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Cited by 163Polymer Surface Interaction StudiesAntimicrobial agents and applicationsMarine Biology and Environmental Chemistry

Recent Advances in a Polydopamine-Mediated Antimicrobial Adhesion System

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Singh, Indu, Dhawan, Gagan, Gupta, Seema, Kumar, Pradeep·2021·Frontiers in Microbiology
DOI 10.3389/fmicb.2020.607099PMC PMC7835282
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Abstract

The drug resistance developed by bacteria during antibiotic treatment has been a call to action for researchers and scientists across the globe, as bacteria and fungi develop ever increasing resistance to current drugs. Innovative antimicrobial/antibacterial materials and coatings to combat such infections have become a priority, as many infections are caused by indwelling implants (e.g., catheters) as well as improving postsurgical function and outcomes. Pathogenic microorganisms that can exist either in planktonic form or as biofilms in water-carrying pipelines are one of the sources responsible for causing water-borne infections. To combat this, researchers have developed nanotextured surfaces with bactericidal properties mirroring the topographical features of some natural antibacterial materials. Protein-based adhesives, secreted by marine mussels, contain a catecholic amino acid, 3,4-dihydroxyphenylalanine (DOPA), which, in the presence of lysine amino acid, empowers with the ability to anchor them to various surfaces in both wet and saline habitats. Inspired by these features, a novel coating material derived from a catechol derivative, dopamine, known as polydopamine (PDA), has been designed and developed with the ability to adhere to almost all kinds of substrates. Looking at the immense potential of PDA, this review article offers an overview of the recent growth in the field of PDA and its derivatives, especially focusing the promising applications as antibacterial nanocoatings and discussing various antimicrobial mechanisms including reactive oxygen species-mediated antimicrobial properties.

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  • PDA itself actively regulates cellular behavior by stimulating osteoblast proliferation, osteogenic differentiation, and mineralized extracellular matrix formation.

    “Beyond this indirect effect, PDA itself actively regulates cellular behavior by stimulating osteoblast proliferation, osteogenic differentiation, and mineralized extracellular matrix formation.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [13]

    In “Cationic Charge Enriched PDA-Fabricated Surfaces” (page unavailable), the review reports increased cell proliferation on PDA-coated zirconia, but the cells described are human gingival fibroblasts, not osteoblasts. “Applications of Polydopamine Nanocoatings” (page unavailable) reports osteogenesis with a PDA-assisted hydroxyapatite coating; it does not establish that PDA itself stimulates osteoblast differentiation or mineralized extracellular matrix formation. (LLM, conf=0.84)

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  1. Adnan N. N. M. Sadrearhami Z. Bagheri A. Nguyen T. K. Wong E. H. Ho K. K. (2018). Exploiting the versatility of polydopamine-coated nanoparticles to deliver nitric oxide and combat bacterial biofilm. Macromol. Rapid Commun. 39: 1800159 10.1002/marc.201800159 29806143 · DOI
  2. Ahmed S. B. Hasane A. Wang Z. Mansurov A. Castrilloìn S. R. V. (2018). Bacterial adhesion to ultrafiltration membranes: role of hydrophilicity, natural organic matter, and cell-surface macromolecules. Environ. Sci. Technol. 52 162– 172. 10.1021/acs.est.7b03682 29182855 · DOI
  3. Ahn B. K. (2017). Perspectives on mussel-inspired wet adhesion. J. Am. Chem. Soc. 139 10166– 10171. 10.1021/jacs.6b13149 28657746 · DOI
  4. Akter N. Chowdhury L. Uddin J. Ullah A. A. Shariare M. H. Azam M. S. (2018). N-halamine functionalization of polydopamine coated Fe3O4 nanoparticles for recyclable and magnetically separable antimicrobial materials. Mater. Res. Exp. 5: 115007 10.1088/2053-1591/aadc56 · DOI
  5. Alfieri M. L. Micillo R. Panzella L. Crescenzi O. Oscurato S. L. Maddalena P. (2017). Structural basis of polydopamine film formation: Probing 5, 6-dihydroxyindole-based eumelanin type units and the porphyrin issue. ACS Appl. Mater. Inter. 10 7670– 7680. 10.1021/acsami.7b09662 28937213 · DOI
  6. Alfieri M. L. Panzella L. Oscurato S. L. Salvatore M. Avolio R. Errico M. E. (2018). The chemistry of polydopamine film formation: The amine-quinone interplay. Biomimetics 3: 26 10.3390/biomimetics3030026 PMC6352855 31105248 · DOI
  7. Alves D. F. Vaz A. T. Grainha T. Rodrigues C. F. Pereira M. O. (2019). Design of an antifungal surface embedding liposomal amphotericin B through a mussel adhesive-inspired coating strategy. Front. Chem. 7: 431 10.3389/fchem.2019.00431 PMC6591271 31275922 · DOI
