Cited by 690Antifungal resistance and susceptibilityFungal and yeast genetics researchBacterial biofilms and quorum sensing

The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.

Candida Biofilms: Threats, Challenges, and Promising Strategies

Open access

Cavalheiro, Mafalda, Teixeira, Miguel Cacho·2018·Frontiers in Medicine

DOI 10.3389/fmed.2018.00028PMC PMC5816785

Open this paper in CoChat — free account Open PDF

Abstract

Candida species are fungal pathogens known for their ability to cause superficial and systemic infections in the human host. These pathogens are able to persist inside the host due to the development of pathogenicity and multidrug resistance traits, often leading to the failure of therapeutic strategies. One specific feature of Candida species pathogenicity is their ability to form biofilms, which protects them from external factors such as host immune system defences and antifungal drugs. This review focuses on the current threats and challenges when dealing with biofilms formed by Candida albicans, Candida glabrata, Candida tropicalis and Candida parapsilosis, highlighting the differences between the four species. Biofilm characteristics depend on the ability of each species to produce extracellular polymeric substances (EPS) and display dimorphic growth, but also on the biofilm substratum, carbon source and other factors. Additionally, the transcriptional control over processes like adhesion, biofilm formation, filamentation and EPS production displays great complexity and diversity within pathogenic yeasts of the Candida genus. These differences not only have implications in the persistence of colonization and infections, but also on antifungal resistance typically found in Candida biofilm cells, potentiated by EPS, that functions as a barrier to drug diffusion, and by the overexpression of drug resistance transporters. The ability to interact with different species in in vivo Candida biofilms is also a key factor to consider when dealing with this problem. Despite many challenges, the most promising strategies that are currently available or under development to limit biofilm formation or to eradicate mature biofilms are discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fmed.2018.00028

Cites

163 of 163 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Comparative schematics the three stages of biofilm formation by Candida albicans, Candida glabrata, Candida tropicalis, and Candida parapsilosis, highlighting the different capacities to produce extracellular matrix (ECM), the varying components present in the ECM, and the ability to exhibit different cell morphologies.CC BY · PubMed Central

