Altered gut microbiota in older adults with mild cognitive impairment: a case-control study
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Introduction: The microbiota-gut-brain axis is implicated in Alzheimer’s disease. Gut microbiota alterations in mild cognitive impairment (MCI) are inconsistent and remain to be understood. This study aims to investigate the gut microbial composition associated with MCI, cognitive functions, and structural brain differences. Methods: A nested case-control study was conducted in a community-based prospective cohort where detailed cognitive functions and structural brain images were collected. Thirty-one individuals with MCI were matched to sixty-five cognitively normal controls by age strata, gender, and urban/rural area. Fecal samples were examined using 16S ribosomal RNA (rRNA) V3–V4 sequencing. Compositional differences between the two groups were identified and correlated with the cognitive functions and volumes/thickness of brain structures. Results: There was no significant difference in alpha and beta diversity between MCIs and cognitively normal older adults. However, the abundance of the genus Ruminococcus, Butyricimonas, and Oxalobacter decreased in MCI patients, while an increased abundance of nine other genera, such as Flavonifractor, were found in MCIs. Altered genera discriminated MCI patients well from controls (AUC = 84.0%) and were associated with attention and executive function. Conclusion: This study provides insights into the role of gut microbiota in the neurodegenerative process.
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Reduced SCFA-producing species and SCFA levels are reported in individuals with mild cognitive impairment and AD patients.
“Several studies have reported reduced SCFAs-producing species and SCFA levels in individuals with mild cognitive impairment (MCI) and AD patients.292–295”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [292]
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Self-citation
- Authors
- Fan, K.-C., Lin, C.-C., Liu, Y.-C., Chao, Y.-P., Lai, Y.-J., Chiu, Y.-L., & Chuang, Y.-F.
- Affiliations
- National Yang Ming Chiao Tung University (TW)
- Cardinal Tien Hospital (TW)
- Chang Gung University (TW)
- Far Eastern Memorial Hospital (TW)
- National Taiwan University (TW)
- Corresponding author
- Chuang, Yi-Fang
- ORCID
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2023-05-25
- Volume
- 15
- Pages
- 1162057-1162057
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC10281289
- OpenAlex
- W4378176560
- Cited by
- 47
- References
- 62
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 16 · 2023: 2
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Shanghai Educational Development Foundation
- Ministry of Science and Technology, Taiwan (MOST110-2321-B418-001)
- Far Eastern Memorial Hospital
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, mild cognitive impairment, microbiota-gut-brain axis, older adults, Alzheimer's disease, Ruminococcus, Butyricimonas, Oxalobacter, Flavonifractor, attention, executive function, brain structure, neurodegeneration, fecal microbiota
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