  8. Ang J. M. Du Y. Tay B. Y. Zhao C. Kong J. Stubbs L. P. (2016). One-pot synthesis of Fe (III)–polydopamine complex nanospheres: Morphological evolution, mechanism, and application of the carbonized hybrid nanospheres in catalysis and Zn–air battery. Langmuir 32 9265– 9275. 10.1021/acs.langmuir.6b02331 27550631 · DOI
  9. Asha A. B. Chen Y. Zhang H. Ghaemi S. Ishihara K. Liu Y. (2018). Rapid mussel-inspired surface zwitteration for enhanced antifouling and antibacterial properties. Langmuir 35 1621– 1630. 10.1021/acs.langmuir.8b03810 30558423 · DOI
  10. Bai Y. Zhang B. Chen L. Lin Z. Zhang X. Ge D. (2018). Facile one-pot synthesis of polydopamine carbon dots for photothermal therapy. Nanoscale Res. Lett. 13 1– 9. 30225652 PMC6141412
  11. Ball V. (2017). Composite materials and films based on melanins, polydopamine, and other catecholamine-based materials. Biomimetics 2: 12 10.3390/biomimetics2030012 PMC6352683 31105175 · DOI
  12. Ball V. (2018). Polydopamine nanomaterials: Recent advances in synthesis methods and applications. Front. Bioeng. Biotechnol. 6: 109 10.3389/fbioe.2018.00109 PMC6108306 30175095 · DOI
  13. Bao X. Zhao J. Sun J. Hu M. Yang X. (2018). Polydopamine nanoparticles as efficient scavengers for reactive oxygen species in periodontal disease. ACS Nano 12 8882– 8892. 10.1021/acsnano.8b04022 30028940 · DOI · Paper page
  14. Barclay T. G. Hegab H. M. Clarke S. R. Ginic-Markovic M. (2017). Versatile surface modification using polydopamine and related polycatecholamines: Chemistry, structure, and applications. Adv. Mater. Interf. 4: 1601192 10.1002/admi.201601192 · DOI
  15. Batul R. Tamanna T. Khaliq A. Yu A. (2017). Recent progress in the biomedical applications of polydopamine nanostructures. Biomater. Sci. 5 1204– 1229. 10.1039/c7bm00187h 28594019 · DOI
  16. Cai R. Tao G. He H. Song K. Zuo H. Jiang W. (2017). One-step synthesis of silver nanoparticles on polydopamine-coated sericin/polyvinyl alcohol composite films for potential antimicrobial applications. Molecules 22: 721 10.3390/molecules22050721 PMC6154384 28468293 · DOI
  17. Chen M. Wen Q. Gu F. Gao J. Zhang C. C. Wang Q. (2018). Mussel chemistry assembly of a novel biosensing nanoplatform based on polydopamine fluorescent dot and its photophysical features. Chem. Eng. J. 342 331– 338. 10.1016/j.cej.2018.02.099 · DOI
  18. Chien H.-W. Chiu T.-H. Stable N. - (2020). halamine on polydopamine coating for high antimicrobial efficiency. Eur. Polym. J. 130: 109654 10.1016/j.eurpolymj.2020.109654 · DOI
  19. Choi S.-H. Jang Y.-S. Jang J.-H. Bae T.-S. Lee S.-J. Lee M.-H. (2019). Enhanced antibacterial activity of titanium by surface modification with polydopamine and silver for dental implant application. J. Appl. Biomater. Funct. Mater. 17: 2280800019847067. 31530071
  20. d’Ischia M. Napolitano A. Ball V. Chen C. T. Buehler M. J. (2014). Polydopamine and eumelanin: From structure–property relationships to a unified tailoring strategy. Acc. Chem. Res. 47 3541– 3550. 10.1021/ar500273y 25340503 · DOI · Paper page
  21. Dhand C. Ong C. Y. Dwivedi N. Varadarajan J. Halleluyah Periayah M. Jianyang Lim E. (2020). Mussel-inspired durable antimicrobial contact lenses: The role of covalent and noncovalent attachment of antimicrobials. ACS Biomater. Sci. Eng. 6 3162– 3173. 10.1021/acsbiomaterials.0c00229 33463280 · DOI
  22. Ding Y. H. Floren M. Tan W. (2016). Mussel-inspired polydopamine for bio-surface functionalization. Biosurf. Biotribol. 2 121– 136. 10.1016/j.bsbt.2016.11.001 29888337 PMC5991493 · DOI
  23. Dong Z. Feng L. Hao Y. Chen M. Gao M. Chao Y. (2018). Synthesis of hollow biomineralized CaCO3–polydopamine nanoparticles for multimodal imaging-guided cancer photodynamic therapy with reduced skin photosensitivity. J. Am. Chem. Soc. 140 2165– 2178. 10.1021/jacs.7b11036 29376345 · DOI
  24. Dong Z. Gong H. Gao M. Zhu W. Sun X. Feng L. (2016). Polydopamine nanoparticles as a versatile molecular loading platform to enable imaging-guided cancer combination therapy. Theranostics 6: 1031 10.7150/thno.14431 PMC4876627 27217836 · DOI
  25. Fan Y.-J. Pham M. T. Huang C.-J. (2018). Development of antimicrobial and antifouling universal coating via rapid deposition of polydopamine and zwitterionization. Langmuir 35 1642– 1651. 10.1021/acs.langmuir.8b01730 30114915 · DOI
  26. Feng J. Xu Z. Luo D. Liu X. (2020). Multiplexed imaging with coordination nanoparticles for cancer diagnosis and therapy. ACS Appl. Bio Mater. 3 713– 720. 10.1021/acsabm.9b01038 35019415 · DOI
  27. Forooshani P. K. Lee B. P. (2017). Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein. J. Polym. Sci. 55 9– 33. 10.1002/pola.28368 PMC5132118 27917020 · DOI · Paper page
  28. Forooshani P. K. Meng H. Lee B. P. (2017). “ Catechol redox reaction: reactive oxygen species generation, regulation, and biomedical applications,” in Advances in Bioinspired and Biomedical Materials, Vol. 1 eds Ito Y. Chen X. I-K Kang (Washington, DC: ACS Symposium Series), 179– 196. 10.1021/bk-2017-1252.ch010 · DOI
