Gut microbiota interacts with intrinsic brain activity of patients with amnestic mild cognitive impairment
Open accessAbstract
AIMS: To explore the potential relationships among gut microbiota (GM), local brain spontaneous activity, and neuropsychological characteristics in amnestic mild cognitive impairment (aMCI) patients. METHODS: Twenty aMCI and 22 healthy control (HC) subjects were recruited. The GM composition was determined by 16S ribosomal RNA gene sequencing. Resting-state functional magnetic resonance imaging scans were performed, and fractional amplitude of low-frequency fluctuations (fALFF) was calculated across different frequencies. The Spearman or Pearson correlation analysis was used to analyze the relationship between spontaneous brain activity and cognitive function, and GM composition. RESULTS: aMCI patients had altered GM state and local spontaneous brain activity as compared with HC subjects. Correlation analysis showed that aMCI and HC groups had different "GM-intrinsic brain activity interaction" patterns. In aMCI group, at the typical band (0.01-0.08 Hz), the relative abundance (RA) of Bacteroides from phylum to genus level was negatively correlated with fALFF value of cerebellar vermis IV-V, and the Ruminococcaceae RA was negatively correlated with fALFF values of left lenticular nucleus and pallidum. The Clostridiaceae RA and Blautia RA were positively correlated with the left cerebellum lobules IV-V at the slow-4 band (0.027-0.073 Hz). The Veillonellaceae RA was positively correlated with fALFF values of left precentral gyrus at the slow-5 band (0.073-0.08 Hz). Correlation analysis showed that Clostridium members (Lachnospiraceae and Blautia) were positively, while Veillonellaceae was negatively, correlated with cognition test. Bacteroides was positively correlated with attention and computation, and negatively correlated with the three-stage command score. CONCLUSIONS: aMCI patients have a specific GM-intrinsic brain activity-cognitive function interaction pattern.
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In a recent human brain imaging study, correlations were made between gut microbiota composition and brain activity patterns in patients with amnestic mild cognitive impairment.
“In a recent human brain imaging study, correlations were made between gut microbiota composition and brain activity patterns in patients with amnestic mild cognitive impairment (220).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [220]
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Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429 · see citing works
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781 · see citing works
Movement‐Related effects in fMRI time‐series
Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350312 · Cited by 3,774 · see citing works
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Dubois, B., Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. L., Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70090-0 · Cited by 3,321 · see citing works
Zou, Q., Zhu, C.-Z., Yang, Y., Zuo, X., Long, X., Cao, Q., Wang, Y., & Zang, Y. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.04.012 · Cited by 2,169 · see citing works
Gut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works
Revising the definition of Alzheimer's disease: a new lexicon
Dubois, B., Feldman, H. H., Jacova, C., Cummings, J. L., DeKosky, S. T., Barberger-Gateau, P., Delacourte, A., Frisoni, G., Fox, N. C., Galasko, D., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70223-4 · Cited by 1,869 · see citing works
Schmahmann, J. D. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2018.07.005 · Cited by 1,625 · see citing works
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513 · see citing works
The oscillating brain: Complex and reliable
Zuo, X., Martino, A. D., Kelly, C. A. M., Shehzad, Z. E., Gee, D. G., Klein, D. F., Castellanos, F. X., Biswal, B. B., & Milham, M. P. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.037 · Cited by 1,460 · see citing works
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works
The Gut Microbiota and Alzheimer’s Disease
Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852 · see citing works
Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease
Jenq, R. R., Taur, Y., Devlin, S. M., Ponce, D. M., Goldberg, J. D., Ahr, K. F., Littmann, E. R., Ling, L., Gobourne, A. C., Miller, L. C., et al. (2015) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2015.04.016 · Cited by 748 · see citing works