Figure 2 Transcription regulatory network described for Candida albicans, Candida glabrata, Candida tropicalis, and Candida parapsilosis, highlighting the transcriptional factors involved in adhesion, extracellular polymeric substances (EPS), filamentation, and biofilm. Green boxes indicate activators and red boxes indicate repressors. Participation of each transcription factor in these processes is indicated by the colored arrows: brown arrows correspond to adhesion, dark blue arrows correspond to EPS, light blue arrows correspond to filamentation, and yellow arrows correspond to biofilm formation.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The biofilm matrix
Flemming, H.-C., & Wingender, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2415 · Cited by 10,137
Biofilm formation as microbial development
O'Toole, G., Kaplan, H. B., & Kolter, R. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.49 · Cited by 3,571
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Riddle of Biofilm Resistance
Lewis, K. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.4.999-1007.2001 · Cited by 2,005
Biofilm Formation by the Fungal Pathogen Candida albicans : Development, Architecture, and Drug Resistance
Chandra, J., Kuhn, D. M., Mukherjee, P. K., Hoyer, L. L., McCormick, T., & Ghannoum, M. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5385-5394.2001 · Cited by 1,578
Guidelines for the management of intravascular catheter-related infections
Mermel, L. A., Farr, B. M., Sherertz, R. J., Raad, I. I., O'Grady, N., Harris, J. S., & Craven, D. E. (2001) · Clinical Infectious Diseases · doi:10.1086/320001 · Cited by 1,449
Biofilms and Device-Associated Infections
Donlan, R. M. (2001) · Emerging infectious diseases · doi:10.3201/eid0702.010226 · Cited by 1,425
Candida biofilms and their role in infection
Douglas, L. J. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00002-1 · Cited by 1,150
Candida Infections of Medical Devices
Kojic, E. M., & Darouiche, R. O. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.255-267.2004 · Cited by 1,055
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2982-2992.2001 · Cited by 983
Poly-ε-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects
Roland, L., Grau, M., Matena, J., Teske, M., Gieseke, M., Kampmann, A., Beyerbach, M., Escobar, H. M., Haferkamp, H., Gellrich, N., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010001 · Cited by 862
Multi-species biofilms: living with friendly neighbors
Elias, S., & Banin, E. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2012.00325.x · Cited by 812
Antifungal Susceptibility of Candida Biofilms: Unique Efficacy of Amphotericin B Lipid Formulations and Echinocandins
Kuhn, D. M., George, T., Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1773-1780.2002 · Cited by 775
Cell Wall and Secreted Proteins of Candida albicans: Identification, Function, and Expression
Chaffin, W. L., López-Ribot, J. L., Casanova, M., Gozalbo, D., & Martínez, J. P. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.130-180.1998 · Cited by 726
A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Nobile, C. J., Fox, E. P., Nett, J. E., Sorrells, T. R., Mitrovich, Q. M., Hernday, A. D., Tuch, B. B., Andes, D. R., & Johnson, A. D. (2012) · Cell · doi:10.1016/j.cell.2011.10.048 · Cited by 711
Inhibition of Candida albicans Biofilm Formation by Farnesol, a Quorum-Sensing Molecule
Ramage, G., Saville, S. P., Wickes, B. L., & Lopez-Ribot, J. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.11.5459-5463.2002 · Cited by 702
Epidemiology and risk factors for invasive candidiasis
Yapar, N. (2014) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s40160 · Cited by 610
Biofilm formation by Candida species on the surface of catheter materials in vitro
Hawser, S. P., & Douglas, L. J. (1994) · Infection and Immunity · doi:10.1128/iai.62.3.915-921.1994 · Cited by 599
Flocculation, adhesion and biofilm formation in yeasts
Verstrepen, K. J., & Klis, F. M. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05072.x · Cited by 589
Pseudomonas - Candida Interactions: An Ecological Role for Virulence Factors
Hogan, D. A., & Kolter, R. (2002) · Science · doi:10.1126/science.1070784 · Cited by 588
A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology
Hogan, D. A., Vik, Å., & Kolter, R. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04349.x · Cited by 575
Forging a Link Between Biofilms and Disease
Potera, C. (1999) · Science · doi:10.1126/science.283.5409.1837 · Cited by 554
Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance
Al-Fattani, M. A., & Douglas, L. J. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46569-0 · Cited by 548
How to build a biofilm: a fungal perspective
Blankenship, J. R., & Mitchell, A. P. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.10.003 · Cited by 530
Candida albicans and Staphylococcus aureus Form Polymicrobial Biofilms: Effects on Antimicrobial Resistance
Harriott, M. M., & Noverr, M. C. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00657-09 · Cited by 526
Candida albicans Biofilms Produce Antifungal-Tolerant Persister Cells
LaFleur, M. D., Kumamoto, C. A., & Lewis, K. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00684-06 · Cited by 521
Critical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo
Nobile, C. J., Andes, D. R., Nett, J. E., Smith, F. J., Yue, F., Phan, Q.-T., Edwards, J. E., Filler, S. G., & Mitchell, A. P. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020063 · Cited by 507
Tyrosol is a quorum-sensing molecule in Candida albicans
Chen, H., Fujita, M., Feng, Q., Clardy, J., & Fink, G. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401416101 · Cited by 500
Comparison of Biofilms Formed byCandidaalbicansandCandidaparapsilosison Bioprosthetic Surfaces
Kuhn, D. M., Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.878-888.2002 · Cited by 485
Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms
Ramage, G. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf049 · Cited by 468
Regulation of Cell-Surface Genes and Biofilm Formation by the C. albicans Transcription Factor Bcr1p
Nobile, C. J., & Mitchell, A. P. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.047 · Cited by 464
