecent developments in membrane targeting antifungal agents to mitigate antifungal resistance
Mehta, D., Saini, V., & Bajaj, A. (2023) · RSC Medicinal Chemistry · doi:10.1039/d3md00151b · Cited by 44
Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options
Amann, V., Kissmann, A., Firacative, C., & Rosenau, F. (2025) · Pharmaceuticals · doi:10.3390/ph18040460 · Cited by 44
Anti-biofilm activity of chlorhexidine digluconate against Candida albicans vaginal isolates
Alvendal, C., Mohanty, S., Bohm‐Starke, N., & Brauner, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238428 · Cited by 41
Río, M. D., de la Canal, L., Pinedo, M., Mora-Montes, H. M., & Regente, M. C. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152875 · Cited by 40
Morphogenic plasticity: the pathogenic attribute of Candida albicans
Prasad, P., & Tippana, M. (2023) · Current Genetics · doi:10.1007/s00294-023-01263-5 · Cited by 41
Secreted Aspartyl Proteases Family: A Perspective Review on the Regulation Of Fungal Pathogenesis
Kulshrestha, A., & Gupta, P. (2023) · Future Microbiology · doi:10.2217/fmb-2022-0143 · Cited by 40
Disruption of Biofilm by Bacteriophages in Clinically Relevant Settings
Kovacs, C. J., Rapp, E. M., McKenzie, S. M., Mazur, M. Z., Mchale, R. P., Brasko, B., Min, M. Y., Burpo, F. J., & Barnhill, J. C. (2023) · Military Medicine · doi:10.1093/milmed/usad385 · Cited by 40
Mechanistic insights into Candida biofilm eradication potential of eucalyptol
Gupta, P., Pruthi, V., & Poluri, K. M. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14940 · Cited by 40
Elmehbad, N. Y., Mohamed, N. A., & El‐Ghany, N. A. A. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.03.076 · Cited by 40
Pathophysiological microenvironments in oral candidiasis
Jørgensen, M. R. (2024) · Apmis · doi:10.1111/apm.13412 · Cited by 42
Gupta, P., Goel, A., Singh, K. R., Meher, M. K., Gulati, K., & Poluri, K. M. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.035 · Cited by 39
Lee, T. Y., Farah, N., Chin, V. K., Lim, J. C. W., Chong, P. P., Basir, R., Lim, W. F., & Loo, Y. S. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.08.010 · Cited by 38
Eldesouky, H. E., Lanman, N. A., Hazbun, T. R., & Seleem, M. N. (2020) · Virulence · doi:10.1080/21505594.2020.1838741 · Cited by 37
Franconi, I., & Lupetti, A. (2023) · Journal of Fungi · doi:10.3390/jof9121188 · Cited by 40
Suppression of hyphal formation and virulence of Candida albicans by natural and synthetic compounds
Khan, F., Bamunuarachchi, N. I., Tabassum, N., Jo, D., Khan, P. D. M. M., & Kim, Y. (2021) · Biofouling · doi:10.1080/08927014.2021.1948538 · Cited by 38
Zhang, M., Yan, H., Lü, M., Wang, D., & Sun, S. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.09.008 · Cited by 38
Candida Pathogenicity and Interplay with the Immune System
Valand, N., & Girija, U. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-67452-6_11 · Cited by 38
de Freitas, M. A., Alves, A. I. D. S., Andrade-Pinheiro, J. C., de Andrade, M. C. L., dos Santos, A. T. L., de Oliveira, T. F., dos Santos, F. D. A. G., Buonafina, M. D. S., Coutinho, H. D. M., de Menezes, I. R. A., et al. (2019) · Antibiotics · doi:10.3390/antibiotics8040250 · Cited by 35
Chevecich, C. C., Müller-Sepúlveda, A., Jara, J. A., López‐Muñoz, R., Santander, R., Budini, M., Escobar, A. F., Quijada, R., Criollo, A., Díaz‐Dosque, M., et al. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03518-z · Cited by 35
Adhesion and biofilm formation by the opportunistic pathogen Candida tropicalis: what do we know?
de Souza, C. M., dos Santos, M. M., Furlaneto-Maia, L., & Furlaneto, M. C. (2023) · Canadian Journal of Microbiology · doi:10.1139/cjm-2022-0195 · Cited by 39
Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens
Singla, R. K., & Dubey, A. K. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666191025154834 · Cited by 35
Kimani, B. G., Kerekes, E. B., Szebenyi, C., Krisch, J., Vágvölgyi, C., Papp, T., & Takó, M. (2021) · Foods · doi:10.3390/foods10071652 · Cited by 35
The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection
Bella, A. A. L., Andersen, M. J., Gervais, N. C., Molina, J. J., Molesan, A., Stuckey, P. V., Wensing, L. F., Nobile, C. J., Shapiro, R. S., Santiago-Tirado, F. H., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade7689 · Cited by 35
Sharafutdinov, I., Ozhegov, G. D., Sabirova, A. E., Новикова, В. В., Lisovskaya, S. А., Мунавировна, Х. А., Рафаэловна, К. А., Bogachev, M. I., & Kayumov, A. R. (2020) · Molecules · doi:10.3390/molecules25030642 · Cited by 34
Metadata
- Authors
- Cavalheiro, M., & Teixeira, M. C.
- Affiliations
- University of Lisbon (PT)
- Corresponding author
- Teixeira, Miguel Cacho
- Venue
- Frontiers in Medicine
- Publisher
- Frontiers Media SA
- Published
- 2018-02-13
- Volume
- 5
- Pages
- 28-28
- ISSN
- 2296-858X (ISSN-L)
- PMC
- PMC5816785
- OpenAlex
- W2792847166
- Cited by
- 690
- References
- 163
- Citations by year
- 2026: 57 · 2025: 85 · 2024: 96 · 2023: 103 · 2022: 114 · 2021: 94 · 2020: 87 · 2019: 38 · 2018: 14
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia (PTDC/BBB-BIO/4004/2014, SFRH/BD/116946/2016, UID/BIO/04565/2013)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida biofilms, Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, extracellular polymeric substances, antifungal resistance, filamentation, fungal pathogenicity, host-pathogen interaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