  29. Forooshani P. K. Polega E. Thomson K. Akream M. S. Pinnaratip R. Trought M. (2019). Antibacterial properties of mussel-inspired polydopamine coatings prepared by simple two-step shaking-assisted method. Front. Chem. 7: 631 10.3389/fchem.2019.00631 PMC6773806 31608272 · DOI
  30. Fruk L. Crocker L. (2019). Flavin Conjugated polydopamine nanoparticles displaying light-driven monooxygenase activity. Front. Chem. 7: 278 10.3389/fchem.2019.00278 PMC6497766 31080793 · DOI
  31. Gao C. Cheng H. Xu N. Li Y. Chen Y. Wei Y. (2019). Poly (dopamine) and Ag nanoparticle-loaded TiO2 nanotubes with optimized antibacterial and ROS-scavenging bioactivities. Nanomedicine 14 803– 818. 10.2217/nnm-2018-0131 30638128 · DOI
  32. Gao C. Wang Y. Han F. Yuan Z. Li Q. Shi C. (2017). Antibacterial activity and osseointegration of silver-coated poly (ether ether ketone) prepared using the polydopamine-assisted deposition technique. J. Mater. Chem. B 5 9326– 9336. 10.1039/c7tb02436c 32264535 · DOI
  33. Ge R. Lin M. Li X. Liu S. Wang W. Li S. (2017). Cu2+-loaded polydopamine nanoparticles for magnetic resonance imaging-guided pH-and near-infrared-light-stimulated thermochemotherapy. ACS Appl. Mater. Inter. 9 19706– 19716. 10.1021/acsami.7b05583 28553876 · DOI
  34. Ghilini F. Pissinis D. E. Miñán A. Schilardi P. L. Diaz C. (2019). How functionalized surfaces can inhibit bacterial adhesion and viability. ACS Biomater. Sci. Eng. 5 4920– 4936. 10.1021/acsbiomaterials.9b00849 33455240 · DOI
  35. Gu G. E. Park C. S. Cho H.-J. Ha T. H. Bae J. Kwon O. S. (2018). Fluorescent polydopamine nanoparticles as a probe for zebrafish sensory hair cells targeted in vivo imaging. Sci. Rep. 8 1– 8. 29535354 PMC5849738
  36. Guan M. Chen Y. Wei Y. Song H. Gao C. Cheng H. (2019). Long-lasting bactericidal activity through selective physical puncture and controlled ions release of polydopamine and silver nanoparticles–loaded TiO2 nanorods in vitro and in vivo. Int. J. Nanomed. 14: 2903 10.2147/ijn.s202625 PMC6497113 31114199 · DOI
  37. Guo A. Mu Q. Cai A. Wang X. (2019). Mussel-inspired green synthesis of Ag-coated polydopamine microspheres for selective antibacterial performance. Micro Nano Lett. 14 394– 398. 10.1049/mnl.2018.5357 · DOI
  38. Han J. Park W. Park S.-J. Na K. (2016). Photosensitizer-conjugated hyaluronic acid-shielded polydopamine nanoparticles for targeted photomediated tumor therapy. ACS Appl. Mater. Inter. 8 7739– 7747. 10.1021/acsami.6b01664 26965036 · DOI
  39. Ho C.-C. Ding S.-J. (2014). Structure, properties and applications of mussel-inspired polydopamine. J. Biomed. Nanotechnol. 10 3063– 3084. 10.1166/jbn.2014.1888 25992429 · DOI
  40. Hong S. H. Sun Y. Tang C. Cheng K. Zhang R. Fan Q. (2017). Chelator-free and biocompatible melanin nanoplatform with facile-loading gadolinium and copper-64 for bioimaging. Bioconjug. Chem. 28 1925– 1930. 10.1021/acs.bioconjchem.7b00245 28595014 · DOI
  41. Hong S. Kim K. Y. Wook H. J. Park S. Y. Lee K. D. Lee D. Y. (2011). Attenuation of the in vivo toxicity of biomaterials by polydopamine surface modification. Nanomedicine 6 793– 801. 21793672
  42. Hong S. Na Y. S. Choi S. Song I. T. Kim W. Y. Lee H. (2012). Non-covalent self-assembly and covalent polymerization co-contribute to polydopamine formation. Adv. Funct. Mater. 22 4711– 4717. 10.1002/adfm.201201156 · DOI
  43. Hong S. Wang Y. Park S. Y. Lee H. (2018). Progressive fuzzy cation-π assembly of biological catecholamines. Sci. Adv. 4: eaat7457 10.1126/sciadv.aat7457 PMC6128673 30202784 · DOI
  44. Huang N. Zhang S. Yang L. Liu M. Li H. Zhang Y. (2015). Multifunctional electrochemical platforms based on the Michael addition/Schiff base reaction of polydopamine modified reduced graphene oxide: Construction and application. ACS Appl. Mater. Inter. 7 17935– 17946. 10.1021/acsami.5b04597 26222894 · DOI
  45. Huang Y. Liu Z. Liu C. Ju E. Zhang Y. Ren J. (2016). Self-assembly of multi-nanozymes to mimic an intracellular antioxidant defense system. Angew. Chem. Int. Ed. 55 6646– 6650. 10.1002/anie.201600868 27098681 · DOI
  46. Jia L. Han F. Wang H. Zhu C. Guo Q. Li J. (2019). Polydopamine-assisted surface modification for orthopaedic implants. J. Orthop. Translat. 17 82– 95. 10.1016/j.jot.2019.04.001 31194087 PMC6551362 · DOI · Paper page
  47. Jia Z. Xiu P. Li M. Xu X. Shi Y. Cheng Y. (2016). Bioinspired anchoring AgNPs onto micro-nanoporous TiO2 orthopedic coatings: trap-killing of bacteria, surface-regulated osteoblast functions and host responses. Biomaterials 75 203– 222. 10.1016/j.biomaterials.2015.10.035 26513414 · DOI
  48. Jiao L. Xu Z. Du W. Li H. Yin M. (2017). Fast preparation of polydopamine nanoparticles catalyzed by Fe2+/H2O2 for visible sensitive smartphone-enabled cytosensing. ACS Appl. Mater. Inter. 9 28339– 28345. 10.1021/acsami.7b10564 28783432 · DOI
  49. Kao H. Chen C. C. Huang Y. R. Chu Y. H. Csík A. Ding S. J. (2019). Metal ion-dependent tailored antibacterial activity and biological properties of polydopamine-coated titanium implants. Surf. Coat. Technol. 378: 124998 10.1016/j.surfcoat.2019.124998 · DOI