Putative Role of β-1,3 Glucans in Candida albicans Biofilm Resistance
Nett, J., Lincoln, L., Marchillo, K., Massey, R., Holoyda, K., Hoff, B., VanHandel, M., & Andes, D. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01056-06 · Cited by 407
Resistance of Candida albicans biofilms to antifungal agents in vitro
Hawser, S., & Douglas, L. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.9.2128 · Cited by 402
Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition
Silva, S., Henriques, M., Martins, A., Oliveira, R., Williams, D., & Azeredo, J. (2009) · Medical Mycology · doi:10.3109/13693780802549594 · Cited by 390
Development and Characterization of an In Vivo Central Venous Catheter Candida albicans Biofilm Model
Andes, D., Nett, J., Oschel, P., Albrecht, R., Marchillo, K., & Pitula, A. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.6023-6031.2004 · Cited by 389
Mixed species biofilms of Candida albicans and Staphylococcus epidermidis
ADAM, B., Baillie, G. S., & Douglas, L. (2002) · Journal of Medical Microbiology · doi:10.1099/0022-1317-51-4-344 · Cited by 374
NRG1, a repressor of filamentous growth in C.albicans, is down‐regulated during filament induction
Braun, B. R., Kadosh, D., & Johnson, A. D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4753 · Cited by 345
Adherence of Candida albicans to denture-base materials with different surface finishes
Radford, D. R., Sweet, S. P., Challacombe, S., & Walter, J. D. (1998) · Journal of Dentistry · doi:10.1016/s0300-5712(97)00034-1 · Cited by 338
Biofilm Matrix Regulation by Candida albicans Zap1
Nobile, C. J., Nett, J. E., Hernday, A. D., Homann, O. R., Deneault, J.-S., Nantel, A., Andes, D. R., Johnson, A. D., & Mitchell, A. P. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000133 · Cited by 337
The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans
Ramage, G., VandeWalle, K., LÃ³pez-Ribot, J. L., & Wickes, B. L. (2002) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(02)00853-4 · Cited by 334
Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa
Cugini, C., Calfee, M. W., Farrow, J. M., Morales, D. K., Pesci, E. C., & Hogan, D. A. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05840.x · Cited by 334
Adhesins in human fungal pathogens: glue with plenty of stick.
de Groot, P. W. J., Bader, O., de Boer, A. D., Weig, M., & Chauhan, N. (2013) · Eukaryotic Cell · doi:10.1128/ec.00364-12 · Cited by 319
Biofilm lifestyle of Candida: a mini review
Seneviratne, C., Jin, L., & Samaranayake, L. (2008) · Oral Diseases · doi:10.1111/j.1601-0825.2007.01424.x · Cited by 317
Novel Entries in a Fungal Biofilm Matrix Encyclopedia
Zarnowski, R., Westler, W. M., Lacmbouh, G. A., Marita, J. M., Bothe, J. R., Bernhardt, J., Lounes-Hadj Sahraoui, A., Fontaine, J., Sanchez, H., Hatfield, R. D., et al. (2014) · mBio · doi:10.1128/mbio.01333-14 · Cited by 315
Role of dimorphism in the development of Candida albicans biofilms
BAILLIE, G. S., & DOUGLAS, L. J. (1999) · Journal of Medical Microbiology · doi:10.1099/00222615-48-7-671 · Cited by 304
Induction of theCandida albicansFilamentous Growth Program by Relief of Transcriptional Repression: A Genome-wide Analysis
Kadosh, D., & Johnson, A. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0073 · Cited by 295
Streptococcus gordonii Modulates Candida albicans Biofilm Formation through Intergeneric Communication
Bamford, C. V., d'Mello, A., Nobbs, A. H., Dutton, L. C., Vickerman, M. M., & Jenkinson, H. F. (2009) · Infection and Immunity · doi:10.1128/iai.00438-09 · Cited by 291
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture
Jiang, H. X., Du, H., Wang, L. M., Wang, P. Z., & Bai, X. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00001 · Cited by 275
Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1 - and SIR -dependent transcriptional silencing
De Las Peñas, A., Pan, S.-J., Castaño, I., Alder, J., Cregg, R., & Cormack, B. P. (2003) · Genes & Development · doi:10.1101/gad.1121003 · Cited by 268
Biofilm formation of Candida albicans is variably affected by saliva and dietary sugars
Jin, Y., Samaranayake, L. P., Samaranayake, Y. H., & Yip, H. K. (2004) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2004.04.011 · Cited by 266
The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteins
Bailey, D., Feldmann, P. J. F., Bovey, M., Gow, N. A., & Brown, A. J. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.18.5353-5360.1996 · Cited by 259
Production of Tyrosol by Candida albicans Biofilms and Its Role in Quorum Sensing and Biofilm Development
Alem, M. A. S., Oteef, M. D. Y., Flowers, T. H., & Douglas, L. (2006) · Eukaryotic Cell · doi:10.1128/ec.00219-06 · Cited by 254
Control of Candida albicans Metabolism and Biofilm Formation by Pseudomonas aeruginosa Phenazines
Morales, D. K., Grahl, N., Okegbe, C., Dietrich, L. E. P., Jacobs, N. J., & Hogan, D. A. (2013) · mBio · doi:10.1128/mbio.00526-12 · Cited by 248
Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans
Birse, C., Irwin, M. Y., Fonzi, W. A., & Sypherd, P. S. (1993) · Infection and Immunity · doi:10.1128/iai.61.9.3648-3655.1993 · Cited by 248
Candida albicans ALS3 and insights into the nature of the ALS gene family
Hoyer, L. L., Payne, T. L., Bell, M., Myers, A. M., & Scherer, S. (1998) · Current Genetics · doi:10.1007/s002940050359 · Cited by 242
APSES Proteins Regulate Morphogenesis and Metabolism in Candida albicans
Doedt, T., Krishnamurthy, S., Bockmühl, D. P., Tebarth, B., Stempel, C., Russell, C. L., Brown, A. J. P., & Ernst, J. F. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0782 · Cited by 237
Farnesol‐induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi
Semighini, C. P., Hornby, J. M., Dumitru, ‎., Nickerson, K. W., & Harris, S. D. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04976.x · Cited by 232
The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans
Schweizer, A., Rupp, S., Taylor, B. N., Röllinghoff, M., & Schröppel, K. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02132.x · Cited by 232
Coaggregation of Streptococcus sanguis and other streptococci with Candida albicans
Jenkinson, H. F., Lala, H. C., & Shepherd, M. G. (1990) · Infection and Immunity · doi:10.1128/iai.58.5.1429-1436.1990 · Cited by 231
Portrait of Candida albicans Adherence Regulators