Liu, P., Wu, L., Peng, G., Han, Y., Tang, R., Ge, J., Zhang, L., Jia, L., Yue, S., Zhou, K., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.05.008 · Cited by 669 · see citing works
Self-citationBerendsen, A. A. M., Kang, J. H., van de Rest, O., Jankovic, N., Kampman, E., Jong, J. C. K., Franco, O. H., Ikram, M. A., Pikhart, H., Nilsson, L. M., et al. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000464269 · Cited by 565 · see citing works
Resting state functional connectivity in preclinical Alzheimer’s disease
Sheline, Y. I., & Raichle, M. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.028 · Cited by 509 · see citing works
Yu, J., Li, J., & Huang, X. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-156 · Cited by 461 · see citing works
Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease
Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449 · see citing works
Han, Y., Wang, J., Zhao, Z., Min, B., Lu, J., Li, K., Yong He, A., & Jia, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.059 · Cited by 442 · see citing works
Jia, X., Wang, J., Sun, H., Zhang, H., Liao, W., Wang, Z., Yan, C., Song, X., & Zang, Y. (2019) · 中国科学通报：英文版 · doi:10.1016/j.scib.2019.05.008 · Cited by 383 · see citing works
Self-citationWang, B., Jiang, X., Cao, M., Ge, J., Bao, Q., Tang, L., Chen, Y., & Li, L. (2016) · Scientific Reports · doi:10.1038/srep32002 · Cited by 380 · see citing works
Self-citationZhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works
Tong, X., Xu, J. Y., Lian, F., Yu, X., Zhao, Y., Xu, L., Zhang, M. H., Zhao, X., Shen, J., Wu, S., et al. (2018) · mBio · doi:10.1128/mbio.02392-17 · Cited by 376 · see citing works
The cerebellum in Alzheimer’s disease: evaluating its role in cognitive decline
Jacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2017) · Brain · doi:10.1093/brain/awx194 · Cited by 339 · see citing works
Impairment and compensation coexist in amnestic MCI default mode network
Qi, Z., Wu, X., Wang, Z., Zhang, N., Dong, H., Yao, L., & Li, K. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.025 · Cited by 323 · see citing works
Sun, J., Xu, J., Yang, B., Chen, K., Kong, Y., Fang, N., Gong, T., Wang, F., Ling, Z., & Liu, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900636 · Cited by 302 · see citing works
Bacteroides fragilis Lipopolysaccharide and Inflammatory Signaling in Alzheimer’s Disease
Lukiw, W. J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01544 · Cited by 290 · see citing works
Insulin resistance predicts brain amyloid deposition in late middle‐aged adults
Willette, A. A., Johnson, S. C., Birdsill, A. C., Sager, M. A., Christian, B., Baker, L. D., Craft, S., Oh, J. M., Statz, E. H., Hermann, B. P., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.03.011 · Cited by 262 · see citing works
Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila
Wu, S.-C., Cao, Z.-S., Chang, K.-M., & Juang, J. (2017) · Nature Communications · doi:10.1038/s41467-017-00040-6 · Cited by 255 · see citing works
Guo, C. C., Tan, R. H., Hodges, J. R., Hu, X., Sami, S. A. K., & Hornberger, M. (2016) · Brain · doi:10.1093/brain/aww003 · Cited by 206 · see citing works
Early-Stage and Preclinical Alzheimer Disease
&NA; (2005) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000184005.22611.cc · Cited by 186 · see citing works
Ling, Z., Jin, C., Xie, T., Cheng, Y., Li, L., & Wu, N. (2016) · Scientific Reports · doi:10.1038/srep30673 · Cited by 185 · see citing works
Tillisch, K., Mayer, E. A., Gupta, A., Gill, Z., Brazeilles, R., Le Nevé, B., van Hylckama Vlieg, J. E. T., Guyonnet, D., Derrien, M., & Labus, J. S. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000493 · Cited by 185 · see citing works
Chinese Version and Norms of the Mini-Mental State Examination
Guo, N. (1988) · Rehabilitation practice and science · doi:10.6315/3005-3846.1745 · Cited by 156 · see citing works
Pan, P., Zhu, L., Yu, T., Shi, H., Zhang, B., Qin, R., Zhu, X., Qian, L., Zhao, H., Zhou, H., et al. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.001 · Cited by 138 · see citing works
Abnormal Amplitude of Low-Frequency Fluctuations of Intrinsic Brain Activity in Alzheimer's Disease
Liu, X., Wang, S., Zhang, X., Wang, Z., Tian, X., & Yong He, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131322 · Cited by 120 · see citing works
Altered functional brain networks in amnestic mild cognitive impairment: a resting-state fMRI study