  50. Khanzada N. K. Rehman S. Leu S. Y. An A. K. (2020). Evaluation of anti-bacterial adhesion performance of polydopamine cross-linked graphene oxide RO membrane via in situ optical coherence tomography. Desalination 479: 114339 10.1016/j.desal.2020.114339 · DOI
  51. Kong X.-J. Wu S. Chen T.-T. Yu R.-Q. Chu X. (2016). MnO2-induced synthesis of fluorescent polydopamine nanoparticles for reduced glutathione sensing in human whole blood. Nanoscale 8 15604– 15610. 10.1039/c6nr04777g 27511888 · DOI
  52. Ku S. H. Park C. B. (2010). Human endothelial cell growth on mussel-inspired nanofiber scaffold for vascular tissue engineering. Biomaterials 31 9431– 9437. 10.1016/j.biomaterials.2010.08.071 20880578 · DOI · Paper page
  53. Larosa V. Remacle C. (2018). Insights into the respiratory chain and oxidative stress. Biosci. Rep. 38: BSR20171492. PMC6167499 30201689
  54. Lee D. J. Lee Y.-T. Zou R. Daniel R. Ko C.-C. (2017). Polydopamine-laced biomimetic material stimulation of bone marrow derived mesenchymal stem cells to promote osteogenic effects. Sci. Rep. 7 1– 14. 10.1155/2016/4851081 29021583 PMC5636820 · DOI
  55. Lee H. A. Ma Y. Zhou F. Hong S. Lee H. (2019). Material-independent surface chemistry beyond polydopamine coating. Acc. Chem. Res. 52 704– 713. 10.1021/acs.accounts.8b00583 30835432 · DOI
  56. Lee H. Dellatore S. M. Miller W. M. Messersmith P. B. (2007). Mussel-inspired surface chemistry for multifunctional coatings. Science 318 426– 430. 10.1126/science.1147241 17947576 PMC2601629 · DOI · Paper page
  57. Lee H. Rho J. Messersmith P. B. (2009). Facile conjugation of biomolecules onto surfaces via mussel adhesive protein inspired coatings. Adv. Mater. 21 431– 434. 10.1002/adma.200801222 19802352 PMC2755254 · DOI · Paper page
  58. Lei W. Ren K. Chen T. Chen X. Li B. Chang H. (2016). Polydopamine nanocoating for effective photothermal killing of bacteria and fungus upon near-infrared irradiation. Adv. Mater. Interfaces 3: 1600767 10.1002/admi.201600767 · DOI
  59. Li F. Yu Y. Wang Q. Yuan J. Wang P. Fan X. (2018). Polymerization of dopamine catalyzed by laccase: Comparison of enzymatic and conventional methods. Enzyme Microb. Technol. 119 58– 64. 10.1016/j.enzmictec.2018.09.003 30243388 · DOI
  60. Li W.-Q. Wang Z. Hao S. He H. Wan Y. Zhu C. (2017). Mitochondria-targeting polydopamine nanoparticles to deliver doxorubicin for overcoming drug resistance. ACS Appl. Mater. Inter. 9 16793– 16802. 10.1021/acsami.7b01540 28481505 · DOI
  61. Li Y. Jiang C. Zhang D. Wang Y. Ren X. Ai K. (2017). Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor. Acta Biomater 47 124– 134. 10.1016/j.actbio.2016.10.010 27721008 · DOI
  62. Li Y. Yang W. Li X. Zhang X. Wang C. Meng X. (2015). Improving osteointegration and osteogenesis of three-dimensional porous Ti6Al4V scaffolds by polydopamine-assisted biomimetic hydroxyapatite coating. ACS Appl. Mater. Inter. 7 5715– 5724. 10.1021/acsami.5b00331 25711714 · DOI · Paper page
  63. Liang Y. Zhao X. Hu T. Han Y. Guo B. (2019). Mussel-inspired, antibacterial, conductive, antioxidant, injectable composite hydrogel wound dressing to promote the regeneration of infected skin. J. Coll. Inter. Sci. 556 514– 528. 10.1016/j.jcis.2019.08.083 31473541 · DOI
  64. Liao J. He S. Guo S. Luan P. Mo L. Li J. (2019). Antibacterial performance of a mussel-inspired polydopamine-treated Ag/graphene nanocomposite material. Materials 12: 3360 10.3390/ma12203360 PMC6829421 31618859 · DOI
  65. Liebscher J. (2019). Chemistry of polydopamine–Scope, variation, and limitation. Eur. J. Org. Chem. 2019 4976– 4994. 10.1002/ejoc.201900445 · DOI
  66. Liebscher J. Mroìwczynìski R. Scheidt H. A. Filip C. Ha?dade N. D. Turcu R. (2013). Structure of polydopamine: A never-ending story? Langmuir 29 10539– 10548. 10.1021/la4020288 23875692 · DOI · Paper page
  67. Lim K. Chua R. R. Y. Ho B. Tambyah P. A. Hadinoto K. Leong S. S. J. (2015). Development of a catheter functionalized by a polydopamine peptide coating with antimicrobial and antibiofilm properties. Acta Biomater. 15 127– 138. 10.1016/j.actbio.2014.12.015 25541344 · DOI
  68. Lin J.-H. Yu C.-J. Yang Y.-C. Tseng W.-L. (2015). Formation of fluorescent polydopamine dots from hydroxyl radical-induced degradation of polydopamine nanoparticles. Phys. Chem. Chem. Phys. 17 15124– 15130. 10.1039/c5cp00932d 25820836 · DOI
  69. Liu C. Yao W. Tian M. Wei J. Song Q. Qiao W. (2018). Mussel-inspired degradable antibacterial polydopamine/silica nanoparticle for rapid hemostasis. Biomaterials 179 83– 95. 10.1016/j.biomaterials.2018.06.037 29980077 · DOI
  70. Liu C.-Y. Huang C.-J. (2016). Functionalization of polydopamine via the aza-Michael reaction for antimicrobial interfaces. Langmuir 32 5019– 5028. 10.1021/acs.langmuir.6b00990 27118187 · DOI
  71. Liu F. He X. Zhang J. Chen H. Zhang H. Wang Z. (2015). Controllable synthesis of polydopamine nanoparticles in microemulsions with pH-activatable properties for cancer detection and treatment. J. Mater. Chem. B 3 6731– 6739. 10.1039/c5tb01159k 32262465 · DOI