Finkel, J. S., Xu, W., Huang, D., Hill, E. M., Desai, J. V., Woolford, C. A., Nett, J. E., Taff, H., Norice, C. T., Andes, D. R., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002525 · Cited by 228
DNA Array Studies Demonstrate Convergent Regulation of Virulence Factors by Cph1, Cph2, and Efg1 in Candida albicans
Lane, S., Birse, C., Zhou, S., Matson, R., & Liu, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104484200 · Cited by 220
Interaction of Candida albicans Cell Wall Als3 Protein with Streptococcus gordonii SspB Adhesin Promotes Development of Mixed-Species Communities
Silverman, R. J., Nobbs, A. H., Vickerman, M. M., Barbour, M. E., & Jenkinson, H. F. (2010) · Infection and Immunity · doi:10.1128/iai.00685-10 · Cited by 219
Characterization of Mucosal Candida albicans Biofilms
Dongari‐Bagtzoglou, A. I., Kashleva, H., Dwivedi, P., Diaz, P. I., & Vasilakos, J. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007967 · Cited by 214
Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1
Murad, A. M. A., D'Enfert, C., Gaillardin, C., Tournu, H., Tekaia, F., Talibi, D., Marechal, D., Marchais, V., Cottin, J., & Brown, A. J. P. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02713.x · Cited by 208
Mucosal biofilms of Candida albicans
Ganguly, S., & Mitchell, A. P. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.06.001 · Cited by 200
Let LuxS speak up in AI-2 signaling
Keersmaecker, S. C. J. D., Sonck, K., & Vanderleyden, J. (2006) · Trends in Microbiology · doi:10.1016/j.tim.2006.01.003 · Cited by 185
Production of extracellular matrix by Candida albicans biofilms
Hawser, S., Baillie, G. S., & Douglas, L. (1998) · Journal of Medical Microbiology · doi:10.1099/00222615-47-3-253 · Cited by 184
Community participation in biofilm matrix assembly and function
Mitchell, K. F., Zarnowski, R., Sanchez, H., Edward, J. A., Reinicke, E. L., Nett, J. E., Mitchell, A. P., & Andes, D. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421437112 · Cited by 183
Interaction of Candida albicans Biofilms with Antifungals: Transcriptional Response and Binding of Antifungals to Beta-Glucans
Vediyappan, G., Rossignol, T., & d'Enfert, C. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01638-09 · Cited by 183
EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays
Sohn, K., Urban, C. F., Brunner, H., & Rupp, S. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03300.x · Cited by 181
The effect of Streptococcus mutans and Candida glabrata on Candida albicans biofilms formed on different surfaces
Pereira‐Cenci, T., Deng, D., Kraneveld, E. A., Manders, E. M. M., Cury, A. A. D. B., ten Cate, J. M., & Wim Crielaard, A. (2008) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2008.02.015 · Cited by 181
Candida Biofilms: Development, Architecture, and Resistance
Chandra, J., & Mukherjee, P. K. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mb-0020-2015 · Cited by 177
The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence
Kelly, M. T., MacCallum, D. M., Clancy, S. D., Odds, F. C., Brown, A. J. P., & Butler, G. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04185.x · Cited by 175
Developmental Expression of a Tandemly Repeated, Proline- and Glutamine-rich Amino Acid Motif on Hyphal Surfaces of Candida albicans
Staab, J. F., Ferrer, C. A., & Sundstrom, P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6298 · Cited by 175
Ability of Candida albicans Mutants To Induce Staphylococcus aureus Vancomycin Resistance during Polymicrobial Biofilm Formation
Harriott, M. M., & Noverr, M. C. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00573-10 · Cited by 175
Rfg1, a Protein Related to the Saccharomyces cerevisiae Hypoxic Regulator Rox1, Controls Filamentous Growth and Virulence in Candida albicans
Kadosh, D., & Johnson, A. D. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.7.2496-2505.2001 · Cited by 171
Characteristics of biofilm formation by Candida tropicalis and antifungal resistance
Bizerra, F. C., Nakamura, C. V., Poersch, C. D. O., Svidzinski, T. I. E., Quesada, R. M. B., Goldenberg, S., Krieger, M. A., & Yamada‐Ogatta, S. F. (2008) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2007.00347.x · Cited by 170
Terpenoids of plant origin inhibit morphogenesis, adhesion, and biofilm formation byCandida albicans
Raut, J. S., Shinde, R. B., Chauhan, N. M., & Karuppayil, S. M. (2012) · Biofouling · doi:10.1080/08927014.2012.749398 · Cited by 169
Biofilm Formation by Candida dubliniensis
Ramage, G., Walle, K. V., Wickes, B. L., & Lopez-Ribot, J. L. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.9.3234-3240.2001 · Cited by 160
Nosocomial Infections and Multidrug-resistant Organisms in Germany
Geffers, C., & Gastmeier, P. (2011) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2011.0087 · Cited by 158
Broad Spectrum Antibacterial and Antifungal Polymeric Paint Materials: Synthesis, Structure–Activity Relationship, and Membrane-Active Mode of Action
Hoque, J., Akkapeddi, P., Yadav, V., Manjunath, G. B., Uppu, D. S. S. M., Konai, M. M., Yarlagadda, V., Sanyal, K., & Haldar, J. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am507482y · Cited by 158
Bloodstream Infections Due to Candida Species in the Intensive Care Unit: Identifying Especially High-Risk Patients to Determine Prevention Strategies
Wenzel, R. P., & Gennings, C. (2005) · Clinical Infectious Diseases · doi:10.1086/430923 · Cited by 158
High frequency of Candida parapsilosis on the hands of healthy hosts
Bonassoli, L. A., Bertoli, M., & Svidzinski, T. I. E. (2004) · Journal of Hospital Infection · doi:10.1016/j.jhin.2004.06.033 · Cited by 153
Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans
Bonhomme, J., Chauvel, M., Goyard, S., Roux, P., Rossignol, T., & d'Enfert, C. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07626.x · Cited by 144
Modification of Surface Properties of Biomaterials Influences the Ability of Candida albicans To Form Biofilms
Chandra, J., Patel, J. D., Li, J., Zhou, G., Mukherjee, P. K., McCormick, T. S., Anderson, J. M., & Ghannoum, M. A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8795-8801.2005 · Cited by 142
Environmental distribution ofCryptococcus neoformansandC. gattiiaround the Mediterranean basin