Initiative, A. D. N., Cai, S., Chong, T., Peng, Y., Shen, W., Li, J., von Deneen, K. M., & Huang, L. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9539-0 · Cited by 117 · see citing works
Anatomical and Functional Deficits in Patients with Amnestic Mild Cognitive Impairment
Han, Y., Lui, S., Kuang, W., Lang, Q., Zou, L., & Jia, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028664 · Cited by 101 · see citing works
Ruminococcus gnavusE1 modulates mucin expression and intestinal glycosylation
Graziani, F., Pujol, A., Nicoletti, C., Dou, S., Maresca, M., Giardina, T., Fons, M., & Perrier, J. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13095 · Cited by 95 · see citing works
Zhou, Y., Yu, F. F., Duong, T. Q., & Initiative, A. D. N. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24550 · Cited by 76 · see citing works
Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis
Lau, W. K., Leung, M.-K., Lee, T. M. C., & Law, A. C. K. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.55 · Cited by 64 · see citing works
Elderly patients have an altered gut-brain axis regardless of the presence of cirrhosis
Bajaj, J. S., Ahluwalia, V., Steinberg, J. L., Hobgood, S. E., Boling, P. A., Godschalk, M., Habib, S., White, M. B., Fagan, A., Gavis, E. A., et al. (2016) · Scientific Reports · doi:10.1038/srep38481 · Cited by 59 · see citing works
Neuroinflammation in Alzheimer’s Disease: Microglia, Molecular Participants and Therapeutic Choices
Wang, H., Shen, Y., Chuang, H.-Y., Chiu, C., Ye, Y., & Zhao, L. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190503151648 · Cited by 42 · see citing works
Frequency-Dependent Altered Functional Connections of Default Mode Network in Alzheimer’s Disease
Li, Y., Yao, H., Lin, P., Zheng, L., Li, C., Zhou, B., Wang, P., Zhang, Z., Wang, L., An, N., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00259 · Cited by 33 · see citing works
Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer’s Disease?
Hegde, V. K., Dhurandhar, N. V., & Reddy, P. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190808 · Cited by 23 · see citing works
Radiomicrobiomics: Advancing Along the Gut-brain Axis Through Big Data Analysis
Santis, S. D., Moratal, D., & Canals, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.055 · Cited by 18 · see citing works
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
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Barrio, C., Arias-Sánchez, S., & Martín-Monzón, I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105640 · Cited by 143 · see citing works
Altered gut microbiota in older adults with mild cognitive impairment: a case-control study
Fan, K.-C., Lin, C.-C., Liu, Y.-C., Chao, Y.-P., Lai, Y.-J., Chiu, Y.-L., & Chuang, Y.-F. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1162057 · Cited by 47 · see citing works
- Authors
- Liu, P., Jia, X., Chen, Y., Yu, Y., Zhang, K., Lin, Y., Wang, B., & Peng, G.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Center for Cognition and Brain Disorders Hangzhou Normal University Hangzhou China
- Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious Diseases College of Medicine The First Affiliated Hospital Zhejiang University Hangzhou China
- Department of Neurology College of Medicine The First Affiliated Hospital Zhejiang University Hangzhou China
- Venue
- CNS Neuroscience & Therapeutics
- Publisher
- Wiley
- Published
- 2020-09-15
- Volume
- 27
- Issue
- 2
- Pages
- 163-173
- ISSN
- 1755-5930 (ISSN-L)
- 1755-5949
- PMC
- PMC7816203
- OpenAlex
- W3084772352
- Cited by
- 87
- References
- 50
- Citations by year
- 2026: 14 · 2025: 8 · 2024: 13 · 2023: 17 · 2022: 24 · 2021: 10 · 2020: 1
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- CNS Neuroscience & Therapeutics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2019YFC0118203, 2016YFC130640, 2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- gut microbiota, amnestic mild cognitive impairment, intrinsic brain activity, resting-state functional connectivity, fractional amplitude of low-frequency fluctuations, cerebellum, Bacteroides, Ruminococcaceae, Clostridiaceae, Blautia, Veillonellaceae, Lachnospiraceae, cognitive function, attention, executive function
- MeSH terms
- Gastrointestinal Microbiome, Aged, Aged, 80 and over, Amnesia, Brain, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Case-Control Studies, Cognitive Dysfunction
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