  72. Liu H. Qu X. Tan H. Song J. Lei M. Kim E. (2019). Role of polydopamine’s redox-activity on its pro-oxidant, radical-scavenging, and antimicrobial activities. Acta Biomater. 88 181– 196. 10.1016/j.actbio.2019.02.032 30818052 · DOI
  73. Liu M. Liu T. Chen X. Yang J. Deng J. He W. (2018). Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing. J. Nanobiotechnol. 16 1– 19. PMC6231251 30419925
  74. Liu M. Zhou J. Yang Y. Zheng M. Yang J. Tan J. (2015). Surface modification of zirconia with polydopamine to enhance fibroblast response and decrease bacterial activity in vitro: a potential technique for soft tissue engineering applications. Coll. Surf. B 136 74– 83. 10.1016/j.colsurfb.2015.06.047 26363269 · DOI · Paper page
  75. Liu Y. Li Z. Yin Z. Zhang H. Gao Y. Huo G. (2020). Amplified photoacoustic signal and enhanced photothermal conversion of polydopamine coated gold nanobipyramids for photo-theranostics and synergistic chemotherapy. ACS Appl. Mater. Inter. 12 14866– 14875. 10.1021/acsami.9b22979 32153178 · DOI
  76. Luo C. Liu W. Luo B. Tian J. Wen W. Liu M. (2017). Antibacterial activity and cytocompatibility of chitooligosaccharide-modified polyurethane membrane via polydopamine adhesive layer. Carbohyd. Polym. 156 235– 243. 10.1016/j.carbpol.2016.09.036 27842818 · DOI
  77. Lynge M. E. van der Westen R. Postma A. Städler B. (2011). Polydopamine—A nature-inspired polymer coating for biomedical science. Nanoscale 3 4916– 4928. 10.1039/c1nr10969c 22024699 · DOI · Paper page
  78. Ma L. Liu F. Lei Z. Wang Z. (2017). A novel upconversion@ polydopamine core@ shell nanoparticle based aptameric biosensor for biosensing and imaging of cytochrome c inside living cells. Biosens. Bioelectron. 87 638– 645. 10.1016/j.bios.2016.09.017 27619527 · DOI
  79. Madhurakkat Perikamana S. K. Lee J. Lee Y. B. Shin Y. M. Lee E. J. Mikos A. G. (2015). Materials from mussel-inspired chemistry for cell and tissue engineering applications. Biomacromolecules 16 2541– 2555. 10.1021/acs.biomac.5b00852 26280621 · DOI
  80. Maier G. P. Butler A. (2017). Siderophores and mussel foot proteins: the role of catechol, cations, and metal coordination in surface adhesion. JBIC J. Biol. Inorg. Chem. 22 739– 749. 10.1007/s00775-017-1451-6 28364222 · DOI
  81. Mallinson D. Mullen A. B. Lamprou D. A. (2018). Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation. J. Mater. Sci. 53 3198– 3209. 10.1007/s10853-017-1806-y 31997831 PMC6956915 · DOI
  82. Maruthapandi M. Natan M. Jacobi G. Banin E. Luong J. H. Gedanken A. (2019). Antibacterial activity against Methicillin-resistant staphylococcus aureus of colloidal polydopamine prepared by carbon dot stimulated polymerization of dopamine. Nanomaterials 9: 1731 10.3390/nano9121731 PMC6955702 31817151 · DOI
  83. Matai I. Garg M. Rana K. Singh S. (2019). Polydopamine functionalized hydrogel beads as magnetically separable antibacterial materials. RSC Adv. 9 13444– 13457. 10.1039/c9ra00623k PMC9063863 35519566 · DOI
  84. Meng H. Forooshani P. K. Joshi P. U. Osborne J. Mi X. Meingast C. (2019). Biomimetic recyclable microgels for on-demand generation of hydrogen peroxide and antipathogenic application. Acta Biomater. 83 109– 118. 10.1016/j.actbio.2018.10.037 30541699 PMC6298039 · DOI
  85. Miao Z.-H. Wang H. Yang H. Li Z.-L. Zhen L. Xu C.-Y. (2015). Intrinsically Mn2+-chelated polydopamine nanoparticles for simultaneous magnetic resonance imaging and photothermal ablation of cancer cells. ACS Appl. Mater. Inter. 7 16946– 16952. 10.1021/acsami.5b06265 26196160 · DOI
  86. Moulay S. (2018). Recent trends in mussel-inspired catechol-containing polymers (A Review). Orient. J. Chem. 34 1153– 1197. 10.13005/ojc/340301 · DOI
  87. Neethu S. Midhun S. J. Radhakrishnan E. Jyothis M. (2020). Surface functionalization of central venous catheter with mycofabricated silver nanoparticles and its antibiofilm activity on multidrug resistant Acinetobacter baumannii. Microb. Pathog. 138: 103832 10.1016/j.micpath.2019.103832 31689474 · DOI
  88. Nieto C. Vega M. A. Marcelo G. del Valle E. M. M. (2018). Polydopamine nanoparticles kill cancer cells. RSC Adv. 8 36201– 36208. 10.1039/c8ra05586f PMC9088449 35558470 · DOI
  89. Niyonshuti I. I. Krishnamurthi V. R. Okyere D. Song L. Benamara M. Tong X. (2020). Polydopamine surface coating synergizes the antimicrobial activity of silver nanoparticles. ACS Appl. Mater. Interfaces 12 40067– 40077. 10.1021/acsami.0c10517 32794690 · DOI
  90. Park D. Kim J. Lee Y. M. Park J. Kim W. J. (2016). Polydopamine hollow nanoparticle functionalized with N-diazeniumdiolates as a nitric oxide delivery carrier for antibacterial therapy. Adv. Healthc. Mater. 5 2019– 2024. 10.1002/adhm.201600150 27331379 · DOI
  91. Park J. Moon H. Hong S. (2019). Recent advances in melanin-like nanomaterials in biomedical applications: A mini review. Biomater. Res. 23 1– 10. 31827881 PMC6889561