Cogliati, M., D’Amicis, R., Zani, A., Montagna, M. T., Caggiano, G., Giglio, O. D., Balbino, S., Donno, A. D., Serio, F., Susever, S., et al. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow045 · Cited by 138
Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans
Holland, L., Schröder, M., Turner, S. A., Taff, H. T., Andes, D. R., Grózer, Z., Gácser, A., Ames, L., Haynes, K., Higgins, D. G., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004365 · Cited by 134
Phenotype switching affects biofilm formation by Candida parapsilosis
Laffey, S. F., & Butler, G. (2005) · Microbiology · doi:10.1099/mic.0.27739-0 · Cited by 132
Candida albicans Transcription Factor Ace2 Regulates Metabolism and Is Required for Filamentation in Hypoxic Conditions
Mulhern, S. M., Logue, M. E., & Butler, G. (2006) · Eukaryotic Cell · doi:10.1128/ec.00155-06 · Cited by 130
Quorum sensing and Candida albicans
Kruppa, M. (2008) · Mycoses · doi:10.1111/j.1439-0507.2008.01626.x · Cited by 129
Invasive candidiasis in immunocompromised hospitalized patients.
Sims, C. R., Ostrosky-Zeichner, L., & Rex, J. H. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.05.015 · Cited by 124
The Basic Helix-Loop-Helix Transcription Factor Cph2 Regulates Hyphal Development in CandidaalbicansPartly via Tec1
Lane, S., Zhou, S., Pan, T., Dai, Q., & Liu, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6418-6428.2001 · Cited by 119
Biofilm formation by five species of Candida on three clinical materials
Estivill, D., Arias, Á., Lana, Á. T., Carrillo‐Muñoz, A. J., & Arévalo, M. P. (2011) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2011.05.019 · Cited by 112
In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms
Katragkou, A., McCarthy, M. W., Alexander, E. L., Antachopoulos, C., Meletiadis, J., Jabra‐Rizk, M. A., Petraitis, V., Roilides, E., & Walsh, T. J. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku374 · Cited by 111
Pseudomonas aeruginosa inhibits in-vitro Candida biofilm development
Bandara, N., Yau, J., Watt, R., Jin, L., & Samaranayake, L. P. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-125 · Cited by 110
Candida albicans biofilm formation in a new in vivo rat model
Řičicová, M., Kucharíková, S., Tournu, H., Hendrix, J., Bujdáková, H., Eldere, J. V., Lagrou, K., & Dijck, P. V. (2009) · Microbiology · doi:10.1099/mic.0.033530-0 · Cited by 110
“It’s a gut feeling” – Escherichia coli biofilm formation in the gastrointestinal tract environment
Rossi, E., Cimdins, A., Lüthje, P., Brauner, A., Sjöling, Å., Landini, P., & Römling, U. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2017.1303660 · Cited by 109
In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections
Wong, S. S. W., Kao, R. Y. T., Yuen, K. Y., Wang, Y., Yang, D., Samaranayake, L. P., & Seneviratne, C. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085836 · Cited by 107
Suppression of fungal growth exhibited by Pseudomonas aeruginosa
Kerr, J. R. (1994) · Journal of Clinical Microbiology · doi:10.1128/jcm.32.2.525-527.1994 · Cited by 102
The antibiotic-lock technique for therapy of ‘highly needed’ infected catheters
Carratalà, J. (2002) · Clinical Microbiology and Infection · doi:10.1046/j.1469-0691.2002.00388.x · Cited by 99
Hypoxic Adaptation by Efg1 Regulates Biofilm Formation by Candida albicans
Stichternoth, C., & Ernst, J. F. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00098-09 · Cited by 97
The DNA Binding Protein Rfg1 Is a Repressor of Filamentation in Candida albicans
Khalaf, R. A., & Zitomer, R. S. (2001) · Genetics · doi:10.1093/genetics/157.4.1503 · Cited by 96
Virulence and pathogenicity ofCandida albicansis enhanced in biofilms containing oral bacteria
Cavalcanti, Y. W., Morse, D. J., da Silva, W. J., Cury, A. A. D. B., Wei, X., Wilson, M. J., Milward, P. J., Lewis, M. A. O., Bradshaw, D. J., & Williams, D. W. (2015) · Biofouling · doi:10.1080/08927014.2014.996143 · Cited by 94
Conserved and Divergent Roles of Bcr1 and CFEM Proteins in Candida parapsilosis and Candida albicans
Ding, C., Vidanes, G. M., Maguire, S. L., Guida, A., Synnott, J. M., Andes, D. R., & Butler, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028151 · Cited by 93
The Extracellular Matrix of Fungal Biofilms
Mitchell, K. F., Żarnowski, R., & Andes, D. R. (2016) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_6 · Cited by 93
Characterization of biofilms formed by Candida parapsilosis, C. metapsilosis, and C. orthopsilosis
Lattif, A. A., Mukherjee, P. K., Chandra, J., Swindell, K., Lockhart, S. R., Diekema, D. J., Pfaller, M. A., & Ghannoum, M. A. (2009) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2009.09.001 · Cited by 92
Farnesol signalling in Candida albicans – more than just communication
Polke, M., Leonhardt, I., Kurzai, O., & Jacobsen, I. D. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2017.1337711 · Cited by 92
Role of Ndt80p in Sterol Metabolism Regulation and Azole Resistance in Candida albicans
Sellam, A., Tebbji, F., & Nantel, A. (2009) · Eukaryotic Cell · doi:10.1128/ec.00074-09 · Cited by 91
Multi-species biofilm of Candida albicans and non-Candida albicans Candida species on acrylic substrate
Pathak, A., Sharma, S., & Shrivastva, P. (2012) · Journal of Applied Oral Science · doi:10.1590/s1678-77572012000100013 · Cited by 87
BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence
Cleary, I. A., Lazzell, A. L., Monteagudo, C. C., Thomas, D. P., & Saville, S. P. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08127.x · Cited by 85
Development of a Gene Knockout System in Candida parapsilosis Reveals a Conserved Role for BCR1 in Biofilm Formation
Ding, C., & Butler, G. (2007) · Eukaryotic Cell · doi:10.1128/ec.00136-07 · Cited by 83
Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans
Holcombe, L. J., McAlester, G., Munro, C. A., Enjalbert, B., Brown, A. J. P., Gow, N. A. R., Ding, C., Butler, G., O'Gara, F., & Morrissey, J. P. (2010) · Microbiology · doi:10.1099/mic.0.037549-0 · Cited by 82
Role of Transcription Factor CaNdt80p in Cell Separation, Hyphal Growth, and Virulence in Candida albicans
Sellam, A., Askew, C., Epp, E., Tebbji, F., Mullick, A., Whiteway, M. S., & Nantel, A. (2010) · Eukaryotic Cell · doi:10.1128/ec.00325-09 · Cited by 82