  92. Patel K. Singh N. Yadav J. Nayak J. M. Sahoo S. K. Lata J. (2018). Polydopamine films change their physicochemical and antimicrobial properties with a change in reaction conditions. Phys. Chem. Chem. Phys. 20 5744– 5755. 10.1039/c7cp08406d 29411802 · DOI
  93. Poinard B. Kamaluddin S. Tan A. Q. Q. Neoh K. G. Kah J. C. Y. (2019). Polydopamine coating enhances mucopenetration and cell uptake of nanoparticles. ACS Appl. Mater. Inter. 11 4777– 4789. 10.1021/acsami.8b18107 30694045 · DOI
  94. Priyam A. Nagar P. Sharma A. K. Kumar P. (2018). Mussel-inspired polydopamine-polyethylenimine conjugated nanoparticles as efficient gene delivery vectors for mammalian cells. Coll. Surf. B 161 403– 412. 10.1016/j.colsurfb.2017.10.063 29121613 · DOI
  95. Qian Y. Zhou X. Zhang F. Diekwisch T. G. Luan X. Yang J. (2019). /PCL scaffold modification including silver impregnation, collagen coating, and electrospinning significantly improve biocompatibility, antimicrobial, and osteogenic properties for orofacial tissue regeneration. ACS Appl. Mater. Inter. 11 37381– 37396. 10.1021/acsami.9b07053 PMC7220812 31517483 · DOI · Paper page
  96. Qiu W. Z. Yang H. C. Xu Z. K. (2018). Dopamine-assisted co-deposition: An emerging and promising strategy for surface modification. Adv. Coll. Interface Sci. 256 111– 125. 10.1016/j.cis.2018.04.011 29776584 · DOI
  97. Rahimnejad M. Zhong W. (2017). Mussel-inspired hydrogel tissue adhesives for wound closure. RSC Adv. 7 47380– 47396. 10.1039/c7ra06743g · DOI · Paper page
  98. Ran H.-H. Cheng X. Gao G. Sun W. Jiang Y.-W. Zhang X. (2020). Colistin-loaded polydopamine nanospheres uniformly decorated with silver nanodots: A nanohybrid platform with improved antibacterial and antibiofilm performance. ACS Appl. Bio Mater. 3 2438– 2448. 10.1021/acsabm.0c00163 35025293 · DOI
  99. Ryu J. H. Messersmith P. B. Lee H. (2018). Polydopamine surface chemistry: A decade of discovery. ACS Appl. Mater. Inter. 10 7523– 7540. 10.1021/acsami.7b19865 PMC6320233 29465221 · DOI · Paper page
  100. Sadrearhami Z. Shafiee F. N. Ho K. K. Kumar N. Krasowska M. Blencowe A. (2019). Antibiofilm nitric oxide-releasing polydopamine coatings. ACS Appl. Mater. Inter. 11 7320– 7329. 10.1021/acsami.8b16853 30688429 · DOI
  101. Singh I. Priyam A. Jha D. Dhawan G. Gautam H. K. Kumar P. (2020). Polydopamine–aminoglycoside nanoconjugates: Synthesis, characterization, antimicrobial evaluation and cytocompatibility. Mater. Sci. Eng. C 107: 110284 10.1016/j.msec.2019.110284 31761233 · DOI
  102. Solano F. (2017). Melanin and melanin-related polymers as materials with biomedical and biotechnological applications—Cuttlefish ink and mussel foot proteins as inspired biomolecules. Int. J. Mol. Sci. 18: 1561 10.3390/ijms18071561 PMC5536049 28718807 · DOI
  103. Song J. Chen P. Liu W. (2019). A superhydrophobic and antibacterial surface coated on cotton fabrics by polydopamine. Fibers Polym. 20 1380– 1386. 10.1007/s12221-019-1183-z · DOI
  104. Song Y. Jiang H. Wang B. Kong Y. Chen J. (2018). Silver-incorporated mussel-inspired polydopamine coatings on mesoporous silica as an efficient nanocatalyst and antimicrobial agent. ACS Appl. Mater. Inter. 10 1792– 1801. 10.1021/acsami.7b18136 29303548 · DOI
  105. Su L. Yu Y. Zhao Y. Liang F. Zhang X. (2016). Strong antibacterial polydopamine coatings prepared by a shaking-assisted method. Sci. Rep. 6: 24420. PMC4832207 27080534
  106. Tang L. Livi K. J. Chen K. L. (2015). Polysulfone membranes modified with bioinspired polydopamine and silver nanoparticles formed in situ to mitigate biofouling. Environ. Sci. Technol. Lett. 2 59– 65. 10.1021/acs.estlett.5b00008 · DOI
  107. Tang L. Mo S. Liu S. G. Liao L. L. Li N. B. Luo H. Q. (2018). Synthesis of fluorescent polydopamine nanoparticles by Michael addition reaction as an analysis platform to detect iron ions and pyrophosphate efficiently and construction of an IMPLICATION logic gate. Sensor Actuat B- Chem. 255 754– 762. 10.1016/j.snb.2017.08.069 · DOI
  108. Tian Y. Lei M. (2019). Polydopamine-based composite nanoparticles with redox-labile polymer shells for controlled drug release and enhanced chemo-photothermal therapy. Nanoscale Res. Lett. 14 1– 10. 31147801 PMC6542907
  109. Tyo A. G. Welch S. Hennenfent M. Forooshani P. K. Lee B. P. Rajachar R. M. (2019). Development and characterization of an antimicrobial polydopamine coating for conservation of Humpback Whales. Front. Chem. 7: 618 10.3389/fchem.2019.00618 PMC6759777 31620421 · DOI
  110. Wang B. B. Quan Y. H. Xu Z. M. Zhao Q. (2020). Preparation of highly effective antibacterial coating with polydopamine/chitosan/silver nanoparticles via simple immersion. Prog. Org. Coat. 149: 105967 10.1016/j.porgcoat.2020.105967 · DOI
  111. Wang C. Zhou J. Wang P. He W. Duan H. (2016). Robust nanoparticle–DNA conjugates based on mussel-inspired polydopamine coating for cell imaging and tailored self-assembly. Bioconjug. Chem. 27 815– 823. 10.1021/acs.bioconjchem.6b00021 26859517 · DOI
  112. Wang D. Wu H. Zhou J. Xu P. Wang C. Shi R. (2018). In situ one-pot synthesis of MOF–polydopamine hybrid nanogels with enhanced photothermal effect for targeted cancer therapy. Adv. Sci. 5: 1800287 10.1002/advs.201800287 PMC6010715 29938191 · DOI
  113. Wang K. Ma Q. Zhang Y. Wang S. Han G. (2020). Ag NPs-assisted synthesis of stable Cu NPs on PET fabrics for antibacterial and electromagnetic shielding performance. Polymers 12: 783 10.3390/polym12040783 PMC7240618 32252237 · DOI
  114. Wang L. Yang X. Cao W. Shi C. Zhou P. Li Q. (2017). Mussel-inspired deposition of copper on titanium for bacterial inhibition and enhanced osseointegration in a periprosthetic infection model. RSC Adv. 7 51593– 51604. 10.1039/c7ra10203h · DOI
  115. Wang Q. Zhang R. Lu M. You G. Wang Y. Chen G. (2017). Bioinspired polydopamine-coated hemoglobin as potential oxygen carrier with antioxidant properties. Biomacromolecules 18 1333– 1341. 10.1021/acs.biomac.7b00077 28323418 · DOI
  116. Wang X. Wang N. Yang Y. Wang X. Liang J. Tian X. (2019). Polydopamine nanoparticles carrying tumor cell lysate as a potential vaccine for colorectal cancer immunotherapy. Biomater. Sci. 7 3062– 3075. 10.1039/c9bm00010k 31140475 · DOI
  117. Wang X. Zhang J. Wang Y. Wang C. Xiao J. Zhang Q. (2016). Multi-responsive photothermal-chemotherapy with drug-loaded melanin-like nanoparticles for synergetic tumor ablation. Biomaterials 81 114– 124. 10.1016/j.biomaterials.2015.11.037 26731575 · DOI
  118. Wang Z. Zhang J. Chen F. Cai K. (2017). Fluorescent miRNA analysis enhanced by mesopore effects of polydopamine nanoquenchers. Analyst 142 2796– 2804. 10.1039/c7an00528h 28682373 · DOI
  119. Wen L. Wanpei H. Qian L. Xu L. Rongsheng C. Hongwei N. (2020). Antibacterial properties of Ag/TiO2/PDA nanofilm on anodized 316L stainless steel substrate under illumination by a normal flashlight. J. Mater. Sci. 2020 1– 13. 10.1007/s10853-020-04610-w PMC7197247 32367893 · DOI
  120. Wu C. Zhang G. Xia T. Li Z. Zhao K. Deng Z. (2015). Bioinspired synthesis of polydopamine/Ag nanocomposite particles with antibacterial activities. Mater. Sci. Eng. C 55 155– 165. 10.1016/j.msec.2015.05.032 26117750 · DOI
  121. Wu H. Liu Y. Huang J. Mao L. Chen J. Li M. (2018). Preparation and characterization of antifouling and antibacterial polysulfone ultrafiltration membranes incorporated with a silver–polydopamine nanohybrid. J. Appl. Polym. Sci. 135: 46430 10.1002/app.46430 · DOI
  122. Wu K. Yang Y. Zhang Y. Deng J. Lin C. (2015). Antimicrobial activity and cytocompatibility of silver nanoparticles coated catheters via a biomimetic surface functionalization strategy. Int. J. Nanomed. 10 7241– 7252. 10.2147/ijn.s92307 PMC4671771 26664115 · DOI
  123. Wu Y. Zhou Y. Xu H. Liu Q. Li Y. Zhang L. (2018). Highly active, superstable, and biocompatible Ag/polydopamine/g-C3N4 bactericidal photocatalyst: synthesis, characterization, and mechanism. ACS Sust. Chem. Eng. 6 14082– 14094. 10.1021/acssuschemeng.8b02620 · DOI
  124. Xiong Y. Xu Z. Li Z. (2019). Polydopamine-based nanocarriers for photosensitizer delivery. Front. Chem. 7: 471 10.3389/fchem.2019.00471 PMC6639787 31355178 · DOI
  125. Xu Q. Chang M. Zhang Y. Wang E. Xing M. Gao L. (2020). PDA/Cu bioactive hydrogel with “Hot Ions Effect” for inhibition of drug-resistant bacteria and enhancement of infectious skin wound healing. ACS Appl. Mater. Interfaces 12 31255– 31269. 10.1021/acsami.0c08890 32530593 · DOI
  126. Yan J. Zhou W. Jia Z. Xiong P. Li Y. Wang P. (2018). Endowing polyetheretherketone with synergistic bactericidal effects and improved osteogenic ability. Acta Biomater. 79 216– 229. 10.1016/j.actbio.2018.08.037 30172936 · DOI
  127. Yang P. Gu Z. Zhu F. Li Y. (2020a). Structural and functional tailoring of melanin-like polydopamine radical scavengers. CCS Chemistry 2 128– 138. 10.31635/ccschem.020.201900077 · DOI
  128. Yang P. Zhang S. Chen X. Liu X. Wang Z. Li Y. (2020b). Recent developments in polydopamine fluorescent nanomaterials. Mater. Horizons 7 746– 761. 10.1039/c9mh01197h · DOI
  129. Yang X. Niu X. Mo Z. Guo R. Liu N. Zhao P. (2019). Electrochemical chiral interface based on the Michael addition/Schiff base reaction of polydopamine functionalized reduced graphene oxide. Electrochim. Acta 319 705– 715. 10.1016/j.electacta.2019.07.040 · DOI
  130. Yang Z. Wu Y. Wang J. Cao B. Tang C. Y. (2016). In situ reduction of silver by polydopamine: A novel antimicrobial modification of a thin-film composite polyamide membrane. Environ. Sci. Technol. 50 9543– 9550. 10.1021/acs.est.6b01867 27479138 · DOI
  131. Yao L. He C. Chen S. Zhao W. Xie Y. Sun S. (2018). Co-deposition of polydopamine and zwitterionic polymer on membrane surface with enhanced stability and antibiofouling property. Langmuir 35 1430– 1439. 10.1021/acs.langmuir.8b01621 30056716 · DOI
  132. Yeroslavsky G. Girshevitz O. Foster-Frey J. Donovan D. M. Rahimipour S. (2015). Antibacterial and antibiofilm surfaces through polydopamine-assisted immobilization of lysostaphin as an antibacterial enzyme. Langmuir 31 1064– 1073. 10.1021/la503911m 25547537 · DOI