Comparison of the Microbial Composition of Voice Prosthesis Biofilms from Patients Requiring Frequent versus Infrequent Replacement
Elving, G. J., van der Mei, H. C., van Weissenbruch, R., Busscher, H. J., & Albers, F. W. J. (2002) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348940211100302 · Cited by 82
The quorum‐sensing molecule E , E ‐farnesol—its variable secretion and its impact on the growth and metabolism of Candida species
Weber, K., Schulz, B., & Ruhnke, M. (2010) · Yeast · doi:10.1002/yea.1769 · Cited by 79
Polyelectrolyte Multilayers Fabricated from Antifungal β-Peptides: Design of Surfaces that Exhibit Antifungal Activity Against Candida albicans
Karlsson, A. J., Flessner, R. M., Gellman, S. H., Lynn, D. M., & Palecek, S. P. (2010) · Biomacromolecules · doi:10.1021/bm100424s · Cited by 78
Transcriptional Response of Candida parapsilosis following Exposure to Farnesol
Rossignol, T., Logue, M. E., Reynolds, K., Grenon, M., Lowndes, N. F., & Butler, G. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01438-06 · Cited by 75
Adherence of Candida sp. to host tissues and cells as one of its pathogenicity features.
Modrzewska, B., & Kurnatowski, P. (2015) · PubMed · Cited by 74
Proteomics of drug resistance in Candida glabrata biofilms
Seneviratne, C. J., Wang, Y., Jin, L., Abiko, Y., & Samaranayake, L. P. (2010) · PROTEOMICS · doi:10.1002/pmic.200900611 · Cited by 74
Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A Streptococcus
Henningham, A., Ericsson, D. J., Langer, K., Casey, L. W., Jovcevski‬, B., Chhatwal, G. S., Aquilina, J. A., Batzloff, M. R., Kobe, B., & Walker, M. J. (2013) · mBio · doi:10.1128/mbio.00509-13 · Cited by 71
Candida glabrata STE12 is required for wild‐type levels of virulence and nitrogen starvation induced filamentation
Calcagno-Pizarelli, A. M., Bignell, E., Warn, P. A., Jones, M. D., Denning, D. W., Mühlschlegel, F. A., Rogers, T. R., & Haynes, K. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03755.x · Cited by 71
Anti-biofilm activity of low-molecular weight chitosan hydrogel against Candida species
Silva-Dias, A., Palmeira‐de‐Oliveira, A., Miranda, I. M., Branco, J., Cobrado, L., Monteiro‐Soares, M., Queiroz, J. A., Pina‐Vaz, C., & Rodrigues, A. G. (2013) · Medical Microbiology and Immunology · doi:10.1007/s00430-013-0311-4 · Cited by 68
Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata
Tscherner, M., Schwarzmüller, T., & Kuchler, K. (2011) · Pharmaceuticals · doi:10.3390/ph4010169 · Cited by 60
ThePlasmodiumrhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth
Ghosh, S., Kennedy, K., Sanders, P. R., Matthews, K. M., Ralph, S. A., Counihan, N. A., & de Koning‐Ward, T. F. (2017) · Cellular Microbiology · doi:10.1111/cmi.12733 · Cited by 60
The APSES transcription factor Efg 1 is a global regulator that controls morphogenesis and biofilm formation in C andida parapsilosis
Connolly, L. A., Riccombeni, A., Grózer, Z., Holland, L., Lynch, D. B., Andes, D. R., Gácser, A., & Butler, G. (2013) · Molecular Microbiology · doi:10.1111/mmi.12345 · Cited by 59
Biofilm formation inCandida glabrata: What have we learnt from functional genomics approaches?
d’Enfert, C., & Janbon, G. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov111 · Cited by 58
C. albicansgrowth, transition, biofilm formation, and gene expression modulation by antimicrobial decapeptide KSL-W
Theberge, S., Semlali, A., Alamri, A. M., Leung, K. P., & Rouabhia, M. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-246 · Cited by 56
Photodynamic antimicrobial chemotherapy (PACT) inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability
Rosseti, I. B., Chagas, L. R., & Costa, M. S. (2013) · Lasers in Medical Science · doi:10.1007/s10103-013-1473-4 · Cited by 56
In vivo Candida glabrata biofilm development on foreign bodies in a rat subcutaneous model
Kucharíková, S., Neirinck, B., Sharma, N., Vleugels, J., Lagrou, K., & Dijck, P. V. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku447 · Cited by 53
Candida albicans aspects of novel silane system–coated titanium and zirconia implant surfaces
Villard, N. M., Seneviratne, C. J., Tsoi, J. K. H., Heinonen, M., & Matinlinna, J. P. (2014) · Clinical Oral Implants Research · doi:10.1111/clr.12338 · Cited by 52
Effect of Antimicrobial Denture Base Resin on Multi-Species Biofilm Formation
Zhang, K., Ren, B., Zhou, X., Xu, H. H. K., Chen, Y. Z., Han, Q., Li, B., Weir, M. D., Li, M., Feng, M., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071033 · Cited by 52
Identification and Functional Characterization of Rca1, a Transcription Factor Involved in both Antifungal Susceptibility and Host Response in Candida albicans
Vandeputte, P., Pradervand, S., Ischer, F., Coste, A. T., Ferrari, S., Harshman, K., & Sanglard, D. (2012) · Eukaryotic Cell · doi:10.1128/ec.00134-12 · Cited by 51
Biofilm formation and C andida albicans morphology on the surface of denture base materials
Susewind, S., Lang, R., & Hahnel, S. (2015) · Mycoses · doi:10.1111/myc.12420 · Cited by 49
Phenylpropanoids of Plant Origin as Inhibitors of Biofilm Formation by Candida albicans
Raut, J. S., Shinde, R. B., Chauhan, N. M., & Karuppayil, S. M. (2014) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1402.02056 · Cited by 49
Possible role of azole and echinocandin lock solutions in the control of Candida biofilms associated with silicone
Cateau, E., Berjeaud, J., & Imbert, C. (2011) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2010.12.016 · Cited by 48
Membrane Proteome-Wide Response to the Antifungal Drug Clotrimazole in Candida glabrata: Role of the Transcription Factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2
Pais, P., Costa, C., Pires, C. M. B. F., Shimizu, K., Chibana, H., & Teixeira, M. C. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.045344 · Cited by 47
Self-citation
The Use of Chitosan to Enhance Photodynamic Inactivation against Candida albicans and Its Drug-Resistant Clinical Isolates
Chien, H., Chen, C.-P., Chen, C.-P., Chang, P.-H., Tsai, T., & Chen, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14047445 · Cited by 47
Anticandidal activity of Pseudomonas aeruginosa strains isolated from clinical specimens
Kaleli̇, İ., Cevahir, N., Demi̇r, M., Yıldırım, U., & Şahin, R. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01322.x · Cited by 46
The Host’s Reply to Candida Biofilm
Nett, J. E. (2016) · Pathogens · doi:10.3390/pathogens5010033 · Cited by 46
Different Consequences of ACE2 and SWI5 Gene Disruptions for Virulence of Pathogenic and Nonpathogenic Yeasts
MacCallum, D. M., Findon, H., Kenny, C. C., Butler, G., Haynes, K., & Odds, F. C. (2006) · Infection and Immunity · doi:10.1128/iai.00817-06 · Cited by 45
Regulation of filamentation in the human fungal pathogen C andida tropicalis
Zhang, Q., Li, T., Guan, G., Yue, H., Liang, W., Cao, C., Dai, Y., & Huang, G. (2015) · Molecular Microbiology · doi:10.1111/mmi.13247 · Cited by 44
New regulators of biofilm development in Candida glabrata
Riera, M., Mogensen, E., d’Enfert, C., & Janbon, G. (2012) · Research in Microbiology · doi:10.1016/j.resmic.2012.02.005 · Cited by 43
A Novel Downstream Regulatory Element Cooperates with the Silencing Machinery to Repress EPA1 Expression in Candida glabrata
Gallegos-García, V., Pan, S., Juárez-Cepeda, J., Ramírez-Zavaleta, C., Martin-del-Campo, M. B., Martínez-Jiménez, V., Castaño, I., Cormack, B., & Peñas, A. D. L. (2012) · Genetics · doi:10.1534/genetics.111.138099 · Cited by 41
Influence of Acetylsalicylic Acid (Aspirin) on Biofilm Production byCandidaSpecies
Stepanović, S., Vuković, D., Jesic, M. M., & Ranin, L. T. (2004) · Journal of Chemotherapy · doi:10.1179/joc.2004.16.2.134 · Cited by 38
Could liposomal amphotericin B (L-AMB) lock solutions be useful to inhibit Candida spp. biofilms on silicone biomaterials?
Toulet, D., Debarre, C., & Imbert, C. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr473 · Cited by 38
Growth, biofilm formation, antifungal susceptibility and oxidative stress resistance of Candida glabrata are affected by different glucose concentrations
Ng, T. S., Desa, M. N. M., Sandai, D. A., Chong, P. P., & Than, L. T. L. (2015) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2015.09.004 · Cited by 38
The Role of Saliva and Serum inCandida albicansBiofllm Formation on Denture Acrylic Surfaces
Nikawa, H., Nishimura, H., Yamamoto, T., Hamada, T., & Samaranayake, L. P. (1996) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v9i1.8290 · Cited by 37
Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial
Bonne, S. L., Mazuski, J. E., Sona, C., Schallom, M. E., Boyle, W., Buchman, T. G., Bochicchio, G. V., Coopersmith, C. M., & Schuerer, D. J. E. (2015) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2015.05.013 · Cited by 34
Molecular investigation of two consecutive nosocomial clusters of Candida tropicalis candiduria using pulsed-field gel electrophoresis.
Rho, J., Shin, J. H., Song, J. W., Park, M., Kee, S. J., Jang, S. J., Park, Y. K., Suh, S., & Ryang, D. W. (2004) · PubMed · Cited by 34
Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison
Pais, P., Costa, C., Cavalheiro, M., Romão, D., & Teixeira, M. C. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00131 · Cited by 34
Self-citation
The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogenCandida glabrata
Santos, R., Costa, C., Mil‐Homens, D., Romão, D., de Carvalho, C. C. C. R., Pais, P., Mira, N. P., Fialho, A. M., & Teixeira, M. C. (2016) · Cellular Microbiology · doi:10.1111/cmi.12686 · Cited by 34
Self-citation
Expression ofCgCDR1,CgCDR2, andCgERG11inCandida glabratabiofilms formed by bloodstream isolates
Song, J. W., Shin, J. H., Kee, S., Kim, S. H., Shin, M., Suh, S., & Ryang, D. W. (2008) · Medical Mycology · doi:10.1080/13693780802210726 · Cited by 33
Shear stress modulates the thickness and architecture of Candida albicans biofilms in a phase‐dependent manner
Mukherjee, P. K., Chand, D. V., Chandra, J., Anderson, J. M., & Ghannoum, M. A. (2008) · Mycoses · doi:10.1111/j.1439-0507.2008.01632.x · Cited by 32
CandidaSpecies Adhesion to Oral Epithelium: Factors Involved and Experimental Methodology Used
Henriques, M., Azeredo, J., & Oliveira, R. (2006) · Critical Reviews in Microbiology · doi:10.1080/10408410601023524 · Cited by 32
A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli
Waldhuber, A., Snyder, G. A., Römmler, F., Cirl, C., Müller, T., Xiao, T. S., Svanborg, C., & Miethke, T. (2016) · Pathogens · doi:10.3390/pathogens5010025 · Cited by 31
Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome
Stead, D., Walker, J., Holcombe, L. J., Gibbs, S. R. S., Yin, Z., Selway, L., Butler, G., Brown, A. J. P., & Haynes, K. (2009) · PROTEOMICS · doi:10.1002/pmic.200800706 · Cited by 29
The Role of Saliva and Serum inCandida albicansBiofllm Formation on Denture Acrylic Surfaces
Nikawa, H., NISHIMURA, H., Yamamoto, T., Hamada, T., & Samaranayake, L. P. (1996) · Microbial Ecology in Health and Disease · doi:10.3109/08910609609167727 · Cited by 29
Management of Candida Biofilms: State Of Knowledge and New Options for Prevention and Eradication
Bujdáková, H. (2016) · Future Microbiology · doi:10.2217/fmb.15.139 · Cited by 27
Mapping of functional domains and characterization of the transcription factor Cph1 that mediate morphogenesis in Candida albicans
Maiti, P., Ghorai, P., Ghosh, S., Kamthan, M., Tyagi, R. K., & Datta, A. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.08.004 · Cited by 24
Antifungal Lock Therapy With Combined 70% Ethanol and Micafungin in a Critically Ill Infant
Piersigilli, F., Auriti, C., Bersani, I., Goffredo, B. M., Bianco, G., Savarese, I., & Dotta, A. (2013) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000116 · Cited by 21
Effectiveness of the Photoactive Dye Methylene Blue versus Caspofungin on the C andida parapsilosis Biofilm in vitro and ex vivo
Černáková, L., Dekkerová, J., Židlíková, K., & Bujdáková, H. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12480 · Cited by 20
Quorum sensing in Candida albicans: farnesol versus farnesoic acid
Riekhof, W. R., & Nickerson, K. W. (2017) · FEBS Letters · doi:10.1002/1873-3468.12694 · Cited by 19
Adhesion and biofilm formation in artificial saliva and susceptibility of yeasts isolated from chronic kidney patients undergoing haemodialysis
Queiroz, P. A., Godoy, J. S. R., Mendonca, P., Pedroso, R. B., Svidzinski, T. I. E., & Negri, M. (2015) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000122 · Cited by 10