  133. Yeroslavsky G. Lavi R. Alishaev A. Rahimipour S. (2016). Sonochemically-produced metal-containing polydopamine nanoparticles and their antibacterial and antibiofilm activity. Langmuir 32 5201– 5212. 10.1021/acs.langmuir.6b00576 27133213 · DOI
  134. Yilmaz A. (2020). The employment of a conformal polydopamine thin layer reduces the cytotoxicity of silver nanoparticles. Turk. J. Zool. 44 126– 133. 10.3906/zoo-1912-38 · DOI
  135. Yuan Z. Tao B. He Y. Liu J. Lin C. Shen X. (2019). Biocompatible MoS2/PDOPA-RGD coating on titanium implant with antibacterial property via intrinsic ROS-independent oxidative stress and NIR irradiation. Biomaterials 217: 119290 10.1016/j.biomaterials.2019.119290 31252244 · DOI
  136. Yun’an Qing L. C. Li R. Liu G. Zhang Y. Tang X. Wang J. (2018). Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies. Int. J. Nanomed. 13: 3311 10.2147/ijn.s165125 PMC5993028 29892194 · DOI
  137. Yuwen L. Sun Y. Tan G. Xiu W. Zhang Y. Weng L. (2018). MoS2@ polydopamine-Ag nanosheets with enhanced antibacterial activity for effective treatment of Staphylococcus aureus biofilms and wound infection. Nanoscale 10 16711– 16720. 10.1039/c8nr04111c 30156245 · DOI
  138. Zhang C. Gong l Xiang l Du Y. Hu W. Zeng H. (2017). Deposition and adhesion of polydopamine on the surfaces of varying wettability. ACS Appl. Mater. Interfaces 9 30943– 30950. 10.1021/acsami.7b09774 28832107 · DOI
  139. Zhang Q. Wang Y. Zhang W. Hickey M. E. Lin Z. Tu Q. (2019). In situ assembly of well-dispersed Ag nanoparticles on the surface of polylactic acid-Au@polydopamine nanofibers for antimicrobial applications. Coll. Surf. B 184: 110506 10.1016/j.colsurfb.2019.110506 31541892 · DOI
  140. Zhao H. Zeng Z. Liu L. Chen J. Zhou H. Huang L. (2018). Polydopamine nanoparticles for the treatment of acute inflammation-induced injury. Nanoscale 10 6981– 6991. 10.1039/c8nr00838h 29610822 · DOI
  141. Zhao Y.-Y. Li L. Yu R.-Q. Chen T.-T. Chu X. (2017). CoOOH-induced synthesis of fluorescent polydopamine nanoparticles for the detection of ascorbic acid. Anal. Methods 9 5518– 5524. 10.1039/c7ay01566f · DOI
  142. Zheng A. Zhang X. Huang Y. Cai Z. Liu X. Liu J. (2018). Polydopamine-assisted versatile modification of a nucleic acid probe for intracellular microRNA imaging and enhanced photothermal therapy. RSC Adv. 8 6781– 6788. 10.1039/c8ra00261d PMC9078363 35540353 · DOI
  143. Zhou C. Song H. Loh J. L. C. She J. Deng L. Liu B. (2018). Grafting antibiofilm polymer hydrogel film onto catheter by SARA SI-ATRP. J. Biomater. Sci., Polym. Ed. 29 2106– 2123. 10.1080/09205063.2018.1507268 30141743 · DOI
  144. Zhou L. Li X. Wang K. Shen F. Zhang L. Li P. (2020). Cu∥-loaded polydopamine coatings with in situ nitric oxide generation function for improved hemocompatibility. Regen. Biomater. 7 153– 160. 10.1093/rb/rbz043 32296534 PMC7147359 · DOI
  145. Zhou P. Deng Y. Lyu B. Zhang R. Zhang H. Ma H. (2014). Rapidly-deposited polydopamine coating via high temperature and vigorous stirring: Formation, characterization and biofunctional evaluation. PLoS One 9: e113087 10.1371/journal.pone.0113087 PMC4240549 25415328 · DOI · Paper page
  146. Zhou T. Yan L. Xie C. Li P. Jiang L. Fang J. (2019). A mussel-inspired persistent ROS-scavenging, electroactive, and osteoinductive scaffold based on electrochemical-driven in situ nanoassembly. Small 15: 1805440 10.1002/smll.201805440 31106983 · DOI · Paper page
  147. Zhu Y. Xin N. Qiao Z. Chen S. Zeng l Zhang Y. (2019). Novel tumor-microenvironment-based sequential catalytic therapy by Fe (II)-engineered polydopamine nanoparticles. ACS Appl. Mater. Inter. 11 43018– 43030. 10.1021/acsami.9b17951 31660723 · DOI
  148. Zhu Z. Su M. (2017). Polydopamine nanoparticles for combined chemo-and photothermal cancer therapy. Nanomaterials 7: 160 10.3390/nano7070160 PMC5535226 28661423 · DOI
  149. Zou Y. Chen X. Yang P. Liang G. Yang Y. Gu Z. (2020). Regulating the absorption spectrum of polydopamine. Sci. Adv. 6: eabb4696 10.1126/sciadv.abb4696 PMC7473670 32917617 · DOI

Authors
Singh, I., Dhawan, G., Gupta, S., & Kumar, P.
Affiliations
  • University of Delhi (IN)
  • Institute of Genomics and Integrative Biology (IN)
Corresponding author
  • Dhawan, Gagan
  • Gupta, Seema
  • Kumar, Pradeep
ORCID
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2021-01-12
Volume
11
Pages
607099-607099
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2020.607099
PMC
PMC7835282
OpenAlex
W3119434710
Cited by
163
References
166
Citations by year
2026: 26 · 2025: 32 · 2024: 37 · 2023: 20 · 2022: 34 · 2021: 14
FWCI
1.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
Keywords
polydopamine, antimicrobial coatings, biofilm inhibition, catheter-related infection, antibiotic resistance, mussel-inspired adhesion, catechol, reactive oxygen species, nanostructured coatings, waterborne diseases, implant-associated infection, antifouling surfaces

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