Sorted by citations

Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Talapko, J., Juzbašić, M., Matijević, T., Pustijanac, E., Bekić, S., Kotris, I., & Škrlec, I. (2021) · Journal of Fungi · doi:10.3390/jof7020079 · Cited by 794
Biocontrol yeasts: mechanisms and applications
Freimoser, F. M., Rueda-Mejia, M. P., Tilocca, B., & Migheli, Q. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2728-4 · Cited by 462
Architecture of the dynamic fungal cell wall
Gow, N. A. R., & Lenardon, M. D. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00796-9 · Cited by 447
Candida parapsilosis: from genes to the bedside
Tóth, R., Nosek, J., Mora-Montes, H. M., Gabaldon, T., Bliss, J. M., Nosanchuk, J. D., Turner, S. A., Butler, G., Vágvölgyi, C., & Gácser, A. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00111-18 · Cited by 327
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Arastehfar, A. A., Gabaldón, T., Garcia‐Rubio, R., Jenks, J. D., Hoenigl, M., Salzer, H. J. F., İlkit, M., Lass‐Flörl, C., & Perlin, D. S. (2020) · Antibiotics · doi:10.3390/antibiotics9120877 · Cited by 302

See all 690

Authors: Cavalheiro, M., & Teixeira, M. C.
Affiliations: University of Lisbon (PT)
Corresponding author: Teixeira, Miguel Cacho
ORCID: Cavalheiro, Mafalda
Teixeira, Miguel Cacho
Venue: Frontiers in Medicine
Publisher: Frontiers Media SA
Published: 2018-02-13
Volume: 5
Pages: 28-28
ISSN: 2296-858X (ISSN-L)
DOI: 10.3389/fmed.2018.00028
PMC: PMC5816785
OpenAlex: W2792847166
Cited by: 690
References: 163
Citations by year: 2026: 57 · 2025: 85 · 2024: 96 · 2023: 103 · 2022: 114 · 2021: 94 · 2020: 87 · 2019: 38 · 2018: 14
FWCI: 8.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Fundação para a Ciência e a Tecnologia (PTDC/BBB-BIO/4004/2014, SFRH/BD/116946/2016, UID/BIO/04565/2013)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: Candida biofilms, Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, extracellular polymeric substances, antifungal resistance, filamentation, fungal pathogenicity, host-pathogen interaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Candida Biofilms: Threats, Challenges, and Promising Strategies

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks